The mouse Snail gene encodes a key regulator of the epithelial-mesenchymal transition

Molecular and Cellular Biology

Volumn 21, Issue 23, 2001, Pages 8184-8188

  Carver, E A ^a   Jiang, R ^a   Lan, Y ^a   Oram, K F ^a   Gridley, T ^a  

^a JACKSON LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; UVOMORULIN; ZINC FINGER PROTEIN;

ANIMAL TISSUE; ARTICLE; CELL POLARITY; DROSOPHILA; EMBRYO; EMBRYO DEVELOPMENT; EPITHELIUM; GASTRULATION; GENETIC TRANSCRIPTION; GERM LAYER; MESENCHYME; MESODERM; MICROVILLUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; TRANSCRIPTION REGULATION;

ABNORMALITIES, MULTIPLE; ADHERENS JUNCTIONS; ANIMALS; CADHERINS; DNA-BINDING PROTEINS; EMBRYO; EMBRYO LOSS; EPITHELIUM; GENE TARGETING; MESODERM; MICE; MICE, KNOCKOUT; MICE, MUTANT STRAINS; PHENOTYPE; RNA, MESSENGER; TRANSCRIPTION FACTORS; ZINC FINGERS;

EID: 0035167812     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.23.8184-8188.2001     Document Type: Article

References (33)

1. The snail gene required for mesoderm formation in Drosophila is expressed dynamically in derivatives of all three germ layers
2. Embryonic expression of Lim-1, the mouse homolog of Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis
3. The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells
4. Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula
5. The Drosophila developmental gene snail encodes a protein with nucleic acid binding fingers
6. The role of E-cadherin and integrins in mesoderm differentiation and migration at the mammalian primitive streak
7. The transcription factor Snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
8. The snail repressor establishes a muscle/notochord boundary in the Ciona embryo
9. Mutations and chromosomal rearrangements affecting the expression of snail, a gene involved in embryonic patterning in Drosophila melanogaster
10. Short-range repression permits multiple enhancers to function autonomously within a complex promoter
11. Snail/Slug family of repressors: Slowly going into the fast lane of development and cancer
12. Human Slug is a repressor that localizes to sites of active transcription
13. The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo
14. Genomic organization and chromosomal localization of the mouse Snail (Sna) gene
15. The Slug gene is not essential for mesoderm or neural crest development in mice
16. A novel Snail-related transcription faction Smuc regulates basic helix-loop-helix transcription factor activities via specific E-box motifs
17. Snail-related transcriptional repressors are required in Xenopus for both the induction of the neural crest and its subsequent migration
18. Twist and snail as positive and negative regulators during Drosophila mesoderm development
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20. Cell movements during vertebrate development: Integrated tissue behaviour versus individual cell migration
21. The transition to endoreduplication in trophoblast giant cells is regulated by the mSna zinc finger transcription factor
22. Cloning and developmental expression of Sna, the murine homolog of the Drosophila snail gene
23. Control of cell behavior during vertebrate development by Slug, a zinc finger gene
24. Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. I Zygotic loci on the second chromosome
25. Dynamic behavior of the cadherin-based cell-cell adhesion system during Drosophila gastrulation
26. Slug is a mediator of epithelial-mesenchymal cell transformation in the developing chicken heart
27. The zinc finger protein Slug causes desmosome dissociation, an initial and necessary step in growth factor-induced epithelial-mesenchymal transition
28. Conserved and divergent roles for members of the Snail family of transcription factors in the chick and mouse embryo
29. A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo
30. Isolation of Sna, a mouse gene homologous to the Drosophila genes snail and escargot: Its expression pattern suggests multiple roles during postimplantation development
31. Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20
32. Expression pattern of the mouse T gene and its role in mesoderm formation
33. Gastrulation and the evolution of development