Transgenic animal bioreactors

Transgenic Research

Volumn 9, Issue 4-5, 2000, Pages 305-320

  Houdebine, L M ^a  

^a CEMAGREF   (France)

Author keywords

Milk; Recombinant proteins; Transgenic animals

Indexed keywords

ARTIFICIAL MATERIALS; BIOLOGICAL PROPERTIES AND PARAMETERS; CLONING; DISEASE CONTROL; DNA FRAGMENT; FURIN; GENE EXPRESSION; PROTEIN PURIFICATION; RECOMBINANT PROTEIN; SOMATIC CELL; TRANSGENE; TRANSGENIC ANIMAL; TRANSGENICS;

EID: 0033672657     PISSN: 09628819     EISSN: None     Source Type: Journal    
DOI: 10.1023/a:1008934912555     Document Type: Review

References (154)

1. Preferential, cooperative binding of DNA topoisomerase II to scaffold-associated regions
2. Stable long term germ-line transmission of transgene integration sites in mice
3. Milking gene therapy
4. Human growth hormone (hGH) secretion in milk of goats after direct transfer of the hGH gene into the mammary gland by using replication-defective retrovirus vectors
5. Intergenic transcription and transinduction of the human β-globin locus
6. The use of episomal vectors for transgenesis
7. Gene targeting in livestock
8. Production of goats by somatic cell nuclear transfer
9. In vivo and in vitro expression of human serum albumin genomic sequences in mammary epithelial cells with β-lactoglobulin and whey acidic protein promoters
10. Stopped at the border boundaries and insulators
11. In vitro comparison of the antigen-binding and stability properties of the various molecular forms of IgA antibodies assembled and produced in CHO cells
12. A 17.6 kbp region located upstream of the rabbit WAP gene directs high level expression of a functional human protein variant in transgenic mouse milk
13. Tet B or not tet B: Advances in tetracycline-inducible gene expression
14. Variation in expression of a bovine alpha-lactalbumin transgene in milk of transgenic mice
15. Production of bovine α-lactalbumin in the milk of transgenic pigs
16. RNA interference: Genetic wand and genetic watchdog
17. Long-distance chromatin mechanisms controlling tissue-specific gene locus activation
18. Engineering passive immunity in transgenic mice secreting virus-neutralizing antibodies in milk
19. Accurate spatial and temporal transgene expression driven by a 3.8-kilobase promoter of the bovine β-casein gene in the lactating mouse mammary gland
20. Transgenic cattle produce reverse-transcribed gene transfer in oocytes
21. αS1-casein is required for the efficient transport of β- and κ-casein from the endoplasmic reticulum to the Golgi apparatus of mammary epithelial cells
22. The mammary gland as a bioreactor: Expression, processing and production of recombinant proteins
23. Beyond 'knock-out' mice: New perspectives for the programmed modification of the mammalian genome
24. Production of proteins in the milk of transgenic livestock: Problems, solutions, and successes
25. Human nerve growth factor beta (hNGF-β): Mammary gland specific expression and production in transgenic rabbits
26. High level expression of the rat whey acidic protein gene is mediated by elements in the promoter and 3' untranslated region
27. Over-expression of the murine polymeric immunoglobulin receptor gene in the mammary gland of transgenic mice
28. High level production of human growth hormone in the milk of transgenic mice: The upstream region of the rabbit whey acidic protein (WAP) gene targets transgene expression to the mammary gland
29. Production of cystic fibrosis transmenbrane conductance regulator in the milk of transgenic mice
30. Variegated transgene expression in mouse mammary gland is determined by the transgene integration locus
31. Distant liaisons: Long-range enhancer-promoter interactions in Drosophila
32. Do transgene arrays form heterochromatin in vertebrates?
33. Myogenic expression of an injectable protease-resistant growth hormone-releasing hormone augments long-term growth in pigs
34. Proteolytic maturation of protein C upon engineering the mouse mammary gland to express furin
35. Seminal vesicle production and secretion of growth hormone into seminal fluid
36. Genetic mosaicism in the generation of transgenic mice
37. Production of chimeric chickens as intermediates for gene transfer
38. Avian embryonic stem cells and their application in the pharmaceutical and poultry industries
39. Production and breeding of transgenic cattle using in vitro embryo production technology
40. Expression and characterization of bispecific single-chain Fv fragments produced in transgenic plants
41. RNA-triggered gene silencing
42. What are ES cells?
43. Nuclear matrix attachment regions antagonize methylation-dependent repression of long-range enhancer promoter interactions
44. Tetracycline-inducible expression systems with reduced basal activity in mammalian cells
45. Natural variation in the genetic code
46. Analysis of control elements for position independent expression of human α-lactalbumin YAC
47. High-level expressing YAC vector for transgenic animal bioreactors
48. Genetic optimization of recombinant glycoprotein production by mammalian cells
49. Repeat-induced gene silencing in mammals
50. Production of human tissue plasminogen activator in transgenic mouse milk
51. Rabbit whey acidic protein concentration in milk, serum, mammary gland extract, and culture medium
52. A mammary specific promoter directs expression of growth hormone not only to the mammary gland, but also to Bergman Glia cells in transgenic mice
53. Exploiting antibody-based technologies to manage environmental pollution
54. Transgene expression in mammary glands of newborn rats
55. Mechanisms for selecting 5' splice sites in mammalian pre-mRNA splicing
56. Production of pharmaceutical proteins from transgenic animals
57. Internal ribosome entry sites (IRESs): Reality and use
58. The mouse histone H2a gene contains a small element that facilitates cytoplasmic accumulation of intronless gene transcripts and of unspliced HIV-1-related mRNAs
59. Generation of transgenic dairy cattle from transgene analyzed and sexed embryos produced in vitro
60. Dual regulation of β-lactoglobulin/human serum albumin gene expression by the extracellular matrix in mammary cells from transgenic mice
61. β-lactoglobulin/human serum albumin fusion genes do not respond accurately to signals from the extracellular matrix in mammary epithelial cells from transgenic mice
62. Validating the Hen as a bioreactor for the production of exogenous proteins in egg whites
63. Expression of an engineered form of recombinant procollagen in mouse milk
64. Production of recombinant spider silk (biosteel(TM)) in the milk of transgenic animals
65. Expression of gene-gun injected plasmid DNA in the ovine mammary gland and in lymph nodes draining the injection site
66. The bladder as a bioreactor: Urothelium production and secretion of growth hormone into urine
67. Insertion of a foreign gene into the β-casein locus by Cre-mediated site-specific recombination
68. Generation of transgenic dairy cattle using 'in vitro' embryo production
69. Therapeutic peptides revisited nature
70. Expression of a bovine β-casein/human lysozyme fusion gene in the mammary gland of transgenic mice
71. Synthetic muscle promoters: Activities exceeding naturally occurring regulatory sequences
72. Production of active anti-CD6 mouse/human chimeric antibodies in the milk of transgenic mice
73. Zona pellucida glycoprotein mZP3 produced in milk of transgenic mice is active as a sperm receptor, but can be lethal to newborns
74. Expression of mouse IgA by transgenic mice, pigs and sheep
75. Expression of active recombinant human alpha 1-antitrypsin in transgenic rabbits
76. The deleterious effects of human erythropoietin gene driven by the rabbit whey acidic protein gene promoter in transgenic rabbits
77. Secretory proteins compete for production in the mammary gland of transgenic mice
78. Establishment of the germ cell lineage in mammals
79. Taking ATIII from goats through clinical trials
80. Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice
81. The modification of milk protein composition through transgenesis: Progress and problems
82. Attempt at transgenesis of the silkworm (Bombyx mori L.) by egg-injection of foreign DNA
83. The microinjection of DNA into early chicken embryo
84. Expression of human blood clotting factor VIII (FVIII) constructs in the mammary gland of transgenic mice and sheep
85. Functions of milk protein gene 5' flanking regions on human growth hormone gene
86. A hybrid bovine β-casein/bGH gene directs transgene expression to the lung and mammary gland of transgenic mice
87. Transgene detection during early murine embryonic development after pronuclear microinjection
88. Transgenic pigs produce functional human factor VIII in milk
89. Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes
90. Heterologous introns can enhance expression of transgenes in mice
91. Mammalian transgenesis by intracytoplasmic sperm injection
92. The effect of various introns and transcription terminators on the efficiency of expression vectors in various cultured cell lines and in the mammary gland of transgenic mice
93. Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators
94. Expression of human lactoferrin in milk of transgenic mice
95. Remodeling of mouse milk glycoconjugates by transgenic expression of a human glycosyltransferase
96. High-level expression of recombinant human fibrinogen in the milk of transgenic mice
97. Mimicry of erythoropoietin by a nonpeptide molecule
98. Positional enhancer-blocking activity of the chicken β-globin insulator in transiently transfected cells
99. Expression of human growth hormone in the milk of transgenic mice
100. Casein gene locus control regions?
101. New life for sperm-mediated transgenesis?
102. Human parathyroid hormone as a secretory peptide in milk of transgenic mice
103. The use of retroviral vectors for gene transfer into bird embryo
104. The mammary gland as a bioreactor: Factors regulating the efficient expression of milk protein-based transgenes
105. Cre-mediated recombination at the murine whey acidic protein (mWAP) locus
106. Biopharmaceutical production in transgenic livestock
107. WAPping gastroenteritis with transgenic antibodies
108. Control of organ-specific demethylation by an element of the T-cell receptor- locus control region
109. Human factor IX transgenic sheep produced by transfer of nuclei from transfected fetal fibroblasts
110. Expression of the whey acidic protein in transgenic pigs impairs mammary development
111. An isologous porcine promoter permits high level expression of human hemoglobin in transgenic swine
112. Transposition of the drosophila element mariner into the chicken germ line
113. Alteration of the quality of milk by expression of sheep beta-lactoglobulin in transgenic mice
114. Insulation of transgenes from chromosomal position effects
115. Expression and characterization of bioactive human thrombopoietin in the milk of transgenic mice
116. Transgenic mice secreting coronavirus neutralizing antibodies into the milk
117. Piecing together more efficient gene expression
118. Use of doxycycline-controlled gene expression to reversibly alter milk-protein composition in transgenic mice
119. Quantitative collection of milk and active recombinant proteins from the mammary glands of transgenic mice
120. Position-independent and copy number related expression of a goat bacterial artificial chromosome α-lactalbumin gene in transgenic mice
121. Recombinant human bile salt-stimulated lipase: An example of defective O-glycosylation of a protein produced in milk of transgenic mice
122. Recombinant human extracellular superoxide dismutase produced in milk of transgenic rabbits
123. Association of the 5'HS4 sequence of the chicken beta-globin locus control region with human EF1 alpha gene promoter induces ubiquitous and high expresssion of human CD55 and CD59 cDNAs in transgenic rabbits
124. Germline transformation of the silkworm Bombyx mori L. using a piggyBac transposon-derived vector
125. Rabbit whey acidic protein gene upstream region controls high-level expression of bovine growth hormone in the mammary gland of transgenic mice
126. Production and characterization of transgenic mice expressing a hGH fusion gene driven by the promoter of mouse whey acidic protein (mWAP) putatively specific to mammary gland
127. Functional expression and germline transmission of a human chromosome fragment in chimaeric mice
128. Chromatin modification by DNA tracking
129. Affinity purification of biologically active and inactive forms of recombinant human protein C produced in porcine mammary gland
130. The chicken, the egg, and the ancient mariner
131. Mammalian artificial chromosomes as tools for gene therapy
132. Cre-mediated gene deletion in the mammary gland
133. Biotechnology for the production of modified and innovative animal products: Transgenic livestock bioreactors
134. Transcriptional enhancers act in cis to suppress position-effect variegation
135. Ligand-inducible and liver-specific target gene expression in transgenic mice
136. Genes encoding a mouse monoclonal antibody are expressed in transgenic mice, rabbits and pigs
137. Expression of whey acidic protein (WAP) genes in tissues other than the mammary gland in normal and transgenic mice expressing mWAP/hGH fusion gene
138. Transgenic alteration of sow milk: Production and characterization bovine a-lactalbumin and IGF-I transgenic swine
139. Position-independent expression of the ovine β-lactoglobulin gene in transgenic mice
140. Toward designer milk
141. Human artificial chromosomes coming into focus
142. Purification of recombinant proteins from sheep's milk
143. Effect of glycosylation on antibody function: Implications for genetic engineering
144. High level expression of active human alpha-1-antitrypsin in the milk of transgenic sheep
145. Small peptides as potent mimetics of the protein hormone erythropoietin
146. Gene targeting in the silkworm by use of a baculovirus
147. Production of active bovine tracheal antimicrobial peptide in milk of transgenic mice
148. Transgene rescue in the mammary gland is associated with transcription but does not require translation of BLG transgenes
149. Stable production of human insulin-like growth factor 1 (IGF-1) in the milk of hemi- and homozygous transgenic rabbits over several generations
150. Transgenic modification of cows milk for value-added processing