Vitamin E: The evidence for multiple roles in cancer

Nutrition and Cancer

Volumn 46, Issue 1, 2003, Pages 1-14

  Sung, Lillian ^b   Greenberg, Mark L ^b   Koren, Gideon ^b   Tomlinson, George A ^b   Tong, Agnes ^b   Malkin, David ^a   Feldman, Brian M ^b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL;

ANTINEOPLASTIC ACTIVITY; ATTENUATION; CANCER CHEMOTHERAPY; CANCER PREVENTION; CANCER RISK; CLINICAL TRIAL; DIGESTIVE SYSTEM CANCER; DRUG EFFECT; HUMAN; LUNG CANCER; MALIGNANT NEOPLASTIC DISEASE; PRACTICE GUIDELINE; PROSTATE CANCER; REVIEW; STOMACH CANCER; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION;

EID: 0141848332     PISSN: 01635581     EISSN: None     Source Type: Journal    
DOI: 10.1207/S15327914NC4601_01     Document Type: Review

References (155)

1. Christen WG, Gaziano JM, and Hennekens CH: Design of Physicians' Health Study II-a randomized trial of beta-carotene, vitamins E and C, and multivitamins, in prevention of cancer, cardiovascular disease, and eye disease, and review of results of completed trials. Ann Epidemiol 10, 125-134, 2000.
2. Hercberg S, Preziosi P, Galan P, Faure H, Arnaud J, et al.: "The SU.VI.MAX Study": a primary prevention trial using nutritional doses of antioxidant vitamins and minerals in cardiovascular diseases and cancers. SUpplementation on VItamines et Mineraux AntioXydants. Food Chem Toxicol 37, 925-930, 1999.
3. Yusuf S, Dagenais G, Pogue J, Bosch J, and Sleight P: Vitamin E supplementation and cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med 342, 154-160, 2000.
4. Anonymous. The alpha-tocopherol, beta-carotene lung cancer prevention study: design, methods, participant characteristics, and compliance. The ATBC Cancer Prevention Study Group. Ann Epidemiol 4, 1-10, 1994.
5. Knekt P, Reunanen A, Mamiemi J, Leino A, and Aromaa A: Low vitamin E status is a potential risk factor for insulin-dependent diabetes mellitus. J Intern Med 245, 99-102, 1999.
6. Knekt P, Heliovaara M, Aho K, Alfthan G, Marniemi J, et al.: Serum selenium, serum alpha-tocopherol, and the risk of rheumatoid arthritis. Epidemiology 11, 402-405, 2000.
7. Prasad KN, Cole WC, Hovland AR, Prasad KC, Nahreini P, et al.: Multiple antioxidants in the prevention and treatment of neurodegenerative disease: analysis of biologic rationale. Curr Opin Neurol 12, 761-770, 1999.
8. Sano M, Ernesto C, Thomas RG, Klauber MR, Schafer K, et al.: A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. N Engl J Med 336, 1216-1222, 1997.
9. Neuhouser ML, Kristal AR, Patterson RE, Goodman PJ, and Thompson IM: Dietary supplement use in the prostate cancer prevention trial: implications for prevention trials. Nutr Cancer 39, 12-18, 2001.
10. Harris RP, Helfand M, Woolf SH, Lohr KN, Mulrow CD, et al.: Current methods of the US Preventive Services Task Force: a review of the process. Am J Prev Med 20, 21-35, 2001.
11. Sokol RJ: Vitamin E. Present Knowledge in Nutrition, Ziegler EE and Filer LJJ (eds). Washington, DC: International Life Sciences Institute, 1996.
12. National Research Council: Recommended Dietary Allowances. Washington, DC: National Academy of Sciences, 1989.
13. Repchinsky C, Welbanks L, et al. (Eds). Compendium of Pharmaceuticals and Specialties. Ottawa, ON: Canadian Pharmacists Association, 2003.
14. Davidson JR: An attempt to inhibit the development of tar-carcinoma in mice. Can Med Assoc J 31, 486-487, 1934.
15. Shklar G and Oh SK: Experimental basis for cancer prevention by vitamin E. Cancer Invest 18, 214-222, 2000.
16. Prasad KN and Edwards-Prasad J: Vitamin E and cancer prevention: recent advances and future potentials. J Am Coll Nutr 11, 487-500, 1992.
17. Tengerdy RP, Mathias MM, and Nockels CF: Vitamin E immunity and disease resistance. In Diet and Resistance to Disease, Phillips M and Baetz A (eds). New York: Plenum Press, 1981, pp 27-42.
18. Zhang YH, Kramer TR, Taylor PR, Li JY, Blot WJ, et al.: Possible immunologic involvement of antioxidants in cancer prevention. Am J Clin Nutr 62, 1477S-1482S, 1995.
19. Meydani SN, Meydani M, Blumberg JB, Leka LS, Siber G, et al.: Vitamin E supplementation and in vivo immune response in healthy elderly subjects. A randomized controlled trial. JAMA 277, 1380-1386, 1997.
20. Schwartz J, Shklar G, and Trickler D: p53 in the anticancer mechanism of vitamin E. Eur J Cancer B Oral Oncol 29B, 313-338, 1993.
21. Shklar G and Schwartz JL: Vitamin E inhibits experimental carcinogenesis and tumour angiogenesis. Eur J Cancer B Oral Oncol 32B, 114-119, 1996.
22. Duthie SJ, Ma A, Ross MA, and Collins AR: Antioxidant supplementation decreases oxidative DNA damage in human lymphocytes. Cancer Res 56, 1291-1295, 1996.
23. van Staden AM, van Rensburg CE, and Anderson R: Vitamin E protects mononuclear leucocyte DNA against damage mediated by phagocyte-derived oxidants. Mutat Res 288, 257-262, 1993.
24. Slaga TJ and Bracken WM: The effects of antioxidants on skin tumor initiation and aryl hydrocarbon hydroxylase. Cancer Res 37, 1631-1635, 1977.
25. Hu JJ, Chi CX, Frenkel K, Smith BN, Henfelt JJ, et al.: Alpha-tocopherol dietary supplement decreases titers of antibody against 5-hydroxymethyl-2'-deoxyuridine (HMdU). Cancer Epidemiol Biomarkers Prev 8, 693-698, 1999.
26. Sahu SN, Edwards-Prasad J, and Prasad KN: Effect of alpha tocopheryl succinate on adenylate cyclase activity in murine neuroblastoma cells in culture. J Am Coll Nutr 7, 285-293, 1988.
27. Sahu SN, Edwards-Prasad J, and Prasad KN: Alpha tocopheryl succinate inhibits melanocyte-stimulating hormone (MSH)-sensitive adenylate cyclase activity in melanoma cells. J Cell Physiol 133, 585-589, 1987.
28. Myers CE, Katki A, and Travis E: Effect of tocopherol and selenium on defenses against reactive oxygen species and their effect on radiation sensitivity. Ann NY Acad Sci 393, 419-425, 1982.
29. Cooney RV, Ross PD, and Bartolini GL: N-Nitrosation and N-nitration of morpholine by nitrogen dioxide: inhibition by ascorbate, glutathione and alpha-tocopherol. Cancer Lett 32, 83-90, 1986.
30. Gairola CC and Chow CK: Dietary vitamin E, hepatic arylhydrocarbon hydroxylase and the metabolic activation of procarcinogens to mutagens. Nutr Cancer 2, 125-128, 1981.
31. Walton JR and Packer L: Free radicals damage and protection: relationship and cellular aging and cancer. In Vitamin E. A Comprehensive Treatise, Machlin LJ (ed). New York: Marcel Dekker, 1980, pp 495-517.
32. Torun M, Akgul S, and Sargin H: Serum vitamin E level in patients with breast cancer. J Clin Pharm Ther 20, 173-178, 1995.
33. Malvy DJ, Arnaud J, Burtschy B, Sommelet D, Leverger G, et al.: Assessment of serum antioxidant micronutrients and biochemical indicators of nutritional status in children with cancer in search of prognostic factors. Int J Vitam Nutr Res 67, 267-271, 1997.
34. Bhuvarahamurthy V, Balasubramanian N, and Govindasamy S: Effect of radiotherapy and chemoradiotherapy on circulating antioxidant system of human-uterine cervical carcinoma. Mol Cell Biochem 158, 17-23, 1996.
35. Palan PR, Mikhail MS, Basu J, and Romney SL: Plasma levels of antioxidant beta-carotene and alpha-tocopherol in uterine cervix dysplasias and cancer. Nutr Cancer 15, 13-20, 1991.
36. Kumagai Y, Pi JB, Lee S, Sun GF, Yamanushi T, et al.: Serum antioxidant vitamins and risk of lung and stomach cancers in Shenyang, China. Cancer Lett 129, 145-149, 1998.
37. Choi MA, Kim BS, and Yu R: Serum antioxidative vitamin levels and lipid peroxidation in gastric carcinoma patients. Cancer Lett 136, 89-93, 1999.
38. Battisti C, Formichi P, Tripodi SA, Vindigni C, Roviello F, et al.: Vitamin E serum levels and gastric cancer: results from a cohort of patients in Tuscany, Italy. Cancer Lett 151, 15-18, 2000.
39. Gerber M, Astre C, Segala C, Saintot M, Scali J, et al.: Oxidant-antioxidant status alterations in cancer patients: relationship to tumor progression. J Nutr 126, 1201S-1207S, 1996.
40. Bohlke K, Spiegelman D, Trichopoulou A, Katsouyanni K, and Trichopoulos D: Vitamins A, C and E and the risk of breast cancer: results from a case-control study in Greece. Br J Cancer 79, 23-29, 1999.
41. Favero A, Parpinel M, and Franceschi S: Diet and risk of breast cancer: major findings from an Italian case-control study. Biomed Pharmacother 52, 109-115, 1998.
42. Mezzetti M, La Vecchia C, Decarli A, Boyle P, Talamini R, et al.: Population attributable risk for breast cancer: diet, nutrition, and physical exercise. JNCI 90, 389-394, 1998.
43. Negri E, La Vecchia C, Franceschi S, D'Avanzo B, Talamini R, et al.: Intake of selected micronutrients and the risk of breast cancer. Int J Cancer 65, 140-144, 1996.
44. Ronco A, De Stefani E, Boffetta P, Deneo-Pellegrini H, Mendilaharsu M, et al.: Vegetables, fruits, and related nutrients and risk of breast cancer: a case-control study in Uruguay. Nutr Cancer 35,111-119, 1999.
45. Buiatti E, Palli D, Bianchi S, Decarli A, Amadori D, et al.: A case-control study of gastric cancer and diet in Italy. III. Risk patterns by histologic type. Int J Cancer 48, 369-374, 1991.
46. Jedrychowski W, Steindorf K, Popiela T, Wahrendorf J, Tobiasz-Adamczyk B, et al.: Risk of colorectal cancer from alcohol consumption at lower vitamin intakes. A hospital-based case-control study in Poland. Rev Environ Health 16, 213-222, 2001.
47. Launoy G, Milan C, Day NE, Pienkowski MP, Gignoux M, et al.: Diet and squamous-cell cancer of the oesophagus: a French multicentre case-control study. Int J Cancer 76, 7-12, 1998.
48. Palli D, Russo A, and Decarli A: Dietary patterns, nutrient intake and gastric cancer in a high-risk area of Italy. Cancer Causes Control 12, 163-172, 2001.
49. Hansson LE, Nyren O, Bergstrom R, Wolk A, Lindgren A, et al.: Nutrients and gastric cancer risk. A population-based case-control study in Sweden. Int J Cancer 57, 638-644, 1994.
50. Tseng M, Murray SC, Kupper LL, and Sandler RS: Micronutrients and the risk of colorectal adenomas. Am J Epidemiol 144, 1005-1014, 1996.
51. Bollschweiler E, Wolfgarten E, Nowroth T, Rosendahl U, Monig SP, et al.: Vitamin intake and risk of subtypes of esophageal cancer in Germany. J Cancer Res Clin Oncol 128, 575-580, 2002.
52. Franceschi S, Bidoli E, Negri E, Zambon P, Talamini R, et al.: Role of macronutrients, vitamins and minerals in tile aetiology of squamous-cell carcinoma of the oesophagus. Int J Cancer 86, 626-631, 2000.
53. Esteve J, Riboli E, Pequignot G, Terracini B, Merletti F, et al.: Diet and cancers of the larynx and hypopharynx: the IARC multi-center study in southwestern Europe. Cancer Causes Control 7, 240-252, 1996.
54. Gridley G, McLaughlin JK, Block G, Blot WJ, Winn DM, et al.: Diet and oral and pharyngeal cancer among blacks. Nutr Cancer 14, 219-225, 1990.
55. Negri E, Franceschi S, Bosetti C, Levi F, Conti E, et al.: Selected micronutrients and oral and pharyngeal cancer. Int J Cancer 86, 122-127, 2000.
56. Hu J, La Vecchia C, Negri E, Chatenoud L, Bosetti C, et al.: Diet and brain cancer in adults: a case-control study in northeast China. Int J Cancer 81, 20-23, 1999.
57. Kirkpatrick CS, White E, and Lee JAH: Case-control study of malignant melanoma in Washington State. II. Diet, alcohol, and obesity. Am J Epidemiol 139, 869-880, 1994.
58. Stryker WS, Stampfer MJ, Stein EA, Kaplan L, Louis TA, et al.: Diet, plasma levels of beta-carotene and alpha-tocopherol, and risk of malignant melanoma. Am J Epidemiol 131, 597-611, 1990.
59. Verreault R, Chu J, Mandelson M, and Shy K: A case-control study of diet and invasive cervical cancer. Int J Cancer 43, 1050-1054, 1989.
60. Wolk A, Gridley G, Niwa S, Lindblad P, McCredie M, et al.: International renal cell cancer study. VII. Role of diet. Int J Cancer 65, 67-73, 1996.
61. Tzonou A, Signorello LB, Lagiou P, Wuu J, Trichopoulos D, et al.: Diet and cancer of the prostate: a case-control study in Greece. Int J Cancer 80, 704-708, 1999.
62. Vlajinac HD, Marinkovic JM, Ilic MD, and Kocev NI: Diet and prostate cancer: a case-control study. Eur J Cancer 33, 101-107, 1997.
63. Vlajinac H, Ilic M, Sipetic S, Marinkovic J, and Kocev N: A case-control study of diet and prostate cancer. Journal of B. U. On. 6, 177-181, 2001.
64. Bidoli E, La Vecchia C, Talamini R, Negri E, Parpinel M, et al.: Micronutrients and ovarian cancer: a case-control study in Italy. Ann Oncol 12, 1589-1593, 2001.
65. Fleischauer AT, Olson SH, Mignone L, Simonsen N, Caputo TA, et al.: Dietary antioxidants, supplements, and risk of epithelial ovarian cancer. Nutr Cancer 40, 92-98, 2001.
66. Moorman PG, Ricciuti MF, Millikan RC, and Newman B: Vitamin supplement use and breast cancer in a North Carolina population. Public Health Nutr 4, 821-827, 2001.
67. White E, Shannon JS, and Patterson RE: Relationship between vitamin and calcium supplement use and colon cancer. Cancer Epidemiol Biomarkers Prev 6, 769-774, 1997.
68. Menkes MS, Comstock GW, Vuilleumier JP, Helsing KJ, Rider AA, et al.: Serum beta-carotene, vitamins A and E, selenium, and the risk of lung cancer. N Engl J Med 315, 1250-1254, 1986.
69. Knekt P, Aromaa A, Maatela J, Aaran RK, Nikkari T, et al.: Serum vitamin E and risk of cancer among Finnish men during a 10-year follow-up. Am J Epidemiol 127, 28-41, 1988.
70. Knekt P: Serum vitamin E level and risk of female cancers. Int J Epidemiol 17, 281-286, 1988.
71. Knekt P, Aromaa A, Maatela J, Alfthan G, Aaran RK, et al.: Serum vitamin E, serum selenium and the risk of gastrointestinal cancer. Int J Cancer 42, 846-850, 1988.
72. Wald NJ, Boreham J, Hayward JL, and Bulbrook RD: Plasma retinol, beta-carotene and vitamin E levels in relation to the future risk of breast cancer. Br J Cancer 49, 321-324, 1984.
73. Helzlsouer KJ, Huang HY, Alberg AJ, Hoffman S, Burke A, et al.: Association between alpha-tocopherol, gamma-tocopherol, selenium, and subsequent prostate cancer. JNCI 92, 2018-2023, 2000.
74. Gann PH, Ma J, Giovannucci E, Willett W, Sacks FM, et al.: Lower prostate cancer risk in men with elevated plasma lycopene levels: results of a prospective analysis. Cancer Res 59, 1225-1230, 1999.
75. Giovannucci E: Gamma-tocopherol: a new player in prostate cancer prevention? JNCI 92, 1966-1967, 2000.
76. Dorgan JF, Sowell A, Swanson CA, Potischman N, Miller R, et al.: Relationships of serum carotenoids, retinol, alpha-tocopherol, and selenium with breast cancer risk: results from a prospective study in Columbia, Missouri (United States). Cancer Causes Control 9, 89-97, 1998.
77. Karagas MR, Greenberg ER, Nierenberg D, Stukel TA, Morris JS, et al.: Risk of squamous cell carcinoma of the skin in relation to plasma selenium, alpha-tocopherol, beta-carotene, and retinol: a nested case-control study. Cancer Epidemiol Biomarkers Prev 6, 25-29, 1997.
78. Lehtinen M, Luostarinen T, Youngman LD, Anttila T, Dillner J, et al.: Low levels of serum vitamins A and E in blood and subsequent risk for cervical cancer: interaction with HPV seropositivity. Nutr Cancer 34, 229-234, 1999.
79. Nomura AMY, Stemmermann GN, Lee J, and Craft NE: Serum micronutrients and prostate cancer in Japanese Americans in Hawaii. Cancer Epidemiol Biomarkers Prev 6, 487-491, 1997.
80. Nomura AM, Ziegler RG, Stemmermann GN, Chyou PH, and Craft NE: Serum micronutrients and upper aerodigestive tract cancer. Cancer Epidemiol Biomarkers Prev 6, 407-412, 1997.
81. Russell MJ, Thomas BS, and Bulbrook RD: A prospective study of the relationship between serum vitamins A and E and risk of breast cancer. Br J Cancer 57, 213-215, 1988.
82. Willett WC, Polk BF, Underwood BA, Stampfer MJ, Pressel S, et al.: Relation of serum vitamins A and E and carotenoids to the risk of cancer. N Engl J Med 310, 430-434, 1984.
83. Helzlsouer KJ, Alberg AJ, Norkus EP, Morris JS, Hoffman SC, et al.: Prospective study of serum micronutrients and ovarian cancer. JNCI 88, 32-37, 1996.
84. Bolton-Smith C and Woodward M: Antioxidant vitamin adequacy in relation to consumption of sugars. Eur J Clin Nutr 49, 124-133, 1995.
85. Singhal S, Gupta P, Mathur B, Banda S, Dandia R, et al.: Educational status and dietary fat and anti-oxidant intake in urban subjects. J Assoc Physicians India 46, 684-688, 1998.
86. Cade JE and Margetts BM: Relationship between diet and smoking - is the diet of smokers different? J Epidemiol Community Health 45, 270-272, 1991.
87. Phillips EL, Arnett DK, Himes JH, McGovern PG, Blackburn H, et al.: Differences and trends in antioxidant dietary intake in smokers and non-smokers, 1980-1992: the Minnesota Heart Survey. Ann Epidemiol 10, 417-423, 2000.
88. Krummel DA, Gordon P, Newcomer RR, Lui X, Christy DM, et al.; Dietary intakes and leisure-time physical activity in West Virginians. WV Med J 97, 295-301, 2001.
89. Bostick RM, Potter JD, McKenzie DR, Sellers TA, Kushi LH, et al.: Reduced risk of colon cancer with high intake of vitamin E: the Iowa Women's Health Study. Cancer Res 53, 4230-4237, 1993.
90. Zheng W, Sellers TA, Doyle TJ, Kushi LH, Potter JD, et al.: Retinol, antioxidant vitamins, and cancers of the upper digestive tract in a prospective cohort study of postmenopausal women. Am J Epidemiol 142, 955-960, 1995.
91. Sellers TA, Bazyk AE, Bostick RM, Kushi LH, Olson JE, et al.: Diet and risk of colon cancer in a large prospective study of older women: an analysis stratified on family history (Iowa, United States). Cancer Causes Control 9, 357-367, 1998.
92. Jansen MC, Bueno-de-Mesquita HB, Buzina R, Fidanza F, Menotti A, et al.: Dietary fiber and plant foods in relation to colorectal cancer mortality: the Seven Countries Study. Int J Cancer 81, 174-179, 1999.
93. Woodson K, Tangrea JA, Barrett MJ, Virtamo J, Taylor PR, et al.: Serum alpha-tocopherol and subsequent risk of lung cancer among male smokers. JNCI 91, 1738-1743, 1999.
94. Eichholzer M, Stahelin HB, Gey KF, Ludin E, and Bernasconi F: Prediction of male cancer mortality by plasma levels of interacting vitamins: 17-year follow-up of the prospective Basel study. Int J Cancer 66, 145-150, 1996.
95. Chan JM, Stampfer MJ, Ma J, Rimm EB, Willett WC, et al.: Supplemental vitamin E intake and prostate cancer risk in a large cohort of men in the United States. Cancer Epidemiol Biomarkers Prev 8, 893-899, 1999.
96. Zhang S, Hunter DJ, Forman MR, Rosner BA, Speizer FE, et al.: Dietary carotenoids and vitamins A, C, and E and risk of breast cancer. JNCI 91, 547-556, 1999.
97. Hunter DJ, Manson JE, Colditz GA, Stampfer MJ, Rosner B, et al.: A prospective study of the intake of vitamins C, E, and A and the risk of breast cancer. N Engl J Med 329, 234-240, 1993.
98. Verhoeven DTH, Assen N, Goldbohm RA, Dorant E, Van 't Veer P, et al.: Vitamins C and E, retinol, beta-carotene and dietary fibre in relation to breast cancer risk: a prospective cohort study. Br J Cancer 75, 149-155, 1997.
99. Malila N, Virtamo J, Virtanen M, Pietinen P, Albanes D, et al.: Dietary and serum alpha-tocopherol, beta-carotene and retinol, and risk for colorectal cancer in male smokers. Eur J Clin Nutr 56, 615-621, 2002.
100. Hartman TJ, Albanes D, Pietinen P, Hartman AM, Rautalahti M, et al.: The association between baseline vitamin E, selenium, and prostate cancer in the alpha-tocopherol, beta-carotene cancer prevention study. Cancer Epidemiol Biomarkers Prev 7, 335-340, 1998.
101. Hunter DJ, Colditz GA, Stampfer MJ, Rosner B, Willett WC, et al.: Diet and risk of basal cell carcinoma of the skin in a prospective cohort of women. Ann Epidemiol 2, 231-239, 1992.
102. Fung TT, Spiegelman D, Egan KM, Giovannucci E, Hunter DJ, et al.: Vitamin and carotenoid intake and risk of squamous cell carcinoma of the skin. Int J Cancer 103, 110-115, 2003.
103. Voorrips LE, Goldbohm RA, Brants HAM, Van Poppel G, Sturmans F, et al.: A prospective cohort study on antioxidant and folate intake and male lung cancer risk. Cancer Epidemiol Biomarkers Prev 9, 357-365, 2000.
104. Papadimitrakopoulou VA, Clayman GL, Shin DM, Myers JN, Gillenwater AM, et al.: Biochemoprevention for dysplastic lesions of the upper aerodigestive tract. Arch Otolaryngol Head Neck Surg 125, 1083-1089, 1999.
105. Benner SE, Winn RJ, Lippman SM, Poland J, Hansen KS, et al.: Regression of oral leukoplakia with alpha-tocopherol: a Community Clinical Oncology Program chemoprevention study. JNCI 85, 44-47, 1993.
106. Heinonen OP, Albanes D, Virtamo J, Taylor PR, Huttunen JK, et al.: Prostate cancer and supplementation with alpha-tocopherol and beta-carotene: incidence and mortality in a controlled trial. JNCI 90, 440-446, 1998.
107. Albanes D, Malila N, Taylor PR, Huttunen JK, Virtamo J, et al.: Effects of supplemental alpha-tocopherol and beta-carotene on colorectal cancer: results from a controlled trial (Finland). Cancer Causes Control 11, 197-205, 2000.
108. Malila N, Taylor PR, Virtanen MJ, Korhonen P, Huttunen JK, et al.: Effects of alpha-tocopherol and beta-carotene supplementation on gastric cancer incidence in male smokers (ATBC Study, Finland). Cancer Causes Control 13, 617-623, 2002.
109. Heinonen OP, Huttunen JK, Albanes D, Haapakoski J, Palmgren J, et al.: The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 330, 1029-1035, 1994.
110. Rautalahti MT, Virtamo JR, Taylor PR, Heinonen OP, Albanes D, et al.: The effects of supplementation with alpha-tocopherol and beta-carotene on the incidence and mortality of carcinoma of the pancreas in a randomized, controlled trial. Cancer 86, 37-42, 1999.
111. Virtamo J, Edwards BK, Virtanen M, Taylor PR, Malila N, et al.: Effects of supplemental alpha-tocopherol and beta-carotene on urinary tract cancer: incidence and mortality in a controlled trial (Finland). Cancer Causes Control 11, 933-939, 2000.
112. Varis K, Taylor PR, Sipponen P, Samloff IM, Heinonen OP, et al.: Gastric cancer and premalignant lesions in atrophic gastritis: a controlled trial on the effect of supplementation with alpha-tocopherol and beta-carotene. The Helsinki Gastritis Study Group. Scand J Gastroenterol 33, 294-300, 1998.
113. Blot WJ, Li JY, Taylor PR, Guo W, Dawsey S, et al.: Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. JNCI 85, 1483-1492, 1993.
114. Li JY, Taylor PR, Li B, Dawsey S, Wang GQ, et al.: Nutrition intervention trials in Linxian, China: multiple vitamin/mineral supplementation, cancer incidence, and disease-specific mortality among adults with esophageal dysplasia. JNCI 85, 1492-1498, 1993.
115. Lockwood K, Moesgaard S, Hanioka T, and Folkers K: Apparent partial remission of breast cancer in 'high risk' patients supplemented with nutritional antioxidants, essential fatty acids and coenzyme Q10. Mol Aspects Med 15, s231-s240, 1994.
116. Lamm DL, Riggs DR, Shriver JS, VanGilder PF, Rach JF, et al.: Megadose vitamins in bladder cancer: a double-blind clinical trial. J Urol 151, 21-26, 1994.
117. Shin DM, Khuri FR, Murphy B, Garden AS, Clayman G, et al.: Combined interferon-alpha, 13-cis-retinoic acid, and alpha-tocopherol in locally advanced head and neck squamous cell carcinoma: novel bioadjuvant phase II trial. J Clin Oncol 19, 3010-3017, 2001.
118. Myers CE, McGuire WP, Liss RH, Ifrim I, Grotzinger K, et al.: Adriamycin: the role of lipid peroxidation in cardiac toxicity and tumor response. Science 197, 165-167, 1977.
119. Myers CE, McGuire W, and Young R: Adriamycin: amelioration of toxicity by alpha-tocopherol. Cancer Treat Rep 60, 961-962, 1976.
120. Lee YC and Byfield JE: Induction of DNA degradation in vivo by adriamycin. JNCI 57, 221-224, 1976.
121. McMillan DC, Sattar N, Talwar D, O'Reilly DSJ, and McArdle CS: Changes in micronutrient concentrations following anti-inflammatory treatment in patients with gastrointestinal cancer. Nutrition 16, 425-428, 2000.
122. Gitanjali G, Ghalaut V, Rakshak M, and Hooda HS: Correlation of lipid peroxidation and alpha-tocopherol supplementation in patients with cervical carcinoma, receiving radical radiotherapy. Gynecol Obstet Invest 48, 197-199, 1999.
123. Jonas CR, Puckett AB, Jones DP, Griffith DP, Szeszycki EE, et al.: Plasma antioxidant status after high-dose chemotherapy: a randomized trial of parenteral nutrition in bone marrow transplantation patients. Am J Clin Nutr 72, 181-189, 2000.
124. Dalloz F, Maingon P, Cottin Y, Briot F, Horiot JC, et al.: Effects of combined irradiation and doxorubicin treatment on cardiac function and antioxidant defenses in the rat. Free Radic Biol Med 26, 785-800, 1999.
125. Faure H, Coudray C, Mousseau M, Ducros V, Douki T, et al.: 5-Hydroxymethyluracil excretion, plasma TBARS and plasma antioxidant vitamins in adriamycin-treated patients. Free Radic Biol Med 20, 979-983, 1996.
126. Weijl NI, Hopman GD, Wipkink-Bakker A, Lentjes EG, Berger HM, et al.: Cisplatin combination chemotherapy induces a fall in plasma antioxidants of cancer patients. Ann Oncol 9, 1331-1337, 1998.
127. Lopez I, Goudou C, Ribrag V, Sauvage C, Hazebroucq G, et al.: Treatment of mucositis with vitamin E during administration of neutropenic antineoplastic agents. Ann Med Interne 145, 405-408, 1994.
128. Wadleigh RG, Redman RS, Graham ML, Krasnow SH, Anderson A, et al.: Vitamin E in the treatment of chemotherapy-induced mucositis. Am J Med 92, 481-484, 1992.
129. Wagdi P, Fluri M, Aeschbacher B, Fikrle A, and Meier B: Cardioprotection in patients undergoing chemo- and/or radiotherapy for neoplastic disease. A pilot study. Jpn Heart J 37, 353-359, 1996.
130. Lenzhofer R, Ganzinger U, Rameis H, and Moser K: Acute cardiac toxicity in patients after doxorubicin treatment and the effect of combined tocopherol and nifedipine pretreatment. J Cancer Res Clin Oncol 106, 143-147, 1983.
131. Whittaker JA and Al-Ismail SA: Effect of digoxin and vitamin E in preventing cardiac damage caused by doxorubicin in acute myeloid leukaemia. Br Med J 288, 283-284, 1984.
132. Legha SS, Wang YM, Mackay B, Ewer M, Hortobagyi GN, et al.: Clinical and pharmacologic investigation of the effects of alpha-tocopherol on adriamycin cardiotoxicity. Ann NY Acad Sci 393, 411-418, 1982.
133. Papila C, Papila I, Bilir M, Cagatay T, Yanardag H, et al.: Effect of vitamin E supplementation on natural killer cell activity in patients with solid tumors. Journal of B.U.On. 4, 435-437, 1999.
134. Gogos CA, Ginopoulos P, Salsa B, Apostolidou E, Zoumbos NC, et al.: Dietary omega-3 polyunsaturated fatty acids plus vitamin E restore immunodeficiency and prolong survival for severely ill patients with generalized malignancy: a randomized control trial. Cancer 82, 395-402, 1998.
135. Dimery IW, Hong WK, Lee JJ, Guillory-Perez C, Pham F, et al.: Phase I trial of alpha-tocopherol effects on 13-cis-retinoic acid toxicity. Ann Oncol 8, 85-89, 1997.
136. Byers T: What can randomized controlled trial tell us about nutrition and cancer prevention? CA Cancer J Clin 49, 353-361, 1999.
137. Cohen HM: Fatigue caused by vitamin E? Calif Med 119, 72, 1973.
138. Bierenbaum ML, Noonan FJ, Machlin LG, Machlin S, Stier A, et al.: The effect of supplemental vitamin E on serum parameters in diabetes, post coronary and normal subjects. Nutr Rep Int 31, 1171-1180, 1985.
139. Corrigan JJ Jr. and Marcus FI: Coagulopathy associated with vitamin E ingestion. JAMA 230, 1300-1301, 1974.
140. Liede KE, Haukka JK, Saxen LM, and Heinonen OP: Increased tendency towards gingival bleeding caused by joint effect of alpha-tocopherol supplementation and acetylsalicylic acid. Ann Med 30, 542-546, 1998.
141. Martin-Jimenez M, Diaz-Rubio E, Gonzalez Larriba JL, and Sangro B: Failure of high-dose tocopherol to prevent alopecia induced by doxorubicin. N Engl J Med 315, 894-895, 1986.
142. Wood LA: Possible prevention of adriamycin-induced alopecia by tocopherol. N Engl J Med 312, 1060, 1985.
143. Rohan TE, Howe GR, Burch JD, and Jain M: Dietary factors and risk of prostate cancer: a case-control study in Ontario, Canada. Cancer Causes Control 6, 145-154, 1995.
144. Riboli E, Gonzalez CA, Lopez-Abente G, Errezola M, Izarzugaza I, et al.: Diet and bladder cancer in Spain: a multi-centre case-control study. Int J Cancer 49, 214-219, 1991.
145. Ekstrom AM, Serafini M, Nyren O, Hansson LE, Ye W, et al.: Dietary antioxidant intake and the risk of cardia cancer and noncardia cancer of the intestinal and diffuse types: a population-based case-control study in Sweden. Int J Cancer 87, 133-140, 2000.
146. Risch HA, Jain M, Choi NW, et al.: Dietary factors and the incidence of cancer of the stomach. Am J Epidemiol 122, 947-959, 1985.
147. Zhang ZF, Kurtz RC, Yu GP, Sun M, Gargon N, et al.: Adenocarcinomas of the esophagus and gastric cardia: the role of diet. Nutr Cancer 27, 298-309, 1997.
148. Ching S, Ingram D, Hahnel R, Beilby J, and Rossi E: Serum levels of micronutrients, antioxidants and total antioxidant status predict risk of breast cancer in a case control study. J Nutr 132, 303-306, 2002.
149. Ghadirian P, Lacroix A, Perret C, Robidoux A, Falardeau M, et al.: Breast cancer risk and nutrient intake among French Canadians in Montreal: a case-control study. Breast 7, 108-113, 1998.
150. Singh RB, Niaz MA, Rastogi V, Beegom HR, and Singh NK: Diet, antioxidants and risk of cancer: a case-control study. J Nutr Environ Med 7, 267-274, 1997.
151. Schuurman AG, Goldbohm RA, Brants HA, and van den Brandt PA: A prospective cohort study on intake of retinol, vitamins C and E, and carotenoids and prostate cancer risk (Netherlands). Cancer Causes Control 13, 573-582, 2002.
152. Zeegers MPA, Goldbohm RA, and Van den Brandt PA: Are retinol, vitamin C, vitamin E, folate and carotenoids intake associated with bladder cancer risk? Results from the Netherlands Cohort Study. Br J Cancer 85, 977-983, 2001.
153. Michaud DS, Pietinen P, Taylor PR, Virtanen M, Virtamo J, et al.: Intakes of fruits and vegetables, carotenoids and vitamins A, E, C in relation to the risk of bladder cancer in the ATBC cohort study. Br J Cancer 87, 960-965, 2002.
154. Wald NJ, Thompson SG, Densem JW, Boreham J, and Bailey A: Serum vitamin E and subsequent risk of cancer. Br J Cancer 56, 69-72, 1987.
155. Stahelin HB, Rosel F, Buess E, and Brubacher G: Cancer, vitamins, and plasma lipids: prospective Basel study. JNCI 73, 1463-1468, 1984.