The expression of fatty acid synthase (FASE) is an early event in the development and progression of squamous cell carcinoma of the lung

Human Pathology

Volumn 31, Issue 9, 2000, Pages 1068-1073

  Piyathilake, Chandrika J ^a   Frost, Andra R ^a   Manne, Upender ^a   Bell, Walter C ^a   Weiss, Heidi ^a   Heimburger, Douglas C ^a   Grizzle, William E ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Fatty acid synthase; Lung carcinoma

Indexed keywords

FATTY ACID SYNTHASE;

ADVANCED CANCER; ARTICLE; BRONCHUS MUCOSA; CANCER GROWTH; CONTROLLED STUDY; CYTOTOXICITY; DISEASE MARKER; EPITHELIUM HYPERPLASIA; FATTY ACID SYNTHESIS; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INVASIVE CARCINOMA; LUNG CARCINOGENESIS; LUNG CARCINOMA; MALIGNANT TRANSFORMATION; PROGNOSIS; SQUAMOUS CELL CARCINOMA;

EID: 0033808261     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1053/hupa.2000.9842     Document Type: Article

References (29)

1. Biologic, physiologic, and technical determinants in surgical therapy for lung cancer
2. Prognosis and survival in resected lung carcinoma based on the new international staging system
3. Animal and bacterial fatty acid synthetase: Structure, function and regulation
4. The animal fatty acid synthase: One gene, one polypeptide, seven enzymes
5. Fatty acid biosynthesis in man; a pathway of minor importance: Purification, optimal assay conditions, and organ distribution of fatty acid synthase
6. Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival
7. Immunohistochemical detection of a fatty acid synthase (OA-519) as a predictor of progression of prostate cancer
8. Expression of fatty acid synthase (FASE) as a predictor of recurrence in stage I breast carcinoma patients
9. Elevated expression of fatty acid synthase and fatty acid synthetic activity in colorectal neoplasia
10. Fatty acid synthesis: A potential selective target for antineoplastic therapy
11. Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells
12. OA-519 (fatty acid synthase) as an independent predictor of pathologic state in adeno-carcinoma of the prostate
13. Expression of OA 519 (Haptoglobin-related protein epitopes) in colorectal carcinomas: Comparison with molecular genetic alterations and metastasis
14. Nuclear accumulation of p53 in colorectal adenocarcinomas: Prognostic importance differs with race and location of the tumor
15. Immunohistochemical evaluation of biomarkers in prostatic and colorectal neoplasia
16. Human fatty acid synthesis is stimulated by a eucaloric low fat, high carbohydrate diet
17. Human fatty acid synthesis is reduced after the substitution of dietary starch for sugar
18. Progestin-induced fatty acid synthetase in breast cancer. From molecular biology to clinical applications
19. Progestin-induced fatty acid synthetase in human mammary tumors: From molecular to clinical studies
20. Expression of oncogenic antigen 519 (OA-519) in prostate cancer is a potential prognostic indicator
21. Fatty acid synthase expression in endometrial carcinoma: Correlation with cell proliferation and hormone receptors
22. Expression of haptoglobin-related protein in primary and metastatic breast cancers
23. Fatty acid synthase expression is increased in neoplastic lesions of the oral tongue
24. Allele-specific chromosome 3p deletions occur at an early stage in the pathogenesis of lung carcinoma
25. Allele-specific loss in chromosome 9p loci in preneoplastic lesions accompanying non-small-cell lung cancers
26. Sequential molecular abnormalities are involved in the multistage development of squamous cell lung carcinoma
27. Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines
28. Fatty acid synthase (FAS): A target for cytotoxic antimetabolites in HL60 promyelocytic leukemia cells