CD45 opposes β-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activated protein kinase

Journal of Neuroscience

Volumn 20, Issue 20, 2000, Pages 7587-7594

  Tan, J ^a   Town, T ^a   Mori, T ^a   Wu, Y ^a   Saxe, M ^a   Crawford, F ^a   Mullan, M ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Alzheimer's disease; CD45; Microlgia; Mitogen activated protein kinase; Neurons; Nitric oxide; Protein tyrosine phosphatase; TNF ; Tyrosine phospatase inhibitor; Amyloid

Indexed keywords

AMYLOID BETA PROTEIN; CD45 ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; POTASSIUM BISPEROXO (1,10 PHENANTHROLINE) OXOVANADATE; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; MICROGLIA; MOUSE; NERVE CELL LESION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; TRANSGENIC MOUSE;

EID: 0034667558     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-20-07587.2000     Document Type: Article

References (30)

1. Microgial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E
2. Nonsteroidal anti-inflammatory drug use and Alzheimer's disease: A case-control study in Rochester, Minnesota, 1980 through 1984
3. Activated microglia mediate neuronal cell injury via nitric oxide mechanism
4. Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of beta-amyloid and prion proteins
5. Neurotrophin signaling via Trks and p75
6. Phosphatase activity toward abnormally phosphorylated tau: Decrease in Alzheimer disease brain
7. Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis
8. Activation of Raf-1 and mitogen-activated protein kinase in murine macrophages partially mimics lipopolysaccharide-inducing events
9. Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins
10. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
11. Immune system-associated antigens on the surface of peripheral blood lymphocytes in patients with Alzheimer's disease
12. The role of CD45 in signal transduction
13. Microglial tyrosine phosphorylation systems in normal and degenerating brain
14. CD40-mediated signal transduction in human airway smooth muscle
15. Increased level of alpha-1-antichymotrypin in brains of patients with Alzheimer's disease correlate with activated astrocytes and are affected by APOE 4 genotype
16. Role of protein tyrosine kinases and phosphatases in isotype switching: Crosslinking CD45 to CD40 inhibits IgE isotype switching in human B cells
17. Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging
18. Immunoreactivity of CD45, a protein phosphotyrosine phosphatase, in Alzheimer's disease
19. CD40 activation boosts T cell immunity in vivo by enhancing T cell clonal expansion and delaying peripheral T cell deletion
20. Beta-Amyloid fibrils activate parallel mitogen-activated protein kinase pathways in microglia and THP1 monocytes
21. Activation of microglial cells by beta-amyloid protein and interferon-gamma
22. Subcellular distribution of protein phosphatases and abnormally phosphorylated tau in the temporal cortex from Alzheimer's disease and control brains
23. Nonsteroidal anti-inflammatory drugs in Alzheimer's disease
24. Inflammation and Alzheimer's disease pathogenesis
25. CD40 signaling of monocyte inflammatory cytokine synthesis through an ERK1/2-dependent pathway. A target of interleukin (il-4) and il-10 anti-inflammatory action
26. Blocking the CD40-CD40L interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion
27. Activation of microglial cells by the CD40 pathway: Relevance to multiple sclerosis
28. Microglial activation resulting from CD40-CD40L interaction after β-amyloid stimulation
29. Ligation of microglial CD40 results in p44/42 mitogen-activated protein kinase-dependent TNF-α production that is opposed by TGF-β1 and IL-10
30. CD40 ligand-dependent T cell activation: Requirement of B7-CD28 signaling through CD40