-
1
-
-
0021683219
-
Evolving use of OKT3 monoclonal antibody for treatment of renal allograft rejection
-
Thistlethwaite, J. R., Jr., A. B. Cosimi, F. L. Delmonico, R. H. Rubin, N. Talkoff-Rubin, P. W. Nelson, L. Fang. and P. S. Russell. 1984. Evolving use of OKT3 monoclonal antibody for treatment of renal allograft rejection. Transplantation 38:695.
-
(1984)
Transplantation
, vol.38
, pp. 695
-
-
Thistlethwaite J.R., Jr.1
Cosimi, A.B.2
Delmonico, F.L.3
Rubin, R.H.4
Talkoff-Rubin, N.5
Nelson, P.W.6
Fang, L.7
Russell, P.S.8
-
2
-
-
0031569177
-
CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice
-
Chatenoud, L., J. Primo, and J. F. Bach. 1997. CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice. J. Immunol. 158:2947.
-
(1997)
J. Immunol.
, vol.158
, pp. 2947
-
-
Chatenoud, L.1
Primo, J.2
Bach, J.F.3
-
3
-
-
0027958044
-
Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice
-
Chatenoud, L., E. Thervet, J. Primo, and J. F. Bach. 1994. Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice. Proc. Natl. Acad. Sci. USA 91:123.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 123
-
-
Chatenoud, L.1
Thervet, E.2
Primo, J.3
Bach, J.F.4
-
4
-
-
0023949756
-
Effects of in vivo administration of anti-T3 monoclonal antibody on T cell function in mice. I. Immunosuppression of transplantation responses
-
Hirsch, R., M. Eckhaus, H. Auchincloss, Jr., D. H. Sachs, and J. A. Bluestone. 1988. Effects of in vivo administration of anti-T3 monoclonal antibody on T cell function in mice. I. Immunosuppression of transplantation responses. J. Immunol. 140:3766.
-
(1988)
J. Immunol.
, vol.140
, pp. 3766
-
-
Hirsch, R.1
Eckhaus, M.2
Auchincloss H., Jr.3
Sachs, D.H.4
Bluestone, J.A.5
-
5
-
-
0033007321
-
Mature T lymphocyte apoptosis-immune regulation in a dynamic and unpredictable antigenic environment
-
Lenardo, M., K. M. Chan, F. Hornung, H. McFarland, R. Siegel, J. Wang, and L. Zheng. 1999. Mature T lymphocyte apoptosis-immune regulation in a dynamic and unpredictable antigenic environment. Annu. Rev. Immunol. 17:221.
-
(1999)
Annu. Rev. Immunol.
, vol.17
, pp. 221
-
-
Lenardo, M.1
Chan, K.M.2
Hornung, F.3
McFarland, H.4
Siegel, R.5
Wang, J.6
Zheng, L.7
-
6
-
-
0033009890
-
The central effectors of cell death in the immune system
-
Rathmell, J. C., and C. B. Thompson. 1999. The central effectors of cell death in the immune system. Annu. Rev. Immunol. 17:781.
-
(1999)
Annu. Rev. Immunol.
, vol.17
, pp. 781
-
-
Rathmell, J.C.1
Thompson, C.B.2
-
7
-
-
0033592984
-
L
-
L. Proc. Natl. Acad. Sci. USA 96:14871.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 14871
-
-
Huang, D.C.1
Hahne, M.2
Schroeter, M.3
Frei, K.4
Fontana, A.5
Villunger, A.6
Newton, K.7
Tschopp, J.8
Strasser, A.9
-
8
-
-
0032031457
-
Functional roles of Fas and Bcl-2-regulated apoptosis of T lymphocytes
-
Van Parijs, L., A. Biuckians, and A. K. Abbas. 1998. Functional roles of Fas and Bcl-2-regulated apoptosis of T lymphocytes. J. Immunol. 160:2065.
-
(1998)
J. Immunol.
, vol.160
, pp. 2065
-
-
Van Parijs, L.1
Biuckians, A.2
Abbas, A.K.3
-
10
-
-
0031255053
-
Induction of T cell clonal anergy results in resistance, whereas CD28-mediated costimulation primes for susceptibility to Fas- and Bax-mediated programmed cell death
-
Boussiotis, V. A., B. J. Lee, G. J. Freeman, J. G. Gribben, and L. M. Nadler. 1997. Induction of T cell clonal anergy results in resistance, whereas CD28-mediated costimulation primes for susceptibility to Fas- and Bax-mediated programmed cell death. J. Immunol. 159:3156.
-
(1997)
J. Immunol.
, vol.159
, pp. 3156
-
-
Boussiotis, V.A.1
Lee, B.J.2
Freeman, G.J.3
Gribben, J.G.4
Nadler, L.M.5
-
11
-
-
0031965469
-
A natural immunological adjuvant enhances T cell clonal expansion through a CD28-dependent, interleukin (IL)-2-independent mechanism
-
Khoruts, A., A. Mondino, K. A. Pape, S. L. Reiner, and M. K. Jenkins. 1998. A natural immunological adjuvant enhances T cell clonal expansion through a CD28-dependent, interleukin (IL)-2-independent mechanism. J. Exp. Med. 187:225.
-
(1998)
J. Exp. Med.
, vol.187
, pp. 225
-
-
Khoruts, A.1
Mondino, A.2
Pape, K.A.3
Reiner, S.L.4
Jenkins, M.K.5
-
12
-
-
0033994661
-
The insulin-like growth factor-I receptor is regulated by CD28 and protects activated T cells from apoptosis
-
Walsh, P. T., and R. O'Connor. 2000. The insulin-like growth factor-I receptor is regulated by CD28 and protects activated T cells from apoptosis. Eur. J. Immunol. 30:1010.
-
(2000)
Eur. J. Immunol.
, vol.30
, pp. 1010
-
-
Walsh, P.T.1
O'Connor, R.2
-
14
-
-
0033151622
-
Reactive oxygen species regulate activation-induced T cell apoptosis
-
Hildeman, D. A., T. Mitchell, T. K. Teague, P. Henson, B. J. Day, J. Kappler, and P. C. Marrack. 1999. Reactive oxygen species regulate activation-induced T cell apoptosis. Immunity 10:735.
-
(1999)
Immunity
, vol.10
, pp. 735
-
-
Hildeman, D.A.1
Mitchell, T.2
Teague, T.K.3
Henson, P.4
Day, B.J.5
Kappler, J.6
Marrack, P.C.7
-
15
-
-
0036069819
-
Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim
-
Hildeman, D. A., Y. Zhu, T. C. Mitchell, P. Bouillet, A. Strasser, J. Kappler, and P. Marrack. 2002. Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim. Immunity 16:759.
-
(2002)
Immunity
, vol.16
, pp. 759
-
-
Hildeman, D.A.1
Zhu, Y.2
Mitchell, T.C.3
Bouillet, P.4
Strasser, A.5
Kappler, J.6
Marrack, P.7
-
16
-
-
0033258120
-
Bcl-2 proteins: Regulators of apoptosis or of mitochondrial homeostasis?
-
Vander Heiden, M. G., and C. B. Thompson. 1999. Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis? Nat. Cell Biol. 1:E209.
-
(1999)
Nat. Cell Biol.
, vol.1
-
-
Vander Heiden, M.G.1
Thompson, C.B.2
-
17
-
-
0030293443
-
CD28/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferation
-
Sperling, A. I., J. A. Auger, B. D. Ehst, I. C. Rulifson, C. B. Thompson, and J. A. Bluestone. 1996. CD28/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferation. J. Immunol. 157:3909.
-
(1996)
J. Immunol.
, vol.1571
, pp. 3909
-
-
Sperling, A.I.1
Auger, J.A.2
Ehst, B.D.3
Rulifson, I.C.4
Thompson, C.B.5
Bluestone, J.A.6
-
20
-
-
0029161649
-
Blocking CD28/B7 with soluble competitors: Immunological phenotype of mCTLA4-Hγ1 transgenic mice
-
Lane, P. 1995. Blocking CD28/B7 with soluble competitors: immunological phenotype of mCTLA4-Hγ1 transgenic mice. Res. Immunol. 146:176.
-
(1995)
Res. Immunol.
, vol.146
, pp. 176
-
-
Lane, P.1
-
21
-
-
0030966217
-
Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement
-
Perez, V. L., L. Van Parijs, A. Biuckians, X. X. Zheng, T. B. Strom, and A. K. Abbas. 1997. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity 6:411.
-
(1997)
Immunity
, vol.6
, pp. 411
-
-
Perez, V.L.1
Van Parijs, L.2
Biuckians, A.3
Zheng, X.X.4
Strom, T.B.5
Abbas, A.K.6
-
22
-
-
0032545452
-
Molecular basis of T cell inactivation by CTLA-4
-
Lee, K. M., E. Chuang, M. Griffin, R. Khattri, D. K. Hong, W. Zhang, D. Straus, L. E. Samelson, C. B. Thompson, and J. A. Bluestone. 1998. Molecular basis of T cell inactivation by CTLA-4. Science 282:2263.
-
(1998)
Science
, vol.282
, pp. 2263
-
-
Lee, K.M.1
Chuang, E.2
Griffin, M.3
Khattri, R.4
Hong, D.K.5
Zhang, W.6
Straus, D.7
Samelson, L.E.8
Thompson, C.B.9
Bluestone, J.A.10
-
23
-
-
0035102196
-
CTLA-4 regulates induction of anergy in vivo
-
Greenwald, R. J., V. A. Boussiotis, R. B. Lorsbach, A. K. Abbas, and A. H. Sharpe. 2001. CTLA-4 regulates induction of anergy in vivo. Immunity 14:145.
-
(2001)
Immunity
, vol.14
, pp. 145
-
-
Greenwald, R.J.1
Boussiotis, V.A.2
Lorsbach, R.B.3
Abbas, A.K.4
Sharpe, A.H.5
-
24
-
-
0033198045
-
The role of CTLA-4 in regulating Th2 differentiation
-
Oosterwegel, M. A., D. A. Mandelbrot, S. D. Boyd, R. B. Lorsbach, D. Y. Jarrett, A. K. Abbas, and A. H. Sharpe. 1999. The role of CTLA-4 in regulating Th2 differentiation. J. Immunol. 163:2634.
-
(1999)
J. Immunol.
, vol.163
, pp. 2634
-
-
Oosterwegel, M.A.1
Mandelbrot, D.A.2
Boyd, S.D.3
Lorsbach, R.B.4
Jarrett, D.Y.5
Abbas, A.K.6
Sharpe, A.H.7
-
25
-
-
0033563265
-
Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses
-
Khattri, R., J. A. Auger, M. D. Griffin, A. H. Sharpe, and J. A. Bluestone. 1999. Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses. J. Immunol. 162:5784.
-
(1999)
J. Immunol.
, vol.162
, pp. 5784
-
-
Khattri, R.1
Auger, J.A.2
Griffin, M.D.3
Sharpe, A.H.4
Bluestone, J.A.5
-
26
-
-
0036232603
-
The role of CTLA-4 in induction and maintenance of peripheral T cell tolerance
-
Eagar, T. N., N. J. Karandikar, J. A. Bluestone, and S. D. Miller. 2002. The role of CTLA-4 in induction and maintenance of peripheral T cell tolerance. Eur. J. Immunol. 32:972.
-
(2002)
Eur. J. Immunol.
, vol.32
, pp. 972
-
-
Eagar, T.N.1
Karandikar, N.J.2
Bluestone, J.A.3
Miller, S.D.4
-
27
-
-
0034653663
-
Absence of host B7 expression is sufficient for long-term murine vascularized heart allograft survival
-
Szot, G. L., P. Zhou, A. H. Sharpe, G. He, O. Kim, K. A. Newell, J. A. Bluestone, and J. R. Thistlethwaite, Jr. 2000. Absence of host B7 expression is sufficient for long-term murine vascularized heart allograft survival. Transplantation 69:904.
-
(2000)
Transplantation
, vol.69
, pp. 904
-
-
Szot, G.L.1
Zhou, P.2
Sharpe, A.H.3
He, G.4
Kim, O.5
Newell, K.A.6
Bluestone, J.A.7
Thistlethwaite J.R., Jr.8
-
28
-
-
0028485743
-
The Fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice
-
Singer, G. G., and A. K. Abbas. 1994, The Fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity 1:365.
-
(1994)
Immunity
, vol.1
, pp. 365
-
-
Singer, G.G.1
Abbas, A.K.2
-
30
-
-
0029097729
-
Fas (CD95) participates in peripheral T cell deletion and associated apoptosis in vivo
-
Mogil, R. J., L. Radvanyi, R. Gonzalez-Quintial, R. Miller, G. Mills, A. N. Theofilopoulos, and D. R. Green. 1995. Fas (CD95) participates in peripheral T cell deletion and associated apoptosis in vivo. Int. Immunol. 7:1451.
-
(1995)
Int. Immunol.
, vol.7
, pp. 1451
-
-
Mogil, R.J.1
Radvanyi, L.2
Gonzalez-Quintial, R.3
Miller, R.4
Mills, G.5
Theofilopoulos, A.N.6
Green, D.R.7
-
31
-
-
0029944667
-
Enhanced and accelerated lymphoproliferation in Fas-null mice
-
Adachi, M., S. Suematsu, T. Suda, D. Watanabe, H. Fukuyama, J. Ogasawara, T. Tanaka, N. Yoshida, and S. Nagata. 1996. Enhanced and accelerated lymphoproliferation in Fas-null mice. Proc. Natl. Acad, Sci. USA 93:2131.
-
(1996)
Proc. Natl. Acad, Sci. USA
, vol.93
, pp. 2131
-
-
Adachi, M.1
Suematsu, S.2
Suda, T.3
Watanabe, D.4
Fukuyama, H.5
Ogasawara, J.6
Tanaka, T.7
Yoshida, N.8
Nagata, S.9
-
32
-
-
0033198142
-
+ T cells
-
+ T cells. J. Immunol. 163:2358.
-
(1999)
J. Immunol.
, vol.163
, pp. 2358
-
-
Newell, K.A.1
He, G.2
Guo, Z.3
Kim, O.4
Szot, G.L.5
Rulifson, I.6
Zhou, P.7
Hart, J.8
Thistlethwaite, J.R.9
Bluestone, J.A.10
-
33
-
-
0030200829
-
The roles of Fas/APO-1 (CD95) and TNF in antigen-induced programmed cell death in T cell receptor transgenic mice
-
Sytwu, H. K., R. S. Liblau, and H. O. McDevitt. 1996. The roles of Fas/APO-1 (CD95) and TNF in antigen-induced programmed cell death in T cell receptor transgenic mice. Immunity 5:17.
-
(1996)
Immunity
, vol.5
, pp. 17
-
-
Sytwu, H.K.1
Liblau, R.S.2
McDevitt, H.O.3
-
34
-
-
0029112253
-
Induction of apoptosis in mature T cells by tumour necrosis factor
-
Zheng, L., G. Fisher, R. E. Miller, J. Peschon, D. H. Lynch, and M. J. Lenardo. 1995. Induction of apoptosis in mature T cells by tumour necrosis factor. Nature 377:348.
-
(1995)
Nature
, vol.377
, pp. 348
-
-
Zheng, L.1
Fisher, G.2
Miller, R.E.3
Peschon, J.4
Lynch, D.H.5
Lenardo, M.J.6
-
35
-
-
0030060153
-
Peripheral T cells undergoing superantigen-induced apoptosis in vivo express B220 and upregulate Fas and Fas ligand
-
Renno, T., M. Hahne, J. Tschopp, and H. R. MacDonald. 1996. Peripheral T cells undergoing superantigen-induced apoptosis in vivo express B220 and upregulate Fas and Fas ligand. J. Exp. Med. 183:431.
-
(1996)
J. Exp. Med.
, vol.183
, pp. 431
-
-
Renno, T.1
Hahne, M.2
Tschopp, J.3
MacDonald, H.R.4
-
36
-
-
0023655998
-
T cell receptor tyrosine phosphorylation: Variable coupling for different activating ligands
-
Klausner, R. D., J. J. O'Shea, H. Luong, P. Ross, J. A. Bluestone, and L. E. Samelson. 1987. T cell receptor tyrosine phosphorylation: variable coupling for different activating ligands. J. Biol. Chem. 262:12654.
-
(1987)
J. Biol. Chem.
, vol.262
, pp. 12654
-
-
Klausner, R.D.1
O'Shea, J.J.2
Luong, H.3
Ross, P.4
Bluestone, J.A.5
Samelson, L.E.6
-
37
-
-
0028079746
-
Delayed kinetics of T lymphocyte anergy and deletion in lpr mice
-
Mixter, P. F., J. Q. Russell, and R. C. Budd. 1994. Delayed kinetics of T lymphocyte anergy and deletion in lpr mice. J. Autoimmun. 7:697.
-
(1994)
J. Autoimmun.
, vol.7
, pp. 697
-
-
Mixter, P.F.1
Russell, J.Q.2
Budd, R.C.3
-
38
-
-
0027266844
-
Studies of T cell deletion and T cell anergy following in vivo administration of SEB to normal and lupus-prone mice
-
Scott, D. E., W. J. Kisch, and A. D. Steinberg. 1993. Studies of T cell deletion and T cell anergy following in vivo administration of SEB to normal and lupus-prone mice. J. Immunol. 150:664.
-
(1993)
J. Immunol.
, vol.150
, pp. 664
-
-
Scott, D.E.1
Kisch, W.J.2
Steinberg, A.D.3
-
39
-
-
0028379675
-
Defective clonal deletion and anergy induction in TCR transgenic lpr/lpr mice
-
Mountz, J. D., H. Bluethmann, T. Zhou. and J. Wu. 1994. Defective clonal deletion and anergy induction in TCR transgenic lpr/lpr mice. Semin. Immunol. 6:27.
-
(1994)
Semin. Immunol.
, vol.6
, pp. 27
-
-
Mountz, J.D.1
Bluethmann, H.2
Zhou, T.3
Wu, J.4
-
40
-
-
0034823168
-
Signaling through CD28 and CTLA-4 controls two distinct forms of T cell anergy
-
Wells, A. D., M. C. Walsh, J. A. Bluestone, and L. A. Turka. 2001. Signaling through CD28 and CTLA-4 controls two distinct forms of T cell anergy. J. Clin. Invest. 108:895.
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 895
-
-
Wells, A.D.1
Walsh, M.C.2
Bluestone, J.A.3
Turka, L.A.4
-
42
-
-
0345476290
-
Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance
-
Wells, A. D., X. C. Li, Y. Li, M. C. Walsh, X. X. Zheng, Z. Wu, G. Nunez, A. Tang, M. Sayegh, W. W. Hancock, T. B. Strom, and L. A. Turka. 1999. Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance. Nat. Med. 5:1303.
-
(1999)
Nat. Med.
, vol.5
, pp. 1303
-
-
Wells, A.D.1
Li, X.C.2
Li, Y.3
Walsh, M.C.4
Zheng, X.X.5
Wu, Z.6
Nunez, G.7
Tang, A.8
Sayegh, M.9
Hancock, W.W.10
Strom, T.B.11
Turka, L.A.12
-
43
-
-
0344613988
-
Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance
-
Li, Y., X. C. Li, X. X. Zheng, A. D. Wells, L. A. Turka, and T. B. Strom. 1999. Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance. Nat. Med. 5:1298.
-
(1999)
Nat. Med.
, vol.5
, pp. 1298
-
-
Li, Y.1
Li, X.C.2
Zheng, X.X.3
Wells, A.D.4
Turka, L.A.5
Strom, T.B.6
-
44
-
-
0033568236
-
Phase 1 trial of a humanized, Fc receptor nonbinding OKT3 antibody, huOKT3γ1(Ala-Ala) in the treatment of acute renal allograft rejection
-
Woodle, E. S., D. Xu, R. A. Zivin, J. Auger, J. Charette, R. O'Laughlin, D. Peace, L. K. Jollife, T. Haverty, J. A. Bluestone, and J. R. Thistlethwaite, Jr. 1999. Phase 1 trial of a humanized, Fc receptor nonbinding OKT3 antibody, huOKT3γ1(Ala-Ala) in the treatment of acute renal allograft rejection. Transplantation 68:608.
-
(1999)
Transplantation
, vol.68
, pp. 608
-
-
Woodle, E.S.1
Xu, D.2
Zivin, R.A.3
Auger, J.4
Charette, J.5
O'Laughlin, R.6
Peace, D.7
Jollife, L.K.8
Haverty, T.9
Bluestone, J.A.10
Thistlethwaite J.R., Jr.11
-
45
-
-
0037198420
-
Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus
-
Herold, K. C., W. Hagopian, J. A. Auger, E. Poumian-Ruiz, L. Taylor, D. Donaldson, S. E. Gitelman, D. M. Harlan, D. Xu, R. A. Zivin, and J. A. Bluestone. 2002. Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N. Engl. J. Med. 346:1692.
-
(2002)
N. Engl. J. Med.
, vol.346
, pp. 1692
-
-
Herold, K.C.1
Hagopian, W.2
Auger, J.A.3
Poumian-Ruiz, E.4
Taylor, L.5
Donaldson, D.6
Gitelman, S.E.7
Harlan, D.M.8
Xu, D.9
Zivin, R.A.10
Bluestone, J.A.11
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