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Volumn 170, Issue 7, 2003, Pages 3645-3652

TGFβ1 inhibits Ca2+-calcineurin-mediated activation in thymocytes

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CALCIUM; EGTAZIC ACID; IONOMYCIN; PHORBOL 13 ACETATE 12 MYRISTATE; RECEPTOR; T LYMPHOCYTE RECEPTOR; TACROLIMUS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 0037378732     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.7.3645     Document Type: Article
Times cited : (36)

References (69)
  • 4
    • 0034022166 scopus 로고    scopus 로고
    • TGF-β influences the life and death decisions of T lymphocytes
    • Wahl, S. M., J. M. Orenstein, and W. Chen. 2000. TGF-β influences the life and death decisions of T lymphocytes. Cytokine Growth Factor Rev. 11:71.
    • (2000) Cytokine Growth Factor Rev. , vol.11 , pp. 71
    • Wahl, S.M.1    Orenstein, J.M.2    Chen, W.3
  • 5
    • 0034065392 scopus 로고    scopus 로고
    • Murine models define the role of TGF-β as a master regulator of immune cell function
    • Letterio, J. J. 2000. Murine models define the role of TGF-β as a master regulator of immune cell function. Cytokine Growth Factor Rev. 11:81.
    • (2000) Cytokine Growth Factor Rev. , vol.11 , pp. 81
    • Letterio, J.J.1
  • 6
    • 0032588796 scopus 로고    scopus 로고
    • Strain dependency of TGFβ1 function during embryogenesis
    • Kallapur, S., I. Ormsby, and T. Doetschman. 1999. Strain dependency of TGFβ1 function during embryogenesis. Mol. Reprod. Dev. 52:341.
    • (1999) Mol. Reprod. Dev. , vol.52 , pp. 341
    • Kallapur, S.1    Ormsby, I.2    Doetschman, T.3
  • 7
  • 8
  • 9
    • 0028171401 scopus 로고
    • Targeted deletion of the TGF-β1 gene causes rapid progression to squamous cell carcinoma
    • Glick, A. B., M. M. Lee, N. Darwiche, A. B. Kulkarni, S. Karlsson, and S. H. Yuspa. 1994. Targeted deletion of the TGF-β1 gene causes rapid progression to squamous cell carcinoma. Genes Dev. 8:2429.
    • (1994) Genes Dev. , vol.8 , pp. 2429
    • Glick, A.B.1    Lee, M.M.2    Darwiche, N.3    Kulkarni, A.B.4    Karlsson, S.5    Yuspa, S.H.6
  • 11
    • 0032720627 scopus 로고    scopus 로고
    • Transforming growth factor β1 enhances platelet aggregation through a non-transcriptional effect on the fibrinogen receptor
    • Hoying, J. B., M. Yin, R. Diebold, I. Ormsby, A. Becker, and T. Doetschman. 1999. Transforming growth factor β1 enhances platelet aggregation through a non-transcriptional effect on the fibrinogen receptor. J. Biol. Chem. 274:31008.
    • (1999) J. Biol. Chem. , vol.274 , pp. 31008
    • Hoying, J.B.1    Yin, M.2    Diebold, R.3    Ormsby, I.4    Becker, A.5    Doetschman, T.6
  • 12
    • 0030598681 scopus 로고    scopus 로고
    • TGFβ1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice
    • Cui, W., D. J. Fowlis, S. Bryson, E. Duffie, H. Ireland, A. Balmain, and R. J. Akhurst. 1996. TGFβ1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice. Cell 86:531.
    • (1996) Cell , vol.86 , pp. 531
    • Cui, W.1    Fowlis, D.J.2    Bryson, S.3    Duffie, E.4    Ireland, H.5    Balmain, A.6    Akhurst, R.J.7
  • 14
    • 0033565626 scopus 로고    scopus 로고
    • Transforming growth factor β1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis
    • Engle, S. J., J. B. Hoying, G. P. Boivin, I. Ormsby, P. S. Gartside, and T. Doetschman. 1999. Transforming growth factor β1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis. Cancer Res. 59:3379.
    • (1999) Cancer Res. , vol.59 , pp. 3379
    • Engle, S.J.1    Hoying, J.B.2    Boivin, G.P.3    Ormsby, I.4    Gartside, P.S.5    Doetschman, T.6
  • 17
    • 0032567104 scopus 로고    scopus 로고
    • The function of TGF-β-mediated innocent bystander suppression associated with physiological self-tolerance in vivo
    • Teng, Y. T., R. M. Gorczynski, and N. Hozumi. 1998. The function of TGF-β-mediated innocent bystander suppression associated with physiological self-tolerance in vivo. Cell. Immunol. 190:51.
    • (1998) Cell. Immunol. , vol.190 , pp. 51
    • Teng, Y.T.1    Gorczynski, R.M.2    Hozumi, N.3
  • 18
    • 0026713026 scopus 로고
    • Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor β, interleukin 4, and prostaglandin E expression in the brain
    • Khoury, S. J., W. W. Hancock, and H. L. Weiner. 1992. Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor β, interleukin 4, and prostaglandin E expression in the brain. J. Exp. Med. 176:1355.
    • (1992) J. Exp. Med. , vol.176 , pp. 1355
    • Khoury, S.J.1    Hancock, W.W.2    Weiner, H.L.3
  • 20
    • 0034121583 scopus 로고    scopus 로고
    • When engineered to produce latent TGF-β1, antigen specific T cells down regulate Th1 cell-mediated autoimmune and Th2 cell-mediated allergic inflammatory processes
    • Thorbecke, G. J., D. T. Umetsu, R. H. deKruyff, G. Hansen, L. Z. Chen, and G. M. Hochwald. 2000. When engineered to produce latent TGF-β1, antigen specific T cells down regulate Th1 cell-mediated autoimmune and Th2 cell-mediated allergic inflammatory processes. Cytokine Growth Factor Rev. 11:89.
    • (2000) Cytokine Growth Factor Rev. , vol.11 , pp. 89
    • Thorbecke, G.J.1    Umetsu, D.T.2    DeKruyff, R.H.3    Hansen, G.4    Chen, L.Z.5    Hochwald, G.M.6
  • 21
    • 0030788348 scopus 로고    scopus 로고
    • Transforming growth factor-β1 induces antigen-specific unresponsiveness in naive T cells
    • Gilbert, K. M., M. Thoman, K. Bauche, T. Pham, and W. O. Weigle. 1997. Transforming growth factor-β1 induces antigen-specific unresponsiveness in naive T cells. Immunol. Invest. 26:459.
    • (1997) Immunol. Invest. , vol.26 , pp. 459
    • Gilbert, K.M.1    Thoman, M.2    Bauche, K.3    Pham, T.4    Weigle, W.O.5
  • 22
    • 0034661662 scopus 로고    scopus 로고
    • Activated self-MHC-reactive T cells have the cytokine phenotype of Th3/T regulatory cell 1 T cells
    • Kitani, A., K. Chua, K. Nakamura, and W. Strober. 2000. Activated self-MHC-reactive T cells have the cytokine phenotype of Th3/T regulatory cell 1 T cells. J. Immunol. 165:691.
    • (2000) J. Immunol. , vol.165 , pp. 691
    • Kitani, A.1    Chua, K.2    Nakamura, K.3    Strober, W.4
  • 23
    • 0033953109 scopus 로고    scopus 로고
    • The inhibitory effects of transforming growth factor-β-1 (TGF-β1) in autoimmune diseases
    • Prud'homme, G. J., and C. A. Piccirillo. 2000. The inhibitory effects of transforming growth factor-β-1 (TGF-β1) in autoimmune diseases. J. Autoimmun. 14:23.
    • (2000) J. Autoimmun. , vol.14 , pp. 23
    • Prud'homme, G.J.1    Piccirillo, C.A.2
  • 24
    • 0026542168 scopus 로고
    • Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor β after antigen-specific triggering
    • Miller, A., O. Lider, A. B. Roberts, M. B. Sporn, and H. L. Weiner. 1992. Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor β after antigen-specific triggering. Proc. Natl. Acad. Sci. USA 89:421.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 421
    • Miller, A.1    Lider, O.2    Roberts, A.B.3    Sporn, M.B.4    Weiner, H.L.5
  • 25
    • 0025179010 scopus 로고
    • The autocrine production of transforming growth factor-β1 during lymphocyte activation: A study with a monoclonal antibody-based ELISA
    • Lucas, C., L. N. Bald, B. M. Fendly, M. Mora-Worms, I. S. Figari, E. J. Patzer, and M. A. Palladino. 1990. The autocrine production of transforming growth factor-β1 during lymphocyte activation: a study with a monoclonal antibody-based ELISA. J. Immunol. 145:1415.
    • (1990) J. Immunol. , vol.145 , pp. 1415
    • Lucas, C.1    Bald, L.N.2    Fendly, B.M.3    Mora-Worms, M.4    Figari, I.S.5    Patzer, E.J.6    Palladino, M.A.7
  • 28
    • 0028989478 scopus 로고
    • Influence of TGF-β on murine thymocyte development in fetal thymus organ culture
    • Plum, J., M. De Smedt, G. Leclercq, and B. Vandekerckhove. 1995. Influence of TGF-β on murine thymocyte development in fetal thymus organ culture. J. Immunol. 154:5789.
    • (1995) J. Immunol. , vol.154 , pp. 5789
    • Plum, J.1    De Smedt, M.2    Leclercq, G.3    Vandekerckhove, B.4
  • 29
    • 0031781378 scopus 로고    scopus 로고
    • The three isoforms of transforming growth factor-β co-stimulate rat T cells and inhibit lymphocyte apoptosis
    • Schiott, A., H. O. Sjogren, and M. Lindvall. 1998. The three isoforms of transforming growth factor-β co-stimulate rat T cells and inhibit lymphocyte apoptosis. Scand. J. Immunol. 48:371.
    • (1998) Scand. J. Immunol. , vol.48 , pp. 371
    • Schiott, A.1    Sjogren, H.O.2    Lindvall, M.3
  • 30
    • 0033775776 scopus 로고    scopus 로고
    • Transforming growth factor-β induces apoptosis in activated murine T cells through the activation of caspase 1-like protease
    • Chung, E. J., S. H. Choi, Y. H. Shim, Y. J. Bang, K. C. Hur, and C. W. Kim. 2000. Transforming growth factor-β induces apoptosis in activated murine T cells through the activation of caspase 1-like protease. Cell. Immunol. 204:46.
    • (2000) Cell. Immunol. , vol.204 , pp. 46
    • Chung, E.J.1    Choi, S.H.2    Shim, Y.H.3    Bang, Y.J.4    Hur, K.C.5    Kim, C.W.6
  • 34
    • 0034131557 scopus 로고    scopus 로고
    • Abrogation of TGFβ signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease
    • Gorelik, L., and R. A. Flavell. 2000. Abrogation of TGFβ signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity 12:171.
    • (2000) Immunity , vol.12 , pp. 171
    • Gorelik, L.1    Flavell, R.A.2
  • 35
    • 0034600070 scopus 로고    scopus 로고
    • Disruption of T cell homeostasis in mice expressing a T cell-specific dominant negative transforming growth factor β II receptor
    • Lucas, P. J., S. J. Kim, S. J. Melby, and R. E. Gress. 2000. Disruption of T cell homeostasis in mice expressing a T cell-specific dominant negative transforming growth factor β II receptor. J. Exp. Med. 191:1187.
    • (2000) J. Exp. Med. , vol.191 , pp. 1187
    • Lucas, P.J.1    Kim, S.J.2    Melby, S.J.3    Gress, R.E.4
  • 36
    • 0034327176 scopus 로고    scopus 로고
    • Cutting edge: TGF-β inhibits Th type 2 development through inhibition of GATA-3 expression
    • Gorelik, L., P. E. Fields, and R. A. Flavell. 2000. Cutting edge: TGF-β inhibits Th type 2 development through inhibition of GATA-3 expression. J. Immunol. 165:4773.
    • (2000) J. Immunol. , vol.165 , pp. 4773
    • Gorelik, L.1    Fields, P.E.2    Flavell, R.A.3
  • 37
    • 0035873731 scopus 로고    scopus 로고
    • Genetic regulation of autoimmune disease: BALB/c background TGF-β1-deficient mice develop necroinflammatory IFN-γ-dependent hepatitis
    • Gorham, J. D., J. T. Lin, J. L. Sung, L. A. Rudner, and M. A. French. 2001. Genetic regulation of autoimmune disease: BALB/c background TGF-β1-deficient mice develop necroinflammatory IFN-γ-dependent hepatitis. J. Immunol. 166:6413.
    • (2001) J. Immunol. , vol.166 , pp. 6413
    • Gorham, J.D.1    Lin, J.T.2    Sung, J.L.3    Rudner, L.A.4    French, M.A.5
  • 40
    • 0030586654 scopus 로고    scopus 로고
    • Phorbol ester and calcium ionophore can replace TCR signals that induce positive selection of CD4 T cells
    • Takahama, Y., and H. Nakauchi. 1996. Phorbol ester and calcium ionophore can replace TCR signals that induce positive selection of CD4 T cells. J. Immunol. 157:1508.
    • (1996) J. Immunol. , vol.157 , pp. 1508
    • Takahama, Y.1    Nakauchi, H.2
  • 41
    • 0021958592 scopus 로고
    • Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester
    • Truneh, A., F. Albert, P. Golstein, and A. M. Schmitt-Verhulst. 1985. Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester. Nature 313:318.
    • (1985) Nature , vol.313 , pp. 318
    • Truneh, A.1    Albert, F.2    Golstein, P.3    Schmitt-Verhulst, A.M.4
  • 43
  • 44
    • 0026090594 scopus 로고
    • FK-506 and cyclosporin A inhibit highly similar signal transduction pathways in human T lymphocytes
    • Lin, C. S., R. C. Boltz, J. J. Siekierka, and N. H. Sigal. 1991. FK-506 and cyclosporin A inhibit highly similar signal transduction pathways in human T lymphocytes. Cell. Immunol. 133:269.
    • (1991) Cell. Immunol. , vol.133 , pp. 269
    • Lin, C.S.1    Boltz, R.C.2    Siekierka, J.J.3    Sigal, N.H.4
  • 46
    • 0027383412 scopus 로고
    • Regulation of CD4 and CD8 expression on mouse T cells: Active removal from the cell surface by two mechanisms
    • Anderson, S. J., and C. Coleclough. 1993. Regulation of CD4 and CD8 expression on mouse T cells: active removal from the cell surface by two mechanisms. J. Immunol. 151:5123.
    • (1993) J. Immunol. , vol.151 , pp. 5123
    • Anderson, S.J.1    Coleclough, C.2
  • 48
    • 0030784252 scopus 로고    scopus 로고
    • FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain
    • Cameron, A. M., F. C. J. Nucifora, E. T. Fung, D. J. Livingston, R. A. Aldape, C. A. Ross, and S. H. Snyder. 1997. FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain. J. Biol. Chem. 272:27582.
    • (1997) J. Biol. Chem. , vol.272 , pp. 27582
    • Cameron, A.M.1    Nucifora, F.C.J.2    Fung, E.T.3    Livingston, D.J.4    Aldape, R.A.5    Ross, C.A.6    Snyder, S.H.7
  • 54
    • 0031879342 scopus 로고    scopus 로고
    • FKBP12 is not required for the modulation of transforming growth factor β receptor I signaling activity in embryonic fibroblasts and thymocytes
    • Bassing, C. H., W. Shou, S. Muir, J. Heitman, M. M. Matzuk, and X. F. Wang. 1998. FKBP12 is not required for the modulation of transforming growth factor β receptor I signaling activity in embryonic fibroblasts and thymocytes. Cell Growth Differ. 9:223.
    • (1998) Cell Growth Differ. , vol.9 , pp. 223
    • Bassing, C.H.1    Shou, W.2    Muir, S.3    Heitman, J.4    Matzuk, M.M.5    Wang, X.F.6
  • 57
    • 0031568407 scopus 로고    scopus 로고
    • A shift from negative to positive selection of autoreactive T cells by the reduced level of TCR signal in TCR-transgenic CD3 ζ-deficient mice
    • Yamazaki, T., H. Arase, S. Ono, H. Ohno, H. Watanabe, and T. Saito. 1997. A shift from negative to positive selection of autoreactive T cells by the reduced level of TCR signal in TCR-transgenic CD3 ζ-deficient mice. J. Immunol. 158:1634.
    • (1997) J. Immunol. , vol.158 , pp. 1634
    • Yamazaki, T.1    Arase, H.2    Ono, S.3    Ohno, H.4    Watanabe, H.5    Saito, T.6
  • 58
    • 0035825644 scopus 로고    scopus 로고
    • Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation
    • Demetriou, M., M. Granovsky, S. Quaggin, and J. W. Dennis. 2001. Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation. Nature 409:733.
    • (2001) Nature , vol.409 , pp. 733
    • Demetriou, M.1    Granovsky, M.2    Quaggin, S.3    Dennis, J.W.4
  • 60
    • 0028296038 scopus 로고
    • Premature escape of doublepositive thymocytes to the periphery of young mice: Possible role in autoimmunity
    • Bonomo, A., P. J. Kehn, and E. M. Shevach. 1994. Premature escape of doublepositive thymocytes to the periphery of young mice: possible role in autoimmunity. J. Immunol. 152:1509.
    • (1994) J. Immunol. , vol.152 , pp. 1509
    • Bonomo, A.1    Kehn, P.J.2    Shevach, E.M.3
  • 61
    • 0030873556 scopus 로고    scopus 로고
    • Differential requirements for survival and proliferation of CD8 naive or memory T cells
    • Tanchot, C., F. A. Lemonnier, B. Perarnau, A. A. Freitas, and B. Rocha. 1997. Differential requirements for survival and proliferation of CD8 naive or memory T cells. Science 276:2057.
    • (1997) Science , vol.276 , pp. 2057
    • Tanchot, C.1    Lemonnier, F.A.2    Perarnau, B.3    Freitas, A.A.4    Rocha, B.5
  • 62
    • 0022461828 scopus 로고
    • Phorbol ester-stimulated T lymphocytes show enhanced adhesion to human endothelial cell monolayers
    • Haskard, D., D. Cavender, and M. Ziff. 1986. Phorbol ester-stimulated T lymphocytes show enhanced adhesion to human endothelial cell monolayers. J. Immunol. 137:1429.
    • (1986) J. Immunol. , vol.137 , pp. 1429
    • Haskard, D.1    Cavender, D.2    Ziff, M.3
  • 63
    • 0024280887 scopus 로고
    • Endothelial adhesiveness for blood neutrophils is inhibited by transforming growth factor-β
    • Gamble, J. R., and M. A. Vadas. 1988. Endothelial adhesiveness for blood neutrophils is inhibited by transforming growth factor-β. Science 242:97.
    • (1988) Science , vol.242 , pp. 97
    • Gamble, J.R.1    Vadas, M.A.2
  • 64
    • 0026096994 scopus 로고
    • Endothelial cell adhesiveness for human T lymphocytes is inhibited by transforming growth factor-β1
    • Gamble, J. R., and M. A. Vadas. 1991. Endothelial cell adhesiveness for human T lymphocytes is inhibited by transforming growth factor-β1. J. Immunol. 146:1149.
    • (1991) J. Immunol. , vol.146 , pp. 1149
    • Gamble, J.R.1    Vadas, M.A.2
  • 65
    • 0034084162 scopus 로고    scopus 로고
    • Regulatory T cells in autoimmmunity
    • Shevach, E. M. 2000. Regulatory T cells in autoimmmunity. Annu. Rev. Immunol. 18:423.
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 423
    • Shevach, E.M.1
  • 66
    • 0035993986 scopus 로고    scopus 로고
    • + T cells secreting transforming growth factor-β1 by altered peptide ligands expressed as self-antigens
    • + T cells secreting transforming growth factor-β1 by altered peptide ligands expressed as self-antigens. Int. Immunol. 14:857.
    • (2002) Int. Immunol. , vol.14 , pp. 857
    • Yamashiro, H.1    Hozumi, N.2    Nakano, N.3
  • 67
    • 0023896896 scopus 로고
    • Autoimmune myocarditis: A paradigm of post-infection autoimmune disease
    • Rose, N. R., A. Herskowitz, D. A. Neumann, and N. Neu. 1988. Autoimmune myocarditis: a paradigm of post-infection autoimmune disease. Immunol. Today 9:117.
    • (1988) Immunol. Today , vol.9 , pp. 117
    • Rose, N.R.1    Herskowitz, A.2    Neumann, D.A.3    Neu, N.4
  • 68
    • 0033104503 scopus 로고    scopus 로고
    • Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-β
    • Yang, X., J. J. Letterio, R. J. Lechleider, L. Chen. R. Hayman, H. Gu, A. B. Roberts, and C. Deng. 1999. Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-β. EMBO J. 18:1280.
    • (1999) EMBO J. , vol.18 , pp. 1280
    • Yang, X.1    Letterio, J.J.2    Lechleider, R.J.3    Chen, L.4    Hayman, R.5    Gu, H.6    Roberts, A.B.7    Deng, C.8
  • 69
    • 0035399833 scopus 로고    scopus 로고
    • The Smad3 protein is involved in TGF-β inhibition of class II transactivator and class II MHC expression
    • Dong, Y., L. Tang, J. J. Letterio, and E. N. Benveniste. 2001. The Smad3 protein is involved in TGF-β inhibition of class II transactivator and class II MHC expression. J. Immunol. 167:311.
    • (2001) J. Immunol. , vol.167 , pp. 311
    • Dong, Y.1    Tang, L.2    Letterio, J.J.3    Benveniste, E.N.4


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