The silence of the genes

Current Opinion in Genetics and Development

Volumn 10, Issue 5, 2000, Pages 562-567

  Plasterk, Ronald HA ^a   Ketting, René F ^a  

^a HUBRECHT INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED RNA; MESSENGER RNA;

CAENORHABDITIS ELEGANS; GENE EXPRESSION; GENE SILENCING; GENETIC ANALYSIS; NEUROSPORA; NONHUMAN; PLANT; PRIORITY JOURNAL; REVIEW; TRANSGENE;

EID: 0033864998     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(00)00128-3     Document Type: Review

References (54)

1. Reversible methylation and inactivation of marker genes in sequentially transformed tobacco plants
2. Flavonoid genes in Petunia: Addition of a limited number of gene copies may lead to a suppression of gene expression
3. Introduction of a chimeric chalcone synthase gene into Petunia results in reversible co-suppression of homologous genes in trans
4. Listening to the silent genes: Transgene silencing, gene regulation and pathogen control
5. Position-dependent methylation and transcriptional silencing of transgenes in inverted T-DNA repeats: Implications for posttranscriptional silencing of homologous host genes in plants
6. Production of aberrant promoter transcripts contributes to methylation and silencing of unlinked homologous promoters in trans
7. Cosuppression in Drosophila: Gene silencing of Alcohol dehydrogenase by white-Adh transgenes is Polycomb dependent
8. Cosuppression comes to the animails
9. RNA-directed de novo methylation of genomic sequences in plants
10. RNA-DNA Interactions and DNA methylation in post-transcriptional gene silencing
11. Systemic acquired silencing: Transgene-specific post-transcriptional silencing is transmitted by grafting from silenced stocks to non-silenced scions
12. Systemic spread of sequence-specific transgene RNA degradation in plants is initiated by localized introduction of ectopic promoterless DNA
13. A viral suppressor of gene silencing in plants
14. De novo methylation and co-suppression induced by a cytoplasmically replicating plant RNA virus
15. Suppression of gene silencing: A general strategy used by diverse DNA and RNA viruses of plants
16. Strong host resistance targeted against a viral suppressor of the plant gene silencing defence mechanism
17. Systemic signalling in gene silencing
18. Arabidobsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance
19. Cosuppression of I transposon activity in Drosophila by I-containing sense and antisense transgenes
20. Taming of transposable elements by homology-dependent gene silencing
21. A genetic link between co-suppression and RNA interference in C. elegans
22. Transgene silencing of the al-1 gene in vegetative cells of Neurospora is mediated by a cytoplasmic effector and does not depend on DNA-DNA interactions or DNA methylation
23. Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase
24. Internuclear gene silencing in Phytophthora infestans
25. Potent and specific genetic interference by double-stranded R NA in Caenorhabditis elegans
26. Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway
27. Double-stranded RNA induces mRNA degradation in Trypanosoma brucei
28. Virus resistance and gene silencing in plants can be induced by simultaneous expression of sense and antisense RNA
29. Specific and heritable genetic interference by double-stranded RNA in Arabidopsis thaliana
30. Specific interference with gene function by double-stranded RNA in early mouse development
31. Double-stranded RNA injection produces null phenotypes in zebrafish
32. Double-stranded RNA induces specific developmental defects in zebrafish embryos
33. RNAi in C. elegans: Soaking in the genome sequence
34. Heritable and inducible genetic interference by double-stranded RNA encoded by transgenes
35. Specific interference by ingested dsRNA
36. RNA interference can target pre-mRNA: Consequences for gene expression in a Caenorhabditis elegans operon
37. High-frequency excision of transposable element Tc 1 in the nematode Caenorhabditis elegans is limited to somatic cells
38. Spontaneous unstable unc-22 IV mutations in C. elegans var. Bergerac
39. Mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNaseD
40. The rde-1 gene, RNA interference, and transposon silencing in C. elegans
41. Distinct features of post-transcriptional gene silencing by antisense transgenes in single copy and inverted T-DNA repeat loci
42. Isolation of quelling-defective (qde) mutants impaired in posttranscripUonal transgene-induced gene silencing in Neurospora crassa
43. Posttranscriptional gene silencing in Neurospora by a RecQ DNA helicase
44. Gene silencing in worms and fungi
45. EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans
46. Arabidopsis mutants impaired in cosuppression
47. A species of small antisense RNA in posttranscriptional gene silencing in plants
48. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
49. Targeted mRNA degradation by double-stranded RNA in vitro
50. RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals
51. Genetic requirements for inheritance of RNAi in C
52. Double-stranded RNA as a template for gene silencing
53. An RNA dependent RNA polymerase gene in Arabidobsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus
54. RNA interference