The myofibroblast: An assessment of controversial issues and a definition useful in diagnosis and research

Ultrastructural Pathology

Volumn 25, Issue 1, 2001, Pages 39-50

  Eyden, B ^a  

^a CHRISTIE HOSPITAL   (United Kingdom)

Author keywords

Electron microscopy; Fibronectin; Fibronexus; Myofibroblast; Myofilament; Smooth muscle actin

Indexed keywords

ALPHA ACTIN; VIMENTIN;

ARTICLE; BASEMENT MEMBRANE; CELL ULTRASTRUCTURE; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; HUMAN; MYOFIBROBLAST; MYOFILAMENT; PRIORITY JOURNAL; SMOOTH MUSCLE;

ACTINS; BASEMENT MEMBRANE; CELL SURFACE EXTENSIONS; CYTOSKELETON; ENDOPLASMIC RETICULUM, ROUGH; FIBROBLASTS; FIBRONECTINS; IMMUNOHISTOCHEMISTRY; INTERCELLULAR JUNCTIONS; MICROFILAMENTS; MICROSCOPY, ELECTRON; MUSCLE, SMOOTH; VIMENTIN;

EID: 0035115666     PISSN: 01913123     EISSN: None     Source Type: Journal    
DOI: 10.1080/019131201300004672     Document Type: Article

References (97)

1. Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction
2. The emerging role of myofibroblasts in soft-tissue neoplasia
3. Low-grade myofibroblastic sarcoma: Analysis of 18 cases in the spectrum of myofibroblastic tumors
4. Appearance of alpha-smooth muscle actin in human eye lens cells of anterior capsular cataract and in cultured bovine lens-forming cells
5. Ultrastructural features of surgically excised subretinal neovascular membranes in the ocular histoplasmosis syndrome
6. Tubular epithelial-myofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomised rats
7. Myofibroblast transformation of cat corneal endothelium by transforming growth factor-β1, -β2, and -β3
8. Myofibroblasts in human granulation tissue
9. The fibronexus: A transmembrane association of fibronectin-containing fibers and bundles of 5 nm microfilaments in hamster and human fibroblasts
10. In vivo codistribution of fibronectin and actin fibers in granulation tissue: Immunofluorescence and electron microscope studies at the myofibroblast surface
11. Localization of the fibronexus at the surface of granulation tissue myofibroblasts using double-label immunogold electron microscopy on ultrathin frozen sections
12. Myofibroblast
13. Brief review of the fibronexus and its significance for myofibroblastic differentiation and tumor diagnosis
14. Stromal aspects of breast carcinoma
15. The myofibroblast: Biologic, pathologic, and theoretical considerations
16. The myofibroblast anchoring strand: The fibronectin connection in wound healing and the possible loci of collagen fibril assembly
17. The myofibroblast: A quarter century after its discovery
18. Differences in the stress fibers between fibroblasts and epithelial cells
19. Agarose embedding: A new method for the ultrastructural examination of the in-situ morphology of cell cultures
20. Fetal and postnatal sera differentially modulate human dermal fibroblast phenotypic and functional features in vitro
21. Myofibroblasts in the healing lapine medial collateral ligament: Possible mechanisms of contraction
22. Myofibroblastic sarcoma
23. Myofibroblastic sarcoma: Author's reply
24. The fibronexus in reactive and tumoral myofibroblasts: Further characterisation by electron microscopy
25. + fibronectin synthesis in human tissues by non-radioactive RNA in situ hybridization: Investigations on carcinoma (oral squamous cell and breast carcinoma), chronic inflammation (rheumatoid arthritis) and fibromatosis (Morbus Dupuytren)
26. Time-dependent pericellular expression of collagen type IV, laminin, and heparan sulfate proteoglycan in myofibroblasts
27. Appearance of the myofibroblastic phenotype in Dupuytren's disease is associated with a fibronectin, laminin, collagen type IV and tenascin extracellular matrix
28. Infantile myofibromatosis: Report of two cases
29. Myofibroblastic tumours: Neoplasias with divergent behaviour. Ultrastructural and flow cytometric analysis
30. Synthesis of extracellular matrix components by human ciliary muscle cells in culture
31. A myofibroblastic tumor: Infantile digital fibroma (recurrent digital fibrous tumor of childhood)
32. Wound contractions, scar contractures and myofibroblasts: A classical case study
33. Proliferative disorders of myofibroblasts
34. Morphological and immunochemical differences between keloid and hypertrophic scar
35. A study of spindle cell sarcomas showing myofibroblastic differentiation
36. Myofibrosarcoma of subcutaneous soft tissue of the cheek
37. Leiomyosarcoma versus myofibrosarcoma: Observations and terminology
38. Contraction and contracture
39. Breast tumors with myofibroblastic differentiation: Clinico-pathological observations in myofibroblastoma and myofibrosarcoma
40. Myofibroblasts in the lamina propria of human seminiferous tubules are dynamic structures of heterogeneous phenotype
41. Dynamics of the expression of cytoskeleton components and adherens molecules by fibroblastic cells in alkali-burned and lacerated corneas
42. The roles of the myofibroblast in idiopathic pulmonary fibrosis: Ultrastructural and immunohistochemical features of sites of active extracellular matrix synthesis
43. The myofibroblast
44. Fibronexus in a case of malignant fibrous histiocytoma
45. Multicystic peritoneal mesothelioma: A fine structure study with special reference to the spectrum of phenotypic differentiation exhibited by mesothelial cells
46. Fibronectin-cytoskeleton relationships
47. The biology of the myofibroblast: Relationship to wound contraction and fibrocontractive diseases
48. Myofibrosarcoma of the head and neck in children
49. Myofibrosarcoma of the breast: Review of the literature on myofibroblastic tumors and criteria for defining myofibroblastic differentiation
50. Extracellular matrix-cytoskeletal connections at the surface of the specialized contractile fibroblast (myofibroblast) in Dupuytren disease
51. Fibronectin filaments and actin microfilaments are organized into a fibronexus in Dupuytren's diseased tissue
52. Contractile cells in rat myocardial scar tissue
53. An ultrastructural study of the smooth muscle cells and nerve endings of the human stomach
54. The ultrastructure of fibromyomatous myometrium and its relationship to infertility
55. Ultrastructure, cytochemistry, and organization of myofilaments in vertebrate smooth muscle cells
56. Electron-microscopic study of bovine arterioclerotic lesions
57. Extracellular matrix of the human aortic media: An ultrastructural histochemical and immunohistochemical study of the adult aortic media
58. Contractile cells in the human scleral spur
59. Intranodal myofibroblastoma: Report of a case
60. Myofibroblastoma of breast: Evidence favoring smooth-muscle rather than myofibroblastic differentiation
61. The ultrastructure of age-associated intimal fibrosis in pulmonary blood vessels
62. Partially bioresorbable vascular grafts in dogs
63. Contractility of myofibroblasts during experimental liver cirrhosis
64. Massive ovarian edema: A clinicopathologic study of five cases including ultrastructural observations and review of the literature
65. Paratesticular plexiform tumour of myofibroblastic origin
66. Heterogeneity in the gingival fibromatoses
67. Fibrous hamartoma of infancy: An immunohistochemical and ultrastructural study
68. Fibroepithelial polyps of the anus: A histologic, immunohistochemical, and ultrastructural study, including comparison with the normal anal subepithelial layer
69. Inflammatory pseudotumor of the uterus
70. Ultrastructure of myofibroblasts and decidualized cells in leiomyomatosis peritonealis disseminata
71. Ultrastructural characteristics of a pleomorphic sarcoma: A possible involvement of myofibroblast
72. Cytoskeletal filaments in the smooth muscle cells of uterine leiomyomata and myometrium: An ultrastructural and immunohistochemical analysis
73. Changes in extracellular matrix materials in the uterine myometrium of rats during pregnancy and postparturition
74. Uterine smooth muscle cells in primary culture
75. Immunohistochemical and ultrastructural analysis of the intimal thickening in coarction of human aorta
76. The muscle coat of the lower esophageal sphincter in patients with achalasia and hypertensive sphincter: An electron microscopic study
77. Myogenic stromal tumor of the male breast (so-called myofibroblastoma)
78. Alpha-smooth muscle actin is transiently expressed by myofibroblasts during wound healing
79. Myofibroblasts from diverse pathologic settings are heterogeneous in their content of actin isoforms and intermediate filament proteins
80. The diagnostic utility of desmin: A study of 584 cases and review of the literature
81. Transformation of rat inner medullary fibroblasts to myofibroblasts in vitro
82. Macrophages, myofibroblasts, and extracellular matrix accumulation in interstitial fibrosis of chronic progressive nephropathy in aged rats
83. Expression of sarcomeric proteins and assembly of myofibrils in the putative myofibroblast cell line BHK-21/C13
84. Cytoskeletal characteristics of myofibroblasts in benign neoplastic and reactive fibroblastic lesions
85. Collagen secretion granules in reactive stromal myofibroblasts, with preliminary observations on their occurrence in spindle cell tumours
86. Primary fibrosaroma and malignant fibrous histiocytoma of bone - A comparative ultrastructural study: Evidence of a spectrum of fibroblastic differentiation
87. Immunohistochemical characterization of atypical fibroxanthoma and dermatofibrosarcoma protuberans
88. Intracellular actin as a marker for myofibroblasts in vitro
89. Pseudoangiomatous stromal hyperplasia (PASH): A mammary stromal tumor with myofibroblastic differentiation
90. Myofibroblastic differentiation in the connective tissues of the amnion and chorion of term human fetal membranes - Implications for fetal membrane rupture and labour
91. Contractile proteins in human cancer cells. Immunofluorescence and electron microscopic study
92. Heterogeneity of myofibroblast phenotypic features: An example of fibroblastic cell plasticity
93. Smooth-muscle-type myofilaments and actin in reactive and neoplastic non-muscle cells
94. Ultrastructural investigations on anterior capsular cataract: Cellular elements and their relationship to basement membrane and collagen synthesis