Uncoupling Protein 2 and Islet Function

Diabetes

Volumn 53, Issue SUPPL. 1, 2004, Pages

  Chan, Catherine B ^a   Saleh, Monique C ^a   Koshkin, Vasilij ^b   Wheeler, Michael B ^b  

^a UNIVERSITY OF PRINCE EDWARD ISLAND   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; SUPEROXIDE; UNCOUPLING PROTEIN 2;

CELL PROTECTION; CHRONIC DISEASE; CONFERENCE PAPER; DISEASE PREDISPOSITION; HYPERGLYCEMIA; HYPERLIPIDEMIA; INSULIN RELEASE; KNOCKOUT MOUSE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS FUNCTION; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRESS;

EID: 0842284795     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.53.2007.s136     Document Type: Conference Paper

References (60)

1. Busch AK, Cordery D, Denyer GS, Biden TJ: Expression profiling of palmitate- and oleate-regulated genes provides novel insights into the effects of chronic lipid exposure on pancreatic β-cell function. Diabetes 51:977-993, 2002
2. Xiao J, Gregersen S, Kruhoffer M, Pedersen SB, Orntoft TF, Hermansen K: The effect of chronic exposure to fatty acids on gene expression in clonal insulin-producing cells: studies using high density oligonucleotide microarray. Endocrinology 142:4777-4784, 2001
3. Prentki M, Corkey BE: Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM? Diabetes 45:273-283, 1996
4. Zhou YT, Shimabukuro M, Koyama K, Lee Y, Wang MY, Trieu F, Newgard CB, Unger RH: Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation. Proc Natl Acad Sci U S A 94:6386-6390, 1997
5. Chan CB, MacDonald PE, Saleh MC, Johns DC, Marban E, Wheeler MB: Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets. Diabetes 48:1482-1486, 1999
6. Gimeno RE, Dembski M, Weng X, Deng N, Shyjan AW, Gimeno CJ, Iris F, Ellis SJ, Woolf EA, Tartaglia LA: Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis. Diabetes 46:900-906, 1997
7. Enerback S, Jacobsson A, Simpson EM, Guerra C, Yamashita H, Harper ME, Kozak LP: Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature 387:90-94, 1997
8. Fleury C, Neverova M, Collins S, Raimbault S, Champigny O, Levi-Meyrueis C, Bouillaud F, Seldin MF, Surwit RS, Ricquier D, Warden CH: Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat Genet 15:269-272, 1997
9. Chan CB, De Leo D, Joseph JW, McQuaid TS, Ha XF, Xu F, Tsushima RG, Pennefather PS, Salapatek AM, Wheeler MB: Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action. Diabetes 50:1302-1310, 2001
10. Brown JEP, Thomas S, Digby JE, Dunmore SJ: Glucose induces and leptin decreases expression of uncoupling protein-2 mRNA in human islets. FEBS Left 513:189-192, 2002
11. Schrauwen P, Hesselink M: UCP2 and UCP3 in muscle controlling body metabolism. J Exp Biol 205:2275-2285, 2002
12. Nicholls DG, Locke RM: Thermogenic mechanisms in brown fat. Physiol Rev 64:1-64, 1984
13. Samec S, Seydoux J, Dulloo A: Role of UCP homologues in skeletal muscles and brown adipose tissue: mediators of thermogenesis or regulators of lipids as fuel substrate? FASEB J 12:715-724, 1998
14. Himms-Hagen J, Harper ME: Physiological role of UCP3 may be export of fatty acids from mitochondria when fatty acid oxidation predominates: an hypothesis. Exp Biol Med 226:78-84, 2001
15. Arsenijevic D, Onuma H, Pecqueur C, Raimbault S, Manning BS, Miroux B, Couplan E, Alves-Guerra MC, Goubern M, Surwit RS, Bouillaud F, Richard D, Collins S, Ricquier D: Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat Genet 26:435-439, 2000
16. Nishikawa T, Edelstein D, Du XL, Yamagishi S, Matsumura T, Kaneda Y, Yorek MA, Beebe D, Oates PJ, Hammes HP, Giardino I, Brownlee M: Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 404:787-790, 2000
17. Wang MY, Shimabukuro M, Lee Y, Trinh KY, Chen JL, Newgard CB, Unger RH: Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves beta-cell function. Diabetes 48:1020-1025, 1999
18. Hong Y, Fink BD, Dillon JS, Sivitz WI: Effects of adenoviral overexpression of uncoupling protein-2 and -3 on mitochondrial respiration in insulinoma cells. Endocrinology 142:249-256, 2001
19. Zhang CY, Baffy G, Perret P, Krauss S, Peroni O, Grujic D, Hagen T, Vidal-Puig AJ, Boss O, Kim YB, Zheng XX, Wheeler MB, Shulman GI, Chan CB, Lowell BB: Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell 105:745-755, 2001
20. Joseph JW, Koshkin V, Zhang CY, Wang J, Lowell BB, Chan CB, Wheeler MB: Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet. Diabetes 51:3211-3219, 2002
21. Nakazaki M, Kakei M, Ishihara H, Koriyama N, Hashiguchi H, Aso K, Fukudome M, Oka Y, Yada T, Tei C: Association of upregulated activity of K(ATP) channels with impaired insulin secretion in UCP1-expressing insulinoma cells. J Physiol 540:781-789, 2002
22. Erecinska M, Bryla J, Michalik M, Meglasson MD, Nelson D: Energy metabolism in islets of Langerhans. Biochim Biophys Acta 1101:273-295, 1992
23. Fink BD, Hong YS, Mathahs MM, Scholz TD, Dillon JS, Sivitz WI: UCP2-dependent proton leak in isolated mammalian mitochondria. J Biol Chem 277:3918-3925, 2002
24. Krauss S, Zhang CY, Lowell BB: A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2. Proc Natl Acad Sci U S A 99:118-122, 2002
25. Kasai H, Suzuki T, Liu TT, Kishimoto T, Takahashi N: Fast and cAMP-sensitive mode of Ca(2+)-dependent exocytosis in pancreatic beta-cells. Diabetes 51 (Suppl. 1):S19-S24, 2002
26. Detimary P, Gilon P, Nenquin M, Henquin JC: Two sites of glucose control of insulin release with distinct dependence on the energy state in pancreatic B-cells. Biochem J 297:455-461, 1994
27. Ashcroft SJ, Weerasinghe LC, Randle PJ: Interrelationship of islet metabolism, adenosine triphosphate content and insulin release. Biochem J 132:223-231, 1973
28. Li LX, Skorpen F, Egeberg K, Jorgensen IH, Grill V: Induction of uncoupling protein 2 mRNA in beta-cells is stimulated by oxidation of fatty acids but not by nutrient oversupply. Endocrinology 143:1371-1377, 2002
29. Roduit R, Morin J, Masse F, Segall L, Roche E, Newgard CB, Assimacopoulos-Jeannet F, Prentki M: Glucose down-regulates the expression of the peroxisome proliferator-activated receptor-alpha gene in the pancreatic beta-cell. J Biol Chem 275:35799-35806, 2000
30. Patane G, Anello M, Piro S, Vigneri R, Purrello F, Rabuazzo AM: Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-gamma inhibition. Diabetes 51:2749-2756, 2002
31. Laybutt DR, Sharma A, Sgroi DC, Gaudet J, Bonner-Weir S, Weir GC: Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia. J Biol Chem 277:10912-10921, 2002
32. Kassis N, Bernard C, Pusterla A, Casteilla L, Penicaud L, Richard D, Ricquier D, Ktorza A: Correlation between pancreatic islet uncoupling protein-2 (UCP2) mRNA concentration and insulin status in rats. Int J Exp Diabetes Res 1:185-193, 2000
33. Saleh MC, Wheeler MB, Chan CB: Uncoupling protein-2: evidence for its function as a metabolic regulator. Diabetologia 45:174-187, 2002
34. Lameloise N, Muzzin P, Prentki M, Assimacopoulos-Jeannet F: Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion? Diabetes 50:803-809, 2001
35. Medvedev AV, Robidoux J, Bai X, Cao WH, Floering LM, Daniel KW, Collins S: Regulation of the uncoupling protein-2 gene in INS-1 β-cells by oleic acid. J Biol Chem 277:42639-42644, 2002
36. Deeney JT, Prentki M, Corkey BE: Metabolic control of beta-cell function. Semin Cell Dev Biol 11:267-275, 2000
37. Shimabukuro M, Zhou YT, Lee Y, Unger RH: Troglitazone lowers islet fat and restores beta cell function of Zucker diabetic fatty rats. J Biol Chem 273:3547-3550, 1998
38. Tordjman K, Standley KN, Bernal-Mizrachi C, Leone TC, Coleman T, Kelly DP, Semenkovich CF: PPARα suppresses insulin secretion and induces UCP2 in insulinoma cells. J Lipid Res 43:936-943, 2002
39. Eto K, Yamashita T, Matsui J, Terauchi Y, Noda M, Kadowaki T: Genetic manipulations of fatty acid metabolism in beta-cells are associated with dysregulated insulin secretion. Diabetes 51 (Suppl. 3):S414-S420, 2002
40. Briaud I, Kelpe CL, Johnson LM, Tran PO, Poitout V: Differential effects of hyperlipidemia on insulin secretion in islets of Langerhans from hyperglycemic versus normoglycemic rats. Diabetes 51:662-668, 2002
41. Ricquier D, Bouilland F: Mitochondrial uncoupling proteins: from mitochondria to the regulation of energy balance. J Physiol 529:3-10, 2000
42. Echtay KS, Brand MD: Coenzyme Q induces GDP-sensitive proton conductance in kidney mitochondria. Biochem Soc Trans 29:763-768, 2001
43. Koshkin V, Wang X, Scherer PE, Chan CB, Wheeler MB: Mitochondrial functional state in clonal pancreatic β-cells exposed to free fatty acids. J Biol Chem 278:19709-19715, 2003
44. Carlsson C, Borg LAK, Welsh N: Sodium palmitate induces partial mitochondrial uncoupling and reactive oxygen species in rat pancreatic islets in vitro. Endocrinology 140:3422-3428, 1999
45. Echtay KS, Murphy MP, Smith RAJ, Talbot DA, Brand MD: Superoxide activates mitochondrial uncoupling protein 2 from the matrix side: studies using targeted antioxidants. J Biol Chem 277:47129-47135, 2002
46. Simonyan RA, Skulachev VP: Thermoregulatory uncoupling in heart muscle mitochondria: involvement of the ATP/ADP antiporter and uncoupling protein. FEBS Lett 436:81-84, 1998
47. a. Wang X, Li H, DeLeo D, Guo VK, Fantas G, Giacca A, Chan CB, Der S, Wheeler MB: Gene and protein kinase expression profiling of reactive oxygen species-associated lipotoxicity in the pancreatic β-cell line MIN6. Diabetes 53:129-140, 2004
48. Yamagishi SI, Edelstein D, Du XL, Kaneda Y, Guzman M, Brownlee M: Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A. J Biol Chem 276:25096-25100, 2001
49. Li LX, Skorpen F, Egeberg K, Jorgensen IH, Grill V: Uncoupling protein-2 participates in cellular defense against oxidative stress in clonal β-cells. Biochem Biophys Res Commun 282:273-277, 2001
50. Bechmann I, Diano S, Warden CH, Bartfai T, Nitsch R, Horvath TL: Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury. Biochem Pharmacol 64:363-367, 2002
51. O'Rahilly S: Uncoupling protein 2: adiposity angel and diabetes devil? Nat Med 7:770-772, 2001
52. Langin D: Diabetes, insulin secretion, and the pancreatic beta-cell mitochondrion. N Engl J Med 345:1772-1774, 2001
53. Marx J: Unraveling the causes of diabetes. Science 296:686-689, 2002
54. Krempler F, Esterbauer H, Weitgasser R, Ebenbichler C, Patsch JR, Miller K, Xie M, Linnemayr V, Oberkofler H, Patsch W: A functional polymorphism in the promoter of UCP2 enhances obesity risk but reduces type 2diabetes risk in obese middle-aged humans. Diabetes 51:3331-3335, 2002
55. Voehringer DW, Hirschberg DL, Xiao J, Lu Q, Roederer M, Lock CB, Herzenberg LA, Steinman L, Herzenberg LA: Gene microarray identification of redox and mitochondrial elements that control resistance or sensitivity to apoptosis. Proc Natl Acad Sci U S A 97:2680-2685, 2000
56. Poitout V, Robertson RP: Secondary β-cell failure in type 2 diabetes: convergence of glucotoxicity and lipotoxicity. Endocrinology 143:339-342, 2002
57. Zhou YP, Cockburn BN, Pugh W, Polonsky KS: Basal insulin hypersecretion in insulin-resistant Zucker diabetic and Zucker fatty rats: role of enhanced fuel metabolism. Metabolism 48:857-864, 1999
58. Chan CB: β-Cell stimulus-secretion coupling defects in rodent models of obesity. Can J Physiol Pharmacol 73:1414-1424, 1995
59. Kibenge MT, Chan CB: Effect of adrenalectomy on the development of a pancreatic islet lesion in fa/fa rats. Diabetologia 39:190-198, 1996
60. Chan CB, MacPhail RM: KATP channel-dependent and -independent pathways of insulin secretion in isolated islets from fa/fa Zucker rats. Biochem Cell Biol 74:403-410, 1996