Low alpha-linolenic acid content of adipose breast tissue is associated with an increased risk of breast cancer

European Journal of Cancer

Volumn 36, Issue 3, 2000, Pages 335-340

  Klein, V ^a   Chajes V ^a   Germain, E ^a   Schulgen, G ^b   Pinault, M ^a   Malvy, D ^e   Lefrancq, T ^a   Fignon, A ^a   Le Floch, O ^a   Lhuillery, C ^c   Bougnoux, P ^a,d  

^a UNIVERSITY HOSPITAL OF TOURS   (France)

^b INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^c CEMAGREF   (France)

^d CHU BRETONNEAU   (France)

^e NONE

Author keywords

Adipose tissue; Alpha linolenic acid; Breast cancer

Indexed keywords

BIOLOGICAL MARKER; LINOLENIC ACID;

ADIPOSE TISSUE; ADULT; AGED; ARTICLE; BIOPSY; BREAST; BREAST CANCER; CASE CONTROL STUDY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIETARY INTAKE; FEMALE; FRANCE; GAS CHROMATOGRAPHY; HISTOCHEMISTRY; HUMAN; LIPID ANALYSIS; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; REGRESSION ANALYSIS; RISK; RISK ASSESSMENT; RISK FACTOR;

ADIPOSE TISSUE; ADULT; AGED; ALPHA-LINOLENIC ACID; BREAST; BREAST DISEASES; BREAST NEOPLASMS; CASE-CONTROL STUDIES; CHROMATOGRAPHY, GAS; DIET; FATTY ACIDS; FEMALE; HUMANS; LOGISTIC MODELS; MIDDLE AGED; ODDS RATIO; RISK;

EID: 0034000680     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(99)00254-3     Document Type: Article

References (30)

1. Cohen LA, Thompson DO, Maeura Y, Choi K, Blank ME, Rose DP. Dietary fat and mammary cancer. I. Promoting effects of different dietary fats on N-nitrosomethylurea-induced rat mammary tumorigenesis. J Natl Cancer Inst 1986, 77, 33-42.
2. Fay MP, Freedman LS, Clifford CK, Midthune DN. Effect of different types and amounts of fat on the development of mammary tumors in rodents: a review. Cancer Res 1997, 57, 3979-3988.
3. Kamano K, Okuyama H, Konishi R, Nagasawa H. Effects of a high-linoleate and high-alpha-linolenate diet on spontaneous mammary tumorigenesis in mice. Anticancer Res 1989, 9, 1903-1908.
4. Fritsche KL, Johnston PV. Effect of dietary alpha-linolenic acid on growth, metastasis, fatty acid profile and prostaglandin production of two murine mammary adenocarcinomas. J Nutr 1990, 120, 1601-1609.
5. Hirose M, Masuda A, Ito N, Kamano K, Okuyama H. Effects of dietary perilla oil, soybean oil and safflower oil on 7,12-dimethylbenz (a) anthracene (DMBA) and 1,2-dimethylhydrazine (DMH)-induced mammary gland and colon carcinogenesis in female SD rats. Carcinogenesis 1990, 11, 731-735.
6. Munoz SF, Silva RA, Lamarque A, Guzman CA, Eynard AR. Protective capability of dietary Zizyphus mistol seed oil, rich in 18/3, n-3, on the development of two murine mammary gland adenocarcinomas with high or low metastatic potential. Prostaglandins Leukot Essent Fatty Acids 1995, 53, 135-138.
7. Chajès V, Sattler W, Stranzl A, Kostner GM. Influence of n-3 fatty acids on the growth of human breast cancer cells in vitro: relationship to peroxides and vitamin E. Breast Cancer Res Treat 1995, 34, 199-212.
8. Franceschi S, Favero A, Decarli A, et al. Intake of macronutrients and risk of breast cancer. Lancet 1996, 347, 1351-1356.
9. De Stefani E, Deneo-Pellegrini H, Mendilaharsu M, Ronco A. Essential fatty acids and breast cancer: a case-control study in Uruguay. Int J Cancer 1998, 76, 491-494.
10. Prentice RL, Pepe M, Self SG. Dietary fat and breast cancer: a quantitative assessment of the epidemiological literature and a discussion of methodological issues. Cancer Res 1989, 49, 3147-3156.
11. Riboli E, Rönnholm H, Saracci R. Biological markers of diet. Cancer Surveys 1987, 6, 685-718.
12. Field CJ, Clandinin MT. Modulation of adipose tissue fat composition by diet: a review. Nutr Res 1984, 4, 743-755.
13. Van Staveren WA, Deurenberg P, Katan MB, et al. Validity of the fatty acid composition of subcutaneous fat tissue microbiopsies as an estimate of the long-term average fatty acid composition of the diet of separate individuals. Am J Epidemiol 1986, 123, 455-463.
14. London SJ, Sacks FM, Caesar J, Stampfer MJ, Siguel E, Willett WC. Fatty acid composition of subcutaneous adipose tissue and diet in postmenopausal US women. Am J Clin Nutr 1991, 54, 340-345.
15. Kohlmeier L, Kohlmeier M. Adipose tissue as a medium for epidemiologic exposure assessment. Environ Health Perspect 1995, 103, 99-106.
16. Bougnoux P, Koscielny S, Chajès V, Descamps P, Couet C, Calais G. Alpha-linolenic acid content of adipose breast tissue: a host determinant of the risk of early metastasis in breast cancer. Br J Cancer 1994, 70, 330-334.
17. Chajès V, Niyongabo T, Lanson M, Fignon A, Couet C, Bougnoux P. Fatty-acid composition of breast and iliac adipose tissue in breast-cancer patients. Int J Cancer 1992, 50, 1-4.
18. Martin JC, Niyongabo T, Moreau L, et al. Essential fatty acid composition of human colostrum triglycerides: its relationship with adipose tissue composition. Am J Clin Nutr 1991, 54, 829-835.
19. Breslow NE, Day NE. Statistical Methods in Cancer Research. Vol. I: The Analysis of Case-Control Studies. Lyon, IARC Scientific Publication, 1980.
20. London SJ, Sacks FM, Stampfer MJ, et al. Fatty acid composition of the subcutaneous adipose tissue and risk of proliferative benign breast disease and breast cancer. J Natl Cancer Inst 1993, 85, 785-793.
21. Petrek JA, Hudgins LC, Levine B, Ho MN, Hirsch J. Breast cancer risk and fatty acids in the abdominal adipose tissues. J Natl Cancer Inst 1994, 86, 53-56.
22. Zhu ZR, Agren J, Männistö S, et al. Fatty acid composition of breast adipose tissue in breast cancer patients and in patients with benign breast disease. Nutr Cancer 1995, 24, 151-160.
23. Eid A, Berry EM. The relationship between dietary fat, adipose tissue composition, and neoplasms of the breast. Nutr Cancer 1988, 11, 173-177.
24. Simonsen N, Van't Veer P, Strain JJ, et al. Adipose tissue omega-3 and omega-6 fatty acid content and breast cancer in the EURAMIC study. Am J Epidemiol 1998, 147, 342-352.
25. Field CJ, Angle A, Clandinin MT. Relationship of diet to the fatty acid composition of human adipose tissue structural and stored lipids. Am J Clin Nutr 1985, 42, 1206-1220.
26. Tjønneland A, Overad K, Thorling E, Ewertz M. Adipose tissue fatty acids as biomarkers of dietary exposure in Danish men and women. J Clin Nutr 1993, 57, 629-633.
27. Carroll KK, Parenteau HI. A suggested mechanism for effects of diet on mammary cancer. Nutr Res 1992, 12, S152-S161.
28. Lhuillery C, Bougnoux P, Groscolas R, Durand G. Time-course study of adipose tissue fatty acids during mammary tumor growth in rats with controlled fat intake. Nutr Cancer 1995, 24, 299-309.
29. Cunnane SC, Chen ZY, Yang J, Liede AC, Hamadeh M, Crawford MA. Alpha-linolenic acid in humans: direct functional role or dietary precursor? Nutrition 1991, 7, 437-439.
30. Chajès V, Lhuillery C, Sattler W, Kostner GM, Bougnoux P. Alpha-tocopherol and hydroperoxide content in breast adipose tissue from patients with breast tumors. Int J Cancer 1996, 67, 170-175.