Overexpression and hyperactivity of breast cancer-associated fatty acid synthase (oncogenic antigen-519) is insensitive to normal arachidonic fatty acid-induced suppression in lipogenic tissues but it is selectively inhibited by tumoricidal alpha-linolenic and gamma-linolenic fatty acids: a novel mechanism by which dietary fat can alter mammary tumorigenesis.

International journal of oncology

Volumn 24, Issue 6, 2004, Pages 1369-1383

  Menendez, Javier A ^a   Ropero, Santiago ^a   Mehmi, Inderjit ^a   Atlas, Ella ^a   Colomer, Ramon ^a   Lupu, Ruth ^a  

^a Evanston Northwestern Research Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID DERIVATIVE; CERULENIN; ENZYME INHIBITOR; FATTY ACID SYNTHASE; GAMMA LINOLENIC ACID; LINOLENIC ACID; MITOGEN ACTIVATED PROTEIN KINASE;

ADIPOCYTE; ARTICLE; BREAST TUMOR; CELL CULTURE; CELL DIVISION; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECT; ENZYMOLOGY; FAT INTAKE; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMAN; METABOLISM; PATHOLOGY; WESTERN BLOTTING;

ADIPOCYTES; ALPHA-LINOLENIC ACID; ARACHIDONIC ACIDS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL DIVISION; CERULENIN; DIETARY FATS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENZYME INHIBITORS; FATTY ACID SYNTHETASE COMPLEX; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GAMMA-LINOLENIC ACID; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; TUMOR CELLS, CULTURED;

EID: 11144348618     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (0)