PPARα suppresses insulin secretion and induces UCP2 in insulinoma cells

Journal of Lipid Research

Volumn 43, Issue 6, 2002, Pages 936-943

  Tordjman, Karen ^a   Standley, Kara N ^a   Bernal Mizrachi, Carlos ^a   Leone, Teresa C ^a   Coleman, Trey ^a   Kelly, Daniel P ^a   Semenkovich, Clay F ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cell failure; Fatty acid oxidation; Lipotoxicity; Peroxisome proliferator activated receptor ; Type 2 diabetes

Indexed keywords

ADENOSINE TRIPHOSPHATE; CARNITINE PALMITOYLTRANSFERASE; CATALASE; CLOFIBRIC ACID; ENZYME INHIBITOR; ETOMOXIR; INSULIN; MESSENGER RNA; PALMITIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; TRIACYLGLYCEROL; UNCOUPLING PROTEIN 2; CARRIER PROTEIN; CELL RECEPTOR; EPOXIDE; FATTY ACID; GLUCOSE; ION CHANNEL; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN 2; TRANSCRIPTION FACTOR;

ADENOVIRUS; ANIMAL CELL; ARTICLE; CANCER CELL; CELL LEVEL; CELL RESPIRATION; ENZYME ACTIVITY; FAT CONTENT; FATTY ACID OXIDATION; GENE EXPRESSION; INSULIN RELEASE; INSULINOMA; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL; PROTEIN INDUCTION; REPORTER GENE; TRANSACTIVATION; VIRUS RECOMBINANT; ANIMAL; CELL CULTURE; GENE VECTOR; GENETICS; METABOLISM; MOUSE; PHYSIOLOGY; PROTEIN SYNTHESIS; RAT; SECRETION;

ADENOSINE TRIPHOSPHATE; ADENOVIRIDAE; ANIMALS; CATALASE; CLOFIBRIC ACID; EPOXY COMPOUNDS; FATTY ACIDS; GENETIC VECTORS; GLUCOSE; INSULIN; INSULINOMA; ION CHANNELS; MEMBRANE TRANSPORT PROTEINS; MICE; MITOCHONDRIAL PROTEINS; PROTEIN BIOSYNTHESIS; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS; TRIGLYCERIDES; TUMOR CELLS, CULTURED;

EID: 0035991114     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Cellular mechanisms of insulin resistance
2. Non-insulin-dependent diabetes mellitus-a genetically programmed failure of the beta cell to compensate for insulin resistance
3. Lipotoxicity of beta-cells in obesity and other causes of fatty acid spillover
4. Insulin sensitivity of blood glucose versus insulin sensitivity of blood free fatty acids normal, obese, and obese-diabetic subjects
5. Rationale and application of fatty, acid oxidation inhibitors in treatment of diabetes mellitus
6. Glucose and insulin stimulate lipoprotein lipase activity in mouse islets and INS-1 cells: A potential link between insulin resistance and β-cell dysfunction
7. Relative hypoglycemia and hyperinsulinemia in mice with heterozygous lipoprotein lipase (LPL) deficiency: Islet LPL regulates insulin secretion
8. Long term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle
9. A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and beta cell oxidation through a process likely coupled to fatty acid oxidation
10. Prolonged elevation of plasma free fatty acids impairs pancreatic β-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes
11. Roles of PPARs in health and disease
12. Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor alpha
13. Role of peroxisome proliferator-activated receptor α in disease of pancreatic β cells
14. A simplified system for generating recombinant adenoviruses
15. p38 mitogen-activated protein kinase activates peroxisome proliferator-activated receptor alpha: A potential role in the cardiac metabolic stress response
16. Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines
17. Intracellular distribution of monoamine oxidase, aspartate aminotransferase, alanine amino-transferase, D-amino acid oxidase and catalase in rat-liver tissue
18. Peroxisome proliferator-activated receptor α deficiency reduces insulin resistance and atherosclerosis in apoE null mice
19. Uncoupling protein 3 transcription is regulated by peroxisome proliferator-activated receptor α in the adult rodent heart
20. Glucose down-regulates the expression of the peroxisome proliferator-activated receptor-α gene in the pancreatic β-cell
21. Differential gene regulation in human versus rodent hepatocytes by peroxisome proliferator-activated receptor (PPAR) α
22. Fatty acids, lipotoxicity and insulin secretion
23. Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice
24. Peroxisome proliferator-activated receptor alpha activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell
25. Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: Mechanism of action
26. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes
27. UCP2-dependent proton leak in isolated mammalian mitochondria
28. Hyperinsulinism in short-chain L-3-hydroxyacyl-CoA dehydrogenase deficiency reveals the importance of β-oxidation in insulin secretion
29. Glucose-induced insulin release in islets of young rats: Time-dependent potentiation and effects of 2-bromostearate
30. Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion
31. More direct evidence for a malonyl-CoA-dependent-carnitine palmitoyltransferase I interaction as a key event in pancreatic β-cell signaling
32. Increased lipogenic capacity of the islets of obese rats: A role in the pathogenesis of NIDDM
33. Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves beta-cell function
34. Glucose-fatty acid cycle to inhibit glucose utilization and oxidation is not operative in fatty acid-cultured islets
35. Lipid rather than glucose metabolism in implicated in altered insulin secretion caused by oleate in INS-1 cells
36. Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat
37. Regulation of insulin secretion by short chain fatty acids
38. Simulation of insulin secretion by long-chain free fatty acids. A direct pancreatic effect
39. Fatty acids rapidly induce the carnitine palmitoyltransferase I gene in the pancreatic β-cell line INS-1
40. Chronic perifusion of rat islets with palmitate suppresses glucose-stimulated insulin release
41. Fatty acid-induced decrease in pyruvate dehydrogenase activity is an important determinant of β-cell dysfunction in the obese db/db mouse
42. Long term exposure to fatty acids and ketones inhibits β-cell functions in human pancreatic islets of Langerhans
43. Identification of a functional peroxisome proliferator-activated responsive element in the murine fatty acid transport protein gene
44. Induction of the acyl-coenzyme A synthetase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter
45. PPARα and PPARγ activators direct a tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene
46. Lipotoxicity of the pancreatic β-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids
47. Are the β-cell signaling molecules malonyl-CoA and cytosolic long chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM?
48. Differential mechanisms of glucose and palmitate in augmentation of insulin secretion in mouse pancreatic islets
49. Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in β cells
50. Essential role of acetyl-CoA carboxylase in the glucose-induced insulin secretion in a pancreatic β-cell line
51. 2+ and insulin secretion responses in the beta cell
52. Effects of bezafibrate on β-cell function of rat pancreatic islets