Uncoupling protein 2: Adiposity angel and diabetes devil?

Nature Medicine

Volumn 7, Issue 7, 2001, Pages 770-772

  O'Rahilly, S ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

UNCOUPLING PROTEIN 2;

BROWN ADIPOSE TISSUE; DIABETES MELLITUS; GENETICS; METABOLIC REGULATION; OBESITY; PRIORITY JOURNAL; PROTEIN FAMILY; SEQUENCE HOMOLOGY; SHORT SURVEY;

ADIPOSE TISSUE, BROWN; ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; ION CHANNELS; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, KNOCKOUT; MITOCHONDRIAL PROTEINS; OBESITY; PROTEINS;

EID: 0034927069     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/89877     Document Type: Short Survey

References (12)

1. Uncoupling protein-2 negatively regulates insulin secretion and promotes β-cell dysfunction in obesity-induced diabetes
2. A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans
3. Mitochondrial uncoupling protein from mouse brown fat. Molecular cloning, genetic mapping, and mRNA expression
4. Thermogenic mechanisms in brown fat
5. Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinemia
6. UCP3: An uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue
7. Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production
8. Energy metabolism in uncoupling protein 3 knock out mice
9. Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean
10. Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets
11. Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves β-cell function
12. Mitochondrial proton leak and the uncoupling protein 1 homologues