Hippocampal lesions cause learning deficits in inbred mice in the Morris water maze and conditioned-fear task

Behavioral Neuroscience

Volumn 111, Issue 1, 1997, Pages 104-113

  Logue, Sheree F ^b   Paylor, Richard ^b   Wehner, Jeanne M ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BRAIN INJURY; CONDITIONED REFLEX; FEAR; HIPPOCAMPUS; MALE; MAZE TEST; MOUSE; NONHUMAN; TASK PERFORMANCE;

ANIMALS; ASSOCIATION LEARNING; CEREBRAL CORTEX; CONDITIONING, CLASSICAL; ESCAPE REACTION; FEAR; HIPPOCAMPUS; MALE; MAZE LEARNING; MENTAL RECALL; MICE; MICE, INBRED STRAINS; MOTOR ACTIVITY; NEURAL PATHWAYS; PROBLEM SOLVING; SPECIES SPECIFICITY;

EID: 0031027229     PISSN: 07357044     EISSN: None     Source Type: Journal    
DOI: 10.1037/0735-7044.111.1.104     Document Type: Article

References (37)

1. Abeliovich, A., Paylor, R., Chen, C., Kim, J. J., Wchner, J. M., & Tonegawa, S. (1993). PKCgamma mutant mice exhibit mild deficits in spatial and contextual learning. Cell, 75, 1263-1271.
2. Aiba, A., Chen, C., Herrup, K., Rosenmund, C., Stevens, C. F., & Tonegawa, S. (1994). Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mice. Cell, 79, 365-375.
3. Alvarado, M. C., & Rudy, J. W. (1995). A comparison of kainic acid plus colchicine and ibotenic acid-induced hippocampal formation damage on four configural tasks in rats. Behavioral Neuroscience, 109, 1052-1062.
4. Bertholet, J. Y., & Crusio, W. E. (1991). Spatial and non-spatial spontaneous alternation and hippocampal mossy fibre distribution in nine inbred mouse strains. Behavioural Brain Research, 43, 197-202.
5. Bolles, R. C., & Fanselow, M. S. (1980). A perceptual-detensive-recuperative model of fear and pain. Behavioral Brain Science, 3, 291-323.
6. Bowers, B. J., Christensen, S. C., Pauley, J. R., Paylor, R., Yuva, L., Dunbar, S. E., & Wehner, J. M. (1995). Protein and molecular characterization of hippocampal protein kinase C in C57BL/6 and DBA/2 mice. Journal of Neurochemistry, 64, 2737-2746.
7. Chen, C., Rainnie, D. G., Greene, R. W., & Tonegawa, S. (1994. October 14). Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-calcium-calmodulin kinase II. Science, 266, 291-294.
8. Crusio, W. E., Schwegler, H., & van Abeelen, J. H. F. (1989). Behavioral responses of novelty and structural variation of the hippocampus in mice: II. Multivariate genetic analysis. Behavioural Brain Research, 32, 81-88.
9. Davis, M. (1992). The role of the amygdala in conditioned fear. In J. P. Aggleton (Ed.), The amygdala: Neurobiological aspects of emotion, memory, and mental dysfunction (pp. 255-306). New York: Wiley-Liss.
10. DiMattia, B. V., & Kesner, R. P. (1988). Spatial cognitive maps: Differential role of parietal cortex and hippocampal formation. Behavioral Neuroscience, 102, 471-480.
11. Eichenbaum, H., Stewart, C., & Morris, R. G. M. (1990). Hippocampal representation in place learning. The Journal of Neuroscience, 10, 3531-3542.
12. Ferraro, T. N., Golden, G. T., Smith, G. G., & Berrettini, W. H. (1995). Differential susceptibility to seizures induced by systemic kainic acid treatment in mature DBA/2J and C57BL/6J mice. Epilepsia, 36, 301-307.
13. Fordyce, D. E., & Wehner, J. M. (1992). Determination of hippocampal protein kinase C using a frozen tissue method: Comparison of synaptosomal and total activity in C57BL/6 and DBA/2 mice. Biochemical and Biophysical Research Communications, 188, 690-694.
14. Kamin, L. J., Brimer, C. J., & Black, A. H. (1963). Conditioned suppression as a monitor of fear of the CS in the course of avoidance training. Journal of Comparative and Physiological Psychology, 56, 497-501.
15. Kim, J. J., & Fanselow, M. S. (1992, May 1). Modality-specific retrograde amnesia of fear. Science, 256, 675-677.
16. LeDoux, J. E. (1992). Brain mechanisms of emotion and emotional learning. Current Opinion in Neurobiology, 2, 191-198.
17. Morris, R. G. M. (1981). Spatial localization does not depend on the presence of local cues. Learning & Motivation, 12, 239-260.
18. Morris, R. G. M., Garrud, P., Rawlins, J. N. P., & O'Keefe, J. (1982). Place navigation impaired in rats with hippocampal lesions. Nature, 297, 681-683.
19. Owen, E. H., Logue, S. F., Rasmussen, D. L., & Wehner, J. M. (1996). Differences in genetic background for animals involved in the assessment of cognitive function. Manuscript submitted for publication.
20. Paylor, R., Baskall, L., & Wehner, J. M. (1993). Behavioral dissociations between C57BL/6 and DBA/2 mice on learning and memory tasks: A hippocampal-dysfunction hypothesis. Psychobiology, 21, 11-26.
21. Paylor, R., Rudy, J. W., & Wehner, J. M. (1991). Acute phorbol ester treatment improves spatial learning performance in rats. Behavioural Brain Research, 45, 189-193.
22. Paylor, R., Tracy, R., Wehner, J., & Rudy, J. W. (1994). DBA/2 and C57BL/6 mice differ in contextual fear but not auditory fear conditioning. Behavioral Neuroscience, 108, 1-8.
23. Phillips, R. G., & LeDoux, J. E. (1992). Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behavioral Neuroscience, 106, 274-285.
24. Phillips, R. G., & LeDoux, J. E. (1994). Lesions of the dorsal hippocampal formation interfere with background but not foreground contextual fear conditioning. Learning & Memory, 1, 34-44.
25. Roullet, P., & Lassalle, J. M. (1990). Genetic variation, hippocampal mossy fibres distribution, novelty reactions and spatial representation in mice. Behavioural Brain Research, 41, 61-69.
26. Rudy, J. W. (1993). Contextual conditioning and auditory cue conditioning dissociate during development. Behavioral Neuroscience, 107, 887-891.
27. Rudy, J. W., & Castro, C. A. (1987). A developmental analysis of brightness discrimination learning in the rat: Evidence for an attentional deficit. Psychobiology, 15, 79-86.
28. Schopke, R., Wolfer, D. P., Lipp, H. P., & Leisinger-Trigona, M. C. (1991). Swimming navigation and structural variations of the infrapyramidal mossy fibers in the hippocampus of the mouse. Hippocampus, 1, 315-328.
29. Schwegler, H., & Lipp, H. P. (1983). Hereditary covariations of neuronal circuitry and behavior: Correlations between the proportions of hippocampal synaptic fields in the regio inferior and two-way avoidance in mice and rats. Behavioural Brain Research, 7, 1-38.
30. Silva, A. J., Paylor, R., Wehner, J. M., & Tonegawa, S. (1992, July 10). Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice. Science, 257, 206-211.
31. Sutherland, R. J., & Dyck, R. H. (1984). Place navigation by rats in a swimming pool. Canadian Journal of Psychology, 38, 322-347.
32. Sutherland, R. J., Kolb, B., & Whishaw, I. Q. (1982). Spatial mapping: Definitive disruption by hippocampal or medial frontal cortical damage in rat. Neuroscience Letters, 31, 271-276.
33. Sutherland, R. J., & Rudy, J. W. (1989). Configural association theory: The role of the hippocampal formation in learning, memory, and amnesia. Psychobiology, 17, 129-144.
34. Upchurch, M., & Wehner, J. M. (1988a). DBA/2Ibg mice are incapable of cholinergically-based learning in the Morris water task. Pharmacology, Biochemistry & Behavior, 29, 325-330.
35. Upchurch, M., & Wehner, J. M. (1988b). Differences between inbred strains of mice in Morris water maze performance. Behavior Genetics, 18, 55-68.
36. Upchurch, M., & Wehner, J. M. (1989). Inheritance of spatial learning ability in inbred mice: A classical genetic analysis. Behavioral Neuroscience, 103, 1251-1258.
37. Wehner, J. M., Sleight, S., & Upchurch, M. (1990). Hippocampal protein kinase C activity is reduced in poor spatial learners. Brain Research, 523, 181-187.