메뉴 건너뛰기




Volumn 5, Issue 11s, 2002, Pages 1055-1057

Alzheimer’s disease: Treatments in discovery and development

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; AMYLOID; AMYLOID BETA ANTIBODY; AMYLOID BETA PROTEIN; ATORVASTATIN; BETA SECRETASE; BETA SECRETASE INHIBITOR; CLIOQUINOL; ENZYME INHIBITOR; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT; UNCLASSIFIED DRUG; VACCINE; ZINC;

EID: 0036828769     PISSN: 10976256     EISSN: 15461726     Source Type: Journal    
DOI: 10.1038/nn940     Document Type: Review
Times cited : (169)

References (29)
  • 2
    • 0033217323 scopus 로고    scopus 로고
    • Therapeutic standards in Alzheimer disease
    • Doody, R. S. Therapeutic standards in Alzheimer disease. Alzheimer Dis. Assoc. Disord. 13, S20-S26 (1999).
    • (1999) Alzheimer Dis. Assoc. Disord , vol.13 , pp. S20-S26
    • Doody, R.S.1
  • 3
    • 0025899041 scopus 로고
    • Amyloid deposition as the central event in the aetiology of Alzheimer’s disease
    • Hardy, J. & Allsop, D. Amyloid deposition as the central event in the aetiology of Alzheimer’s disease. Trends Pharmacol. 12, 383-388 (1991).
    • (1991) Trends Pharmacol , vol.12 , pp. 383-388
    • Hardy, J.1    Allsop, D.2
  • 4
    • 0026631036 scopus 로고
    • The seminal role of ß-amyloid in the pathogenesis of Alzheimer Disease
    • Joachim, C. L. & Selkoe, D. J. The seminal role of ß-amyloid in the pathogenesis of Alzheimer Disease. Alzheimer Dis. Assoc. Disord. 6, 7-34 (1992).
    • (1992) Alzheimer Dis. Assoc. Disord , vol.6 , pp. 7-34
    • Joachim, C.L.1    Selkoe, D.J.2
  • 5
    • 0032105394 scopus 로고    scopus 로고
    • The role of A beta 42 in Alzheimer’s disease
    • (Paris)
    • Younkin, S. G. The role of A beta 42 in Alzheimer’s disease. J. Physiol. (Paris) 92, 289-292 (1998).
    • (1998) J. Physiol , vol.92 , pp. 289-292
    • Younkin, S.G.1
  • 6
    • 0033600274 scopus 로고    scopus 로고
    • Translating cell biology into therapeutic advances in Alzheimer’s disease
    • Selkoe, D. J. Translating cell biology into therapeutic advances in Alzheimer’s disease. Nature 399, A23-A31 (1999).
    • (1999) Nature , vol.399 , pp. A23-A31
    • Selkoe, D.J.1
  • 7
    • 0034628448 scopus 로고    scopus 로고
    • Protease inhibitors: Current status and future prospects
    • Leung, D., Abbenante, G. & Fairlie, D. P. Protease inhibitors: current status and future prospects. J. Med. Chem. 43, 305-341 (2000).
    • (2000) J. Med. Chem , vol.43 , pp. 305-341
    • Leung, D.1    Abbenante, G.2    Fairlie, D.P.3
  • 8
    • 18444417998 scopus 로고    scopus 로고
    • Aph-1 and pen-2 are required for Notch pathway signaling, y-secretase cleavage of APP, and presenilin protein accumulation
    • Francis, R. et al. Aph-1 and pen-2 are required for Notch pathway signaling, y-secretase cleavage of APP, and presenilin protein accumulation. Dev. Cell 3, 85-97 (2002).
    • (2002) Dev. Cell , vol.3 , pp. 85-97
    • Francis, R.1
  • 9
    • 0036548070 scopus 로고    scopus 로고
    • Y-secretase, Notch, Aß and Alzheimer’s disease: Where do the presenilins fit in?
    • Sisodia, S. S. & St George-Hyslop, P. H. y-secretase, Notch, Aß and Alzheimer’s disease: where do the presenilins fit in? Nat. Rev. Neurosci. 3, 281-290 (2002).
    • (2002) Nat. Rev. Neurosci , vol.3 , pp. 281-290
    • Sisodia, S.S.1    St George-Hyslop, P.H.2
  • 10
    • 0033595706 scopus 로고    scopus 로고
    • ß-secretase cleavage of Alzheimer’s amyloid precursor protein by the transmembrane aspartic protease BACE
    • Vassar, R. et al. ß-secretase cleavage of Alzheimer’s amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286, 735-741 (1999).
    • (1999) Science , vol.286 , pp. 735-741
    • Vassar, R.1
  • 11
    • 0034613320 scopus 로고    scopus 로고
    • Structure of the protease domain of memapsin 2 (ß-secretase) complexed with inhibitor
    • Hong, L. et al. Structure of the protease domain of memapsin 2 (ß-secretase) complexed with inhibitor. Science 290, 150-153 (2000).
    • (2000) Science , vol.290 , pp. 150-153
    • Hong, L.1
  • 12
    • 0035116273 scopus 로고    scopus 로고
    • Mice deficient in BACE1, the Alzheimer’s ß-secretase, have normal phenotype and abolished ß-amyloid generation
    • Luo, Y. et al. Mice deficient in BACE1, the Alzheimer’s ß-secretase, have normal phenotype and abolished ß-amyloid generation. Nat. Neurosci. 4, 231-232 (2001).
    • (2001) Nat. Neurosci , vol.4 , pp. 231-232
    • Luo, Y.1
  • 13
    • 84984772385 scopus 로고    scopus 로고
    • Ecretase as a target for the treatment of Alzheimer’s disease
    • Citron M. ß-secretase as a target for the treatment of Alzheimer’s disease. J. Neurosci. Res. (in press).
    • J. Neurosci. Res
    • Citron, M.1
  • 14
    • 0033518251 scopus 로고    scopus 로고
    • Purification and cloning of amyloid precursor protein ß-secretase from human brain
    • Sinha, S. et al. Purification and cloning of amyloid precursor protein ß-secretase from human brain. Nature 402, 537-540 (1999).
    • (1999) Nature , vol.402 , pp. 537-540
    • Sinha, S.1
  • 15
    • 0035479004 scopus 로고    scopus 로고
    • Transgenic mouse models of Alzheimer’s disease
    • Hock, B. J. & Lamb, B. T. Transgenic mouse models of Alzheimer’s disease. Trends Genet. 17, S7-S12 (2001).
    • (2001) Trends Genet , vol.17 , pp. SS7-S12
    • Hock, B.J.1    Lamb, B.T.2
  • 16
    • 0032839878 scopus 로고    scopus 로고
    • Plaque busters: Strategies to inhibit amyloid formation in Alzheimer’s disease
    • Soto, C. Plaque busters: strategies to inhibit amyloid formation in Alzheimer’s disease. Mol. Med. Today 5, 343-350 (1999).
    • (1999) Mol. Med. Today , vol.5 , pp. 343-350
    • Soto, C.1
  • 17
    • 0034964390 scopus 로고    scopus 로고
    • Treatment with a copper-zinc chelator markedly and rapidly inhibits ß-amyloid accumulation in Alzheimer’s disease transgenic mice
    • Cherny, R. A. et al. Treatment with a copper-zinc chelator markedly and rapidly inhibits ß-amyloid accumulation in Alzheimer’s disease transgenic mice. Neuron 30, 665-676 (2001).
    • (2001) Neuron , vol.30 , pp. 665-676
    • Cherny, R.A.1
  • 18
    • 0037188472 scopus 로고    scopus 로고
    • The galvanization of ß-amyloid in Alzheimer’s disease
    • Bush, A. & Tanzi, R. E. The galvanization of ß-amyloid in Alzheimer’s disease. Proc. Natl. Acad. Sci. USA 99, 7317-7319 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 7317-7319
    • Bush, A.1    Tanzi, R.E.2
  • 19
    • 0033536163 scopus 로고    scopus 로고
    • Immunization with amyloid-ß attenuates Alzheimer-disease-like pathology in the PDAPP mouse
    • Schenk, D. et al. Immunization with amyloid-ß attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400, 173-177 (1999).
    • (1999) Nature , vol.400 , pp. 173-177
    • Schenk, D.1
  • 20
    • 0033835996 scopus 로고    scopus 로고
    • Peripherally administered antibodies against amyloid ß-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
    • Bard, F. et al. Peripherally administered antibodies against amyloid ß-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat. Med. 6, 916-919 (2000).
    • (2000) Nat. Med , vol.6 , pp. 916-919
    • Bard, F.1
  • 21
    • 0035902619 scopus 로고    scopus 로고
    • Peripheral anti-Aß antibody alters CNS and plasma A ß clearance and decreases brain Aß burden in a mouse model of Alzheimer’s disease
    • De Mattos, R. B. et al. Peripheral anti-Aß antibody alters CNS and plasma A ß clearance and decreases brain Aß burden in a mouse model of Alzheimer’s disease. Proc. Natl. Acad. Sci. USA 98, 8850-8855 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 8850-8855
    • De Mattos, R.B.1
  • 22
    • 0000676441 scopus 로고    scopus 로고
    • Companies halt first Alzheimer vaccine trial
    • Steinberg, D. Companies halt first Alzheimer vaccine trial. The Scientist 16, 22-23 (2002).
    • (2002) The Scientist , vol.16 , pp. 22-23
    • Steinberg, D.1
  • 23
    • 0035693924 scopus 로고    scopus 로고
    • Inflammation, autotoxicity and Alzheimer disease
    • McGeer, P. L. & McGeer, E. G. Inflammation, autotoxicity and Alzheimer disease. Neurobiol. Aging 22, 799-809 (2001).
    • (2001) Neurobiol. Aging , vol.22 , pp. 799-809
    • McGeer, P.L.1    McGeer, E.G.2
  • 24
    • 0035829592 scopus 로고    scopus 로고
    • A subset of NSAIDs lower amyloidogenic Aß42 independently of cyclooxygenase activity
    • Weggen, S. et al. A subset of NSAIDs lower amyloidogenic Aß42 independently of cyclooxygenase activity. Nature 414, 212-216 (2001).
    • (2001) Nature , vol.414 , pp. 212-216
    • Weggen, S.1
  • 25
    • 0033772113 scopus 로고    scopus 로고
    • Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors
    • Wolozin, B., Kellman, W., Ruosseau, P., Celesia, G. G. & Siegel, G. Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Arch. Neurol. 57, 1439-1443 (2000).
    • (2000) Arch. Neurol , vol.57 , pp. 1439-1443
    • Wolozin, B.1    Kellman, W.2    Ruosseau, P.3    Celesia, G.G.4    Siegel, G.5
  • 27
    • 0001504829 scopus 로고    scopus 로고
    • Simvastatin strongly reduces levels of Alzheimer’s disease ß-amyloid peptides Aß42 and Aß40 in vitro and in vivo
    • Fassbender, K. et al. Simvastatin strongly reduces levels of Alzheimer’s disease ß-amyloid peptides Aß42 and Aß40 in vitro and in vivo. Proc. Natl. Acad. Sci. USA 98, 5856-5861 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 5856-5861
    • Fassbender, K.1
  • 28
    • 0035888328 scopus 로고    scopus 로고
    • Cholesterol modification as an emerging strategy for the treatment of Alzheimer’s disease
    • Golde, T. E. & Eckman, C. B. Cholesterol modification as an emerging strategy for the treatment of Alzheimer’s disease. Drug Discov. Today 6, 1049-1055 (2001).
    • (2001) Drug Discov. Today , vol.6 , pp. 1049-1055
    • Golde, T.E.1    Eckman, C.B.2
  • 29
    • 0034795651 scopus 로고    scopus 로고
    • Acyl-coenzyme A: Cholesterol acyltransferase modulates the generation of the amyloid ß-peptide
    • Puglielli, L. et al. Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid ß-peptide. Nat. Cell Biol. 3, 905-912 (2001).
    • (2001) Nat. Cell Biol , vol.3 , pp. 905-912
    • Puglielli, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.