-
2
-
-
0034785496
-
Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis
-
Yang, J., and Liu, Y. 2001. Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. Am. J. Pathol. 159:1465-1475.
-
(2001)
Am. J. Pathol.
, vol.159
, pp. 1465-1475
-
-
Yang, J.1
Liu, Y.2
-
3
-
-
0036322007
-
Evidence that fibroblasts derive from epithelium during tissue fibrosis
-
doi:10.1172/JCI200215518
-
Iwano, M., et al. 2002. Evidence that fibroblasts derive from epithelium during tissue fibrosis. J. Clin. Invest. 110:341-350. doi:10.1172/JCI200215518.
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 341-350
-
-
Iwano, M.1
-
4
-
-
0036854980
-
Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy
-
doi:10.1172/JCI200216219
-
Yang, J., et al. 2002. Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy. J. Clin. Invest. 110:1525-1538. doi:10.1172/JCI200216219.
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 1525-1538
-
-
Yang, J.1
-
5
-
-
0034799176
-
Renal fibrosis: Collagen composition and assembly regulates epithelial-mesenchymal transdifferentiation
-
Zeisberg, M., et al. 2001. Renal fibrosis: collagen composition and assembly regulates epithelial-mesenchymal transdifferentiation. Am. J. Pathol. 159:1313-1321.
-
(2001)
Am. J. Pathol.
, vol.159
, pp. 1313-1321
-
-
Zeisberg, M.1
-
6
-
-
0036138824
-
Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis
-
Yang, J., and Liu, Y. 2002. Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis. J. Am. Soc. Nephrol. 13:96-107.
-
(2002)
J. Am. Soc. Nephrol.
, vol.13
, pp. 96-107
-
-
Yang, J.1
Liu, Y.2
-
7
-
-
0030670132
-
Early role of Fspl in epithelial-mesenchymal transformation
-
Okada, H., Danoff, T.M., Kalluri, R., and Neilson, E.G. 1997. Early role of Fspl in epithelial-mesenchymal transformation. Am. J. Physiol. 273:F563-F574.
-
(1997)
Am. J. Physiol.
, vol.273
-
-
Okada, H.1
Danoff, T.M.2
Kalluri, R.3
Neilson, E.G.4
-
8
-
-
0032842887
-
Transforming growth factor-beta regulates tubular epithelial-myofibroblast transdifferentiation in vitro
-
Fan, J.M., et al. 1999. Transforming growth factor-beta regulates tubular epithelial-myofibroblast transdifferentiation in vitro. Kidney Int. 56:1455-1467.
-
(1999)
Kidney Int.
, vol.56
, pp. 1455-1467
-
-
Fan, J.M.1
-
9
-
-
0036233040
-
Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation
-
Strutz, F., et al. 2002. Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation. Kidney Int. 61:1714-1728.
-
(2002)
Kidney Int.
, vol.61
, pp. 1714-1728
-
-
Strutz, F.1
-
10
-
-
0036785218
-
Hepatocyte growth factor gene therapy and angiotensin II blockade synergistically attenuate renal interstitial fibrosis in mice
-
Yang, J., Dai, C., and Liu, Y. 2002. Hepatocyte growth factor gene therapy and angiotensin II blockade synergistically attenuate renal interstitial fibrosis in mice. J. Am. Soc. Nephrol. 13:2464-2477.
-
(2002)
J. Am. Soc. Nephrol.
, vol.13
, pp. 2464-2477
-
-
Yang, J.1
Dai, C.2
Liu, Y.3
-
11
-
-
0030975645
-
TGF-beta in kidney fibrosis: A target for gene therapy
-
Border, W.A., and Noble, N.A. 1997. TGF-beta in kidney fibrosis: a target for gene therapy. Kidney Int. 51:1388-1396.
-
(1997)
Kidney Int.
, vol.51
, pp. 1388-1396
-
-
Border, W.A.1
Noble, N.A.2
-
13
-
-
0037302348
-
TGF-beta signal transduction and mesangial cell fibrogenesis
-
Schnaper, H.W., Hayashida, T., Hubchak, S.C., and Poncelet, A.C. 2003. TGF-beta signal transduction and mesangial cell fibrogenesis. Am. J. Physiol. Renal Physiol. 284:F243-F252.
-
(2003)
Am. J. Physiol. Renal Physiol.
, vol.284
-
-
Schnaper, H.W.1
Hayashida, T.2
Hubchak, S.C.3
Poncelet, A.C.4
-
14
-
-
0033638127
-
Molecular basis of renal fibrosis
-
Eddy, A.A. 2000. Molecular basis of renal fibrosis. Pediatr. Nephrol. 15:290-301.
-
(2000)
Pediatr. Nephrol.
, vol.15
, pp. 290-301
-
-
Eddy, A.A.1
-
15
-
-
0032540207
-
Transforming growth factor-beta receptor types I and II are expressed in renal tubules and are increased after chronic unilateral ureteral obstruction
-
Sutaria, P.M., Ohebshalom, M., McCaffrey, T.A., Vaughan, E.D., Jr., and Felsen, D. 1998. Transforming growth factor-beta receptor types I and II are expressed in renal tubules and are increased after chronic unilateral ureteral obstruction. Life Sci. 62:1965-1972.
-
(1998)
Life Sci.
, vol.62
, pp. 1965-1972
-
-
Sutaria, P.M.1
Ohebshalom, M.2
McCaffrey, T.A.3
Vaughan Jr., E.D.4
Felsen, D.5
-
16
-
-
0034903605
-
ILK interactions
-
Wu, C. 2001. ILK interactions. J. Cell Sci. 114:2549-2550.
-
(2001)
J. Cell Sci.
, vol.114
, pp. 2549-2550
-
-
Wu, C.1
-
17
-
-
0035969233
-
Integrin-linked kinase (ILK) and its interactors: A new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes
-
Wu, C., and Dedhar, S. 2001. Integrin-linked kinase (ILK) and its interactors: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes. J. Cell Biol. 155:505-510.
-
(2001)
J. Cell Biol.
, vol.155
, pp. 505-510
-
-
Wu, C.1
Dedhar, S.2
-
18
-
-
0032787837
-
Integrin-linked kinase (ILK): A regulator of integrin and growth-factor signalling
-
Dedhar, S., Williams, B., and Hannigan, G. 1999. Integrin-linked kinase (ILK): a regulator of integrin and growth-factor signalling. Trends Cell Biol. 9:319-323.
-
(1999)
Trends Cell Biol.
, vol.9
, pp. 319-323
-
-
Dedhar, S.1
Williams, B.2
Hannigan, G.3
-
19
-
-
0034104592
-
Cell-substrate interactions and signaling through ILK
-
Dedhar, S. 2000. Cell-substrate interactions and signaling through ILK. Curr. Opin. Cell Biol. 12:250-256.
-
(2000)
Curr. Opin. Cell Biol.
, vol.12
, pp. 250-256
-
-
Dedhar, S.1
-
20
-
-
0031962084
-
Integrin-linked protein kinase regulates fibronectin matrix assembly. E-cadherin expression, and tumorigenicity
-
Wu, C., et al. 1998. Integrin-linked protein kinase regulates fibronectin matrix assembly, E-cadherin expression, and tumorigenicity. J. Biol. Chem. 273:528-536.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 528-536
-
-
Wu, C.1
-
21
-
-
0035432903
-
Integrin-linked kinase as a as a candidate downstream effector in proteinuria
-
Kretzler, M., et al. 2001. Integrin-linked kinase as a as a candidate downstream effector in proteinuria. FASEB J 15:1843-1845.
-
(2001)
FASEB J.
, vol.15
, pp. 1843-1845
-
-
Kretzler, M.1
-
22
-
-
0035152114
-
The distribution and regulation of integrin-linked kinase in normal and diabetic kidneys
-
Guo, L., Sanders, P.W., Woods, A., and Wu, C. 2001. The distribution and regulation of integrin-linked kinase in normal and diabetic kidneys. Am. J. Pathol. 159:1735-1742.
-
(2001)
Am. J. Pathol.
, vol.159
, pp. 1735-1742
-
-
Guo, L.1
Sanders, P.W.2
Woods, A.3
Wu, C.4
-
23
-
-
0030611757
-
Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling
-
Nakao, A., et al. 1997. Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling. Nature. 389:631-635.
-
(1997)
Nature
, vol.389
, pp. 631-635
-
-
Nakao, A.1
-
24
-
-
0033789680
-
The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells
-
Batlle, E., et al. 2000. The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat. Cell Biol. 2:84-89.
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 84-89
-
-
Batlle, E.1
-
25
-
-
0031105408
-
Cell lines with extended in vitro growth potential from human renal proximal tubule: Characterization, response to inducers, and comparison with established cell lines
-
Racusen, L.C., et al. 1997. Cell lines with extended in vitro growth potential from human renal proximal tubule: characterization, response to inducers, and comparison with established cell lines. J. Lab. Clin. Med. 129:318-329.
-
(1997)
J. Lab. Clin. Med.
, vol.129
, pp. 318-329
-
-
Racusen, L.C.1
-
26
-
-
0032750817
-
Hepatocyte growth factor promotes renal epithelial cell survival by dual mechanisms
-
Liu, Y. 1999. Hepatocyte growth factor promotes renal epithelial cell survival by dual mechanisms. Am. J. Physiol. 277:F624-F633.
-
(1999)
Am. J. Physiol.
, vol.277
-
-
Liu, Y.1
-
27
-
-
0037849935
-
Transforming growth factor-β1 potentiates renal tubular epithelial cell death by a mechanism independent of Smad signaling
-
Dai, C., Yang, J., and Liu, Y. 2003. Transforming growth factor-β1 potentiates renal tubular epithelial cell death by a mechanism independent of Smad signaling. J. Biol. Chem. 278:12537-12545.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 12537-12545
-
-
Dai, C.1
Yang, J.2
Liu, Y.3
-
28
-
-
0034912450
-
PAI-1 deficiency attenuates the fibrogenic response to ureteral obstruction
-
Oda, T., et al. 2001. PAI-1 deficiency attenuates the fibrogenic response to ureteral obstruction. Kidney Int. 60:587-596.
-
(2001)
Kidney Int.
, vol.60
, pp. 587-596
-
-
Oda, T.1
-
30
-
-
0028832482
-
Renoprotective effect of enalapril in uninephrectomized spontaneously hypertensive rats with neonatal streptozotocin-induced diabetes
-
Sato, Y., et al. 1995. Renoprotective effect of enalapril in uninephrectomized spontaneously hypertensive rats with neonatal streptozotocin-induced diabetes. Diabetes Res. Clin. Pract. 29:153-161.
-
(1995)
Diabetes Res. Clin. Pract.
, vol.29
, pp. 153-161
-
-
Sato, Y.1
-
31
-
-
0032911053
-
Up-regulation of hepatocyte growth factor receptor: An amplification and targeting mechanism for hepatocyte growth factor action in acute renal failure
-
Liu, Y., et al. 1999. Up-regulation of hepatocyte growth factor receptor: an amplification and targeting mechanism for hepatocyte growth factor action in acute renal failure. Kidney Int. 55:442-453.
-
(1999)
Kidney Int.
, vol.55
, pp. 442-453
-
-
Liu, Y.1
-
32
-
-
13344270369
-
The molecular architecture of focal adhesions
-
Jockusch, B.M., et al. 1995. The molecular architecture of focal adhesions. Annu. Rev. Cell Dev. Biol. 11:379-416.
-
(1995)
Annu. Rev. Cell Dev. Biol.
, vol.11
, pp. 379-416
-
-
Jockusch, B.M.1
-
33
-
-
0034702253
-
Cloning of an isoform of integrin-linked kinase (ILK) that is upregulated in HT-144 melanoma cells following TGF-beta1 stimulation
-
Janji, B., Melchior, C., Vallar, L., and Kieffer, N. 2000. Cloning of an isoform of integrin-linked kinase (ILK) that is upregulated in HT-144 melanoma cells following TGF-beta1 stimulation. Oncogene. 19:3069-3077.
-
(2000)
Oncogene
, vol.19
, pp. 3069-3077
-
-
Janji, B.1
Melchior, C.2
Vallar, L.3
Kieffer, N.4
-
34
-
-
0036587571
-
Transforming growth factor beta signal transduction
-
Dennler, S., Goumans, M.J., and ten Dijke, P. 2002. Transforming growth factor beta signal transduction. J. Leukoc. Biol. 71:731-740.
-
(2002)
J. Leukoc. Biol.
, vol.71
, pp. 731-740
-
-
Dennler, S.1
Goumans, M.J.2
Ten Dijke, P.3
-
35
-
-
0034574298
-
How cells read TGF-beta signals
-
Massague, J. 2000. How cells read TGF-beta signals. Nat. Rev. Mol. Cell Biol. 1:169-178.
-
(2000)
Nat. Rev. Mol. Cell Biol.
, vol.1
, pp. 169-178
-
-
Massague, J.1
-
36
-
-
0036014928
-
Smad7 inhibits fibrotic effect of TGF-beta on renal tubular epithelial cells by blocking smad2 activation
-
Li, J.H., et al. 2002. Smad7 inhibits fibrotic effect of TGF-beta on renal tubular epithelial cells by blocking smad2 activation. J. Am. Soc. Nephrol. 13:1464-1472.
-
(2002)
J. Am. Soc. Nephrol.
, vol.13
, pp. 1464-1472
-
-
Li, J.H.1
-
37
-
-
0035185853
-
Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism
-
Bhowmick, N.A., et al. 2001. Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. Mol. Biol. Cell 12:27-36.
-
(2001)
Mol. Biol. Cell.
, vol.12
, pp. 27-36
-
-
Bhowmick, N.A.1
-
38
-
-
0036617188
-
TGFbeta3-induced activation of RhoA/Rho-kinase pathway is necessary but not sufficient for epithelio-mesenchymal transdifferentiation: Implications for palatogenesis
-
Kaartinen, V., Haataja, L., Nagy, A., Heisterkamp, N., and Groffen, J. 2002. TGFbeta3-induced activation of RhoA/Rho-kinase pathway is necessary but not sufficient for epithelio-mesenchymal transdifferentiation: implications for palatogenesis. Int. J. Mol. Med. 9:563-570.
-
(2002)
Int. J. Mol. Med.
, vol.9
, pp. 563-570
-
-
Kaartinen, V.1
Haataja, L.2
Nagy, A.3
Heisterkamp, N.4
Groffen, J.5
-
39
-
-
0036673109
-
Regulation of fibronectin matrix, deposition and cell proliferation by the PINCH-ILK-CH-ILKBP complex
-
Guo, L., and Wu, C. 2002. Regulation of fibronectin matrix, deposition and cell proliferation by the PINCH-ILK-CH-ILKBP complex. FASEB J. 16:1298-1300.
-
(2002)
FASEB J.
, vol.16
, pp. 1298-1300
-
-
Guo, L.1
Wu, C.2
-
40
-
-
0035972170
-
A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading
-
Tu, Y., Huang, Y., Zhang, Y., Hua, Y., and Wu, C. 2001. A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading. J. Cell Biol. 153:585-598.
-
(2001)
J. Cell Biol.
, vol.153
, pp. 585-598
-
-
Tu, Y.1
Huang, Y.2
Zhang, Y.3
Hua, Y.4
Wu, C.5
-
41
-
-
0037059789
-
Molecular dissection of actopaxin-integrin-linked kinase-Paxillin interactions and their role in subcellular localization
-
Nikolopoulos, S.N., and Turner, C.E. 2002. Molecular dissection of actopaxin-integrin-linked kinase-Paxillin interactions and their role in subcellular localization. J. Biol. Chem. 277:1568-1575.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 1568-1575
-
-
Nikolopoulos, S.N.1
Turner, C.E.2
-
42
-
-
0035950544
-
Mammary epithelial-specific expression of the integrin-linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice
-
White, D.E., Cardiff, R.D., Dedhar, S., and Muller, W.J. 2001 Mammary epithelial-specific expression of the integrin-linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice. Oncogene. 20:7064-7072.
-
(2001)
Oncogene
, vol.20
, pp. 7064-7072
-
-
White, D.E.1
Cardiff, R.D.2
Dedhar, S.3
Muller, W.J.4
-
43
-
-
0032827029
-
Embryonic renal epithelia: Induction, nephrogenesis, and cell differentiation
-
Horster, M.F., Braun, G.S., and Huber, S.M. 1999. Embryonic renal epithelia: induction, nephrogenesis, and cell differentiation. Physiol. Rev. 79:1157-1191.
-
(1999)
Physiol. Rev.
, vol.79
, pp. 1157-1191
-
-
Horster, M.F.1
Braun, G.S.2
Huber, S.M.3
-
44
-
-
0032819810
-
Cadherins and their connections: Adhesion junctions have broader functions
-
Steinberg, M.S., and McNutt, P.M. 1999. Cadherins and their connections: adhesion junctions have broader functions. Curr. Opin. Cell Biol. 11:554-560.
-
(1999)
Curr. Opin. Cell Biol.
, vol.11
, pp. 554-560
-
-
Steinberg, M.S.1
McNutt, P.M.2
-
45
-
-
0037032804
-
Composition and formation of intercellular junctions in epithelial cells
-
Knust E., and Bossinger, O. 2002. Composition and formation of intercellular junctions in epithelial cells. Science. 298:1955-1959.
-
(2002)
Science
, vol.298
, pp. 1955-1959
-
-
Knust, E.1
Bossinger, O.2
-
46
-
-
0033784843
-
The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
-
Cano, A., et al. 2000. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat. Cell Biol 2:76-83.
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 76-83
-
-
Cano, A.1
-
47
-
-
0035804215
-
Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/-human colon carcinoma cells
-
Tan, C., et al. 2001. Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cells. Oncogene. 20:133-140.
-
(2001)
Oncogene
, vol.20
, pp. 133-140
-
-
Tan, C.1
-
48
-
-
0030943367
-
Localization of fibronectin matrix assembly sites on fibroblasts and endothelial cells
-
Christopher, R.A., Kowalczyk, A.P., and McKeown-Longo, P.J. 1997. Localization of fibronectin matrix assembly sites on fibroblasts and endothelial cells. J. Cell Sci. 110:569-581.
-
(1997)
J. Cell Sci.
, vol.110
, pp. 569-581
-
-
Christopher, R.A.1
Kowalczyk, A.P.2
McKeown-Longo, P.J.3
-
49
-
-
0034611008
-
Integrin dynamics and matrix assembly: Tensin-dependent translocation of alpha(5)beta(1) integrins promotes early fibronectin fibrillogenesis
-
Pankov, R., et al. 2000. Integrin dynamics and matrix assembly: tensin-dependent translocation of alpha(5)beta(1) integrins promotes early fibronectin fibrillogenesis. J. Cell Biol. 148:1075-1090.
-
(2000)
J. Cell Biol.
, vol.148
, pp. 1075-1090
-
-
Pankov, R.1
-
50
-
-
0037107551
-
Fibronectin at a glance
-
Pankov, R., and Yamada, KM. 2002. Fibronectin at a glance. J. Cell Sci. 115:3861-3863.
-
(2002)
J. Cell Sci.
, vol.115
, pp. 3861-3863
-
-
Pankov, R.1
Yamada, K.M.2
-
51
-
-
0028786294
-
Integrin activation and cytoskeletal interaction are essential for the assembly of a fibronectin matrix
-
Wu, C., Keivens, V.M., O'Toole, T.E., McDonald, J.A., and Ginsberg, M.H. 1995. Integrin activation and cytoskeletal interaction are essential for the assembly of a fibronectin matrix. Cell. 83:715-724.
-
(1995)
Cell
, vol.83
, pp. 715-724
-
-
Wu, C.1
Keivens, V.M.2
O'Toole, T.E.3
McDonald, J.A.4
Ginsberg, M.H.5
-
52
-
-
0034676338
-
The integrin linked kinase (ILK) induces an invasive phenotype via AP-1 transcription factor-dependent upregulation of matrix metalloproteinase 9 (MMP-9)
-
Troussard, A.A., et al. 2000. The integrin linked kinase (ILK) induces an invasive phenotype via AP-1 transcription factor-dependent upregulation of matrix metalloproteinase 9 (MMP-9). Oncogene. 19:5444-5452.
-
(2000)
Oncogene
, vol.19
, pp. 5444-5452
-
-
Troussard, A.A.1
-
53
-
-
0035844257
-
Ca2+-independent smooth muscle contraction. A novel function for integrin-linked kinase
-
Deng, J.T., Van Lierop, J.E., Sutherland, C., and Walsh, M.P. 2001. Ca2+-independent smooth muscle contraction. A novel function for integrin-linked kinase. J. Biol. Chem. 276:16365-16373.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 16365-16373
-
-
Deng, J.T.1
Van Lierop, J.E.2
Sutherland, C.3
Walsh, M.P.4
-
54
-
-
0035661067
-
Advanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products (RAGE)
-
doi:10.1172/JCI200111951
-
Oldfield, M.D., et al. 2001. Advanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products (RAGE). J. Clin. Invest. 108:1853-1863. doi:10.1172/JCI200111951.
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 1853-1863
-
-
Oldfield, M.D.1
-
55
-
-
0035990920
-
Integrin-linked kinase, a promising cancer therapeutic target: Biochemical and biological properties
-
Yoganathan, N., et al. 2002. Integrin-linked kinase, a promising cancer therapeutic target: biochemical and biological properties. Pharmacol. Ther. 93:233-242.
-
(2002)
Pharmacol. Ther.
, vol.93
, pp. 233-242
-
-
Yoganathan, N.1
|