Diabetes, insulin secretion, and the pancreatic beta-cell mitochondrion

New England Journal of Medicine

Volumn 345, Issue 24, 2001, Pages 1772-1774

  Langin, Dominique ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; FLAVINE ADENINE NUCLEOTIDE; POTASSIUM CHANNEL; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; UNCOUPLING PROTEIN 2;

ANIMAL MODEL; ARTICLE; GENETIC ANALYSIS; GENETIC VARIABILITY; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; INSULIN RELEASE; INSULIN RESISTANCE; KNOCKOUT MOUSE; MITOCHONDRIAL RESPIRATION; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; DIABETES MELLITUS; DIABETES MELLITUS, TYPE 2; HUMANS; INSULIN; ION CHANNELS; ISLETS OF LANGERHANS; MEMBRANE TRANSPORT PROTEINS; MICE; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; OBESITY; PROTEINS;

EID: 0035857151     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM200112133452412     Document Type: Article

References (5)

1. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β cell dysfunction, and type 2 diabetes
2. Increased uncoupling protein-2 levels in β-cells are associated with impaired glucose-stimulated insulin secretion: Mechanism of action
3. Uncoupling protein 2: A possible link between fatty acid excess and impaired glucose-induced insulin secretion?
4. Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production
5. Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinemia