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Volumn 23, Issue 2, 2003, Pages 629-635

The Tor pathway regulates gene expression by linking nutrient sensing to histone acetylation

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE; HISTONE DEACETYLASE; PROTEIN; PROTEIN ABF1; PROTEIN ESA1; PROTEIN RPD3; RAP PROTEIN; RAPAMYCIN; RIBOSOME PROTEIN; TARGET OF RAPAMYCIN KINASE; UNCLASSIFIED DRUG;

EID: 0037223438     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.23.2.629-635.2003     Document Type: Article
Times cited : (136)

References (49)
  • 1
    • 0033567954 scopus 로고    scopus 로고
    • NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p
    • Allard, S., R. T. Utley, J. Savard, A. Clarke, P. Grant, C. J. Brandl, L. Pillus, J. L. Workman, and J. Côté. 1999. NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p. EMBO J. 18:5108-5119.
    • (1999) EMBO J. , vol.18 , pp. 5108-5119
    • Allard, S.1    Utley, R.T.2    Savard, J.3    Clarke, A.4    Grant, P.5    Brandl, C.J.6    Pillus, L.7    Workman, J.L.8    Côté, J.9
  • 2
    • 0033540030 scopus 로고    scopus 로고
    • The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors
    • Beck, T., and M. N. Hall. 1999. The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors. Nature 402:689-692.
    • (1999) Nature , vol.402 , pp. 689-692
    • Beck, T.1    Hall, M.N.2
  • 3
    • 0032516080 scopus 로고    scopus 로고
    • The TOR (target of rapamycin) signal transduction pathway regulates the stability of translation initiation factor eIF4G in the yeast Saccharomyces cerevisiae
    • Berset, C., H. Trachsel, and M. Altmann. 1998. The TOR (target of rapamycin) signal transduction pathway regulates the stability of translation initiation factor eIF4G in the yeast Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 95:4264-4269.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 4264-4269
    • Berset, C.1    Trachsel, H.2    Altmann, M.3
  • 5
    • 0035933521 scopus 로고    scopus 로고
    • Recruitment of HAT complexes by direct activator interactions with the ATM-related Tra1 subunit
    • Brown, C. E., L. Howe, K. Sousa, S. C. Alley, M. J. Carrozza, S. Tan, and J. L. Workman. 2001. Recruitment of HAT complexes by direct activator interactions with the ATM-related Tra1 subunit. Science 292:2333-2337.
    • (2001) Science , vol.292 , pp. 2333-2337
    • Brown, C.E.1    Howe, L.2    Sousa, K.3    Alley, S.C.4    Carrozza, M.J.5    Tan, S.6    Workman, J.L.7
  • 6
    • 0033573016 scopus 로고    scopus 로고
    • The TOR signaling cascade regulates gene expression in response to nutrients
    • Cardenas, M. E., N. S. Cutler, M. C. Lorenz, C. J. D. Como, and J. Heitman. 1999. The TOR signaling cascade regulates gene expression in response to nutrients. Genes Dev. 13:3271-3279.
    • (1999) Genes Dev. , vol.13 , pp. 3271-3279
    • Cardenas, M.E.1    Cutler, N.S.2    Lorenz, M.C.3    Como, C.J.D.4    Heitman, J.5
  • 7
    • 0034700103 scopus 로고    scopus 로고
    • A chemical genomics approach toward understanding the global functions of the target of rapamycin protein (TOR)
    • Chan, T. F., J. Carvalho, L. Riles, and X. F. Zheng. 2000. A chemical genomics approach toward understanding the global functions of the target of rapamycin protein (TOR). Proc. Natl. Acad. Sci. USA 97:13227-13232.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 13227-13232
    • Chan, T.F.1    Carvalho, J.2    Riles, L.3    Zheng, X.F.4
  • 8
    • 0032965152 scopus 로고    scopus 로고
    • Esa1p is an essential histone acetyltransferase required for cell cycle progression
    • Clarke, A. S., J. E. Lowell, S. J. Jacobson, and L. Pillus. 1999. Esa1p is an essential histone acetyltransferase required for cell cycle progression. Mol. Cell. Biol. 19:2515-2526.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 2515-2526
    • Clarke, A.S.1    Lowell, J.E.2    Jacobson, S.J.3    Pillus, L.4
  • 9
    • 0035860714 scopus 로고    scopus 로고
    • The GATA transcription factors GLN3 and GAT1 link TOR to salt stress in Saccharomyces cerevisiae
    • Crespo, J. L., K. Daicho, T. Ushimaru, and M. N. Hall. 2001. The GATA transcription factors GLN3 and GAT1 link TOR to salt stress in Saccharomyces cerevisiae. J. Biol. Chem. 276:34441-34444.
    • (2001) J. Biol. Chem. , vol.276 , pp. 34441-34444
    • Crespo, J.L.1    Daicho, K.2    Ushimaru, T.3    Hall, M.N.4
  • 11
    • 0036211013 scopus 로고    scopus 로고
    • Histone acetylation: A switch between repressive and permissive chromatin
    • Eberharter, A., and P. B. Becker. 2002. Histone acetylation: A switch between repressive and permissive chromatin. EMBO Rep. 3:224-229.
    • (2002) EMBO Rep. , vol.3 , pp. 224-229
    • Eberharter, A.1    Becker, P.B.2
  • 12
    • 0034193776 scopus 로고    scopus 로고
    • Sir2 links chromatin silencing, metabolism, and aging
    • Guarente, L. 2000. Sir2 links chromatin silencing, metabolism, and aging. Genes Dev. 14:1021-1026.
    • (2000) Genes Dev. , vol.14 , pp. 1021-1026
    • Guarente, L.1
  • 13
    • 0033592983 scopus 로고    scopus 로고
    • Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins
    • Hardwick, J. S., F. G. Kuruvilla, J. K. Tong, A. F. Shamji, and S. L. Schreiber. 1999. Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins. Proc. Natl. Acad. Sci. USA 96:14866-14870.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 14866-14870
    • Hardwick, J.S.1    Kuruvilla, F.G.2    Tong, J.K.3    Shamji, A.F.4    Schreiber, S.L.5
  • 14
    • 0033064319 scopus 로고    scopus 로고
    • Mapping DNA interaction sites of chromosomal proteins using immunoprecipitation and polymerase chain reaction
    • Hecht, A., and M. Grunstein. 1999. Mapping DNA interaction sites of chromosomal proteins using immunoprecipitation and polymerase chain reaction. Methods Enzymol. 304:399-414.
    • (1999) Methods Enzymol. , vol.304 , pp. 399-414
    • Hecht, A.1    Grunstein, M.2
  • 15
    • 0029817763 scopus 로고    scopus 로고
    • Spreading of transcriptional repressor SIR3 from telomeric heterochromatin
    • Hecht, A., S. Strahl-Bolsinger, and M. Grunstein. 1996. Spreading of transcriptional repressor SIR3 from telomeric heterochromatin. Nature 383:92-96.
    • (1996) Nature , vol.383 , pp. 92-96
    • Hecht, A.1    Strahl-Bolsinger, S.2    Grunstein, M.3
  • 16
    • 0034722888 scopus 로고    scopus 로고
    • The rapamycin-sensitive signal transduction pathway as a target for cancer therapy
    • Hidalgo, M., and E. K. Rowinsky. 2000. The rapamycin-sensitive signal transduction pathway as a target for cancer therapy. Oncogene 19:6680-6686.
    • (2000) Oncogene , vol.19 , pp. 6680-6686
    • Hidalgo, M.1    Rowinsky, E.K.2
  • 17
    • 0037087576 scopus 로고    scopus 로고
    • Dynamics of global histone acetylation and deacetylation in vivo: Rapid restoration of normal histone actylation status upon removal of activators and repressors
    • Klein, C., and K. Struhl. 1994. Protein kinase A mediates growth-regulated expression of yeast ribosomal protein genes by modulating RAP1 transcriptional activity. Mol. Cell. Biol. 14:1920-1928
    • (2002) Genes Dev. , vol.16 , pp. 743-752
    • Katan-Khaykovich, Y.1    Struhl, K.2
  • 18
    • 0028209313 scopus 로고
    • Protein kinase A mediates growth-regulated expression of yeast ribosomal protein genes by modulating RAP1 transcriptional activity
    • Katan-Khaykovich, Y., and K. Struhl. 2002. Dynamics of global histone acetylation and deacetylation in vivo: Rapid restoration of normal histone actylation status upon removal of activators and repressors. Genes Dev. 16:743-752
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 1920-1928
    • Klein, C.1    Struhl, K.2
  • 19
    • 0034645038 scopus 로고    scopus 로고
    • Mechanism of metabolic control: Target of rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factors
    • Komeili, A., K. P. Wedaman, E. K. O'Shea, and T. Powers. 2000. Mechanism of metabolic control: Target of rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factors. J. Cell Biol. 151:863-878.
    • (2000) J. Cell Biol. , vol.151 , pp. 863-878
    • Komeili, A.1    Wedaman, K.P.2    O'Shea, E.K.3    Powers, T.4
  • 20
    • 0033542436 scopus 로고    scopus 로고
    • Binding of TBP to promoters in vivo is stimulated by activators and requires Pol II holoenzyme
    • Kuras, L., and K. Struhl. 1999. Binding of TBP to promoters in vivo is stimulated by activators and requires Pol II holoenzyme. Nature 399:609-613.
    • (1999) Nature , vol.399 , pp. 609-613
    • Kuras, L.1    Struhl, K.2
  • 21
    • 0032929162 scopus 로고    scopus 로고
    • DNA-binding requirements of the yeast protein Rap1p as selected in silico from ribosomal protein gene promoter sequences
    • Lascaris, R. F., W. H. Mager, and R. J. Planta. 1999. DNA-binding requirements of the yeast protein Rap1p as selected in silico from ribosomal protein gene promoter sequences. Bioinformatics 15:267-277.
    • (1999) Bioinformatics , vol.15 , pp. 267-277
    • Lascaris, R.F.1    Mager, W.H.2    Planta, R.J.3
  • 22
    • 0037087573 scopus 로고    scopus 로고
    • Specific targeting and constitutive association of histone deacetylase complexes during transcriptional repression
    • Li, J., Q. Lin, W. Wang, P. Wade, and J. Wong. 2002. Specific targeting and constitutive association of histone deacetylase complexes during transcriptional repression. Genes Dev. 16:687-692.
    • (2002) Genes Dev. , vol.16 , pp. 687-692
    • Li, J.1    Lin, Q.2    Wang, W.3    Wade, P.4    Wong, J.5
  • 23
    • 0034934774 scopus 로고    scopus 로고
    • Promoter-specific binding of Rap1 revealed by genome-wide maps of protein-DNA association
    • Lieb, J. D., X. Liu, D. Botstein, and P. O. Brown. 2001. Promoter-specific binding of Rap1 revealed by genome-wide maps of protein-DNA association. Nat. Genet. 28:327-334.
    • (2001) Nat. Genet. , vol.28 , pp. 327-334
    • Lieb, J.D.1    Liu, X.2    Botstein, D.3    Brown, P.O.4
  • 24
    • 0034703217 scopus 로고    scopus 로고
    • Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
    • Lin, S. J., P. A. Defossez, and L. Guarente. 2000. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289:2126-2128.
    • (2000) Science , vol.289 , pp. 2126-2128
    • Lin, S.J.1    Defossez, P.A.2    Guarente, L.3
  • 25
    • 0027931137 scopus 로고
    • Modulation of transcription of rRNA genes by rapamycin
    • Mahajan, P. B. 1994. Modulation of transcription of rRNA genes by rapamycin. Int. J. Immunopharmacol. 16:711-721.
    • (1994) Int. J. Immunopharmacol. , vol.16 , pp. 711-721
    • Mahajan, P.B.1
  • 26
    • 0035928843 scopus 로고    scopus 로고
    • Bench to bedside: The development of rapamycin and its application to stent restenosis
    • Marx, S. O., and A. R. Marks. 2001. Bench to bedside: The development of rapamycin and its application to stent restenosis. Circulation 104:852-855.
    • (2001) Circulation , vol.104 , pp. 852-855
    • Marx, S.O.1    Marks, A.R.2
  • 27
    • 0034127687 scopus 로고    scopus 로고
    • In Saccharomyces cerevisiae, expression of arginine catabolic genes CAR1 and CAR2 in response to exogenous nitrogen availability is mediated by the Ume6 (CargRI)-Sin3 (CargRII)-Rpd3 (CargRIII) complex
    • Messenguy, F., F. Vierendeels, B. Scherens, and E. Dubois. 2000. In Saccharomyces cerevisiae, expression of arginine catabolic genes CAR1 and CAR2 in response to exogenous nitrogen availability is mediated by the Ume6 (CargRI)-Sin3 (CargRII)-Rpd3 (CargRIII) complex. J. Bacteriol. 182:3158-3164.
    • (2000) J. Bacteriol. , vol.182 , pp. 3158-3164
    • Messenguy, F.1    Vierendeels, F.2    Scherens, B.3    Dubois, E.4
  • 28
    • 0035313756 scopus 로고    scopus 로고
    • Enzymatic activities of Sir2 and chromatin silencing
    • Moazed, D. 2001. Enzymatic activities of Sir2 and chromatin silencing. Curr. Opin. Cell Biol. 13:232-238.
    • (2001) Curr. Opin. Cell Biol. , vol.13 , pp. 232-238
    • Moazed, D.1
  • 30
    • 0029069323 scopus 로고
    • Nutrient availability and the RAS/cyclic AMP pathway both induce expression of ribosomal protein genes in Saccharomyces cerevisiae but by different mechanisms
    • Neuman-Silberberg, F. S., S. Bhattacharya, and J. R. Broach. 1995. Nutrient availability and the RAS/cyclic AMP pathway both induce expression of ribosomal protein genes in Saccharomyces cerevisiae but by different mechanisms. Mol. Cell. Biol. 15:3187-3196.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 3187-3196
    • Neuman-Silberberg, F.S.1    Bhattacharya, S.2    Broach, J.R.3
  • 31
    • 0033532045 scopus 로고    scopus 로고
    • Protein kinase C enables the regulatory circuit that connects membrane synthesis to ribosome synthesis in Saccharomyces cerevisiae
    • Nierras, C. R., and J. R. Warner. 1999. Protein kinase C enables the regulatory circuit that connects membrane synthesis to ribosome synthesis in Saccharomyces cerevisiae. J. Biol. Chem. 274:13235-13241.
    • (1999) J. Biol. Chem. , vol.274 , pp. 13235-13241
    • Nierras, C.R.1    Warner, J.R.2
  • 32
    • 0036310982 scopus 로고    scopus 로고
    • The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation
    • Peng, T., T. R. Golub, and D. M. Sabatini. 2002. The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation. Mol. Cell. Biol. 22:5575-5584.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 5575-5584
    • Peng, T.1    Golub, T.R.2    Sabatini, D.M.3
  • 33
    • 0031407447 scopus 로고    scopus 로고
    • Regulation of ribosome synthesis in yeast
    • Planta, R. J. 1997. Regulation of ribosome synthesis in yeast. Yeast 13:1505-1518.
    • (1997) Yeast , vol.13 , pp. 1505-1518
    • Planta, R.J.1
  • 35
    • 0032915417 scopus 로고    scopus 로고
    • Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae
    • Powers, T., and P. Walter. 1999. Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae. Mol. Biol. Cell 10:987-1000.
    • (1999) Mol. Biol. Cell , vol.10 , pp. 987-1000
    • Powers, T.1    Walter, P.2
  • 37
    • 0034515772 scopus 로고    scopus 로고
    • Coordinate regulation of yeast ribosomal protein genes is associated with targeted recruitment of Esa1 histone acetylase
    • Reid, J. L., V. R. Iyer, P. O. Brown, and K. Struhl. 2000. Coordinate regulation of yeast ribosomal protein genes is associated with targeted recruitment of Esa1 histone acetylase. Mol. Cell 6:1297-1307.
    • (2000) Mol. Cell , vol.6 , pp. 1297-1307
    • Reid, J.L.1    Iyer, V.R.2    Brown, P.O.3    Struhl, K.4
  • 38
    • 0035971180 scopus 로고    scopus 로고
    • The Tor kinases link nutrient sensing to cell growth
    • Rohde, J., J. Heitman, and M. E. Cardenas. 2001. The Tor kinases link nutrient sensing to cell growth. J. Biol. Chem. 276:9583-9586.
    • (2001) J. Biol. Chem. , vol.276 , pp. 9583-9586
    • Rohde, J.1    Heitman, J.2    Cardenas, M.E.3
  • 39
    • 0029856225 scopus 로고    scopus 로고
    • HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription
    • Rundlett, S. E., A. A. Carmen, R. Kobayashi, S. Bavykin, B. M. Turner, and M. Grunstein. 1996. HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. Proc. Natl. Acad. Sci. USA 93:14503-14508.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 14503-14508
    • Rundlett, S.E.1    Carmen, A.A.2    Kobayashi, R.3    Bavykin, S.4    Turner, B.M.5    Grunstein, M.6
  • 40
    • 0032560117 scopus 로고    scopus 로고
    • Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3
    • Rundlett, S. E., A. A. Carmen, N. Suka, B. M. Turner, and M. Grunstein. 1998. Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3. Nature 392:831-835.
    • (1998) Nature , vol.392 , pp. 831-835
    • Rundlett, S.E.1    Carmen, A.A.2    Suka, N.3    Turner, B.M.4    Grunstein, M.5
  • 41
    • 0034644525 scopus 로고    scopus 로고
    • TOR, a central controller of cell growth
    • Schmelzle, T., and M. N. Hall. 2000. TOR, a central controller of cell growth. Cell 103:253-262.
    • (2000) Cell , vol.103 , pp. 253-262
    • Schmelzle, T.1    Hall, M.N.2
  • 42
    • 0032403058 scopus 로고    scopus 로고
    • The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease
    • Schmidt, A., T. Beck, A. Koller, J. Kunz, and M. N. Hall. 1998. The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease. EMBO J. 17:6924-6931.
    • (1998) EMBO J. , vol.17 , pp. 6924-6931
    • Schmidt, A.1    Beck, T.2    Koller, A.3    Kunz, J.4    Hall, M.N.5
  • 43
    • 0034721255 scopus 로고    scopus 로고
    • Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
    • Shapiro, A. M., J. R. Lakey, E. A. Ryan, G. S. Korbutt, E. Toth, G. L. Warnock, N. M. Kneteman, and R. V. Rajotte. 2000. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N. Engl. J. Med. 343:230-238.
    • (2000) N. Engl. J. Med. , vol.343 , pp. 230-238
    • Shapiro, A.M.1    Lakey, J.R.2    Ryan, E.A.3    Korbutt, G.S.4    Toth, E.5    Warnock, G.L.6    Kneteman, N.M.7    Rajotte, R.V.8
  • 45
    • 0032915376 scopus 로고    scopus 로고
    • A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors
    • Smith, J. S., E. Caputo, and J. D. Boeke. 1999. A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors. Mol. Cell. Biol. 19:3184-3197.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 3184-3197
    • Smith, J.S.1    Caputo, E.2    Boeke, J.D.3
  • 46
    • 0033538531 scopus 로고    scopus 로고
    • Fundamentally different logic of gene regulation in eukaryotes and prokaryotes
    • Struhl, K. 1999. Fundamentally different logic of gene regulation in eukaryotes and prokaryotes. Cell 98:1-4.
    • (1999) Cell , vol.98 , pp. 1-4
    • Struhl, K.1
  • 47
    • 0025881033 scopus 로고
    • Separation of transcriptional activation and silencing functions of the RAP1-encoded repressor/activator protein 1: Isolation of viable mutants affecting both silencing and telomere length
    • Sussel, L., and D. Shore. 1991. Separation of transcriptional activation and silencing functions of the RAP1-encoded repressor/activator protein 1: Isolation of viable mutants affecting both silencing and telomere length. Proc. Natl. Acad. Sci. USA 88:7749-7753.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 7749-7753
    • Sussel, L.1    Shore, D.2
  • 48
    • 0033229970 scopus 로고    scopus 로고
    • The economics of ribosome biosynthesis in yeast
    • Warner, J. R. 1999. The economics of ribosome biosynthesis in yeast. Trends Biochem. Sci. 24:437-440.
    • (1999) Trends Biochem. Sci. , vol.24 , pp. 437-440
    • Warner, J.R.1
  • 49
    • 0031596416 scopus 로고    scopus 로고
    • 0 program of transcriptional repression in yeast by interfering with the TOR signaling pathway
    • 0 program of transcriptional repression in yeast by interfering with the TOR signaling pathway. Mol. Cell. Biol. 18:4463-4470.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 4463-4470
    • Zaragoza, D.1    Ghavidel, A.2    Heitman, J.3    Schultz, M.C.4


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