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Volumn 10, Issue 1, 2004, Pages 3-9

TGF-β, T-cell tolerance and anti-CD3 therapy

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CALCIUM; CD3 ANTIBODY; CD40 LIGAND MONOCLONAL ANTIBODY; CYCLOSPORIN A; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; FC RECEPTOR; TACROLIMUS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

EID: 0742269689     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmed.2003.11.007     Document Type: Short Survey
Times cited : (23)

References (51)
  • 1
    • 0141796312 scopus 로고    scopus 로고
    • TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes
    • Belghith M., et al. TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes. Nat. Med. 9:2003;1202-1208.
    • (2003) Nat. Med. , vol.9 , pp. 1202-1208
    • Belghith, M.1
  • 2
    • 0033491636 scopus 로고    scopus 로고
    • T lymphocyte tolerance: From thymic deletion to peripheral control mechanisms
    • Stockinger B. T lymphocyte tolerance: from thymic deletion to peripheral control mechanisms. Adv. Immunol. 71:1999;229-265.
    • (1999) Adv. Immunol. , vol.71 , pp. 229-265
    • Stockinger, B.1
  • 3
    • 0028296038 scopus 로고
    • Premature escape of double-positive thymocytes to the periphery of young mice. Possible role in autoimmunity
    • Bonomo A., et al. Premature escape of double-positive thymocytes to the periphery of young mice. Possible role in autoimmunity. J. Immunol. 152:1994;1509-1514.
    • (1994) J. Immunol. , vol.152 , pp. 1509-1514
    • Bonomo, A.1
  • 4
    • 0037364976 scopus 로고    scopus 로고
    • Regulatory T cells in transplantation tolerance
    • Wood K.J., Sakaguchi S. Regulatory T cells in transplantation tolerance. Nat. Rev. Immunol. 3:2003;199-210.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 199-210
    • Wood, K.J.1    Sakaguchi, S.2
  • 5
    • 0036597371 scopus 로고    scopus 로고
    • + suppressor T cells: More questions than answers
    • + suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2:2002;389-400.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 389-400
    • Shevach, E.M.1
  • 6
    • 0034642534 scopus 로고    scopus 로고
    • Cbl-b regulates the CD28 dependence of T-cell activation
    • Chiang Y.J., et al. Cbl-b regulates the CD28 dependence of T-cell activation. Nature. 403:2000;216-220.
    • (2000) Nature , vol.403 , pp. 216-220
    • Chiang, Y.J.1
  • 7
    • 0035825644 scopus 로고    scopus 로고
    • Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation
    • Demetriou M., et al. Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation. Nature. 409:2001;733-739.
    • (2001) Nature , vol.409 , pp. 733-739
    • Demetriou, M.1
  • 8
    • 0034093737 scopus 로고    scopus 로고
    • Signal transduction by the TCR for antigen
    • Kane L.P., et al. Signal transduction by the TCR for antigen. Curr. Opin. Immunol. 12:2000;242-249.
    • (2000) Curr. Opin. Immunol. , vol.12 , pp. 242-249
    • Kane, L.P.1
  • 9
    • 0033953109 scopus 로고    scopus 로고
    • The inhibitory effects of transforming growth factor-β1 (TGF-β1) in autoimmune diseases
    • Prud'homme G.J., Piccirillo C.A. The inhibitory effects of transforming growth factor-β1 (TGF-β1) in autoimmune diseases. J. Autoimmun. 14:2000;23-42.
    • (2000) J. Autoimmun. , vol.14 , pp. 23-42
    • Prud'Homme, G.J.1    Piccirillo, C.A.2
  • 10
    • 0036700341 scopus 로고    scopus 로고
    • Expression of transgene encoded TGF-β in islets prevents autoimmune diabetes in NOD mice by a local mechanism
    • Grewal I.S., et al. Expression of transgene encoded TGF-β in islets prevents autoimmune diabetes in NOD mice by a local mechanism. J. Autoimmun. 19:2002;9-22.
    • (2002) J. Autoimmun. , vol.19 , pp. 9-22
    • Grewal, I.S.1
  • 11
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S., et al. Control of regulatory T cell development by the transcription factor Foxp3. Science. 299:2003;1057-1061.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1
  • 12
    • 0035801335 scopus 로고    scopus 로고
    • + regulatory T cells is mediated by cell surface-bound transforming growth factor β
    • + regulatory T cells is mediated by cell surface-bound transforming growth factor β J. Exp. Med. 194:2001;629-644.
    • (2001) J. Exp. Med. , vol.194 , pp. 629-644
    • Nakamura, K.1
  • 13
    • 0027521572 scopus 로고
    • Interleukin-10-deficient mice develop chronic enterocolitis
    • Kuhn R., et al. Interleukin-10-deficient mice develop chronic enterocolitis. Cell. 75:1993;263-274.
    • (1993) Cell , vol.75 , pp. 263-274
    • Kuhn, R.1
  • 14
    • 0026799402 scopus 로고
    • Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease
    • Shull M.M., et al. Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease. Nature. 359:1992;693-699.
    • (1992) Nature , vol.359 , pp. 693-699
    • Shull, M.M.1
  • 15
    • 0027531528 scopus 로고
    • Transforming growth factor β1 null mutation in mice causes excessive inflammatory response and early death
    • Kulkarni A.B., et al. Transforming growth factor β1 null mutation in mice causes excessive inflammatory response and early death. Proc. Natl. Acad. Sci. U. S. A. 90:1993;770-774.
    • (1993) Proc. Natl. Acad. Sci. U. S. A. , vol.90 , pp. 770-774
    • Kulkarni, A.B.1
  • 16
    • 0033682056 scopus 로고    scopus 로고
    • + immunoregulatory T cells that control autoimmune diabetes
    • + immunoregulatory T cells that control autoimmune diabetes. Immunity. 12:2000;431-440.
    • (2000) Immunity , vol.12 , pp. 431-440
    • Salomon, B.1
  • 17
    • 0032538819 scopus 로고    scopus 로고
    • + T cells
    • + T cells. J. Exp. Med. 188:1998;1849-1857.
    • (1998) J. Exp. Med. , vol.188 , pp. 1849-1857
    • Chen, W.1
  • 18
    • 0037099613 scopus 로고    scopus 로고
    • + regulatory T cells can mediate suppressor function in the absence of transforming growth factor β1 production and responsiveness
    • + regulatory T cells can mediate suppressor function in the absence of transforming growth factor β1 production and responsiveness. J. Exp. Med. 196:2002;237-246.
    • (2002) J. Exp. Med. , vol.196 , pp. 237-246
    • Piccirillo, C.A.1
  • 19
    • 0141461418 scopus 로고    scopus 로고
    • + regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation
    • + regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat. Med. 9:2003;1144-1150.
    • (2003) Nat. Med. , vol.9 , pp. 1144-1150
    • Edinger, M.1
  • 20
    • 0037026001 scopus 로고    scopus 로고
    • + immunoregulatory T cells: New therapeutics for graft-versus-host disease
    • + immunoregulatory T cells: new therapeutics for graft-versus-host disease. J. Exp. Med. 196:2002;401-406.
    • (2002) J. Exp. Med. , vol.196 , pp. 401-406
    • Cohen, J.L.1
  • 21
    • 0036345337 scopus 로고    scopus 로고
    • Origin of regulatory T cells with known specificity for antigen
    • Apostolou I., et al. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 3:2002;756-763.
    • (2002) Nat. Immunol. , vol.3 , pp. 756-763
    • Apostolou, I.1
  • 22
    • 0037310650 scopus 로고    scopus 로고
    • CD28/B7 regulation of anti-CD3-mediated immunosuppression in vivo
    • Tang Q., et al. CD28/B7 regulation of anti-CD3-mediated immunosuppression in vivo. J. Immunol. 170:2003;1510-1516.
    • (2003) J. Immunol. , vol.170 , pp. 1510-1516
    • Tang, Q.1
  • 23
    • 0141920662 scopus 로고    scopus 로고
    • + regulatory T cells
    • + regulatory T cells. J. Immunol. 171:2003;3348-3352.
    • (2003) J. Immunol. , vol.171 , pp. 3348-3352
    • Tang, Q.1
  • 24
    • 0037385314 scopus 로고    scopus 로고
    • + T regulatory cells
    • + T regulatory cells. Nat. Immunol. 4:2003;337-342.
    • (2003) Nat. Immunol. , vol.4 , pp. 337-342
    • Khattri, R.1
  • 25
    • 0037385330 scopus 로고    scopus 로고
    • + regulatory T cells
    • + regulatory T cells. Nat. Immunol. 4:2003;330-336.
    • (2003) Nat. Immunol. , vol.4 , pp. 330-336
    • Fontenot, J.D.1
  • 26
    • 0038434099 scopus 로고    scopus 로고
    • Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis
    • Gambineri E., et al. Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis. Curr. Opin. Rheumatol. 15:2003;430-435.
    • (2003) Curr. Opin. Rheumatol. , vol.15 , pp. 430-435
    • Gambineri, E.1
  • 27
    • 0141886225 scopus 로고    scopus 로고
    • Cutting edge: Diabetes-associated quantitative trait locus, Idd4, is responsible for the IL-12p40 overexpression defect in nonobese diabetic (NOD) mice
    • Simpson P.B., et al. Cutting edge: diabetes-associated quantitative trait locus, Idd4, is responsible for the IL-12p40 overexpression defect in nonobese diabetic (NOD) mice. J. Immunol. 171:2003;3333-3337.
    • (2003) J. Immunol. , vol.171 , pp. 3333-3337
    • Simpson, P.B.1
  • 28
    • 0037097593 scopus 로고    scopus 로고
    • Tolerance induction of alloreactive T cells via ex vivo blockade of the CD40:CD40L costimulatory pathway results in the generation of a potent immune regulatory cell
    • Taylor P.A., et al. Tolerance induction of alloreactive T cells via ex vivo blockade of the CD40:CD40L costimulatory pathway results in the generation of a potent immune regulatory cell. Blood. 99:2002;4601-4609.
    • (2002) Blood , vol.99 , pp. 4601-4609
    • Taylor, P.A.1
  • 29
    • 0034327171 scopus 로고    scopus 로고
    • Cutting edge: Anti-CD154 therapeutic antibodies induce infectious transplantation tolerance
    • Graca L., et al. Cutting edge: anti-CD154 therapeutic antibodies induce infectious transplantation tolerance. J. Immunol. 165:2000;4783-4786.
    • (2000) J. Immunol. , vol.165 , pp. 4783-4786
    • Graca, L.1
  • 30
    • 0141629548 scopus 로고    scopus 로고
    • Dominant transplantation tolerance
    • Graca L., et al. Dominant transplantation tolerance. Curr. Opin. Immunol. 15:2003;499-506.
    • (2003) Curr. Opin. Immunol. , vol.15 , pp. 499-506
    • Graca, L.1
  • 31
    • 0036604283 scopus 로고    scopus 로고
    • - regulatory cells mediate dominant transplantation tolerance
    • - regulatory cells mediate dominant transplantation tolerance. J. Immunol. 168:2002;5558-5565.
    • (2002) J. Immunol. , vol.168 , pp. 5558-5565
    • Graca, L.1
  • 32
    • 0037243827 scopus 로고    scopus 로고
    • R cells suppress innate immune pathology through cytokine-dependent mechanisms
    • R cells suppress innate immune pathology through cytokine-dependent mechanisms. J. Exp. Med. 197:2003;111-119.
    • (2003) J. Exp. Med. , vol.197 , pp. 111-119
    • Maloy, K.J.1
  • 33
    • 0347895101 scopus 로고    scopus 로고
    • + cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype
    • + cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype. Nature. 421:2003;388-392.
    • (2003) Nature , vol.421 , pp. 388-392
    • Kemper, C.1
  • 35
    • 0141703239 scopus 로고    scopus 로고
    • + T cells through TGF-β-TGF-β receptor interactions in type 1 diabetes
    • + T cells through TGF-β-TGF-β receptor interactions in type 1 diabetes. Proc. Natl. Acad. Sci. U. S. A. 100:2003;10878-10883.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 10878-10883
    • Green, E.A.1
  • 36
    • 0142219250 scopus 로고    scopus 로고
    • Transforming growth factor (TGF)-β1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-β1-mediated fibrosis
    • Kitani A., et al. Transforming growth factor (TGF)-β1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-β1-mediated fibrosis. J. Exp. Med. 198:2003;1179-1188.
    • (2003) J. Exp. Med. , vol.198 , pp. 1179-1188
    • Kitani, A.1
  • 37
    • 0033775776 scopus 로고    scopus 로고
    • Transforming growth factor-β induces apoptosis in activated murine T cells through the activation of caspase1-like protease
    • Chung E.J., et al. Transforming growth factor-β induces apoptosis in activated murine T cells through the activation of caspase1-like protease. Cell. Immunol. 204:2000;46-54.
    • (2000) Cell. Immunol. , vol.204 , pp. 46-54
    • Chung, E.J.1
  • 38
    • 0030788348 scopus 로고    scopus 로고
    • Transforming growth factor-β1 induces antigen-specific unresponsiveness in naive T cells
    • Gilbert K.M., et al. Transforming growth factor-β1 induces antigen-specific unresponsiveness in naive T cells. Immunol. Invest. 26:1997;459-472.
    • (1997) Immunol. Invest. , vol.26 , pp. 459-472
    • Gilbert, K.M.1
  • 39
    • 0033565626 scopus 로고    scopus 로고
    • Transforming growth factor β1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis
    • Engle S.J., et al. Transforming growth factor β1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis. Cancer Res. 59:1999;3379-3386.
    • (1999) Cancer Res. , vol.59 , pp. 3379-3386
    • Engle, S.J.1
  • 40
    • 0036408818 scopus 로고    scopus 로고
    • Gene transfection and expression of transforming growth factor-β1 in nonobese diabetic mouse islets protects β-cells in syngeneic islet grafts from autoimmune destruction
    • Suarez-Pinzon W.L., et al. Gene transfection and expression of transforming growth factor-β1 in nonobese diabetic mouse islets protects β-cells in syngeneic islet grafts from autoimmune destruction. Cell Transplant. 11:2002;519-528.
    • (2002) Cell Transplant. , vol.11 , pp. 519-528
    • Suarez-Pinzon, W.L.1
  • 41
    • 0029618694 scopus 로고
    • Early-onset multifocal inflammation in the transforming growth factor β1-null mouse is lymphocyte mediated
    • Diebold R.J., et al. Early-onset multifocal inflammation in the transforming growth factor β1-null mouse is lymphocyte mediated. Proc. Natl. Acad. Sci. U. S. A. 92:1995;12215-12219.
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 12215-12219
    • Diebold, R.J.1
  • 42
    • 0037378732 scopus 로고    scopus 로고
    • 2+-Calcineurin-mediated activation in thymocytes
    • 2+-Calcineurin- mediated activation in thymocytes. J. Immunol. 170:2003;3645-3652.
    • (2003) J. Immunol. , vol.170 , pp. 3645-3652
    • Bommireddy, R.1
  • 43
    • 0242584870 scopus 로고    scopus 로고
    • TGF-β1 regulates lymphocyte homeostasis by preventing activation and subsequent apoptosis of peripheral lymphocytes
    • Bommireddy R., et al. TGF-β1 regulates lymphocyte homeostasis by preventing activation and subsequent apoptosis of peripheral lymphocytes. J. Immunol. 170:2003;4612-4622.
    • (2003) J. Immunol. , vol.170 , pp. 4612-4622
    • Bommireddy, R.1
  • 44
    • 0037867066 scopus 로고    scopus 로고
    • 2+ influx, and NFATc translocation causing inhibition of T cell differentiation
    • 2+ influx, and NFATc translocation causing inhibition of T cell differentiation. J. Exp. Med. 197:2003;1689-1699.
    • (2003) J. Exp. Med. , vol.197 , pp. 1689-1699
    • Chen, C.H.1
  • 45
    • 0035324638 scopus 로고    scopus 로고
    • 2 prevents graft-versus-host disease by selectively depleting donor T cells activated by recipient alloantigens
    • 2 prevents graft-versus-host disease by selectively depleting donor T cells activated by recipient alloantigens. J. Immunol. 166:2001;5835-5839.
    • (2001) J. Immunol. , vol.166 , pp. 5835-5839
    • Yu, X.Z.1
  • 46
    • 0037314237 scopus 로고    scopus 로고
    • Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3γ1(Ala-Ala)
    • Herold K.C., et al. Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3γ1(Ala-Ala). J. Clin. Invest. 111:2003;409-418.
    • (2003) J. Clin. Invest. , vol.111 , pp. 409-418
    • Herold, K.C.1
  • 47
    • 0034131557 scopus 로고    scopus 로고
    • Abrogation of TGFβ signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease
    • Gorelik L., Flavell R.A. Abrogation of TGFβ signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity. 12:2000;171-181.
    • (2000) Immunity , vol.12 , pp. 171-181
    • Gorelik, L.1    Flavell, R.A.2
  • 48
    • 0034600070 scopus 로고    scopus 로고
    • Disruption of T cell homeostasis in mice expressing a T cell-specific dominant negative transforming growth factor βiI receptor
    • Lucas P.J., et al. Disruption of T cell homeostasis in mice expressing a T cell-specific dominant negative transforming growth factor βII receptor. J. Exp. Med. 191:2000;1187-1196.
    • (2000) J. Exp. Med. , vol.191 , pp. 1187-1196
    • Lucas, P.J.1
  • 49
    • 0037100520 scopus 로고    scopus 로고
    • Induced disruption of the transforming growth factor β type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable
    • Leveen P., et al. Induced disruption of the transforming growth factor β type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable. Blood. 100:2002;560-568.
    • (2002) Blood , vol.100 , pp. 560-568
    • Leveen, P.1
  • 50
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    • Tivol E.A., et al. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity. 3:1995;541-547.
    • (1995) Immunity , vol.3 , pp. 541-547
    • Tivol, E.A.1
  • 51
    • 0033104503 scopus 로고    scopus 로고
    • Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-β
    • Yang X., et al. Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-β EMBO J. 18:1999;1280-1291.
    • (1999) EMBO J. , vol.18 , pp. 1280-1291
    • Yang, X.1


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