Nonequivalent nuclear location of immunoglobulin alleles in B lymphocytes

Nature Immunology

Volumn 2, Issue 9, 2001, Pages 848-854

  Skok, Jane A ^a   Brown, Karen E ^a   Azuara, Veronique ^a   Caparros, Marie Laure ^a   Baxter, Jonathan ^a   Takacs, Katalin ^a   Dillon, Niall ^a   Gray, David ^b   Perry, Robert P ^c   Merkenschlager, Matthias ^a   Fisher, Amanda G ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c FOX CHASE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DNA BINDING PROTEIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LAMBDA CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; NUCLEAR PROTEIN; RNA;

ALLELE; ALLELIC EXCLUSION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CELL ISOLATION; CELL MATURATION; CELL SPECIFICITY; CELL STRUCTURE; CELL TRANSFORMATION; CONTROLLED STUDY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE ACTIVATION; GENE EXPRESSION; GENE LOCATION; GENETIC MANIPULATION; GENETIC TRANSCRIPTION; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

ALLELES; ANIMALS; B-LYMPHOCYTES; CELL LINE, TRANSFORMED; CELL NUCLEUS; CELLS, CULTURED; CENTROMERE; CLONE CELLS; GENE REARRANGEMENT, B-LYMPHOCYTE; GENES, IMMUNOGLOBULIN; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; IN SITU HYBRIDIZATION, FLUORESCENCE; LYMPHOCYTE ACTIVATION; MICE; RNA, MESSENGER; SPLEEN;

EID: 0035554683     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni0901-848     Document Type: Article

References (38)

1. Monoallelic expression: 'There can only be one
2. Clonal selection and learning in the antibody system
3. Generation and regeneration of cells of the B-lymphocyte lineage
4. The V(D)J recombination activating gene, RAG-I
5. Frequency and characterization of phenotypic Ig heavy chain allelically included IgM-expressing B cells in mice
6. Perturbation of nuclear architecture by long-distance chromosome interactions
7. Perinuclear localization of chromatin facilitates transcriptional silencing
8. Dynamic repositioning of genes in the nucleus of lymphocytes preparing for cell division
9. Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin
10. Positions of potential: Nuclear organization and gene expression
11. Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets
12. A functional enhancer suppresses silencing of a transgene and prevents its localization close to centromeric heterochromatin
13. Nuclear localization and histone acetylation: A pathway for chromatin opening and transcriptional activation of the human β-globin locus
14. Transcription factor dosage affects changes in higher order chromatin structure associated with activation of a heterochromatic gene
15. The Ikaros gene is required for the development of all lymphoid lineages
16. Binding of Ikaros to the λ5 promoter silences transcription through a mechanism that does not require heterochromatin formation
17. γ I heavy chain transgenes are responsive to IFN-γ repression and CD40 ligation
18. H-2 restricted T-B cell interactions involved in polyspecific B cell responses mediated by soluble antigen
19. Polypeptide chains of human γ-globulin: Cellular localization by fluorescent antibody
20. Gene targeting in the Igκ locus: Efficient generation of λ chain-expressing B cells, independent of gene rearrangements in Igκ
21. Immunoglobulin class switching; Molecular and cellular analysis
22. Lymphoproliferative disorders in IL-7 transgenic mice: Expansion of immature B cells which retain macrophage potential
23. s mRNA
24. Cμ-containing transcripts initiate heterogeneously within the IgH enhancer region and contain a novel 5'-nontranslatable exon
25. HD, recombination
26. Lipopolysaccharide-induced transcription of the κ immunoglobulin locus occurs on both alleles and is independent of methylation status
27. Re-modelling of nuclear architecture in quiescent and senescent human fibroblasts
28. Receptor selection in B and T Lymphocytes
29. Transcriptional and posttranscriptional control of immunoglobulin mRNA production during B lymphocyte development
30. Establishment and characterization of BALB/c lymphoma lines with B cell properties
31. Somatic point mutations in unrearranged immunoglobulin gene segments encoding the variable region of λ light chains
32. Organisation of the constant-region gene family of the mouse immunoglobulin heavy chain
33. H gene families reveals a common organization for three Igh haplotypes
34. Mapping of heavy chain genes for mouse immunoglobulins M and D
35. The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene
36. B cell development regulated by gene rearrangement: Arrest of maturation by membrane-bound Dμ protein and selection of DH element reading frames