Tobramycin analogues with C-5 aminoalkyl ether chains intended to mimic rings III and IV of paromomycin

Tetrahedron

Volumn 59, Issue 7, 2003, Pages 983-993

  Hanessian, Stephen ^a   Tremblay, Martin ^a   Swayze, Eric E ^b  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b Ibis Therapeutics   (United States)

Author keywords

Amidine; Aminoglycoside; Antibacterial activity; Guanidine; Ribosome

Indexed keywords

ETHER DERIVATIVE; KANAMYCIN A; KANAMYCIN B; NEAMINE; PAROMOMYCIN; TOBRAMYCIN;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; RIBOSOME; SPECIES DIFFERENCE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

EID: 0037429028     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(02)01624-1     Document Type: Article

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