Binding of tobramycin leads to conformational changes in yeast tRNAAsp and inhibition of aminoacylation

EMBO Journal

Volumn 21, Issue 4, 2002, Pages 760-768

  Walter, Frank ^a   Pütz, Joern ^a   Giegé, Richard ^a   Westhof, Eric ^a  

^a INST DE BIOL MOLEC ET CELLULAIRE   (France)

Author keywords

Aminoacyl tRNA synthetase; Antibiotics; Fluorescence spectrometry; Pharmacology; Translation

Indexed keywords

AMINOGLYCOSIDE; TOBRAMYCIN; TRANSFER RNA;

AMINOACYLATION; ANISOTROPY; ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; DRUG MECHANISM; DRUG PROTEIN BINDING; NONHUMAN; PRIORITY JOURNAL; RNA TRANSLATION; YEAST;

ACYLATION; BASE SEQUENCE; CARBOHYDRATE SEQUENCE; FLUORESCENCE POLARIZATION; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; RNA, FUNGAL; RNA, TRANSFER, ASP; SACCHAROMYCES CEREVISIAE; TOBRAMYCIN;

EID: 0037084261     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/21.4.760     Document Type: Article

References (38)

1. rRNA chemical groups required for aminoglycoside binding
2. Yeast tRNA(Asp) recognition by its cognate class II aminoacyl-tRNA synthetase
3. Identity switches between tRNAs aminoacylated by class I glutaminyl- and class II aspartyl-tRNA synthetases
4. Structure of aspartate-tRNA from brewer's yeast
5. Universal rules and idiosyncratic features in tRNA identity
6. Rational drug design and highthroughput techniques for RNA targets
7. Synthetic inhibitors of the processing of pretransfer RNA by the ribonuclease P ribozyme: Enzyme inhibitors which act by binding to substrate
8. Aminoglycoside binding to human and bacterial A-site rRNA decoding region constructs
9. Saccharide-RNA recognition in an aminoglycoside antibiotic-RNA aptamer complex
10. Aminoglycoside binding in the major groove of duplex RNA: The thermodynamic and electrostatic forces that govern recognition
11. 32PPi-ATP isotope-exchange reaction catalyzed by the yeast valyl-tRNA synthetase: Order of substrate binding and effect of tRNA
12. Purpuromycin: An antibiotic inhibiting tRNA aminoacylation
13. tRNA(Phe) binds aminoglycoside antibiotics
14. Inhibitors of amino acid activation
15. Large scale purification and structural properties of yeast aspartyl-tRNA synthetase
16. Calculating thermodynamic data for transitions of any molecularity from equilibrium melting curves
17. Inhibition of an HIV-1 Tat-derived peptide binding to TAR RNA by aminoglycoside antibiotics
18. Aminoglycoside binding displaces a divalent metal ion in a tRNA-neomycin B complex
19. The structure of an AspRS-tRNA(Asp) complex reveals a tRNA-dependent control mechanism
20. Recognition of cognate transfer RNA by the 30S ribosomal subunit
21. Relaxation of a transfer RNA specificity by removal of modified nucleotides
22. Influence of tRNA tertiary structure and stability on aminoacylation by yeast aspartyl-tRNA synthetase
23. Identity elements for specific aminoacylation of yeast tRNA(Asp) by cognate aspartyl-tRNA synthetase
24. Neomycin, spermine and hexaaminecobalt (III) share common structural motifs in converting B- to A-DNA
25. Asp tertiary structure in solution and areas of interaction of the tRNA with aspartyl-tRNA synthetase. A comparative study of the yeast phenylalanine system by phosphate alkylation experiments with ethylnitrosourea
26. A eubacterial Mycobacterium tuberculosis tRNA synthetase is eukaryote-like and resistant to a eubacterial specific antisynthetase drug
27. Aminoacyl tRNA synthetases as targets for new anti-infectives
28. Modulation of RNA function by aminoglycoside antibiotics
29. Compilation of tRNA sequences and sequences of tRNA genes
30. Photo-induced labelling of Escherichia coli ribosomes by a tobramycin analog
31. Aminoglycoside antibiotics are able to specifically bind the 5′-untranslated region of thymidylate synthase messenger RNA
32. Deciphering RNA recognition: Aminoglycoside binding to the hammerhead ribozyme
33. Inhibitors of protein synthesis
34. Crystal structure of paromomycin docked into the eubacterial ribosomal decoding A site
35. Aminoglycoside-RNA interactions
36. RNA molecules that specifically and stoichiometrically bind aminoglycoside antibiotics with high affinities
37. Crystallographic refinement of yeast aspartic acid transfer RNA
38. Small molecules that selectively block RNA binding of HIV-1 Rev protein inhibit Rev function and viral production