Immunohistochemical expression of fatty acid synthase, apoptotic- regulating genes, proliferating factors, and ras protein product in colorectal adenomas, carcinomas, and adjacent nonneoplastic mucosa

Clinical Cancer Research

Volumn 5, Issue 12, 1999, Pages 4111-4118

  Visca, Paolo ^a   Alò, Piero Luigi ^b   Del Nonno, Franca ^a   Botti, Claudio ^a   Trombetta, Giorgio ^b   Marandino, Ferdinando ^a   Filippi, Stefania ^a   Di Tondo, Ugo ^b   Donnorso, Raffaele Perrone ^a  

^a REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID SYNTHASE; RAS PROTEIN;

APOPTOSIS; ARTICLE; CANCER STAGING; CANCER SURVIVAL; COLON CARCINOGENESIS; COLON MUCOSA; COLORECTAL CARCINOMA; COLORECTAL TUMOR; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADENOMA; ANTIGENS, CD95; APOPTOSIS; CARCINOMA; COLORECTAL NEOPLASMS; FATTY ACID SYNTHETASE COMPLEX; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GROWTH SUBSTANCES; HUMANS; IMMUNOHISTOCHEMISTRY; INTESTINAL MUCOSA; KI-67 ANTIGEN; MALE; MIDDLE AGED; ONCOGENE PROTEIN P21(RAS); PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-MYC; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0033386501     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Kikuchi, Y., Dinjens, W. N. M., and Bosman, F. T. Proliferation and apoptosis in proliferative lesions of the colon and rectum. Virchows Arch., 431: 111-117, 1997.
2. Langlois, N. E. I., Lamb, J., Eremin, O., and Heys, S. D. Apoptosis in colorectal carcinoma occurring in patients aged 45 years and under: relationship to prognosis, mitosis, and immunohistochemical demonstration of p53, c-myc and bcl-2 protein products. J. Pathol., 182: 392-397, 1997.
3. Baker, S. J., Preisinger, A. C., Jessup, J. M., Paraskeva, C., Markowitz, S., Willson, J. K. V., Hamilton, S., and Vogelstein, B. p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis. Cancer Res., 50: 7717-7722. 1990.
4. Melhem, M. F., Meisler, A. I., Finley, G. G., Bryce, W. H., Jons, M. O., Tribby, I. I., Pipas, J. M., and Koski, R. A. Distribution of cells expressing myc proteins in human colorectal epithelium, polyps, and malignant tumors. Cancer Res., 52: 5853-5864, 1992.
5. Sinicrope, F. A., Ruan, R. S., Cleary, K. R., Stephens, L. C., Lee, J. J., and Levin, B. bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis. Cancer Res., 55: 237-241, 1995.
6. Magrisso, I. J., Richmond, R. E., Carter, J. H., Pross, C. B., Gilfillen, R. A., and Carter, H. W. Immunohistochemical detection of RAS, JUN, FOS and p53 oncoprotein expression in human colorectal adenomas and carcinomas. Lab. Invest., 69: 674-681, 1993.
7. McCarthy, A. D., and Hardie, D. G. Fatty acid synthase: an example of protein evolution by gene fusion. Trends. Biochem. Sci., 9: 60-63, 1984.
8. Paulaskis, J. D., and Sul, H. S. Hormonal regulation of mouse fatty acid synthase gene transcription in liver. J. Biol. Chem., 264: 574-577, 1989.
9. Weiss, L., Hoffmann, G. E., Schreiber, R., Andres, H., Fuchs, E., and Korber, E. Fatty-acid biosynthesis in man: a pathway of minor importance. Biol. Chem. Hoppe-Seyler, 367: 905-912, 1986.
10. Pizer, E. S., Lax, S. F., Kuhajda, F. P., Pasternack, G. R., and Kurman, R. J. Fatty acid synthase expression in endometrial carcinoma. Correlation with cell proliferation and hormone receptors. Cancer (Phila.), 83: 528-537, 1998.
11. Alò, P. L., Visca, P., Marci, A., Mangoni, A., Botti, C., and Di Tondo, U. Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients. Cancer (Phila.), 77: 474-482, 1996.
12. Milgraum, L. Z., Witters, L. A., Pasternack, G. R., and Kuhajda, F. P. Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma. Clin. Cancer Res., 11: 2115-2120, 1997.
13. Rashid, A., Pizer, E. S., Moga, M., Milgraum, L. Z., Zahurak, M., Pasternack, G. R., Kuhajda, F. P., and Hamilton, S. R. Elevated expression of fatty acid synthase and fatty acid synthetic activity in colorectal neoplasia. Am. J. Pathol., 150: 201-208, 1997.
14. Hsu, S. M., Raine, L., Fanger, H. The use of avidin-biotin peroxidase complex (ABC) in immunoperoxidase technique: a comparison between ABC and unlabelled antibody (PAP) procedures. J. Histochem. Cytochem., 29: 577-580, 1981.
15. Kaklamanis, L., Savage, A., Motersen, N., Tsiotos, P., Doussis-Anagnostopoulou, I., Biddolph, S., Whitehouse, R., Harris, R. A., and Gatter, K. C. Early expression of bcl-2 protein in the adenomacarcinoma sequence of colorectal neoplasia. J. Pathol., 179: 10-14, 1996.
16. Mueller, J., Mueller, E., Hoepner, I., Jutting, J., Bethke, B., Stolte, M., and Hofler, H. Expression of bcl-2 and p53 in de novo and exadenoma colon carcinoma: a comparative immunohistochemical study. J. Pathol, 180: 159-265, 1996.
17. Baretton, G. B., Diebold, J., Christoforis, G., Vogt, M., Muller, C., Dopfer, K., Schneiderbanger, K., Schmidt, M., and Lohrs, U. Apoptosis and immunohistochemical bcl-2 expression in colorectal adenomas and carcinomas. Aspects of carcinogenesis and prognostic significance. Cancer (Phila.), 77: 255-264, 1996.
18. Hamelin, R., Laurent-Puig, P., Olschwang, S., Jego, N., Asselain, B., Remvikos, Y., Girodet, J., Salmon, R. J., and Thomas, G. Association of p53 mutations with short survival in colorectal cancer. Gastroenterology, 106: 42-48, 1994.
19. Yamaguchi, A., Kurosawa, Y., Kanno, M., Yonemura, Y., and Miwa, I. Expression of p53 protein in colorectal cancer and its relationship to short time prognosis. Cancer (Phila.), 70: 2778-2784, 1992.
20. Dixon, W. J., (ed.), BMDP Statistical Software, pp. 143-208, 519- 537, 555-559. Berkeley, CA: University of California Press, 1985.
21. Shurbaji, M. S., Kalbfleisch, J. H., and Thurmond, T. S. Immunohistochemical detection of fatty acid synthase (OA-519) as a predictor of progression of prostate cancer. Hum. Pathol., 27: 917-921, 1996.
22. Shurbaji, M. S., Kuhajda, F. P, Pasternack, G. P., and Thurmond, T. S. Expression of oncogenic 519 (OA-519) in prostate cancer is a potential prognostic indicator. Am. J. Clin. Pathol., 97: 686-691, 1991.
23. Pizer, E. S., Jackisch, C., Wood, F. D., Pasternack, G. R., Davidson, N. E., and Kuhayda, F. P. Inhibition of fatty acid synthesis induces cell death in human breast cancer cells. Cancer Res., 56: 2745-2747. 1996.
24. Roux-Dosseto, M., Romain, S., Dussault, N., Desideri, C., Piana, L., Bonnier, P., Tubiana, N., and Martin, P. M. c-myc gene amplification in selected node-negative breast cancer patients correlates with high rate of early relapse. Eur. J. Cancer, 28A: 1600-1604, 1992.
25. Hehir, D. J., McGreal, G., Kirwan, W. O., Kealy, W., and Brady, M. P. c-myc oncogene expression: a marker for female at risk of breast carcinoma. J. Surg. Oncol., 54: 207-210, 1993.
26. Flohil, C. C., Janssen, P. A., and Bosman, F. T. Expression of bcl-2 protein in hyperplastic polyps, adenomas, and carcinomas of the colon. J. Pathol., 178: 393-397, 1996.
27. Lu, Q. L., Abel, P., Foster, C. S., and Lalani, E. N. Bcl-2: role in epithelial differentiation and oncogenesis. Hum. Pathol., 27: 102-110, 1996.
28. Bosari, S., Moneghini, L., Graziani, D., Lee, A. K. C., Murray, J. J., Coggi, G., and Viale, G. Bcl-2 oncoprotein in colorectal hyperplastic polyps, adenomas, and adenocarcinomas. Hum. Pathol., 26: 534-540, 1995.
29. Horan Hand, P., Thor, A., Wunderlich, D., Muraro, R., Caruso, A., and Schlom, J. Monoclonal antibodies of predefined specificity detect activated ras gene expression in human mammary and colon carcinomas. Proc. Natl. Acad. Sci. USA, 81: 5227-5231, 1984.
30. ras in normal and malignant human tissue: lack of association with proliferation and malignancy. Proc. Natl. Acad. Sci. USA, 84: 3234-3238, 1987.
31. Jansson, D. S., Radosevich, J. A., Carney, W. P., Rosen, S. T., Schlom, J., Staren, E. D., Hyser, M. J., and Gould, V. E. An immunohistochemical analysis of ras oncogene expression in epithelial neoplasm of the colon. Cancer (Phila.), 65: 1329-1337, 1990.
32. Pizer, E. S., Wood, F. D., Pasternack, G. R., and Kuhajda, F. P. Fatty acid synthase (FAS): a target for cytotoxic antimetabolites in HL60 promyelocytic leukemia cells. Cancer Res., 56: 745-751, 1996.
33. Pizer, E. P., Wood, F. W., Heine, H. S., Romantsev, F. R., Pasternack, G. R., and Kuhajda, F. P. Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer. Cancer Res., 56: 1189-1193, 1996.