Identification and characterization of the murine Rag1 promoter

Molecular Immunology

Volumn 34, Issue 12-13, 1997, Pages 939-954

  Fuller, Kevin ^a   Storb, Ursula ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Rag1 gene promoter; V(D)J recombination

Indexed keywords

BINDING PROTEIN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; BINDING SITE; DNA SEQUENCE; GENE MUTATION; GENE REARRANGEMENT; GENETIC RECOMBINATION; GENETIC TRANSCRIPTION; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; STEM CELL; T LYMPHOCYTE; TATA BOX; TRANSCRIPTION INITIATION;

ANIMALIA; MURINAE;

EID: 0031417336     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(97)00000-X     Document Type: Article

References (70)

1. Alonso, C. R., Pesce, C. G. and Kornblihtt, A. R. (1996) The CCAAT-binding proteins CPI and NF-I cooperate with ATF-2 in the transcription of the fibronectin gene. J. Biol. Chem. 271, 22271-9.
2. Alt, F. W., Oltz, E. M., Young, F., Gorman, J., Taccioli, G. and Chen, J. (1992) VDJ Recombination. Immunol. Today 13, 306-314.
3. Bain, G., Gruenwald, S. and Murre, C. (1993) E2A and E2-2 are subunits of B-cell-specific E2 box DNA-binding proteins. Mol. Cell. Biol. 13, 3522-3529.
4. Bain, G., Maandag, E. C. R., Izon, D. J., Amsen, D., Kruisbeek, A. M., Weintraub, B. C., Krop, I., Schlissesl, M. S., Feeney, A. J., van Roon, M., van der Valk, M., te Riele, H. P. J., Berns, A. and Murre, C. (1994) E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Cell 79, 885-892.
5. Benoist, C. and Mathis, D. (1990) Regulation of major histocompatibility complex class-II genes : X, Y and other letters of the alphabet. Annu. Rev. Immunol. 8, 681-715.
6. H segments that were introduced into the genome of a murine Pre-B cell line. Cell 37, 105-112.
7. Brandle, D., Muller, C., Tulicke, T., Hengartner, H. and Pircher, H. (1992) Engagement of the T-cell receptor during positive selection in the thymus down-regulates RAG-1 expression. Proc. Natl. Acad. Sci. U.S.A. 89, 9529-9533.
8. Brownstein, R. H., Silverman, G. A., Little, R. D., Burke, D. T., Korsemeyer, S. J., Schlessinger, D. and Olson, M. V. (1989) Isolation of single-copy human genes from a library of yeast artificial chromosome clones. Science 244, 1348-1352.
9. Burke, D., Rossi, J., Leung, J., Koos, D. and Tilghman, S. (1991) A mouse genomic library of yeast artificial chromosome clones. Mammalian Gen. 1, 65.
10. Burke, T. W. and Kadonaga, J. T. (1996) Drosophila TFIID binds to a conserved downstream basal promoter element that is present in many TATA-box-deficient promoters. Genes and Dev. 10, 711-724.
11. Carlson, L. M., Oettinger, M. A., Schatz, D. G., Masteller, E. L., Hurley, E. A., McCormack, W. T., Baltimore, D. and Thompson, C. B. (1991) Selective expression of RAG-2 in chicken B cells undergoing immunoglobulin gene conversions. Cell 64, 201-208.
12. Chun, J. J. M., Schatz, D. G., Oettinger, M. A., Jaenish, R. and Baltimore, D. (1991) The Recombination Activation Gene-1 (RAG-1) transcript is present in the murine central nervous system. Cell 64, 189-200.
13. Czerny, T., Schaffner, G. and Busslinge, M. (1993) DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site. Genes and Dev. 7, 2048-2061.
14. Dignam, J. D., Lebovitz, R. M. and Roeder, R. G. (1983) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucl. Acids Res. 11, 1475-1489.
15. Dildrop, R., Ma, A., Zimmerman, K., Hsu, E., Tesfaye, A., DePinho, R. and Alt, F. (1989) IgH enhancer-mediated deregulation of N-myc gene expression in transgenic mice : generation of lymphoid neoplasias that lack c-myc expression. EMBO J. 8, 1121-1128.
16. Eisenbeis, C., Singh, H. and Storb, U. (1993) PU.1 is a component of a multiprotein complex which binds an essential site in the murine immunoglobulin λ2-4 enhancer. Mol. Cell. Biol. 13, 6452-6461.
17. Eisenbeis, C., Singh, H. and Storb, U. (1995) Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator. Genes and Dev. 9, 1377-1387.
18. Ernst, P., Hahm, K. and Smale, S. T. (1993) Both LyF-1 and an Ets protein interact with a critical promoter element in the murine terminal transferase gene. Mol. Cell. Biol. 13, 2982-2992.
19. Ernst, P., Hahm, K., Trinh, L., David, J. N., Roussel, M. F., Turck, C. W. and Smale, S. T. (1996) A potential role for ELF-1 in terminal transferase gene regulation. Mol. Cell. Biol. 16, 6121-6131.
20. Feldhaus, A. L., Mbangkollo, D., Arvin, K. L., Klug, C. A. and Singh, H. (1992) Blyf, a novel cell-type-and stage-specific regulator of the B-lymphocyte gene mb-1. Mol. Cell. Biol. 12, 1126-1133.
21. Frohman, M. A., Dush, M. K. and Martin, G. R. (1988) Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. Proc. Natl. Acad. Sci. U.S.A. 85, 8998-9002.
22. Gallo, M. L., Pergola, F., Daniels, G. A. and Lieber, M. R. (1994) Distinct roles for RAG-1 in the initiation of V(D)J recombination and in the resolution of coding ends. J. Biol. Chem. 269, 22188-22192.
23. Genetta, T., Ruezinsky, D. and Kadesch, T. (1994) Displacement of an E-box-binding represser by basic helix-loop-helix proteins : implications for B-cell specificity of the immunoglobulin heave-chain enhancer. Mol. Cell. Biol. 14, 6153-6163.
24. Georgopoulos, K., Bigby, M., Wang, J.-H., Molnar, A., Wu, P., Winandy, S. and Sharpe, A. (1994) The Ikaros gene is required for the development of all lympoid lineages. Cell 79, 143-156.
25. Grawunder, U., Liu, T. M., Schatz, D. G., Werner, A., Rolink, A. G., Melchers, F. and Winkler, T. (1995) Down-regulation of RAG1 and RAG2 gene expression in pre-B cells after functional immunoglobulin heavy chain rearrangement. Immunity 3, 601-608.
26. Greenhalgh, P., Olesen, C. E. M. and Steiner, L. A. (1993) Characterization and expression of recombination activating genes (RAG-1 and RAG-2) in Xenopua laevis. Jour. of Immunol. 151, 3100-3110.
27. Guthrie, C., and Fink, G. R. (1991) Guide to Yeast Genetics and Molecular Biology. Methods in Enzymology.
28. Gutman, G., Warner, N. C. and Harris, A. W. (1981) Immunoglobulin production by murine B-lymphoma cells. Clin. Immun. Immunopath. 18, 230-244.
29. Hagman, J., Rudin, C., Haasch, D., Chaplin, D. and Storb, U. (1990) A novel enhancer in the immunoglobulin λ locus is duplicated and functionally independent of NFκB. Genes and Dev. 4, 978-992.
30. Hahn, S., Buratowski, S., Sharp, P. and Guarente, L. (1989) Yeast TATA-binding protein TFIID binds to TATA elements with both consensus and non-consensus DNA sequences. Proc. Natl. Acad. Sci. U.S.A. 86, 5718-5722.
31. Hambor, J. E., Mennone, J., Coon, M. E., Hanke, J. H. and Kavathas, P. (1993) Identification and characterization of an Alu-containing, T-cell-specific enhancer located in the last intron of the human CD8 alpha gene. Mol. Cell. Biol. 13, 7056-7070.
32. Ho, S. N., Hunt, H. D., Horton, R. M., Pullen, J. K. and Pease, L. R. (1989) Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77, 51-59.
33. Jabrane-Ferrat, N., Fontes, J. D., Boss, J. M. and Peterlin, B. M. (1996) Complex architecture of major histocompatibility complex II promoters: reiterated motifs and conserved protein-protein interactions. Mol. Cell. Biol. 16, 4683-4690.
34. Kearney, J. F., Radbruch, A., Liesegang, B. and Rajewsky, K. (1979) A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines. J. Immunol. 123, 1548-1550.
35. Kim, K. J., Kanellopoulos-Langeuin, C., Merwin, R., Sachs, D. and Asofsky, R. (1979) Establishment and characterization of Balb/c lymphoma lines with B cell properties. J. Immunol. 122, 549-554.
36. Kitagawa, T., Mori, K., Kishi, H., Tagoh, H., Nagata, T., Kurioka, H. and Muraguchi, A. (1996) Chromatin structure and transcriptional regulation of human RAG-1 gene. Blood 88, 3785-3791.
37. Ko, L. J. and Engel, J. D. (1993) DNA-binding specificities of the GATA transcription factor family. Mol. Cell. Bio. 13, 4011-4022.
38. Koshland, M. (1995) Personal Communication concerning the J chain promoter.
39. Kozak, M. (1987) An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucl. Acids Res. 15, 8125-8148.
40. Kozmik, Z., Wang, S., Dorfler, P., Adams, B. and Susslinger, M. (1992) The promoter of the CD 19 gene is a target for the B-cell-specific transcription factor BSAP. Mol. Cell. Biol. 12, 2662-2672.
41. Kurioka, H., Kishi, H., Isshiki, H., Tagoh, H., Mori, K., Kitagawa, T., Nagata, T., Dohi, K. and Muraguchi, A. (1996) Isolation and characterization of a TATA-less promoter for the human RAG-1 gene. Mol. Immun. 33, 1059-1066.
42. Leber, R., Moore, B. and Meek, K. (1995) Characterization of the promoter element of the RAG-2 gene. Abstract. The Ninth International Congress of Immunology. San Fransisco, CA.
43. Lin, H. and Grosschedl, R. (1995) Failure of B-cell differentiation in mice lacking the transcription factor EBF. Nature 376, 263-267.
44. Liu, J.-K., Bergman, Y. and Zaret, K. S. (1988) The mouse albumin promoter and distal upstream site are simultaneously DNase I hypersensitive in liver chromatin and bind similar liver-abundant factors in vitro. Genes and Dev. 2, 528-541.
45. Ma, A., Fischer, P., Dildrop, R., Oltz, E., Rathburn, G., Achacoso, P., Stall, A. and Alt, F. W. (1992) Surface IgM mediated regulation of RAG gene expression in Eu-N-myc B cell lines. EMBO 11, 2727-2734.
46. Martensson, I.-L. and Melchers, F. (1994) Pre-B cell-specific λ5 gene expression due to suppression in non pre-B cells. Inter. Immunol. 6, 868-872.
47. Masterson, E. and Thompson, C. (1996) Unpublished data.
48. Menetski, J. P. and Gellert, M. (1990) V(D)J recombination activity in lymphoid cell lines is increased by agents that elevate cAMP. Proc. Natl. Acad. Sci. U.S.A. 87, 9324-9328.
49. Merike, M. and Orkin, S. H. (1993) DNA-binding specificity of GATA family to transcription factors. Mol. Cell. Bio. 13, 3999-4010.
50. Milos, P. M. and Zaret, K. (1992) A ubiquitous factor is required for C/EBP-related proteins to form stable transcription complexes on an albumin promoter segment in vitro. Genes and Dev. 6, 991-1004.
51. Mombaerts, P., Iacomini, J., Johnson, R. S., Herrup, K., Tonegawa, S. and Papaioannou, V. E. (1992) RAG-1 deficient mice have no mature B and T lymphocytes. Cell 68, 869-877.
52. Muraguchi, A., Tagoh, H., Kitagawa, T. and Kishi, H. (1994) Induction of recombination activation gene (RAG) transcription in a human lymphoid progenitor cell line by recombinant cytokines and a bone marrow-derived stromal line. J. Cell Biochem. 18.D: 457.
53. Neale, G. A. M., Fitzgerald, T. J. and Goorha, R. M. (1992) Expression of the V(D) J recombinase gene, RAG-1, is tightly regulated and involves both transcriptional and post-transcriptional controls. Mol. Immunol. 29, 1457-1466.
54. Oettinger, M. A., Schatz, D. G., Gorka, C. and Baltimore, D. (1990) RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248, 1517-1523.
55. Oettinger, M. S., Stanger, B., Schatz, D. G., Glaser, T., Call, K., Housman, D. and Baltimore, D. (1992) The Recombination Activating Genes, RAG-1 and RAG-2 are on chromosome 11p in humans and chromosome 2p in mice. Immunogen. 35, 97-101.
56. preB gene. Eur. J. Immunol. 22, 31-36.
57. Paige, C. J., Kincade, P. W. and Ralph, P. (1978) Murine B cell leukemia line with inducible surface immunoglobulin expression. J. Immunol. 121, 641-650.
58. Schatz, D.G. and Jerold, J. M. C. (1992) V(D)J recombination and the transgenic brain blues. New Biol. 4, 188-196.
59. Schatz, D. G., Oettinger, M. A. and Baltimore, D. (1989) The V(D)J recombination activating gene, RAG-1. Cell 59, 1035-1048.
60. Schreiber, E., Matthias, P., Muller, M. M. and Schaffner, W. (1989) Rapid detection of octamer binding proteins with "miniextracts", prepared from a small number of cells. Nucl. Acids. Res. 17, 6419.
61. Shinkai, Y., Rathburn, G., Lam, K.-P., Oltz, E. M., Stewart, V., Mendelsohn, M., Charron, J., Datta, M., Young, F., Stall, A. M. and Alt, F. W. (1992) RAG-2 deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 69, 855-867.
62. Smale, S. T. and Baltimore, D. (1989) The "initiator" as a transcription control element. Cell 57, 103-113.
63. Takeda, S., Masteller, E. L., Thompson, C. B. and Buerstedde, J.-M. (1992) RAG-2 expression is not essential for chicken immunoglobulin gene conversion. Proc. Natl. Acad. Sci. 89, 4023-4027.
64. Travis, A., Hagman, J. and Grosschedl, R. (1991) Heterogenously initiated transcription from the pre-B-and B-cell-specific mb-1 promoter. Analysis of the requirement for upstream factor binding sites and initiation site sequences. Mol. Cell. Biol. 11, 5756-5766.
65. Urbanek, P., Wang, Z.-Q., Fetka, I., Wagner, E. F. and Busslinger, M. (1994) Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP. Cell 79, 901-912.
66. Voronova, A. F. and Lee, F. (1994) The E2A and tal-1 helix-loop-helix proteins associate in vivo and are modulated by Id proteins during interleukin 6 induced myeloid differentiation. Proc. Natl. Acad. Sci. U.S.A. 91, 5952-5956.
67. Wayne, J., Suh, H., Misulovin, Z., Sokol, K., Inaba, K. and Nussenzweig, M. (1994) A regulatory role for recombinase activating genes, RAG-1 and RAG-2, in T cell development. Immunity 1, 95-107.
68. Wilson, A., Held, W. and MacDonald, H. R. (1994) Two waves of recombinase gene expression in developing thymocytes. J. Exp. Med. 179, 1355-1360.
69. Wright, K. L., Vilen, B. J., Itoh-Lindstrom, Y., Moore, T. L., Li, G., Criscitiello, M., Cogswell, P., Clark, J. B. and Ting, J. P.-Y. (1994) CCAAT box binding protein NF-Y facilitates in vivo recruitment of upstream DNA binding transcription factors. EMBO J. 13, 4042-4053.
70. Zhuang, Y., Soriano, P. and Weintraub, H. (1994) The helix-loop-helix gene E2A is required for B cell formation. Cell 79, 875-884.