-
1
-
-
0021861539
-
Unresponsiveness to glucose in a streptozotocin model of diabetes, inappropriate insulin and glucagon responses to a reduction of glucose concentration
-
Leahy JL, Weir GC: Unresponsiveness to glucose in a streptozotocin model of diabetes, inappropriate insulin and glucagon responses to a reduction of glucose concentration. Diabetes 34:653-659, 1985
-
(1985)
Diabetes
, vol.34
, pp. 653-659
-
-
Leahy, J.L.1
Weir, G.C.2
-
2
-
-
0028874383
-
Evolution of β-cell dysfunction in the male Zucker diabetic fatty rat
-
Tokuyama Y, Sturis J, DePaoli AM, et al: Evolution of β-cell dysfunction in the male Zucker diabetic fatty rat. Diabetes 44:1447-1457, 1995
-
(1995)
Diabetes
, vol.44
, pp. 1447-1457
-
-
Tokuyama, Y.1
Sturis, J.2
DePaoli, A.M.3
-
3
-
-
0028675041
-
Post-GLUT-2 defects in β-cells of non-insulin dependent diabetic obese rats
-
Ohneda M, Johnson JH, Lee YH, et al: Post-GLUT-2 defects in β-cells of non-insulin dependent diabetic obese rats. Am J Physiol 267:E968-E974, 1994
-
(1994)
Am J Physiol
, vol.267
-
-
Ohneda, M.1
Johnson, J.H.2
Lee, Y.H.3
-
4
-
-
0028833276
-
Caloric restriction in obese pre-diabetic rats prevents beta-cell depletion, loss of beta-cell Glut 2 and glucose incompetence
-
Ohneda M, Inman LR, Unger RH: Caloric restriction in obese pre-diabetic rats prevents beta-cell depletion, loss of beta-cell Glut 2 and glucose incompetence. Diabetologia 38:173-179, 1995
-
(1995)
Diabetologia
, vol.38
, pp. 173-179
-
-
Ohneda, M.1
Inman, L.R.2
Unger, R.H.3
-
5
-
-
0029151863
-
Lipotoxicity in the pathogenesis of obesity-dependent NIDDM, genetic and clinical implications
-
Unger RH: Lipotoxicity in the pathogenesis of obesity-dependent NIDDM, genetic and clinical implications. Diabetes 44:863-870, 1995
-
(1995)
Diabetes
, vol.44
, pp. 863-870
-
-
Unger, R.H.1
-
6
-
-
0028268936
-
Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and bio-synthesis through a glucose fatty acid cycle
-
Zhou YP, Grill VE: Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and bio-synthesis through a glucose fatty acid cycle. J Clin Invest 93:870-876, 1994
-
(1994)
J Clin Invest
, vol.93
, pp. 870-876
-
-
Zhou, Y.P.1
Grill, V.E.2
-
7
-
-
0027947379
-
β-Cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: Impairment in adipocyte-β-cell relationships
-
Lee Y, Hirose H, Ohneda M, et al: β-Cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: Impairment in adipocyte-β-cell relationships. Proc Natl Acad Sci USA 91:10878-10882, 1994
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 10878-10882
-
-
Lee, Y.1
Hirose, H.2
Ohneda, M.3
-
8
-
-
0025877358
-
β-Cell insensitivity to glucose in the GK rat, a spontaneous nonobese model for type II diabetes
-
Portha B, Serradas P, Bailbe D, et al: β-Cell insensitivity to glucose in the GK rat, a spontaneous nonobese model for type II diabetes. Diabetes 40:486-491, 1991
-
(1991)
Diabetes
, vol.40
, pp. 486-491
-
-
Portha, B.1
Serradas, P.2
Bailbe, D.3
-
9
-
-
0021220641
-
Abnormal glucose regulation of insulin secretion in models of reduced B-cell mass
-
Leahy JL, Bonner-Weir S, Weir GC: Abnormal glucose regulation of insulin secretion in models of reduced B-cell mass. Diabetes 33:667-673, 1984
-
(1984)
Diabetes
, vol.33
, pp. 667-673
-
-
Leahy, J.L.1
Bonner-Weir, S.2
Weir, G.C.3
-
10
-
-
0026666964
-
Possible role of glycogen accumulation in B-cell glucotoxicity
-
Malaisse WJ, Marynissen G, Senor A: Possible role of glycogen accumulation in B-cell glucotoxicity. Metabolism 41:814-819, 1992
-
(1992)
Metabolism
, vol.41
, pp. 814-819
-
-
Malaisse, W.J.1
Marynissen, G.2
Senor, A.3
-
11
-
-
0029783411
-
Impaired β-cell function with chronic hyperglycemia: "Overworked β-cell" hypothesis
-
Leahy JL: Impaired β-cell function with chronic hyperglycemia: "Overworked β-cell" hypothesis. Diabetes Rev 4:298-319, 1996
-
(1996)
Diabetes Rev
, vol.4
, pp. 298-319
-
-
Leahy, J.L.1
-
12
-
-
0027994097
-
Overexpression of hexokinase I in isolated islets of Langerhans via recombinant adenovirus: Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels
-
Becker TC, BeltrandelRio H, Neol RJ, et al: Overexpression of hexokinase I in isolated islets of Langerhans via recombinant adenovirus: Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels. J Biol Chem 269:21234-21238, 1994
-
(1994)
J Biol Chem
, vol.269
, pp. 21234-21238
-
-
Becker, T.C.1
BeltrandelRio, H.2
Neol, R.J.3
-
13
-
-
0030874158
-
Changes in pancreatic islet glucokinase and hexokinase activities with increasing age, obesity, and the onset of diabetes
-
Cockburn BN, Ostrega DM, Kubstrup C, et al: Changes in pancreatic islet glucokinase and hexokinase activities with increasing age, obesity, and the onset of diabetes. Diabetes 46:1434-1439, 1997
-
(1997)
Diabetes
, vol.46
, pp. 1434-1439
-
-
Cockburn, B.N.1
Ostrega, D.M.2
Kubstrup, C.3
-
14
-
-
0027937185
-
Proinsulin processing in the regulated and the constitutive secretory pathway
-
Halban PA: Proinsulin processing in the regulated and the constitutive secretory pathway. Diabetologia 37:S65-S72, 1994 (suppl)
-
(1994)
Diabetologia
, vol.37
, Issue.SUPPL.
-
-
Halban, P.A.1
-
15
-
-
0030857288
-
Stages of regulated exocytosis
-
Martin Thomas FJ: Stages of regulated exocytosis. Trend Cell Biol 7:271-276, 1997
-
(1997)
Trend Cell Biol
, vol.7
, pp. 271-276
-
-
Martin Thomas, F.J.1
-
16
-
-
0029911348
-
Prevention of hyperglycemia in the Zucker diabetic fatty rat by treatment with metformin or troglitazone
-
Sreenan S, Sturis J, Pugh W, et al: Prevention of hyperglycemia in the Zucker diabetic fatty rat by treatment with metformin or troglitazone. Am J Physol 271:E742-E747, 1996
-
(1996)
Am J Physol
, vol.271
-
-
Sreenan, S.1
Sturis, J.2
Pugh, W.3
-
17
-
-
0014042613
-
Method for the isolation of intact islet of Langerhans from the rat pancreas
-
Lacy PE, Kostianovsky M: Method for the isolation of intact islet of Langerhans from the rat pancreas. Diabetes 16:35-39, 1967
-
(1967)
Diabetes
, vol.16
, pp. 35-39
-
-
Lacy, P.E.1
Kostianovsky, M.2
-
18
-
-
0029849247
-
Fasting and decreased B cell sensitivity: Important role for fatty acid-induced inhibition of PDH activity
-
Zhou YP, Priestman DA, Randle PJ, et al: Fasting and decreased B cell sensitivity: Important role for fatty acid-induced inhibition of PDH activity. Am J Physiol 270:E988-E994, 1996
-
(1996)
Am J Physiol
, vol.270
-
-
Zhou, Y.P.1
Priestman, D.A.2
Randle, P.J.3
-
19
-
-
0026726773
-
Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3
-
Smeekens SP, Montag AG, Thomas G, et al: Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3. Proc Natl Acad Sci USA 89:8822-8826, 1992
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 8822-8826
-
-
Smeekens, S.P.1
Montag, A.G.2
Thomas, G.3
-
20
-
-
0028099196
-
Regulation by glucose of the biosynthesis of PC2, PC3 and proinsulin in (ob/ob) mouse islets of Langerhans
-
Martin SK, Carroll R, Benig M, et al: Regulation by glucose of the biosynthesis of PC2, PC3 and proinsulin in (ob/ob) mouse islets of Langerhans. FEBS Lett 356:279-292, 1994
-
(1994)
FEBS Lett
, vol.356
, pp. 279-292
-
-
Martin, S.K.1
Carroll, R.2
Benig, M.3
-
21
-
-
0027989677
-
Alterations in pulsatile insulin secretion in the Zucker diabetic fatty rat
-
Sturis J, Pugh WL, Tang J, et al: Alterations in pulsatile insulin secretion in the Zucker diabetic fatty rat. Am J Physiol 267:E250-E259, 1994
-
(1994)
Am J Physiol
, vol.267
-
-
Sturis, J.1
Pugh, W.L.2
Tang, J.3
-
22
-
-
0018850985
-
A simple, rapid, and sensitive DNA assay procedure
-
Labarca C, Paigen K: A simple, rapid, and sensitive DNA assay procedure. Anal Biochem 102:344-352, 1980
-
(1980)
Anal Biochem
, vol.102
, pp. 344-352
-
-
Labarca, C.1
Paigen, K.2
-
23
-
-
0017682216
-
Effect of iodoacetate, mannoheptulose and 3-O-methyl glucose on the secretory function and metabolism of isolated islets
-
Zawalich WS, Pagliara AS, Matschinsky FM: Effect of iodoacetate, mannoheptulose and 3-O-methyl glucose on the secretory function and metabolism of isolated islets. Endocrinology 100:1276-1282, 1977
-
(1977)
Endocrinology
, vol.100
, pp. 1276-1282
-
-
Zawalich, W.S.1
Pagliara, A.S.2
Matschinsky, F.M.3
-
24
-
-
0027479441
-
Glucose sensing in pancreatic islet beta cells: The key role of glucokinase and the glycolytic intermediate
-
German MS: Glucose sensing in pancreatic islet beta cells: The key role of glucokinase and the glycolytic intermediate. Proc Natl Acad Sci USA 90:1781-1785, 1993
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 1781-1785
-
-
German, M.S.1
-
25
-
-
0029966507
-
Activation of stimulus-secretion coupling in pancreatic β-cell by specific products of glucose metabolism: Evidence for privileged signaling by glycolysis
-
Mertz RJ, Worley JF III, Spencer B, et al: Activation of stimulus-secretion coupling in pancreatic β-cell by specific products of glucose metabolism: Evidence for privileged signaling by glycolysis. J Biol Chem 271:4838-4845, 1996
-
(1996)
J Biol Chem
, vol.271
, pp. 4838-4845
-
-
Mertz, R.J.1
Worley III, J.F.2
Spencer, B.3
-
26
-
-
0029131453
-
Antidiabetic agents: A new class of reversible carnitine palmitoyltransferase I inhibitors
-
Anderson RC, Balestra M, Bell PA, et al: Antidiabetic agents: A new class of reversible carnitine palmitoyltransferase I inhibitors. J Med Chem 38:3448-3450, 1995
-
(1995)
J Med Chem
, vol.38
, pp. 3448-3450
-
-
Anderson, R.C.1
Balestra, M.2
Bell, P.A.3
-
27
-
-
0029071517
-
Metabolic coupling factors in pancreatic β-cell signal transduction
-
Newgard CB, McGarry JD: Metabolic coupling factors in pancreatic β-cell signal transduction. Annu Rev Biochem 64:689-719, 1995
-
(1995)
Annu Rev Biochem
, vol.64
, pp. 689-719
-
-
Newgard, C.B.1
McGarry, J.D.2
-
29
-
-
0030004317
-
Cooling inhibits exocytosis in single mouse pancreatic B-cells by suppression of granule mobilization
-
Lond
-
Renström E, Eliasson L, et al: Cooling inhibits exocytosis in single mouse pancreatic B-cells by suppression of granule mobilization. J Physiol (Lond) 494:41-52, 1996
-
(1996)
J Physiol
, vol.494
, pp. 41-52
-
-
Renström, E.1
Eliasson, L.2
-
31
-
-
8944246315
-
(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16,21- dimethyleno-1H,13H-dibenzol [e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3 (2H)-dione (LY333531) and related analogues: Isozyme selective inhibitors of protein kinase Cβ
-
Jirousek MR, Gilig JR, Gonzalez CM, et al: (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16,21-dimethyleno-1H, 13H-dibenzol [e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3 (2H)-dione (LY333531) and related analogues: Isozyme selective inhibitors of protein kinase Cβ. J Med Chem 39:2664-2671, 1996
-
(1996)
J Med Chem
, vol.39
, pp. 2664-2671
-
-
Jirousek, M.R.1
Gilig, J.R.2
Gonzalez, C.M.3
-
32
-
-
0030030660
-
A Wortmannin-sensitive signal transduction pathway is involved in the stimulation of insulin release by vasoactive intestinal polypeptide and pituitary adenylate cyclaseactivating polypeptide
-
Straub SG, Sharp GW: A Wortmannin-sensitive signal transduction pathway is involved in the stimulation of insulin release by vasoactive intestinal polypeptide and pituitary adenylate cyclaseactivating polypeptide. J Biol Chem 271:1660-1668, 1996
-
(1996)
J Biol Chem
, vol.271
, pp. 1660-1668
-
-
Straub, S.G.1
Sharp, G.W.2
-
33
-
-
0028984185
-
2+-channel activity in mouse pancreatic beta-cells stimulated with calmidazolium (compound R24571)
-
2+-channel activity in mouse pancreatic beta-cells stimulated with calmidazolium (compound R24571). FEBS Lett 369: 315-320, 1995
-
(1995)
FEBS Lett
, vol.369
, pp. 315-320
-
-
Kindmark, H.1
Köhler, M.2
Larsson, O.3
-
34
-
-
0031436635
-
The molecular genetics of rodent single gene obesities
-
Leibel RL, Chung WK, Chua SC Jr: The molecular genetics of rodent single gene obesities. J Biol Chem 272:31937-31940, 1997
-
(1997)
J Biol Chem
, vol.272
, pp. 31937-31940
-
-
Leibel, R.L.1
Chung, W.K.2
Chua Jr., S.C.3
-
35
-
-
0031913829
-
Role of apoptosis in failure of β-cell mass compensation for insulin resistance and β-cell defects in the male Zucker diabetic fatty rat
-
Pick A, Clark J, Kubstrup C, et al: Role of apoptosis in failure of β-cell mass compensation for insulin resistance and β-cell defects in the male Zucker diabetic fatty rat. Diabetes 47:358-364, 1998
-
(1998)
Diabetes
, vol.47
, pp. 358-364
-
-
Pick, A.1
Clark, J.2
Kubstrup, C.3
-
36
-
-
0028230040
-
What β-cell defect could lead to hyperproinsulinemia in NIDDM? Some clues from recent advances made in understanding the proinsulin-processing mechanism
-
Rhodes CJ, Alarcon C: What β-cell defect could lead to hyperproinsulinemia in NIDDM? Some clues from recent advances made in understanding the proinsulin-processing mechanism. Diabetes 43:511-517, 1994
-
(1994)
Diabetes
, vol.43
, pp. 511-517
-
-
Rhodes, C.J.1
Alarcon, C.2
-
37
-
-
0030029605
-
Are the β-cell signaling molecules malonyl-CoA and cytosolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM?
-
Prentki M, Corkey BE: Are the β-cell signaling molecules malonyl-CoA and cytosolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM? Diabetes 45:273-283, 1996
-
(1996)
Diabetes
, vol.45
, pp. 273-283
-
-
Prentki, M.1
Corkey, B.E.2
-
38
-
-
0030950231
-
Beta-cell hypersensitivity to glucose following 24-h exposure of rat islets to fatty acids
-
Hosokawa H, Corkey BE, Leahy JL: Beta-cell hypersensitivity to glucose following 24-h exposure of rat islets to fatty acids. Diabetologia 40:392-397, 1997
-
(1997)
Diabetologia
, vol.40
, pp. 392-397
-
-
Hosokawa, H.1
Corkey, B.E.2
Leahy, J.L.3
-
39
-
-
0032030866
-
Chronic exposure to free fatty acid reduces pancreatic β-cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation
-
Bollheimer LC, Skelly R, Chester MW, et al: Chronic exposure to free fatty acid reduces pancreatic β-cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation. J Clin Invest 101:1094-1101, 1998
-
(1998)
J Clin Invest
, vol.101
, pp. 1094-1101
-
-
Bollheimer, L.C.1
Skelly, R.2
Chester, M.W.3
-
40
-
-
0032522368
-
A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moieties
-
Skelly RH, Bollheimer LC, Wicksteed BL, et al: A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moieties. Biochem J 331:553-561, 1998
-
(1998)
Biochem J
, vol.331
, pp. 553-561
-
-
Skelly, R.H.1
Bollheimer, L.C.2
Wicksteed, B.L.3
-
41
-
-
0029133141
-
Intracellular transport of proinsulin in pancreatic β-cells, structural maturation probed by disulfide accessibility
-
Huang XF, Arvan P: Intracellular transport of proinsulin in pancreatic β-cells, structural maturation probed by disulfide accessibility. J Biol Chem 270:20417-20423, 1996
-
(1996)
J Biol Chem
, vol.270
, pp. 20417-20423
-
-
Huang, X.F.1
Arvan, P.2
|