Pathological relevance of epithelial and mesenchymal phenotype plasticity

Pathology Research and Practice

Volumn 195, Issue 6, 1999, Pages 379-389

  Guarino, Marcello ^a,b,c   Micheli, Pietro ^a,b   Pallotti, Francesco ^a,b   Giordano, Ferdinando ^a,b  

^a AO Dei Colli Hospital for Infectious Diseases D Cotugno   (Italy)

^b DESIO HOSPITAL   (Italy)

^c NONE   (Italy)

Author keywords

Cleft palate; Malignant mixed mullerian tumours; Preeclampsia; Sarcomas; Sarcomatoid carcinomas; Tissue repair; Tumour progression; Wilm's tumour

Indexed keywords

CELL RECEPTOR; GROWTH FACTOR; TRANSCRIPTION FACTOR;

ADULT DISEASE; BONE TUMOR; CARCINOGENESIS; CELL DIFFERENTIATION; CELL MOTILITY; CLEFT PALATE; EMBRYO DEVELOPMENT; EPITHELIUM; EXTRACELLULAR MATRIX; FIBROSIS; HUMAN; INFLAMMATION; MESENCHYME; MIXED MULLERIAN TUMOR; MORPHOGENESIS; NEPHROBLASTOMA; ONCOGENE; PATHOGENESIS; PHENOTYPE; PLASTICITY; PREECLAMPSIA; REVIEW; SARCOMA; SOFT TISSUE TUMOR; TISSUE TYPES; TUMOR GROWTH;

EID: 0033055046     PISSN: 03440338     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0344-0338(99)80011-9     Document Type: Review

References (59)

1. Abeln ECA, Smit VTHB, Wessels JE, de Leeuw WJF, Cornelisse CJ, Fleuren GJ (1997) Molecular genetic evidence for the conversion hypothesis of the origin of malignant mixed Mullerian tumours. J Pathol 183: 424-431
2. Alpha SY (1998) The morphogenetic role of cadherin cell adhesion molecules in human cancer: a thematic review. Cancer Invest 16: 252-261
3. Birchmeier W, Behrens J (1994) Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim Biphys Acta 1198: 11-26
4. Birchmeier W, Birchmeier C (1994) Mesenchymal-epithelial transitions. Bioessays 16: 305-307
5. Boyer B, Roche S, Denoyelle M, Thiery JP (1997) Src and Ras are involved in separate pathways in epithelial cell scattering. EMBO J 16: 5904-5913
6. Brunet CL, Sharpe PM, Ferguson MWJ (1995) Inhibition of TGF-beta3 (but not TGF-beta1 or TGF-beta2) activity prevents normal mouse embryonic palate fusion. Int J Dev Biol 39: 345-355
7. Buisson AC, Gilles C, Polette M, Zahm JM, Birembaut P, Tournier JM (1996) Wound repair-induced expression of stromelysins is associated with the acquisition of a mesenchymal phenotype in human respiratory epithelial cells. Lab Invest 74: 658-669
8. Christ B, Ordahl CP (1995) Early stages of chick somite development. Anat Embryol 191: 381-396
9. Cui W, Fowlis DJ, Bryson S, Duffie E, Ireland H, Balmain A, Akhurst RJ (1996) TGF-beta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice. Cell 86: 531-542
10. Dahl E, Koseki H, Balling R (1997) Pax genes and organogenesis. Bioessays 19: 755-765
11. Dardick I, Schatz JE, Colgan TJ (1992) Osteogenic sarcoma with epithelial differentiation Ultrastruct Pathol 16: 463-474
12. Davies JA, Garrod DR (1997) Molecular aspects of the epithelial phenotype. Bioessays 19: 699-704
13. Dressler GR (1997) Genetic control of kidney development. Adv Nephrol 26: 1-17
14. Fafeur V, Tulasne D, Quéva C, Vercamer C, Dimster V, Mattot V, Stéhelin D, Desbiens X, Vandenbunder B (1997) The ETS1 transcription factor is expressed during epithelial-mesenchymal transitions in the chick embryo and is activated in scatter factor-stimulated MDCK epithelial cells. Cell Growth Differ 8: 655-665
15. Ferguson MWJ (1991) The orofacial region. In: Wigglesworth JS, Singer DB (Eds) Textbook of Fetal and Perinatal Pathology, 2nd vol., pp 843-880. Blackwell Scientific Publications, Oxford
16. Fleming S (1997) Genetics of renal tumours. Cancer Metastasis Rev 16: 127-140
17. Frisch SM (1997) The epithelial cell default-phenotype hypothesis and its implications for cancer. Bioessays 19: 705-709
18. Gilles C, Polette M, Birembaut P, Brunner N, Thompson EW (1997) Expression of c-ets-1 mRNA is associated with an invasive, EMT-derived phenotype in breast carcinoma cell lines. Clin Exp Metastasis 15: 519-526
19. Gilles C, Polette M, Piette J, Birembaut P, Foidart JM (1994) Epithelial-to-mesenchymal transition in HPV-33-transfected cervical keratinocytes is associated with increased invasiveness and expression of gelatinase A. Int J Cancer 59: 661-666
20. Gilles C, Polette M, Piette J, Delvigne AC, Thompson EW, Foidart JM, Birembaut P (1996) Vimentin expression in cervical carcinomas: association with invasive and migratory potential. J Pathol 180: 175-180
21. Guarino M (1995) Epithelial-to-mesenchymal change of differentiation. From embryogenetic mechanism to pathological patterns. Histol Histopathol 10: 171-184
22. Guarino M, Christensen L (1994) Immunohistochemical analysis of extracellular matrix components in synovial sarcoma. J Pathol 172: 279-286
23. Guarino M, Giordano F (1995) Experimental induction of epithelial-mesenchymal interconversions. Exp Toxicol Pathol 47: 325-334
24. Guarino M, Giordano F, Pallotti F, Polizzotti G, Tricomi P, Cristofori E (1998) Malignant mixed Mullerian tumor of the uterus. Features favoring its origin from a common cell clone and an epithelial-to-mesenchymal transformation mechanism of histogenesis. Tumori 84: 383-389
25. Guarino M, Tricomi P, Giordano F, Cristofori E (1996) Sarcomatoid carcinomas: pathological and histopathogenetic considerations. Pathology 28: 298-305
26. Guillou L, Wadden C, Coindre JM, Krausz T, Fletcher DCM (1997) "Proximal-type" epithelioid sarcoma, a distinctive aggressive neoplasm showing rhabdoid features. Clinicopathologic, immunohistochemical, and ultrastructural study of a series. Am J Surg Pathol 21: 130-146
27. Hazelbag HM, Van den Broek LJCM, Fleuren GJ, Taminiau AHM, Hogendoorn PCW (1997) Distribution of extracellular matrix components in adamantinoma of long bones suggests fibrous-to-epithelial transformation. Hum Pathol 28: 183-188
28. Hazelbag HM, Wessels JW, Mollevangers O, Van den Berg E, Molenaar WM, Hogendoorn PC (1997) Cytogenetic analysis of adamantinoma of long bones: further indications for a common histogenesis with osteofibrous dysplasia. Cancer Genet Cytogenet 97: 5-11
29. Hendrix MJC, Seftor EA, Chu YW, Trevor KT, Seftor EB (1996) Role of intermediate filaments in migration, invasion and metastasis. Cancer Metastasis Rev 15: 507-525
30. Hendrix MJC, Seftor EA, Seftor REB, Trevor KT (1997) Experimental co-expression of vimentin and keratin intermediate filaments in human breast cancer cells results in phenotypic interconversion and increased invasive behavior. Am J Pathol 150: 483-495
31. Kaartinen V, Cui XM, Heisterkamp N, Groffen J, Shuler CF (1997) Transforming growth factor-beta3 regulates transdifferentiation of medial edge epithelium during palatal fusion and associated degradation of the basement membrane. Dev Dyn 209: 255-260
32. Kanwar YS, Carone FA, Kumar A, Wada J, Ota K, Wallner EI (1997) Role of extracellular matrix, growth factors, and proto-oncogenes in metanephric development. Kidney Int 52: 589-606
33. Lewis JE, Olsen KD, Sebo TJ (1997) Spindle cell carcinoma of the larynx: review of 26 cases including DNA content and immunohistochemistry. Hum Pathol 28: 664-673
34. Lim KH, Zhou Y, Janatpour M, McMaster M, Bass K, Chun SH, Fisher SJ (1997) Human cytotrophoblast differentiation /invasion is abnormal in pre-eclampsia. Am J Pathol 157: 1809-1818
35. Lochter A, Galosy S, Muschler J, Freedman N, Werb Z, Bissell MJ (1997) Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a pre-malignant phenotype in mammary epithelial cells. J Cell Biol 139: 1861-1872
36. Martel C, Harper F, Cereghini S, Noe V, Mareel M, Cremisi C (1997) Inactivation of retinoblastoma family proteins by SV40 T antigen results in creation of a hepatocyte growth factor/scatter factor autocrine loop associated with an epithelial-fibroblastoid conversion and invasiveness. Cell Growth Differ 8: 165-178
37. Miyagawa K, Kent J, Moore A, Charlieu JP, Little MH, Williamson KA, Kelsey a, Brown KW, Hassam S, Briner J, Hayashi Y, Hirai H, Yazaki Y, van Heyningen V, Hastie ND (1998) Loss of WT1 function leads to ectopic myogenesis in Wilm's tumour. Nature Genet 18: 15-17
38. Miyagawa K, Kent J, Schedl A, van Heyningen V, Hastie ND (1994) Wilm's tumour - a case of disrupted development. J Cell Sci 18 (Suppl): 1-5
39. Nappi O, Glasner SD, Swanson PE, Wick MR (1994) Biphasic and monophasic sarcomatoid carcinomas of the lung. A reappraisal of "carcinosarcomas" and "spindle cell carcinomas". Am J Clin Pathol 102: 331-340
40. Peringa J, Molenaar WM, Timens W (1994) Integrins and extracellular matrix-proteins in the different components of the Wilm's tumour. Virchows Arch 425: 113-119
41. Polette M, Gilles C, de Bentzmann S, Gruenert D, Tournier JM, Birembaut P (1998) Association of fibroblastoid features with the invasive phenotype in human bronchial cancer cell lines. Clin Exp Metastasis 16: 105-112
42. Portella G, Cumming SA, Liddell J, Cui W, Ireland H, Akhurst RJ, Balmain A (1998) Transforming growth factor beta is essential for spindle cell conversion of mouse skin carcinoma in vivo: implications for tumor invasion. Cell Growth Differ 9: 393-404
43. Portella G, Liddell J, Crombie R, Haddow S, Clarke M, Stoler AB, Balmain A (1994) Molecular mechanisms of invasion and metastasis during mouse skin tumour progression. Invasion Metastasis 14: 7-16
44. Pritchard-Jones K (1997) Malignant origin of the stromal component of Wilm's tumor. J Natl Cancer Inst 89: 1089-1091
45. Pritchard-Jones K, Hawkins MM (1997) Biology of Wilm's tumour. Lancet 349: 663-664
46. Proetzel G, Pawlowski SA, Wiles MW, Yin M, Boivin GP, Howles PN, Ding J, Ferguson MWJ, Doetschman T (1995) Transforming growth factor-beta3 is required for secondary palate fusion. Nature Genet 11: 409-414
47. Rodier JM, Valles AM, Denoyelle M, Thiery JP, Boyer B (1995) pp60c-src is a positive regulator of growth factor-induced cell scattering in a rat bladder carcinoma cell line. J Cell Biol 131: 761-773
48. Rosenberg AE, O'Connell JX, Dickersin R, Bhan AK (1993) Expression of epithelial markers in malignant fibrous histiocytoma of the musculoskeletal system: an immunohistochemical and electron microscopic study. Hum Pathol 24: 284-293
49. Savagner P, Yamada KM, Thiery JP (1997) The zinc-finger protein Slug causes desmosome dissociation, and initial and necessary step for growth factor-induced epithelial-mesenchymal transition. J Cell Biol 137: 1403-1419
50. Strutz F, Okada H, Lo CW, Danoff T, Carone RL, Tomaszewski JE, Neilson EG (1995) Identification and characterization of a fibroblast marker: FSPI. J Cell Biol 130: 393-405
51. Van den Broecke C, Vleminckx K, de Bruyne G, van Hoorde L, Vakaet L, van van Roy F, Marcel M (1996) Morphotypic plasticity in vitro and in nude mice of epithelial mouse mammary cells (NMuMG) displaying an epithelioid (e) or a fibroblastic (f) morphotype in culture. Clin Exp Metastasis 14: 282-296
52. Vanderburg CR, Hay ED (1996) E-cadherin transforms embryonic corneal fibroblasts to stratified epithelium with desmosomes. Acta Anat 157: 87-104
53. Vermeulen S, van Marck V, van Hoorde L, van Roy F, Bracke M, Mareel M (1996) Regulation of the invasion suppressor function of the cadherin/catenin complex. Pathol Res Pract 192: 694-707
54. Vicovac L, Aplin JD (1996) Epithelial-mesenchymal transition during trophoblast differentiation. Acta Anat 156: 202-216
55. Wernert N (1997) The multiple roles of tumour stroma. Virchows Arch 430: 433-443
56. Williams DJ, de Swiet M (1997) The pathophysiology of pre-eclampsia. Intensive Care Med 23: 620-629
57. Woodhouse EC, Chuaqui RF, Liotta LA (1997) General mechanisms of metastasis. Cancer 80: 1529-1537
58. Zhou Y, Damsky CH, Chiu K, Roberts JM, Fisher SJ (1993) Preeclampsia is associated with abnormal expression of adhesion mulecules by invasive cytotrophoblasts. J Clin Invest 91: 950-960
59. Zutter MM, Santoro SA, Staatz WD, Tsung YL (1995) Re-expression of alpha-2-beta1 integrin abrogates the malignant phenotype of breast carcinoma cells. Proc Natl Acad Sci USA 92: 7411-7415