Stepwise activation of the immunoglobulin μ heavy chain gene locus

EMBO Journal

Volumn 20, Issue 22, 2001, Pages 6394-6403

  Chowdhury, D ^a   Sen, R ^a  

^a BRANDEIS UNIVERSITY   (United States)

Author keywords

B cells; Gene expression; Hyperacetylation; Immunoglobulin heavy chain

Indexed keywords

HISTONE; IMMUNOGLOBULIN MU CHAIN; INTERLEUKIN 7;

5' UNTRANSLATED REGION; ACETYLATION; ANIMAL CELL; ARTICLE; B LYMPHOCYTE DIFFERENTIATION; CONTROLLED STUDY; GENE ACTIVATION; GENE EXPRESSION; GENE LOCUS; GENE REARRANGEMENT; GENETIC RECOMBINATION; GENOME; GERM LINE; MOUSE; NONHUMAN; ONTOGENY; PRIORITY JOURNAL; PROTEIN DOMAIN; REGULATORY MECHANISM;

ACETYLATION; ANIMALS; ANTIGENS, CD19; B-LYMPHOCYTES; BINDING SITES; CELL DIFFERENTIATION; CELLS, CULTURED; CHROMATIN; DEOXYRIBONUCLEASES; DNA; GENE REARRANGEMENT, B-LYMPHOCYTE; HISTONES; IMMUNOGLOBULIN MU-CHAINS; INTERLEUKIN-7; MICE; MICE, INBRED BALB C; MODELS, GENETIC; PRECIPITIN TESTS; PROTEIN STRUCTURE, TERTIARY; RECOMBINATION, GENETIC;

ANIMALIA;

EID: 0035890244     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.22.6394     Document Type: Article

References (56)

1. Role of interleukin-7 in T-cell development from hematopoietic stem cells
2. H rearrangement by promoter-enhancer approximation
3. J recombination does not require germ line transcription of the recombining variable gene segment
4. IL-7 reconstitutes multiple aspects of v-Abl-mediated signaling
5. Transcriptional silencing in yeast is associated with reduced nucleosome acetylation
6. TCRβ and TCRα gene enhancers confer tissue- and stage-specificity on V(D)J recombination events
7. H locus
8. Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor
9. Analysis of the B-cell progenitor compartment at the level of single cells
10. Sequences affecting the V(D)J recombinational activity of the IgH intronic enhancer in a transgenic substrate
11. Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate
12. Nuclease hypersensitive sites in chromatin
13. Accessibility changes across the mouse Igh-V locus during B cell development
14. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow
15. Core histone hyperacetylation co-maps with generalized DNase 1 sensitivity in the chicken β-globin chromosomal domain
16. A direct link between core histone acetylation and transcriptionally active chromatin
17. H gene family repertoire of resting B cells. Preferential use of D-proximal families early in development may be due to distinct B cell subsets
18. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
19. Activation of NF-KB/Rel occurs early during neoplastic transformation of mammary cells
20. Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome
21. A survey of protein-DNA interaction sites within the murine immunoglobulin heavy chain locus reveals a particularly complex pattern around the DQ52 element
22. A second promoter and enhancer element within the immunoglobulin heavy chain locus
23. Functional GATA-3 binding sites within murine CD8α upstream regulatory sequences
24. Enhancer-dependent and -independent steps in the rearrangement of a human T cell receptor δ transgene
25. Transitions in histone acetylation reveal boundaries of three separately regulated neighboring loci
26. H genes occurs in the newly generated repertoire of neonatal and adult mice
27. Overexpression of Bcl-2 does not rescue impaired B lymphopoiesis in IL-7 receptor-deficient mice but can enhance survival of mature B cells
28. Frequency of VH81x usage during B cell development: Initial decline in usage is independent of Ig heavy chain cell surface expression
29. Modulation of the IL-7 dose-response threshold during pro-B cell differentiation is dependent on pre-B cell receptor expression
30. Chromatin remodeling by the T cell receptor (TCR)-β gene enhancer during early T cell development. Implications for the control of TCR-β locus recombination
31. Stimulation of V(D)J recombination by histone acetylation
32. A role for histone acetylation in the developmental regulation of VDJ recombination
33. Enhancer control of local accessibility to V(D)J recombinase
34. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
35. DNA methylation and chromatin modification
36. A V(D)J recombinase-inducible B-cell line: Role of transcriptional enhancer elements in directing V(D)J recombination
37. Virus infection leads to localized hyperacetylation of histones H3 and H4 at the IFN-β promoter
38. Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions
39. The interleukin 7 receptor is required for T cell receptor γ locus accessibility to the V(D)J recombinase
40. V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer
41. DNA methylation: A molecular lock
42. Accessibility control of antigen-receptor variable-region gene assembly: Role of cis-acting elements
43. Function of the TCRα enhancer in αβ and γδ T cells
44. Accessibility control of variable region gene assembly during T-cell development
45. Regulation of expression of T cell γ chain, L3T4 and Ly-2 messages in Abelson/Moloney virus-transformed T cell lines
46. Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vitro
47. The language of covalent histone modifications
48. Changes in the V(H) gene repertoire of developing precursor B lymphocytes in mouse bone marrow mediated by the pre-B cell receptor
49. Definition of a T-cell receptor β gene core enhancer of V(D)J recombination by transgenic mapping
50. Murine pro-B cells require IL-7 and its receptor complex to up-regulate IL-7Rα, terminal deoxynucleotidyltransferase and Cμ expression
51. Control of V(D)J recombinational accessibility of the Dβ1 gene segment at the TCRβ locus by a germline promoter
52. Deletion of germline promoter PDβ1 from the TCRβ locus causes hypermethylation that impairs Dβ1 recombination by multiple mechanisms
53. Review: Chromatin structural features and targets that regulate transcription
54. Alteration of nucleosome structure as a mechanism of transcriptional regulation
55. H gene segments in pre-B-cell lines
56. H gene segments is mediated by cis elements