A role for histone acetylation in the developmental regulation of V(D)J recombination

Science

Volumn 287, Issue 5452, 2000, Pages 495-498

  McMurry, Michelle Taylor ^a   Krangel, Michael S ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE ACETYLTRANSFERASE; HISTONE H3; IMMUNOGLOBULIN; RECOMBINASE; T LYMPHOCYTE RECEPTOR;

ACETYLATION; ANIMAL CELL; ARTICLE; CHROMATIN STRUCTURE; CONTROLLED STUDY; DEVELOPMENTAL BIOLOGY; ENHANCER REGION; GENETIC RECOMBINATION; IMMUNOGLOBULIN GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; THYMOCYTE; TRANSGENIC MOUSE;

ACETYLATION; ANIMALS; CHROMATIN; DNA NUCLEOTIDYLTRANSFERASES; DNA-BINDING PROTEINS; ENHANCER ELEMENTS (GENETICS); GENE REARRANGEMENT, T-LYMPHOCYTE; GENES, T-CELL RECEPTOR ALPHA; GENES, T-CELL RECEPTOR BETA; GENES, T-CELL RECEPTOR DELTA; HISTONES; HOMEODOMAIN PROTEINS; HUMANS; MICE; MICE, TRANSGENIC; NUCLEAR PROTEINS; PROTEIN SORTING SIGNALS; RECOMBINATION, GENETIC; T-LYMPHOCYTES; TRANSGENES; VDJ RECOMBINASES;

ANIMALIA; MUS MUSCULUS;

EID: 0034695501     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.287.5452.495     Document Type: Article

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39. We thank B. Sleckman, Y. Zhuang, and C. Doyle for comments on the manuscript and encouragement, and C. Hernandez-Munain for advice. Supported by NIH grant GM 41052. M.T.M. was supported in part by an NIH Medical Scientist Training Grant and a United Negro College Fund-Merck Graduate Science Research Dissertation Fellowship.