Factors that influence formation of B cell repertoire

Immunologic Research

Volumn 21, Issue 2-3, 2000, Pages 195-202

  Feeney, A J ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

B cell repertoire; Disease susceptibility; Immunoglobulin genes; V(D)J recombination

Indexed keywords

ARTICLE; B LYMPHOCYTE; DISEASE PREDISPOSITION; GENE REARRANGEMENT; GENETIC RECOMBINATION; GENETIC SUSCEPTIBILITY; HAEMOPHILUS INFLUENZAE TYPE B; HUMAN; IMMUNOGENETICS; IMMUNOGLOBULIN GENE; NONHUMAN; PRIORITY JOURNAL;

EID: 0033843853     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1385/IR:21:2-3:195     Document Type: Article

References (36)

1. Somatic generation of antibody diversity
2. The variable genes of the human immunoglobulin κ locus
3. The human immunoglobulin κ locus consists of two copies that are organized in opposite polarity
4. Human cord blood κ repertoire
5. Expressed human immunoglobulin κ genes and their hypermutation
6. A directory of human germ-line Vκ segments reveals a strong bias in their usage
7. + cells
8. Two pairs of recombination signals are sufficient to cause immunoglobulin V-(D)-J joining
9. V(D)J recombination: A functional definition of the joining signals
10. Structure and evolution of mammalian V(H)families
11. κ Light chain rearrangement in mouse fetal liver
12. Mouse V(H)7183 recombination signal sequences mediate recombination more frequently than those of V(H)J558
13. Decreased frequency of rearrangement due to synergistic effect of nucleotide changes in the heptamer and nonamer of the recombination signal sequence of the Vκ gene A2b, which is associated with increased susceptibility of Navajos to Haemophilus influenzae type b disease
14. Differential usage of V(H) gene segments is mediated by cis elements
15. Sequence of the spacer in the RSS affects V(D)J rearrangement frequency and correlates with non-random Vκ usage in vivo
16. Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals
17. New alleles of IGKV genes A2 and A18 suggest significant polymorphism of the human IGKV locus
18. Isoelectic focusing of human antibody to the Haemophilus influenzae type b capsular polysaccharide: Restricted and identical spectrotypes in adults
19. An idiotypic marker associated with a germ-line encoded κ light chain variable region that predominates the vaccine-induced human antibody response to the Haemophilus influenzae b polysaccharide
20. Diversity of immunoglobulin light chain usage in the human immune response to Haemophilus influenzae type b capsular polysaccharide
21. Restricted immunoglobulin VH usage and VDJ combinations in the human response to Haemophilus influenzae type b capsular polysaccharide
22. Clonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b polysaccharide. IV. The less frequently expressed V(L) are heterogenous
23. Genetic factors in Haemophilus influenzae type b disease susceptibility and antibody acquisition
24. Haemophilus influenzae disease in the White Mountain Apaches: Molecular epidemiology of a high risk population
25. A defective VκA2 allele in Navajos which may play a role in increased susceptibility to Haemophilus influenzae type b disease
26. Clonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b polysaccharide III. A single VκII gene and one of several Jκ genes are joined by an invariant arginine to form the most common L chain V region
27. Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences
28. Predominance of the prototypic T15 anti-phosphorylcholine junctional sequence in neonatal pre-B cells
29. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene
30. Individual V(H) promoters vary in strength, but the frequency of rearrangement of those V(H) genes does not correlate with promoter strength nor enhancer-independence
31. Coding end sequence can markedly affect the initiation of V(D)J recombination
32. Asymmetric processing of coding ends and the effect of coding end nucleotide composition on V(D)J recombination
33. The composition of coding joints formed in V(D)J recombination is strongly affected by the nucleotide sequence of the coding ends and their relationship to the recombination signal sequences
34. The basis for the mechanistic bias for deletional over inversional V(D)J recombination
35. The role of recombination signal sequences in the preferential joining by deletion in D(H)-J(H) recombination and in the ordered rearrangement of the IgH locus
36. Immunoglobulin D(H) recombination signal sequence targeting