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Volumn 6, Issue 3, 1997, Pages 225-233

B cell development under the condition of allelic inclusion

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN;

EID: 0030888193     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80325-8     Document Type: Article
Times cited : (204)

References (52)
  • 1
    • 0041646843 scopus 로고
    • Joining of immunoglobulin heavy chain gene segments: Implications from a chromosome with evidence of three D-JH fusions
    • Alt, F.W., and Baltimore, D. (1982). Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions. Proc. Natl. Acad. Sci. USA 79, 4118-4122.
    • (1982) Proc. Natl. Acad. Sci. USA , vol.79 , pp. 4118-4122
    • Alt, F.W.1    Baltimore, D.2
  • 2
    • 0019442186 scopus 로고
    • Heavy chain variable region contribution to the NPb family of antibodies: Somatic mutation evident in a γ2a variable region
    • Bothwell, A.L., Paskind, M., Reth, M., Imanishi-Kari, T., Rajewsky, K., and Baltimore, D. (1981 ). Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a γ2a variable region. Cell 24, 625-637.
    • (1981) Cell , vol.24 , pp. 625-637
    • Bothwell, A.L.1    Paskind, M.2    Reth, M.3    Imanishi-Kari, T.4    Rajewsky, K.5    Baltimore, D.6
  • 4
    • 0029553058 scopus 로고
    • Immunoglobulin heavy chain gene replacement: A mechanism of receptor editing
    • Chen, C., Nagy, Z., Prak, E.L., and Weigert, M. (1995). Immunoglobulin heavy chain gene replacement: a mechanism of receptor editing. Immunity 3, 747-755.
    • (1995) Immunity , vol.3 , pp. 747-755
    • Chen, C.1    Nagy, Z.2    Prak, E.L.3    Weigert, M.4
  • 5
    • 0027207924 scopus 로고
    • A common sequence motif near nonhomologous recombination breakpoints involving Ig sequences
    • Chou, C.L., and Morrison, S.L. (1993). A common sequence motif near nonhomologous recombination breakpoints involving Ig sequences. J. Immunol. 150, 5350-5360.
    • (1993) J. Immunol. , vol.150 , pp. 5350-5360
    • Chou, C.L.1    Morrison, S.L.2
  • 6
    • 0019428880 scopus 로고
    • B220: A B cell-specific member of the T200 glycoprotein family
    • Coffman, R.L., and Weissman, I.L. (1981). B220: a B cell-specific member of the T200 glycoprotein family. Nature 289, 681-683.
    • (1981) Nature , vol.289 , pp. 681-683
    • Coffman, R.L.1    Weissman, I.L.2
  • 7
    • 0021680612 scopus 로고
    • Rat anti-T15 monoclonal antibodies with specificity for VH-and VH-VL epitopes
    • Desaymard, C., Giusti, A.M., and Scharff, M.D. (1984). Rat anti-T15 monoclonal antibodies with specificity for VH-and VH-VL epitopes. Mol. Immunol. 21, 961-967.
    • (1984) Mol. Immunol. , vol.21 , pp. 961-967
    • Desaymard, C.1    Giusti, A.M.2    Scharff, M.D.3
  • 8
    • 0023223072 scopus 로고
    • A new V gene ex pressed in λ-2 light chains of the mouse
    • Dildrop, R., Cause, A., Müller, W., and Rajewsky, K. (1987). A new V gene ex pressed in λ-2 light chains of the mouse. Eur. J. Immunol. 17, 731-734.
    • (1987) Eur. J. Immunol. , vol.17 , pp. 731-734
    • Dildrop, R.1    Cause, A.2    Müller, W.3    Rajewsky, K.4
  • 9
    • 0027476466 scopus 로고
    • Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development
    • Ehlich, A., Schaal, S., Gu, H., Kitamura, D., Müller, W., and Rajewsky, K. (1993). Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development. Cell 72, 695-704.
    • (1993) Cell , vol.72 , pp. 695-704
    • Ehlich, A.1    Schaal, S.2    Gu, H.3    Kitamura, D.4    Müller, W.5    Rajewsky, K.6
  • 10
    • 0023718496 scopus 로고
    • Vregion sequences of anti-DNA and anti-RNA autoantibodies from NZB/NZW F1 mice
    • Eilat, D., Webster, D.M., and Rees, A.R. (1988). Vregion sequences of anti-DNA and anti-RNA autoantibodies from NZB/NZW F1 mice. J. Immunol. 141, 1745-1753.
    • (1988) J. Immunol. , vol.141 , pp. 1745-1753
    • Eilat, D.1    Webster, D.M.2    Rees, A.R.3
  • 11
    • 0026019627 scopus 로고
    • Differentiation of growth signal requirement of B lymphocyte precursoris directed by expression of immunoglobulin
    • Era, T., Ogawa, M., Nishikawa, S., Okamoto, M., Honjo, T., Akagi, K., Miyazaki, J., and Yamamura, K. (1991). Differentiation of growth signal requirement of B lymphocyte precursoris directed by expression of immunoglobulin. EMBO J. 10, 337-342.
    • (1991) EMBO J. , vol.10 , pp. 337-342
    • Era, T.1    Ogawa, M.2    Nishikawa, S.3    Okamoto, M.4    Honjo, T.5    Akagi, K.6    Miyazaki, J.7    Yamamura, K.8
  • 12
    • 0024444922 scopus 로고
    • Flow cytometric analysis of cell proliferation dynamics in the B cell compartment of the mouse
    • Förster, I., Vieira, P., and Rajewsky, K.(1989). Flow cytometric analysis of cell proliferation dynamics in the B cell compartment of the mouse. Int. Immunol. 1, 321-331.
    • (1989) Int. Immunol. , vol.1 , pp. 321-331
    • Förster, I.1    Vieira, P.2    Rajewsky, K.3
  • 13
    • 0027452074 scopus 로고
    • Mice lacking TdT: Mature animals with an immature lymphocyte repertoire
    • Gilfillan, S., Dierich, A., Lemeur, M., Benoist, C., and Mathis, D. (1993). Mice lacking TdT: mature animals with an immature lymphocyte repertoire. Science 261, 1175-1178.
    • (1993) Science , vol.261 , pp. 1175-1178
    • Gilfillan, S.1    Dierich, A.2    Lemeur, M.3    Benoist, C.4    Mathis, D.5
  • 15
    • 0027280936 scopus 로고
    • Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting
    • Gu, H., Zou, Y.R., and Rajewsky, K. (1993). Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell 73, 1155-1164.
    • (1993) Cell , vol.73 , pp. 1155-1164
    • Gu, H.1    Zou, Y.R.2    Rajewsky, K.3
  • 16
    • 0023906071 scopus 로고
    • Identification of a murine pan-T cell antigen which is also expressed during the terminal phases of B cell differentiation
    • Gulley, M.L., Ogata, L.C., Thorson, J.A., Dailey, M.O., and Kemp, J.D. (1988). Identification of a murine pan-T cell antigen which is also expressed during the terminal phases of B cell differentiation. J. Immunol. 140, 3751-3757.
    • (1988) J. Immunol. , vol.140 , pp. 3751-3757
    • Gulley, M.L.1    Ogata, L.C.2    Thorson, J.A.3    Dailey, M.O.4    Kemp, J.D.5
  • 17
    • 0025868702 scopus 로고
    • Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow
    • Hardy, R.R., Carmack, C.E., Shinton, S.A., Kemp, J.D., and Hayakawa, K. (1991). Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173, 1213-1225.
    • (1991) J. Exp. Med. , vol.173 , pp. 1213-1225
    • Hardy, R.R.1    Carmack, C.E.2    Shinton, S.A.3    Kemp, J.D.4    Hayakawa, K.5
  • 18
    • 0027241252 scopus 로고
    • Endogenous Ig production in μ transgenic mice. I. Allelic exclusion at the level of expression
    • Imanishi-Kari, T., Bandyopadhay, S., Busto, P., and Huang, C.A. (1993). Endogenous Ig production in μ transgenic mice. I. Allelic exclusion at the level of expression. J. Immunol. 150, 3311-3326.
    • (1993) J. Immunol. , vol.150 , pp. 3311-3326
    • Imanishi-Kari, T.1    Bandyopadhay, S.2    Busto, P.3    Huang, C.A.4
  • 19
    • 0027417869 scopus 로고
    • Shutdown of class switch recombination by deletion of a switch region control element
    • Jung, S., Rajewsky, K., and Radbruch, A. (1993). Shutdown of class switch recombination by deletion of a switch region control element. Science 259, 984-987.
    • (1993) Science , vol.259 , pp. 984-987
    • Jung, S.1    Rajewsky, K.2    Radbruch, A.3
  • 21
    • 0347418394 scopus 로고    scopus 로고
    • Construction of cDNA from single unstimulated B lymphocytes: Method and application to the study of expressed antibody repertoires in FACS-sorted murine B cell subsets
    • L.A. Herzenberg, L.A. Herzenberg, D.M. Weir, and C. Blackwell, eds. (Oxford: Blackwell Scientific Publications), in press
    • Kantor, A.B., Merrill, C.E., and Hillson, J.L. (1997). Construction of cDNA from single unstimulated B lymphocytes: method and application to the study of expressed antibody repertoires in FACS-sorted murine B cell subsets. In Handbook of Experimental Immunology, 5th Edition, L.A. Herzenberg, L.A. Herzenberg, D.M. Weir, and C. Blackwell, eds. (Oxford: Blackwell Scientific Publications), in press.
    • (1997) Handbook of Experimental Immunology, 5th Edition
    • Kantor, A.B.1    Merrill, C.E.2    Hillson, J.L.3
  • 23
    • 0022502863 scopus 로고
    • Recombination between an expressed immunoglobulin heavy-chain gene and a germline variable gene segment in a Ly 1 + B-cell lymphoma
    • Kleinfield, R., Hardy, R.R., Tarlinton, D., Dangl, J., Herzenberg, L.A., and Weigert, M. (1986). Recombination between an expressed immunoglobulin heavy-chain gene and a germline variable gene segment in a Ly 1 + B-cell lymphoma. Nature 322, 843-846.
    • (1986) Nature , vol.322 , pp. 843-846
    • Kleinfield, R.1    Hardy, R.R.2    Tarlinton, D.3    Dangl, J.4    Herzenberg, L.A.5    Weigert, M.6
  • 24
    • 0027369562 scopus 로고
    • Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes
    • Komori, T., Okada, A., Stewart, V., and Alt, F.W. (1993). Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes. Science 261, 1171-1175.
    • (1993) Science , vol.261 , pp. 1171-1175
    • Komori, T.1    Okada, A.2    Stewart, V.3    Alt, F.W.4
  • 25
    • 0026328818 scopus 로고
    • Generation and analysis of interleukin-4 deficient mice
    • Kühn, R., Rajewsky, K., and Müller, W. (1991). Generation and analysis of interleukin-4 deficient mice. Science 254, 707-710.
    • (1991) Science , vol.254 , pp. 707-710
    • Kühn, R.1    Rajewsky, K.2    Müller, W.3
  • 26
    • 0016786609 scopus 로고
    • Studies of surface immunoglobulins on human B lymphocytes. I. Dissociation of cell-bound immunoglobulins with acid pH or at 37°C
    • Kumagai, K., Abo, T., Sekizawa, T., and Sasaki, M. (1975). Studies of surface immunoglobulins on human B lymphocytes. I. Dissociation of cell-bound immunoglobulins with acid pH or at 37°C. J. Immunol. 115, 982-987.
    • (1975) J. Immunol. , vol.115 , pp. 982-987
    • Kumagai, K.1    Abo, T.2    Sekizawa, T.3    Sasaki, M.4
  • 28
  • 29
    • 0027275497 scopus 로고
    • The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver
    • Li, Y.S., Hayakawa, K., and Hardy, R.R. (1993).The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J. Exp. Med. 178, 951-960.
    • (1993) J. Exp. Med. , vol.178 , pp. 951-960
    • Li, Y.S.1    Hayakawa, K.2    Hardy, R.R.3
  • 30
    • 0029886467 scopus 로고    scopus 로고
    • Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development
    • Löffert, D., Ehlich, A., Müller, W., and Rajewsky, K. (1996). Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development. Immunity 4, 133-144.
    • (1996) Immunity , vol.4 , pp. 133-144
    • Löffert, D.1    Ehlich, A.2    Müller, W.3    Rajewsky, K.4
  • 31
    • 0027174495 scopus 로고
    • Affinity maturation leads to differential expression of multiple copies of a κ light-chain transgene
    • Lozano, F., Rada, C., Jarvis, J.M., and Milstein, C. (1993). Affinity maturation leads to differential expression of multiple copies of a κ light-chain transgene. Nature 363, 271-273.
    • (1993) Nature , vol.363 , pp. 271-273
    • Lozano, F.1    Rada, C.2    Jarvis, J.M.3    Milstein, C.4
  • 32
    • 0021092716 scopus 로고
    • Expression and regulation of immunoglobulin heavy chain genes transfected into lymphoid cells
    • Neuberger, M.S. (1983). Expression and regulation of immunoglobulin heavy chain genes transfected into lymphoid cells. EMBO J. 2, 1373-1378.
    • (1983) EMBO J. , vol.2 , pp. 1373-1378
    • Neuberger, M.S.1
  • 34
    • 0030584886 scopus 로고    scopus 로고
    • Structural elements controlling anti-DNA antibody affinity and their relationship to anti-phosphorylcholine activity
    • Pewzner-Jung, Y., Simon, T., and Eilat, D. (1996). Structural elements controlling anti-DNA antibody affinity and their relationship to anti-phosphorylcholine activity. J. Immunol. 156, 3065-3073.
    • (1996) J. Immunol. , vol.156 , pp. 3065-3073
    • Pewzner-Jung, Y.1    Simon, T.2    Eilat, D.3
  • 35
    • 0030006070 scopus 로고    scopus 로고
    • Clonal selection and learning in the antibody system
    • Rajewsky, K. (1996). Clonal selection and learning in the antibody system. Nature 381, 751-758.
    • (1996) Nature , vol.381 , pp. 751-758
    • Rajewsky, K.1
  • 36
    • 0018179467 scopus 로고
    • Analysis of the repertoire of anti-NP antibodies in C57BL/6 mice by cell fusion. I. Characterization of antibody families in the primary and hyperimmune response
    • Reth, M., Hämmerling, G.J., and Rajewsky, K. (1978). Analysis of the repertoire of anti-NP antibodies in C57BL/6 mice by cell fusion. I. Characterization of antibody families in the primary and hyperimmune response. Eur. J. Immunol. 8, 393-400.
    • (1978) Eur. J. Immunol. , vol.8 , pp. 393-400
    • Reth, M.1    Hämmerling, G.J.2    Rajewsky, K.3
  • 37
    • 0018578942 scopus 로고
    • Analysis of the repertoire of anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies in C57BL/6 mice by cell fusion. II. Characterization of idiotopes by monoclonal anti-idiotope antibodies
    • Reth, M., Imanishi-Kari, T., and Rajewsky, K. (1979). Analysis of the repertoire of anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies in C57BL/6 mice by cell fusion. II. Characterization of idiotopes by monoclonal anti-idiotope antibodies. Eur. J. Immunol. 9, 1004-1013.
    • (1979) Eur. J. Immunol. , vol.9 , pp. 1004-1013
    • Reth, M.1    Imanishi-Kari, T.2    Rajewsky, K.3
  • 38
    • 0022557584 scopus 로고
    • A novel VH to VHDJH joining mechanism in heavy-chain-negative (null) pre-B cells results in heavy-chain production
    • Reth, M., Gehrmann, P., Petrac, E., and Wiese, P. (1986). A novel VH to VHDJH joining mechanism in heavy-chain-negative (null) pre-B cells results in heavy-chain production. Nature 322, 840-842.
    • (1986) Nature , vol.322 , pp. 840-842
    • Reth, M.1    Gehrmann, P.2    Petrac, E.3    Wiese, P.4
  • 39
    • 0030049985 scopus 로고    scopus 로고
    • A subpopulation of B220+ cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors
    • Rolink, A., ten Boekel, E., Melchers, F., Fearon, D.T., Krop, I., and Andersson, J. (1996). A subpopulation of B220+ cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors. J. Exp. Med. 183, 187-194.
    • (1996) J. Exp. Med. , vol.183 , pp. 187-194
    • Rolink, A.1    Ten Boekel, E.2    Melchers, F.3    Fearon, D.T.4    Krop, I.5    Andersson, J.6
  • 40
    • 0023178186 scopus 로고
    • A new variable region in mouse immunoglobulin λ light chains
    • Sanchez, P., and Cazenave, P.A. (1987). A new variable region in mouse immunoglobulin λ light chains. J. Exp. Med. 166, 265-270.
    • (1987) J. Exp. Med. , vol.166 , pp. 265-270
    • Sanchez, P.1    Cazenave, P.A.2
  • 41
    • 0025730210 scopus 로고
    • Vλ-Jλ rearrangements are restricted within a V-J-C recombination unit in the mouse
    • Sanchez, P., Nadel, B., and Cazenave, P.A. (1991). Vλ-Jλ rearrangements are restricted within a V-J-C recombination unit in the mouse. Eur. J. Immunol. 21, 907-911.
    • (1991) Eur. J. Immunol. , vol.21 , pp. 907-911
    • Sanchez, P.1    Nadel, B.2    Cazenave, P.A.3
  • 42
    • 0025924279 scopus 로고
    • Assessment of cytokines by immunofluorescence and the paraformaldehydesaponin procedure
    • Sander, B., Andersson, J., and Andersson, U. (1991). Assessment of cytokines by immunofluorescence and the paraformaldehydesaponin procedure. Immunol. Rev. 119, 65-85.
    • (1991) Immunol. Rev. , vol.119 , pp. 65-85
    • Sander, B.1    Andersson, J.2    Andersson, U.3
  • 43
    • 0023186608 scopus 로고
    • Monoclonal anti-allotype antibody towards BALB/c IgM: Analysis of specificity and site of a V-C crossover in recombinant strain BALB-Igh-Va/Igh-Cb
    • Schüppel, R., Wilke, J., and Weiler, E. (1987). Monoclonal anti-allotype antibody towards BALB/c IgM: analysis of specificity and site of a V-C crossover in recombinant strain BALB-Igh-Va/Igh-Cb. Eur. J. Immunol. 17, 739-741.
    • (1987) Eur. J. Immunol. , vol.17 , pp. 739-741
    • Schüppel, R.1    Wilke, J.2    Weiler, E.3
  • 44
    • 0027406812 scopus 로고
    • Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes
    • Shinkai, Y., Koyasu, S., Nakayama, K., Murphy, K.M., Loh, D.Y., Reinherz, E.L., and Alt, F.W. (1993). Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes. Science 259, 822-825.
    • (1993) Science , vol.259 , pp. 822-825
    • Shinkai, Y.1    Koyasu, S.2    Nakayama, K.3    Murphy, K.M.4    Loh, D.Y.5    Reinherz, E.L.6    Alt, F.W.7
  • 45
    • 0024283912 scopus 로고
    • 'Enhancer-constitutive' vectors for the expression of recombinant antibodies
    • Simon, T., and Rajewsky, K. (1988). 'Enhancer-constitutive' vectors for the expression of recombinant antibodies. Nucl. Acids Res. 16, 354.
    • (1988) Nucl. Acids Res. , vol.16 , pp. 354
    • Simon, T.1    Rajewsky, K.2
  • 46
    • 0027691148 scopus 로고
    • Targeted insertion of avariable region gene intothe immunoglobulin heavy chain locus
    • Taki, S., Meiering, M., and Rajewsky, K. (1993). Targeted insertion of avariable region gene intothe immunoglobulin heavy chain locus. Science 262, 1268-1271.
    • (1993) Science , vol.262 , pp. 1268-1271
    • Taki, S.1    Meiering, M.2    Rajewsky, K.3
  • 47
    • 0028979455 scopus 로고
    • Rearrangement of upstream DH and VH genes to a rearranged immunoglobulin variable region geneinserted into the DQ52-JH region of the immunoglobulin heavy chain locus
    • Taki, S., Schwenk, F., and Rajewsky, K. (1995). Rearrangement of upstream DH and VH genes to a rearranged immunoglobulin variable region geneinserted into the DQ52-JH region of the immunoglobulin heavy chain locus. Eur. J. Immunol. 25, 1888-1896.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 1888-1896
    • Taki, S.1    Schwenk, F.2    Rajewsky, K.3
  • 48
    • 0023646810 scopus 로고
    • Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
    • Thomas, K.R., and Capecchi, M.R. (1987). Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51, 503-512.
    • (1987) Cell , vol.51 , pp. 503-512
    • Thomas, K.R.1    Capecchi, M.R.2
  • 49
    • 0027478391 scopus 로고
    • Receptor editing in self-reactive bone marrow B cells
    • Tiegs, S.L., Russell, D.M., and Nemazee, D. (1993). Receptor editing in self-reactive bone marrow B cells. J. Exp. Med. 177, 1009-1020.
    • (1993) J. Exp. Med. , vol.177 , pp. 1009-1020
    • Tiegs, S.L.1    Russell, D.M.2    Nemazee, D.3
  • 50
    • 0020455463 scopus 로고
    • A theory of allelic and isotypic exclusion for immunoglobulin genes
    • Wabl, M., and Steinberg, C. (1982). A theory of allelic and isotypic exclusion for immunoglobulin genes. Proc. Natl. Acad. Sci. USA 79, 6976-6978.
    • (1982) Proc. Natl. Acad. Sci. USA , vol.79 , pp. 6976-6978
    • Wabl, M.1    Steinberg, C.2
  • 51
    • 0025139262 scopus 로고
    • Molecularcloning of the murine BP-1/6C3 antigen: A member of the zinc-dependent metallopeptidase family
    • Wu, Q., Lahti, J.M., Air, G.M., Burrows, P.D., and Cooper, M.D. (1990). Molecularcloning of the murine BP-1/6C3 antigen: a member of the zinc-dependent metallopeptidase family. Proc. Natl. Acad. Sci. USA 87, 993-997.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 993-997
    • Wu, Q.1    Lahti, J.M.2    Air, G.M.3    Burrows, P.D.4    Cooper, M.D.5
  • 52
    • 0027447365 scopus 로고
    • Gene targeting in the IgK locus: Efficient generation of λ chain-expressing B cells, independent of gene rearrangements in Igκ
    • Zou, Y.R., Takeda, S., and Rajewsky, K. (1993). Gene targeting in the IgK locus: efficient generation of λ chain-expressing B cells, independent of gene rearrangements in Igκ. EMBO J. 12, 811-820.
    • (1993) EMBO J. , vol.12 , pp. 811-820
    • Zou, Y.R.1    Takeda, S.2    Rajewsky, K.3


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