Probing the functional requirements of the L-haba side-chain of amikacin - Synthesis, 16S A-site rRNA binding, and antibacterial activity

Tetrahedron

Volumn 59, Issue 7, 2003, Pages 995-1007

  Hanessian, Stephen ^a   Kornienko, Alexander ^a   Swayze, Eric E ^b  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b Ibis Therapeutics   (United States)

Author keywords

Aminoglycoside; Antibacterial activity; Hydroxyurea; Ribosome

Indexed keywords

AMIKACIN; CARBON; CARBOXYLIC ACID DERIVATIVE; HYDROXIDE; HYDROXYL GROUP; KANAMYCIN A; KANAMYCIN B; PAROMOMYCIN; RNA 16S; TOBRAMYCIN; UREA DERIVATIVE;

ACYLATION; ANTIBACTERIAL ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG BINDING; DRUG POTENCY; DRUG SYNTHESIS; ESCHERICHIA COLI; IC 50; NONHUMAN; PRIORITY JOURNAL; RIBOSOME; SPECIES DIFFERENCE; STAPHYLOCOCCUS AUREUS;

EID: 0037429032     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(02)01625-3     Document Type: Article

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75. Preliminary antibacterial testing against resistant (and sensitive) strains on a panel of bacteria were graciously done at Pathogenesis (now Chiron Corporation, Emeryville, CA). We thank Ms Lynn Barker for her expert assistance.