메뉴 건너뛰기




Volumn 171, Issue 7, 2003, Pages 3333-3337

Cutting edge: Diabetes-associated quantitative trait locus, Idd4, is responsible for the IL-12p40 overexpression defect in nonobese diabetic (NOD) mice

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; COMPLEMENTARY DNA; INTERLEUKIN 12; PROTEIN P40; RNA;

EID: 0141886225     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.7.3333     Document Type: Article
Times cited : (27)

References (16)
  • 1
    • 0031423760 scopus 로고    scopus 로고
    • The nonobese diabetic mouse as a model of autoimmune diabetes: Immune dysregulation gets the NOD
    • Delovitch, T. L., and B. Singh. 1997. The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD. Immunity 7:727.
    • (1997) Immunity , vol.7 , pp. 727
    • Delovitch, T.L.1    Singh, B.2
  • 2
    • 0033486824 scopus 로고    scopus 로고
    • Localizing quantitative trait loci in the NOD mouse model of type 1 diabetes
    • Lyons, P. A., and L. S. Wicker. 1999. Localizing quantitative trait loci in the NOD mouse model of type 1 diabetes. Curr. Dir. Autoimmun. 1:208.
    • (1999) Curr. Dir. Autoimmun. , vol.1 , pp. 208
    • Lyons, P.A.1    Wicker, L.S.2
  • 3
    • 0028922437 scopus 로고
    • Genetic control of autoimmune diabetes in the NOD mouse
    • Wicker, L. S., J. A. Todd, and L. B. Peterson. 1995. Genetic control of autoimmune diabetes in the NOD mouse. Annu. Rev. Immunol. 13:179.
    • (1995) Annu. Rev. Immunol. , vol.13 , pp. 179
    • Wicker, L.S.1    Todd, J.A.2    Peterson, L.B.3
  • 4
    • 0033939014 scopus 로고    scopus 로고
    • Aberrant macrophage cytokine production is a conserved feature among autoimmune-prone mouse strains: Elevated interleukin (IL)-12 and an imbalance in tumor necrosis factor-α and IL-10 define a unique cytokine profile in macrophages from young nonobese diabetic mice
    • Alleva, D. G., R. P. Pavlovich, C. Grant, S. B. Kaser, and D. I. Beller. 2000. Aberrant macrophage cytokine production is a conserved feature among autoimmune-prone mouse strains: elevated interleukin (IL)-12 and an imbalance in tumor necrosis factor-α and IL-10 define a unique cytokine profile in macrophages from young nonobese diabetic mice. Diabetes 49:1106.
    • (2000) Diabetes , vol.49 , pp. 1106
    • Alleva, D.G.1    Pavlovich, R.P.2    Grant, C.3    Kaser, S.B.4    Beller, D.I.5
  • 5
    • 0035106949 scopus 로고    scopus 로고
    • SJL and NOD macrophages are uniquely characterized by genetically programmed, elevated expression of the IL-12(p40) gene, suggesting a conserved pathway for the induction oforgan-specific autoimmunity
    • Alleva, D. G., E. B. Johnson, J. Wilson, D. I. Beller, and P. J. Conlon. 2001. SJL and NOD macrophages are uniquely characterized by genetically programmed, elevated expression of the IL-12(p40) gene, suggesting a conserved pathway for the induction oforgan-specific autoimmunity. J. Leukocyte Biol. 69:440.
    • (2001) J. Leukocyte Biol. , vol.69 , pp. 440
    • Alleva, D.G.1    Johnson, E.B.2    Wilson, J.3    Beller, D.I.4    Conlon, P.J.5
  • 6
    • 0032534683 scopus 로고    scopus 로고
    • 1 lupus-prone mice and the Leishmania major-susceptible BALB/c strain
    • 1 lupus-prone mice and the Leishmania major-susceptible BALB/c strain. J. Immunol. 161:6878.
    • (1998) J. Immunol. , vol.161 , pp. 6878
    • Alleva, D.G.1    Kaser, S.B.2    Beller, D.I.3
  • 7
    • 0035424898 scopus 로고    scopus 로고
    • Dendritic cells from nonobese diabetic mice exhibir a defect in NF-κB regulation due to a hyperactive IκB kinase
    • Weaver, D. J., Jr., B. Poligone, T. Bui, U. M. Abdel-Motal, A. S. Baldwin, Jr., and R. Tisch. 2001. Dendritic cells from nonobese diabetic mice exhibir a defect in NF-κB regulation due to a hyperactive IκB kinase. J. Immunol. 167:1461.
    • (2001) J. Immunol. , vol.167 , pp. 1461
    • Weaver D.J., Jr.1    Poligone, B.2    Bui, T.3    Abdel-Motal, U.M.4    Baldwin A.S., Jr.5    Tisch, R.6
  • 10
    • 0030962503 scopus 로고    scopus 로고
    • Increased in vitro interleukin-12 production by peripheral blood in high-risk IDDM first degree relatives
    • Szelachowska, M., A. Kretowski, and I. Kinalska. 1997. Increased in vitro interleukin-12 production by peripheral blood in high-risk IDDM first degree relatives. Horm. Metab. Res. 29:168.
    • (1997) Horm. Metab. Res. , vol.29 , pp. 168
    • Szelachowska, M.1    Kretowski, A.2    Kinalska, I.3
  • 12
    • 0032769575 scopus 로고    scopus 로고
    • Genotypic and phenotypic characterization of six new recombinant congenic srrains derived from NOD/Shi and GBA/J genomes
    • Reifsnyder, P. C., J. C. Flynn,A. L. Gavin, E. A. Simone, J. J. Sharp, L. Herberg, and E. H. Leiter. 1999. Genotypic and phenotypic characterization of six new recombinant congenic srrains derived from NOD/Shi and GBA/J genomes. Mamm. Genome 10:161.
    • (1999) Mamm. Genome , vol.10 , pp. 161
    • Reifsnyder, P.C.1    Flynn, J.C.2    Gavin, A.L.3    Simone, E.A.4    Sharp, J.J.5    Herberg, L.6    Leiter, E.H.7
  • 13
    • 0030140381 scopus 로고    scopus 로고
    • Production of congenic mouse strains carrying NOD-derived diabetogenic genetic intervals: An approach for the genetic dissection of complex traits
    • Yui, M. A., K. Muralidharan, B. Moreno-Altamirano, G. Perrin, K. Chestnut, and E. K. Wakeland. 1996. Production of congenic mouse strains carrying NOD-derived diabetogenic genetic intervals: an approach for the genetic dissection of complex traits. Mamm. Genome 7:331.
    • (1996) Mamm. Genome , vol.7 , pp. 331
    • Yui, M.A.1    Muralidharan, K.2    Moreno-Altamirano, B.3    Perrin, G.4    Chestnut, K.5    Wakeland, E.K.6
  • 14
    • 0036560003 scopus 로고    scopus 로고
    • Polymorphisms in the Il2b gene affect structure and expression of IL-12 in NOD and other autoimmune-prone mouse strains
    • Ymer, S. I., D. Huang, G. Penna, S. Gregori, K. Branson, L. Adorini, and G. Morahan. 2002. Polymorphisms in the Il2b gene affect structure and expression of IL-12 in NOD and other autoimmune-prone mouse strains. Genes Immun. 3:151.
    • (2002) Genes Immun. , vol.3 , pp. 151
    • Ymer, S.I.1    Huang, D.2    Penna, G.3    Gregori, S.4    Branson, K.5    Adorini, L.6    Morahan, G.7
  • 15
    • 0036097734 scopus 로고    scopus 로고
    • Congenic mapping of the diabetogenic locus Idd4 to a 5.2-cM region of chromosome 11 in NOD mice: Identification of two potential candidate subloci
    • Grattan, M., Q. S. Mi, C. Meagher, and T. L. Delovirch. 2002. Congenic mapping of the diabetogenic locus Idd4 to a 5.2-cM region of chromosome 11 in NOD mice: identification of two potential candidate subloci. Diabetes 51:215.
    • (2002) Diabetes , vol.51 , pp. 215
    • Grattan, M.1    Mi, Q.S.2    Meagher, C.3    Delovirch, T.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.