Effects of adenoviral overexpression of uncoupling protein-2 and -3 on mitochondrial respiration in insulinoma cells

Endocrinology

Volumn 142, Issue 1, 2001, Pages 249-256

  Hong, Y ^a   Fink, B D ^a   Dillon, J S ^a   Sivitz, W I ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; INSULIN; MANGANESE SUPEROXIDE DISMUTASE; OLIGOMYCIN; SUCCINIC ACID; UNCOUPLING PROTEIN 1;

ARTICLE; BROWN ADIPOSE TISSUE; CANCER CELL CULTURE; CONTROLLED STUDY; GENE OVEREXPRESSION; GLUCOSE OXIDATION; HUMAN; HUMAN ADENOVIRUS 2; HUMAN CELL; INSULIN RELEASE; INSULINOMA; LIPID METABOLISM; LIPID OXIDATION; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; OXIDATION; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTON TRANSPORT;

EID: 0035117975     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.142.1.7889     Document Type: Article

References (41)

1. Thermogenic mechanisms in brown fat
2. Uncoupling proteins 2 and 3: Potential regulators of mitochondrial energy metabolism
3. Induction of uncoupling protein-2 mRNA by troglitazone in the pancreatic islets of Zucker diabetic fatty rats
4. Uncoupling protein-2, a novel gene linked to obesity and hyperinsulinemia
5. Cloning and characterization of an uncoupling protein homolog: A potential molecular mediator of human thermogenesis
6. Kupffer cells are a dominant site of uncoupling protein 2 expression in rat liver
7. UCP3: An uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue
8. Uncoupling protein-3: A new member of the mitochondrial carrier family with tissue-specific expression
9. BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast
10. UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells
11. The significance and mechanism of mitochondrial proton conductance
12. UCP1, UCP2 and UCP3: Are they true uncouplers of respiration?
13. Assessment of uncoupling activity of uncoupling protein 3 using a yeast heterologous expression system
14. Recombinant human uncoupling protein-3 increases thermogenesis in yeast cells
15. Properties of the human long and short isoforms of the uncoupling protein-3 expressed in yeast cells
16. UCP2 and UCP3 rise in starved rat skeletal muscle but mitochondrtal proton conductance is unchanged
17. The bioenergetics of brown fat mitochondria from UCP1-ablated mice. Ucp1 is not involved in fatty acid-induced de-energization ("incoupling")
18. Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves βcell function
19. Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets
20. Redox gene therapy for ischemia/reperfusion injury of the liver reduces AP1 and NF-κB activation
21. Fasting and leptin modulate adipose and muscle uncoupling protein: Divergent effects between messenger ribonucleic acid and protein expression
22. Immunohistochemical localization of antioxidant enzymes in adult Syrian hamster tissues and during kidney development
23. Bioluminometric assay of ADP and ATP at high ATP/ADP ratios: Assay of ADP after enzymatic removal of ATP
24. Regulation of antioxidant enzymes
25. Distribution of manganese-dependent superoxide dismutase in the human brain
26. A monoclonal antibody against COOH-terminal peptide of human liver manganese superoxide dismutase
27. The uncoupling proteins, a review
28. Uncoupling protein-3 expression in rodent skeletal muscle is modulated by food intake but not by changes in environmental temperature
29. Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin
30. Elevated free fatty acids induce uncoupling protein 3 expression in muscle: A potential explanation for the effect of fasting
31. Uncoupling protein-3 gene expression in skeletal muscle during development is regulated by nutritional factors that alter circulating non-esterified fatty acids
32. Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean
33. Diet-induced changes in uncoupling proteins in obesity-prone and obesity-resistant strains of mice
34. Activators of peroxisome proliferator-activated receptor-alpha induce the expression of the uncoupling protein-3 gene in skeletal muscle: A potential mechanism for the lipid intake-dependent activation of uncoupling protein-3 gene expression at birth
35. Uncoupling protein 3 is reduced in skeletal muscle of NIDDM patients
36. Overexpression of GLUT4 in mice causes up-regulation of UCP3 mRNA in skeletal muscle
37. Troglitazone lowers islet fat and restores β cell function of Zucker diabetic fatty rats
38. Concentration dependence and time course of the effects of glucose on adenine and guanine nucleotides in mouse pancreatic islets
39. Temporal sequence of metabolic and ionic events in glucose-stimulated clonal pancreatic beta-cells (HIT)
40. Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation