Leaving the neighborhood: Molecular mechanisms involved during epithelial-mesenchymal transition

BioEssays

Volumn 23, Issue 10, 2001, Pages 912-923

  Savagner, P ^a  

^a INSTITUT DE GÉNÉTIQUE MOLÉCULAIRE DE MONTPELLIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CTNNB1 PROTEIN, HUMAN; CYTOSKELETON PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; TRANSACTIVATOR PROTEIN;

ANIMAL; CELL ADHESION; CELL DIFFERENTIATION; CYTOLOGY; CYTOSKELETON; DESMOSOME; EPITHELIUM CELL; GENETIC TRANSCRIPTION; HUMAN; MESODERM; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; BETA CATENIN; CELL ADHESION; CELL DIFFERENTIATION; CYTOSKELETAL PROTEINS; CYTOSKELETON; DESMOSOMES; EPITHELIAL CELLS; HUMANS; MESODERM; PHOSPHORYLATION; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

GASTROPODA;

EID: 0034798707     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/bies.1132     Document Type: Review

References (85)

1. Modulations of the epithelial phenotype during embryogenesis and cancer progression
2. Structure and function of Hepatocyte Growth Factor
3. Wnt signaling and cancer
4. Alternative splicing in fibroblast growth factor receptor 2 is associated with induced epithelial-mesenchymal transition in rat bladder carcinoma cells
5. Cbl-transforming variants trigger a cascade of molecular alterations that lead to epithelial mesenchymal conversion
6. Activation of both MAP kinase and phosphatidylinositide 3-kinase by Ras is required for hepatocyte growth factor/scatter factor-induced adherens junction disassembly
7. Src and Ras are involved in separate pathways in epithelial cell scattering
8. Differential signaling by alternative HGF isoforms through c-Met: Activation of both MAP kinase and PI 3-kinase pathways is insufficient for mitogenesis
9. Protein-tyrosine phosphatase alpha regulates Src family kinases and alters cell-substratum adhesion
10. Tyrosine phosphorylation and src family kinases control keratinocyte cell-cell adhesion
11. The catalytic activity of the Src family kinases is required to disrupt cadherin-dependent cell-cell contacts
12. Regulation of cadherin adhesive activity
13. Adhesive but not lateral E-cadherin complexes require calcium and catenins for their formation
14. NH2-terminal deletion of beta-catenin results in stable colocalization of mutant beta-catenin with adenomatous polyposis coli protein and altered MDCK cell adhesion
15. Expression of the cytoplasmic domain of E-cadherin induces precocious mammary epithelial alveolar formation and affects cell polarity and cell-matrix integrity
16. The nonreceptor protein tyrosine phosphatase PTP1B binds to the cytoplasmic domain of N-cadherin and regulates the cadherin-actin linkage
17. Molecular mechanisms of hormone-mediated Mullerian duct regression: Involvement of beta-catenin
18. Regulation of cadherin-mediated cell-cell adhesion by the Rho family GTPases
19. Activation of the small GTPases Rac is sufficient to disrupt cadherin-dependent cell-cell adhesion in normal human keratinocytes
20. Desmosomes: Intercellular adhesive junctions specialized for attachment of intermediate filaments
21. The alpha isoform of protein kinase C is involved in signaling the response of desmosomes to wounding in cultured epithelial cells
22. Plakophilin-3, a novel armadillo-like protein present in nuclei and desmosomes of epithelial cells
23. Desmoplakin is required early in development for assembly of desmosomes and cytoskeletal linkage
24. Desmosomal localization of beta-catenin in the skin of plakoglobin null-mutant mice
25. Development of desmosomal adhesion between MDCK cells following calcium switching
26. Continual assembly of half-desmosomal structures in the absence of cell contacts and their frustrated endocytosis: A coordinated Sisyphus cycle
27. Cell-cell dissociation upon epithelial cell scattering requires a step mediated by the proteasome
28. Phosphorylation of the desmoplakin COOH terminus negatively regulates its interaction with keratin intermediate filament networks
29. Two-hybrid analysis reveals fundamental differences in direct interactions between desmoplakin and cell type-specific intermediate filaments
30. Transmembrane signaling for adhesive regulation of desmosomes and hemidesmosomes, and for cell-cell datachment induced by pemphigus IgG in cultured keratinocytes: Involvement of protein kinase C
31. Activation of protein kinase C modulates cell-cell and cell-substratum adhesion of a human colorectal carcinoma cell line and restores 'normal' epithelial morphology
32. Protein kinase C activation upregulates intercellular adhesion of alpha-catenin-negative human colon cancer cell variants via induction of desmosomes
33. The expression of desmoglein isoforms in cultured human keratinocytes is regulated by calcium, serum, and protein kinase C
34. All-trans retinoic acid compromises desmosome expression in human epidermis
35. Regulation of desmosomal cell adhesion in human tumour cells by polyunsaturated fatty acids
36. The role of integrins alpha 2 beta 1 and alpha 3 beta 1 in cell-cell and cell-substrate adhesion of human epidermal cells
37. (Alpha)3(beta)1 integrin regulates epithelial cytoskeletal organization
38. Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130 Cas
39. Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice
40. Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation
41. PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway
42. Integrins ans GTPases in tumour cell growth, motility and invasion
43. Evidence that cadherins play a role in the downregulation of integrin expression that occurs during keratinocyte terminal differentiation
44. Cross talk between adhesion molecules: Control of N-cadherin activity by intracellular signals elicited by beta1 and beta3 integrins in migrating neural crest cells
45. Cell-extracellular matrix interactions and EGF are important regulators of the basal mammary epithelial cell phenotype
46. Molecular basis for leukocyte integrin alpha(E)beta(7) adhesion to epithelial (E)-cadherin
47. Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER
48. The nonreceptor tyrosine kinase fer mediates cross-talk between N-cadherin and beta1-integrins
49. Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways
50. Matrix metalloproteinases: Multifunctional contributors to tumor progression
51. The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis
52. Effector domain mutants of Rho dissociate cytoskeletal changes from nuclear signaling and cellular transformation
53. Effectors for the Rho GTPases
54. ERM proteins in cell adhesion and membrane dynamics
55. Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members
56. Mechanisms for de novo biogenesis of an apical membrane compartment in groups of simple epithelial cells surrounded by extracellular matrix
57. Regulation and function of the interaction between the APC tumour suppressor protein and EB1
58. Accumulation of a microtubule-binding protein, pp170, at desmosomal plaques
59. Rearrangements of desmosomal and cytoskeletal proteins during the transition from epithelial to fibroblastoid organization in cultured rat bladder carcinoma cells
60. Onset of re-epithelialization after skin injury correlates with a reorganization of keratin filaments in wound edge keratinocytes: Defining a potential role for keratin 16
61. Isolation of Sna, a mouse gene homologous to the Drosophila genes snail and escargot: Its expression pattern suggests multiple roles during postimplantation development
62. Control of cell behavior during vertebrate development by Slug, a zinc finger gene
63. Expression of snail2, a second member of the zebrafish snail family, in cephalic mesendoderm and presumptive neural crest of wild-type and spadetail mutant embryos
64. Induction of the prospective neural crest of Xenopus
65. The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition
66. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
67. The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells
68. Slug mRNA is expressed by specific mesodermal derivatives during rodent organogenesis
69. The Slug gene is not essential for mesoderm or neural crest development in mice
70. Slug, a zinc finger gene previously implicated in the early patterning of the mesoderm and the neural crest, is also involved in chick limb development
71. SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein
72. The transition to endoreduplication in trophoblast giant cells is regulated by the mSNA zinc finger transcription factor
73. Definition of the DNA-binding site repertoire for the Drosophila transcription factor SNAIL
74. A novel snail-related transcription factor Smuc regulates basic helix-loop-helix transcription factor activities via specific E-box motifs
75. Human Slug is a repressor that localizes to sites of active transcription
76. The candidate Wilms' tumour gene is involved in genitourinary development
77. E-cadherin is a WT1 target gene
78. The epithelial cell default-phenotype hypothesis and its implications for cancer
79. Mechanisms identified in the transcriptional control of epithelial gene expression
80. RB and c-Myc activate expression of the E-cadherin gene in epithelial cells through interaction with transcription factor AP-2
81. Epithelial mesenchymal transition by c-Fos estrogen receptor activation involves nuclear translocation of beta-catenin and upregulation of beta-catenin/lymphoid enhancer binding factor-1 transcriptional activity
82. The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor
83. Genomics, the cytoskeleton and motility