Epithelial cell plasticity in development and tumor progression

Cancer and Metastasis Reviews

Volumn 18, Issue 1, 1999, Pages 31-42

  Thiery, Jean Paul ^a,b,c   Chopin, Dominique ^a,b  

^a INSTITUT CURIE   (France)

^b HENRI MONDOR HOSPITAL   (France)

^c INSTITUT CURIE   (France)

Author keywords

Carcinomas; Epithelial mesenchymal transition; Growth factor signaling

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR RECEPTOR; GROWTH FACTOR RECEPTOR; LIGAND; SCATTER FACTOR; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR ALPHA; TYROSINE KINASE RECEPTOR; UVOMORULIN;

ARTICLE; BLADDER CARCINOMA; CARCINOGENESIS; CELL PROLIFERATION; EPITHELIUM CELL; GASTRULATION; HUMAN; IN VITRO STUDY; METASTASIS; NEURAL CREST; NONHUMAN; ONCOGENE RAS; ONCOGENE SRC; PLASTICITY; PREDICTION; PRIORITY JOURNAL; REGULATOR GENE; SIGNAL TRANSDUCTION; TUMOR GROWTH;

ANIMALS; CARCINOMA; CELL TRANSFORMATION, NEOPLASTIC; DISEASE PROGRESSION; EPITHELIAL CELLS; HUMANS; NEOPLASM METASTASIS; URINARY BLADDER NEOPLASMS;

EID: 0032848957     PISSN: 01677659     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006256219004     Document Type: Article

References (86)

1. Lengauer C, Kinzler KW, Vogelstein B: Genetic instabilities in human cancers. Nature 396: 643-649, 1998
2. Shackney SE, Shankey TV: Common patterns of genetic evolution in human solid tumors. Cytometry 29: 1-27, 1997
3. Fagnou C, Michon J, Peter M, Oberlin O, Zucker JM, Magdelenat H, Delattre O: Presence of tumor cells in bone marrow but not in blood is associated with adverse prognosis in patients with Ewing's tumor. J Clin Invest 16: 1707-1711, 1998
4. Thibodeau SN, Bren G, Shaid D: Microsatellite instability in cancer of the proximnal colon. Science 260: 816-819, 1993
5. Lothe A, Peltomäki P, Meling GI, Aaltonen LA, Nystriöm-Lahti M et al.: Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history. Cancer Res 53: 5849-5852, 1993
6. Kochhar R, Halling KC, McDonnell S, Shaid DJ, French AM, O'Connell MJ, Nagorney DM, Thibodeau SN: Allelic imbalance and microsatellite instability in resected Duke's colorectal cancer. Diagnost Mol Pathol 6: 78-84, 1997
7. Ogunbiyi OA, Goodfellow PJ, Herfarth K, Gagliardi G, Swanson PE, Binbaum EH, Read TE, Fleshman JW, Kodner IJ, Moley JF: Confirmation that chromosome 18q allelic loss in colon cancer is a prognostic indicator. J Clin One 16: 427-433, 1998
8. Carethers JM, Hawn MT, Greenson JK, Hitchcock CL, Boland CR: Prognostic significance of allelic loss at chromosome 18q21 for stage II colorectal cancer. Gastroenterology 114: 1188-1195, 1998
9. Folkman J: New perspectives in clinical oncology from angiogenesis research. Eur J Cancer 32A: 2534-2539, 1996
10. Fox SB: Tumor angiogenesis and prognosis. Histopathology 30: 294-301, 1997
11. Viens P, Pernault-Llorea F, Jacquemier J, Gravis C, Cowen D, Bertucci F, Houvenaeghel G, Blaise D, Maraninchi D: High dose chemotherapy and haematopoietic stem cell transplantation for inflammmatory breast cancer: pathologic response and outcome. Bone Marrow Transplantation 21: 249-254, 1998
12. Kinzler KW, Vogelstein B: Landscaping the cancer terrain. Science 280: 1036-1037, 1998
13. Watson KL, Justice RW, Bryant P: Drosophila in cancer research: the first fifty tumor suppressor genes. Development 18: 19-33, 1994
14. Gilbert SF: Developmental Biology. Fifth edition. Massachusetts Sinauer Associates Inc. Publishers, Sanderland, 1997
15. Jouanneau J, Tucker GC, Boyer B, Valleś AM, Thiery JP: Epithelial cell plasticity in neoplasia. Cancer Cells 3: 525-529, 1991
16. Savagner P, Boyer B, Valles AM, Jouanneau J, Thiery IP: Modulations of the epithelial phenotype during embryogenesis and cancer progression. In: Dickson R, Lipmann M (eds) Mammary tumorigenesis and malignant progression. Kluwer Academic Publishers, Dordrecht, The Netherlands, 1994, pp 229-249
17. Birchmeier C, Birchmeier W, Brand-Saberi B: Epithelialmesenchymal transitions in cancer progression. Acta Anal 156: 217-226, 1996
18. Leptin M, Casal J, Grunewald B, Reuter R: Mechanisms of early Drosophila mesoderm formation. In: Stern CD, Ingham PW (eds) Gastrulation. The Company of Biologists, 1992, pp 23-31
19. Morize P, Christiansen AE, Costa M, Parks S, Wieschaus E: Hyperactivation of the folded gastrulation pathway induces specific cell shape changes. Development 125: 589-597, 1998
20. Hacker U, Perrimon N: DRhoGEF2 encodes a member of the Dbl family of oncogenes and controls cell shape changes during gastrulation in Drosophila. Genes & Development 12: 274-284, 1998
21. Keller R: Early embryonic development of Xenopus laevis. In: Kay KB, Peng BH (eds) Methods in Cell Biology. Xenapus laevis: practical uses in Cell and Molecular Biology. Academic Press, 1991, pp 61-113
22. Niehrs C, Keller R, Cho KWY, De Robertis EM: The homeobox gene goosecoid controls cell migration in xenopus embryos. Cell 72: 491-503, 1993
23. Pannese M, Polo C, Andreazzoli M, Vignali R, Kablar B, Barsacchi G, Boncinelli E: The Xenopus homologue of Otx2 is a maternal homeobox gene that demarcates and specifies anterior body region. Development 121: 707-720, 1995
24. Broders F, Thiery JP: Contribution of cadherins to directional cell migration and histogenesis in xenopus embryos. Cell Adh Com 3: 419-440, 1995
25. Kim S-H, Yamamoto A, Bouwmeester T, Agius E, De Robertis EM: The role of paraxial protocadherin in selective adhesion and cell movements of the mesoderm during Xenopus gastrulation. Development 125: 4681-4691, 1998
26. Le Douarin N: The Neural Crest. Cambridge University Press, 1982.
27. Thiery JP, Duband JL, Dufour S: Adhesion systems in morphogenesis and cell migration during avian embryogenesis. In: Morphoregulatory Molecules. John Wiley and Sons, New York, 1990, pp 597-625
28. Duband JL, Monier F, Delannet M, Newgreen D: Epithelium-mesenchyme transition during neural crest development. Acta Anat 154: 63-78, 1996
29. Nieto AM, Sargent MC, Wilkinson DG, Cooke J: Control of cell behavior during vertebrate development by Slug, a zinc finger gene. Science 264: 835-839, 1994
30. Mancilla A, Mayor R: Neural crest formation in Xenopus laevis: mechanisms of Xslug induction. Dev Biol 177: 580-589, 1996
31. Glazer L, Shilo B-Z: The Drosophila FGF-R homolog is expressed in the embryonic tracheal system and appears to be required for directed tracheal cell expension. Gene Der 5: 697-705, 1991
32. Hacohen N, Kramer S, Sutherland D, Hiromi Y, Krasnow D: Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. Cell 92: 253-263, 1998
33. Bellusci S, Grindley J, Emoto H, Itoh N, Hogan BL: Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung. Development 124: 4867-4878, 1997
34. Peters K, Werner S, Liao X, Wert S, Whitsett J, Williams L: Targeted expression of a dominant negative FGF receptor blocks branching morphogenesis and epithelial differentiation of the mouse lung. EMBO J 13: 3296-3301, 1994
35. Niemann C, Brinkmann V, Spitzer E, Hartmann G, Sachs M, Naundorf H, Birchmeier W: Reconstitution of mammary gland development in vitro: requirement of c-met and c-erbB2 signaling for branching and alveolar morphogenesis. J Cell Biol 143: 533-545, 1998
36. Boccaccio C, Ando M, Tamagnone L, Bardelli A, Michieli P, Battistini C, Comoglio PM: Induction of epithelial tubules by growth factor HGF depends on the STAT pathway. Nature 391: 285-288, 1998
37. Tchao R: Novel forms of epithelial cell motility on collagen and on glass surfaces. Cell Motil 4: 333-341, 1982
38. Boyer B, Tucker GC, Vallés AM, Gavrilovic J, Thiery JP: Reversible transition towards a fibroblastic phenotype in a rat carcinoma cell line. Int J Cancer 4: 69-75, 1989
39. Vallés AM, Tucker G, Thiery JP, Boyer B: Alternative patterns of mitogenesis and cell scattering induced by acidic FGF as a function of cell density in a rat bladder carcinoma cell line. Cell Regulation 4: 975-988, 1990
40. Vallés AM, Boyer B, Tucker GC, Badet J, Barritault D, Thiery JP: Acidic fibroblast growth factor is a modulator of epithelial plasticity in a rat bladder carcinoma cell line. Proc Natl Acad Sci USA 87: 1124-1128, 1990
41. Gavrilovic J, Moens G, Thiery JP, Jouanncau J: Expression of TGFα induces a motile fibroblast-like phenotype with extracellular matrix-degrading potential in a rat bladder carcinoma cell line. Cell Regulation 1: 1003-1014, 1990
42. Bellusci S, Moens G, Gaudino G, Comoglio P, Nakamura T, Thiery JP, Jouanneau J: Creation of an hepatocyte growth factor/scatter factor autocrine loop in carcinoma cells induces invasive properties associated with increased oncogenic potential. Oncogene 9: 1091-1099, 1994
43. Boyer B, Vallés AM, Thiery JP: Model systems of epithelium mesenchyme transition. Acta Anat 156: 227-239, 1996
44. Savagner P, Vallés AM, Jouanneau J, Yamada K, Thiery JP: Alternative splicing in Fibroblast Growth Factor receptor 2 is associated with induced epithelial- mesenchymal transition in rat bladder carcinoma cells. Mol Biol Cell 5: 851-862, 1994
45. Boyer B, Dufour S, Thiery JP: E-cadherin expression during the acidic FGF-induced dispersion of a rat bladder carcinoma cell line. Exp Cell Res 201: 347-357, 1992
46. Boyer B, Thiery JP: Cyclic AMP Distinguishes between two functions of acidic FGF in a rat bladder carcinoma cell line. J Cell Biol 120: 767-776, 1993
47. Rodier JM, Vallés AM, Denoyelle M, Thiery JP, Boyer B: pp60c-Src is a positive regulator of growth factor-induced cell scattering in a rat bladder carcinoma cell line. J Cell Biol 131: 761-773, 1995
48. Boyer B, Roche S, Denoyelle M, Thiery JP: Src and ras are involved in separate pathways in epithelial cell scattering. EMBO J 16: 5904-5943, 1997
49. Savagner P, Yamada KM, Thiery JP: The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition. J Cell Biol 137: 1403-1419, 1997
50. Tucker GC, Delouvée A, Jouanneau J, Gavrilovic J, Moens G, Vallés AM, Thiery JP: Amplilication of invasiveness in organotypic cultures after NBT-II rat bladder carcinoma stimulation with in vitro scattering factors. Cell Adh Com 11: 297-309, 1991
51. Jouanneau J, Moens G, Bourgeois Y, Poupon MF, Thiery JP: A minority of carcinoma cells producing acidic fibroblast growth factor induces a community effect for tumor progression. Proc Natl Acad Sci USA 91: 286-290, 1994
52. Gurdon JB, Lemaire P, Kato K: Community effects in related phenomena in development. Cell 75: 831-834, 1993
53. Jouanneau J, Plouet J, Moens G, Thiery JP: FGF-2 and FGF-1 expressed in rat bladder carcinoma cells have similar angiogenic potential but different tumorigenic properties in vivo. Oncogene 14: 671-676, 1997
54. Bellusci S, Moens G, Thiery JP, Jouanneau J: A scatter factor-like factor is produced by a metastatic variant of a bladder carcinoma line. J Cell Science 107: 1277-1287, 1994
55. Aaronson SA: Growth factors and cancer. Science 254: 1146-1152, 1991
56. Fan Z, Mendelsohn J: Therapeutic application of anti-growth factor receptor antibodies. Curr Op Oncology 10: 67-73, 1998
57. Chodak GW, Hospelhorn V, Judge SM, Mayforth R, Koeppen H, Sasse J: Increased levels of fibroblasl growth factor-like activity in urine from patients with bladder or kidney cancer. Cancer Res 48: 2083-2088, 1988
58. Chopin DK, Caruelle JP, Colombel M, Palcy S, Ravery V, Caruelle D, Abbou C, Barritault D: Increased immunodetection of acidic fibroblast growth factor in bladder cancer, detectable in urine. J Urol 150: 1126-1130, 1993
59. Nguyen M, Watanabe H, Budson AE, Richie JP, Folkman J: Elevaled levels of the angiogenic peptide basic fibroblast growth factor in urine of bladder cancer patients. J Natl Cancer Inst 85: 241-242, 1993
60. Yan G, Fukabori Y, McBride G, Nikolaropolous S, McKeehan WL: Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independance and malignancy. Mol Cell Biol 13: 4513-4522, 1993
61. Yamaguchi F, Saya H, Bruner JM, Morrison RS: Differential expression of two fibroblast growth factor-receptor genes is associated with malignant progression in human astrocytomas. Proc Natl Acad Sci USA 91: 484-488, 1994
62. Nakagawara A, Arima-Nakagawara M, Azar CG, Seavarda NJ, Brodeur GM: Clinical significance of expression of neurotrophic factors and their receptors in neuroblastoma. Progress of clinical and biological research 385: 155-161, 1994
63. Kim IY, Ahn HJ, Long S, Oefelein MG, Osyasu R, Kolowski KM, Lee C: Loss of expression of transforming growth factor beta receptors is associated with poor prognosis in prostate cancer patients. Clin Cancer Res 4: 1625-1630, 1998
64. Werner S, Weinberg W, Liao X, Peters KG, Blessing M, Yuspa SH, Weiner RL, Williams LT: Targeted expression of a dominant-negative FGF receptor mutant in the epidermis of transgenic mice reveals a role of FGF in keratinocyte organization and differentiation. EMBO J 12: 2635-2643, 1993
65. Werner S, Smola H, Liao X, Longaker MT, Krieg T, Hofschneider PH, Williams LT: The function of KGF in morphogenesis of epithelium and reepitheliasation of wounds. Science 266: 819-822, 1994
66. Itoh H, Hattori Y, Sakamoto H, Ishii H, Kishi T, Sasaki H, Yoshida T, Koono M, Sugimura T, Terada M: Preferential alternative splicing in cancer generates a K-sam messenger RNA with higher transforming activity. Cancer Res 54: 3237-3241, 1994
67. Chesi M et al.: Frequent translocation t(4;14)(p16.3; q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3. Nature Genet 16: 260-264, 1997
68. Ornitz DM, Leder P: Ligand specificity and heparin dependence of fibroblast growth factor receptors 1 and 3. J Biol Chem 267: 16305-16311, 1992
69. Kanai M, Göke M, Tsunekawa S, Podolsky D: Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a rowel 66-kDa phosphoprotein. J Biol Chem 272: 6621-6628, 1997
70. Naski MC, Wang Q, Xu J, Ornitz DM: Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia. Nature Genet 13: 233-237, 1996
71. Webster M, D'Avis PY, Robertson SC, Donhogue DJ: Profound ligand-independent kinase activation of fibroblast growth factor receptor 3 by the activation loop mutation responsible for a lethal skeletal dysplasia, thanatophoric dysplasia type II. Mol Cell Biol 16: 4081-4087, 1996a
72. Webster M, Donhogue DJ: Consitutive activation of fibroblast growth factor receptor 3 by the transmembrane domain mutation found in achondroplasia. EMBO J 15: 520-527, 1996b
73. Colvin JS, Bohne BA, Harding GW, McEwen DG, Ornitz DM: Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3. Nature Genet 12: 390-397, 1996
74. Deng C, Wynshaw-Boris A, Zhou F, Kuo A, Leder P: Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell 84: 911-921, 1996
75. Ricol D, Cappellen D, El Marjou A, Gil-Diez de Medina S, Girault J-M, Ferry G, Tucker G, Poupon M-F, Chopin D, Thiery JP, Radvanyi F: Tumour suppressive properties of fibroblast growth hitler receptor 2-HIb in human bladder cancer. Oncogene (in press) 1999
76. Birchmeier W, Behrens J: Cadherin expression in carcinomas: role in the formation of cell junction and the prevention of invasiveness. Biochem Biophys Acta 1198: 11-26, 1994
77. Gil-Diez de Medina S, Popov Z, Chopin DK, Southgate J, Tucker G, Delouvée A, Thiery JP, Radvanyi F: Relationship between E-cadherin and Fibroblast Growth Factor Receptor 2b expression in bladder carcinomas. Oncogene (in press) 1999
78. Schmidt L et al.: Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas. Nature Genet 16: 68-73, 1997
79. Kolibaba KS, Druker BJ: Protein tyrosine kinases and cancer. Biochimica et Biophysica Acta 1333: 217-248, 1997
80. Ravery V, Colombel M, Popov Z, Bastuji S, Patard JJ, Bellot J, Abbou CC, Fradet Y, Chopin DK: Prognostic value of epidermal growth factor-receptor, T138 and T43 expression in bladder cancer. Br J Cancer 71: 196-200, 1995
81. Kobrin MS, Yamanaka Y, Friess H, Lopez ME, Kore M: Aberrant expression of type I fibroblast growth factor receptor in human pancreatic adenocarcinomas. Cancer Res 53: 4741-4744, 1993
82. Jacquemier J, Adelaide J, Parc P, Penault-Llorca F, Planche J, DeLapeyriere O, Birnbaum D: Expression of the FGFRI gene in human breast carcinoma cells. Int J Cancer 59: 373-378, 1994
83. Xiao S et al.: FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome. Nature Genet 18: 84-87, 1998
84. Feng S, Wang F, Matsuhara A, Kan M, McKeehan WL: Fibroblast growth factor receptor 2 limits and receptor 1 accelerates tumorigenicity of prostate epithelial cells. Cancer Res 57: 5369-5378, 1997
85. El Marjou A, Delouvée A, Thiery JP, Radvanyi F: A positive autocrine loop EGF-R/ligands is involved in chemically-induced mouse bladder turnout progression. Submitted 1999
86. Boyer B, Thiery JP: Epithelium megenchyme interconversion as example of epithelial plasticity. Apmis 101: 257-268, 1993