Basis for prokaryotic specificity of action of aminoglycoside antibiotics

EMBO Journal

Volumn 18, Issue 11, 1999, Pages 3133-3138

  Recht, Michael I ^a   Douthwaite, Stephen ^b   Puglisi, Joseph D ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

A site; Antibiotic resistance; Decoding region; Ribosome; rRNA

Indexed keywords

ADENOSINE; AMINOGLYCOSIDE; ANTIBIOTIC AGENT; GUANOSINE; RIBOSOME RNA;

ANTIBIOTIC RESISTANCE; ARTICLE; CHEMISTRY; DRUG ACTIVITY; DRUG BINDING; DRUG SPECIFICITY; DRUG STRUCTURE; ESCHERICHIA COLI; EUKARYOTE; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PLASMID; PRIORITY JOURNAL; PROKARYOTE; RIBOSOME; RNA BINDING;

ADENOSINE; AMINO ACID SUBSTITUTION; AMINOGLYCOSIDES; AMPICILLIN; ANTI-BACTERIAL AGENTS; BASE SEQUENCE; BINDING SITES; DRUG RESISTANCE, MICROBIAL; ESCHERICHIA COLI; EUKARYOTIC CELLS; GUANOSINE; METHYLATION; MICROBIAL SENSITIVITY TESTS; RIBOSOMES; RNA, RIBOSOMAL, 16S; SPECIES SPECIFICITY; SPECTINOMYCIN; SUBSTRATE SPECIFICITY; SULFURIC ACID ESTERS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; EUKARYOTA; PROKARYOTA;

EID: 0033152492     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/18.11.3133     Document Type: Article

References (26)

1. Alangaden, G.J., Kreiswirth, B.N., Aouad, A., Khetarpal, M., Igno, F.R., Moghazeh, S.L., Manavathu, E.K. and Lerner, S.A. (1998) Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis. Antimicrob. Agents Chemother., 42, 1295-1297.
2. Davies, J., Gorini, L. and Davis, B.D. (1965) Misreading of RNA codewords induced by aminoglycoside antibiotics. Mol. Pharmacol., 1, 93-106.
3. DeStasio, E.A. and Dahlberg, A.E. (1990) Effects of mutagenesis of a conserved base-paired site near the decoding region of Escherichia coli 16S ribosomal RNA. J. Mol. Biol., 212, 127-133.
4. DeStasio, E.A., Moazed, D., Noller, H.F. and Dahlberg, A.E. (1989) Mutations in 16S ribosomal RNA disrupt antibiotic-RNA interactions. EMBO J., 8, 1213-1216.
5. Edelmann, P. and Gallant, J. (1977) Mistranslation in E.coli. Cell, 10, 131-137.
6. Edlind, T.D. (1989) Susceptibility of Giardia lamblia to aminoglycoside protein synthesis inhibitors: correlation with rRNA structure. Antimicrob. Agents Chemother., 33, 484-488.
7. Fourmy, D., Recht, M.I., Blanchard, S.C. and Puglisi, J.D. (1996) Structure of the A site of E.coli 16S ribosomal RNA complexed with an aminoglycoside antibiotic. Science, 274, 1367-1371.
8. Gale, E.F., Cundliffe, E., Reynolds, P.E., Richmond, M.H. and Waring, M.J. (1981) The Molecular Basis of Antibiotic Action. John Wiley & Sons, London.
9. Gutell, R.R. (1994) Collection of small subunit (16S-and 16S-like) ribosomal RNA structures: 1994. Nucleic Acids Res., 22, 3502-3507.
10. Hui, A.S., Eaton, D.H. and de Boer, H.A. (1988) Mutagenesis at the mRNA decoding site in the 16S ribosomal RNA using the specialized ribosome system in Escherichia coli. EMBO J., 7, 4383-4388.
11. Johanson, U. and Hughes, D. (1995) A new mutation in 16S rRNA of Escherichia coli conferring spectinomycin resistance. Nucleic Acids Res., 23, 464-466.
12. Moazed, D. and Noller, H.F. (1987) Interaction of antibiotics with functional sites in 16S ribosomal RNA. Nature, 327, 389-394.
13. Palmer, E. and Wilhelm, J.M. (1978) Mistranslation in a eucaryotic organism. Cell, 13, 329-334.
14. Powers, T. and Noller, H.F. (1991) A functional pseudoknot in 16S ribosomal RNA. EMBO J., 10, 2203-2214.
15. Powers, T. and Noller, H.F. (1993) Allele-specific structure probing of plasmid-derived 16S ribosomal RNA from Escherichia coli. Gene, 123, 75-80.
16. Prammananan, T., Sander, P., Brown, B.A., Frischkorn, K., Onyi, G.O., Zhang, Y., Bottger, E.C. and Wallace, R.J., Jr (1998) A single 16S ribosomal RNA substitution is responsible for resistance to amikacin and other 2-deoxystreptamine aminoglycosides in Mycobacterium abscessus and Mycobacterium chelonae. J. Infect. Dis., 177, 1573-1581.
17. Recht, M.I., Fourmy, D., Blanchard, S.C., Dahlquist, K.D. and Puglisi, J.D. (1996) RNA sequence determinants for aminoglycoside binding to an A-site rRNA model oligonucleotide. J. Mol. Biol., 262, 421-436.
18. Recht, M.I., Douthwaite, S., Dahlquist, K.D. and Puglisi, J.D. (1999) Effect of mutations in the A site of 16S rRNA on aminoglycoside antibiotic-ribosome interaction. J. Mol. Biol., 286, 33-43.
19. Sigmund, C.D., Ettayebi, M., Borden, A. and Morgan, E.A. (1988) Antibiotic resistance mutations in ribosomal RNA genes of Escherichia coli. Methods Enzymol., 164, 673-690.
20. Skeggs, P.A., Thompson, J. and Cundliffe, E. (1985) Methylation of 16S ribosomal RNA and resistance to aminoglycoside antibiotics in clones of Streptomyces lividans carrying DNA from Streptomyces tenjimariensis. Mol. Gen. Genet., 200, 415-421.
21. Sparling, P.F., Modolell, J., Takeda, Y. and Davis, B.D. (1968) Ribosomes from Escherichia coli merodiploids heterozygous for resistance to streptomycin and spectinomycin. J. Mol. Biol., 37, 407-421.
22. Stern, S., Moazed, D. and Noller, H.F. (1988) Structural analysis of RNA using chemical and enzymatic probing monitored by primer extension. Methods Enzymol., 164, 481-489.
23. Wilhelm, J.M., Pettitt, S.E. and Jessop, J.J. (1978) Aminoglycoside antibiotics and eukaryotic protein synthesis: structure-function relationships in the stimulation of misreading with a wheat embryo system. Biochemistry, 17, 1143-1149.
24. Woodcock, J., Moazed, D., Cannon, M., Davies, J. and Noller, H.F. (1991) Interaction of antibiotics with A-and P-site-specific bases in 16S ribosomal RNA. EMBO J., 10, 3099-3103.
25. Yoshizawa, S., Fourmy, D. and Puglisi, J.D. (1998) Structural origins of gentamicin antibiotic action. EMBO J., 17, 6437-6448.
26. Zimmermann, R.A., Thomas, C.L. and Wower, J. (1990) Structure and function of rRNA in the decoding domain and in the peptidyl transferase center. In Hill, W.E., Dahlberg, A., Garrett, R.A., Moore, P.B., Schlessinger, D. and Warner, J.R. (eds), The Ribosome: Structure, Function and Evolution. American Society for Microbiology, Washington, DC, pp. 331-347.