Secondary V(D)J recombination in B-1 cells

Nature

Volumn 397, Issue 6717, 1999, Pages 355-359

  Qin, Xiao Feng ^a   Schwers, Stephan ^c   Yu, Wong ^a   Papavasiliou, Fotini ^a   Suh, Heikyung ^a   Nussenzweig, Andre ^b   Rajewsky, Klaus ^c   Nussenzweig, Michel C ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; IMMUNOGLOBULIN; MESSENGER RNA;

ANIMAL CELL; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE; CELL GROWTH; CELL MATURATION; GENE EXPRESSION; GENE REARRANGEMENT; GERMINAL CENTER; LYMPHOID ORGAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, NUCLEAR; B-LYMPHOCYTES; CELL DIVISION; DNA HELICASES; DNA-BINDING PROTEINS; GENE REARRANGEMENT, B-LYMPHOCYTE; GENES, RAG-1; IMMUNOGLOBULIN IDIOTYPES; IMMUNOGLOBULIN J-CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MICE; MICE, INBRED STRAINS; NUCLEAR PROTEINS; PERITONEUM; POLYMERASE CHAIN REACTION; RECOMBINATION, GENETIC;

ANIMALIA;

EID: 0033611469     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/16933     Document Type: Article

References (30)

1. Hayakawa, K., Hardy, R. R., Parks, D. R. & Herzenberg, L. A. The "Ly-1 B" cell subpopulation in normal immunodefective, and autoimmune mice. J. Exp. Med. 157, 202-218 (1983).
2. Hayakawa, K. et al. Ly-1 B cells: functionally distinct lymphocytes that secrete IgM autoantibodies. Proc. Natl Acad. Sci. USA 81, 2494-2498 (1984).
3. Hayakawa, K., Hardy, R. R., Herzenberg, L. A. & Herzenberg, L. A. Progenitors for Ly-1 B cells are distinct from progenitors for other B cells. J. Exp. Med. 161, 1554-1568 (1985).
4. Tarakhovsky, A. Bar Mitzvah for B-1 cells: how will they grow up? J. Exp. Med. 185, 981-984 (1997).
5. Hikida, M. et al. Reexpression of RAG-1 and RAG-2 genes in activated mature mouse B cells. Science 274, 2092-2094 (1996).
6. Han, S., Zheng, B., Schatz, D. G., Spanopoulou, E. & Kelsoe, G. Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells. Science 274, 2094-2097 (1996).
7. Papavasiliou, F. et al. V(D)J recombination in mature B cells: a new mechanism for diversification of antibody responses. Science 278, 298-301 (1997).
8. Han, S. et al. V(D)J recombinase activity in a subset of germinal center B lymphocytes. Science 278, 301-305 (1997).
9. Pelanda, R., Schaal, S., Torres, R. M. & Rajewsky, K. A prematurely expressed Ig(kappa) transgene, but not V(kappa)J(kappa) gene segment targeted into the Ig(kappa) locus, can rescue B cell development in lambda5-deficient mice. Immunity 5, 229-239 (1996).
10. Sonoda, E. et al. B cell development under the condition of allelic inclusion. Immunity 6, 225-233 (1997).
11. Pelanda, R. et al. Receptor editing in a transgenic mouse model: site efficiency and role in B cell tolerance and antibody diversification. Immunity 7, 765-777 (1997).
12. Stall, A. M. et al. Rearrangement and expression of endogenous immunoglobulin genes occur in many murine B cells expressing transgenic membrane IgM. Proc. Natl Acad. Sci. USA 85, 3546-3550 (1988).
13. Taki, S., Meiering, M. & Rajewsky, K. Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus. Science 262, 1268-1271 (1993).
14. H gene replacement in hyperselected B cells of the quasimonoclonal mouse. J. Immunol. 159, 5795-5801 (1997).
15. Spanopoulou, E. et al. Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice. Genes Dev. 8, 1030-1042 (1994).
16. Taccioli, G. E. et al. Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. Science 265, 1442-1445 (1994).
17. Nussenzweig, A. et al. Requirement for Ku80 in growth and V(D)J recombination. Nature 382, 551-555 (1996).
18. Murakami, M. et al. Oral administration of lipopolysaccharides activates B-1 cells in the peritoneal cavity and lamina propria of the gut and induces autoimmune symptoms in an autoantibody transgenic mouse. J. Exp. Med. 180, 111-121 (1994).
19. Arnold, L. W., Pennell, C. A., McCray, S. K. & Clarke, S. H. Development of B-1 cells: segregation of phosphatidyl choline-specific B cells to the B-1 population occurs after immunoglobulin gene expression. J. Exp. Med. 179, 1585-3595 (1994).
20. Tiegs, S. L., Russell, D. M. & Nemazee, D. Receptor editing in self-reactive bone marrow B cells. J. Exp. Med. 177, 1009-1020 (1993).
21. Gay, D., Saunders, T., Camper, S. & Weigert, M. Receptor editing: an approach by autoreactive B cells to escape tolerance. J. Exp. Med. 177, 999-1008 (1993).
22. Nemazee, D. A. & Bürki, K. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class 1 antibody genes. Nature 337, 562-566 (1989).
23. Goodnow, C. C., Crosbie, J., Jorgensen, H., Brink, R. A. & Basten, A. Induction of self-tolerance in mature peripheral B lymphocytes. Nature 342, 385-391 (1989).
24. Murakami, M. et al. Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice. Nature 357, 77-80 (1992).
25. Pulendran, B., Kannourakis, G., Nouri, S., Smith, K. G. & Nossal, G. J. Soluble antigen can cause enhanced apoptosis of germinal centre B cells. Nature 375, 331-334 (1995).
26. Shokat, K. M. & Goodnow, C. C. Antigen-induced B-cell death and elimination during germinal-centre immune responses. Nature 375, 334-338 (1995).
27. Lalor, P. A., Stall, A. M., Adams, S. & Herzenberg, L. A. Permanent alteration of the murine Ly-1 B repertoire due to selective depletion of Ly-1 B cells in neonatal animals. Eur. J. Immunol. 19, 501-506 (1989).
28. Tsubata, T., Murakami, M. & Honjo, T. Antigen-receptor cross-linking induces peritoneal B-cell apoptosis in normal but not autoimmunity-prone mice. Curr. Biol. 4, 8-17 (1994).
29. Murakami, M. et al. Effects of breeding environments on generation and activation of autoreactive B-1 cells in anti-red blood cell autoantibody transgenic mice. J. Exp. Med. 185, 791-794 (1997).
30. Ehlich, A., Martin, V., Muller, W. & Rajewsky, K. Analysis of the B-cell progenitor compartment at the level of single cells. Curr. Biol. 4, 573-583 (1994).