Lipoxygenase modulation to reverse carcinogenesis

Cancer Research

Volumn 61, Issue 17, 2001, Pages 6307-6312

  Shureiqi, I ^a   Lippman, S M ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONATE 12 LIPOXYGENASE; ARACHIDONATE 15 LIPOXYGENASE; ARACHIDONATE 5 LIPOXYGENASE; CORIOLIC ACID; LIPOXYGENASE; LIPOXYGENASE INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT; POLYUNSATURATED FATTY ACID;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CANCER CELL CULTURE; CANCER INHIBITION; CANCER PREVENTION; CARCINOGENESIS; COLORECTAL CANCER; FATTY ACID METABOLISM; PRIORITY JOURNAL; REVIEW;

ANIMALS; CHEMOPREVENTION; HUMANS; ISOENZYMES; LIPOXYGENASE; NEOPLASMS;

EID: 0035417925     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (101)

1. Lipoxygenases: Occurrence, functions, catalysis, and acquisition of substrate
2. Cyclooxygenase and lipoxygenase inhibitors in cancer therapy
3. The role of fat, fatty acids, and total energy intake in the etiology of human colon cancer
4. In vivo activation of an ω-6 oxygenase in human skin
5. Synthesis of hydroxy fatty acids from linoleic acid by human blood platelets
6. Chemoprevention of colorectal cancer
7. Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis
8. 15-LOX-1: A novel molecular target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells
9. PPARδ is an APC-regulated target of nonsteroidal anti-inflammatory drugs
10. Polyunsaturated fat, cholesterol and large bowel tumorigenesis
11. Metabolism of exogenous and endogenous arachidonic acid in cancer
12. Dietary fat and colon cancer: Modulating effect of types and amount of dietary fat on ras-p21 function during promotion and progression stages of colon cancer
13. Fish oil blocks azoxymethaneinduced rat colon tumorigenesis by increasing cell differentiation and apoptosis rather than decreasing cell proliferation
14. Alteration of murine mammary tumorigenesis by dietary enrichment with n-3 fatty acids in fish oil
15. In vivo stimulation of DNA synthesis and induction of ornithine decarboxylase in rat colon by fatty acid hydroperoxides, autoxidation products of unsaturated fatty acids
16. Endothelial cell proliferation may be mediated via the production of endogenous lipoxygenase metabolites
17. Modulation of the epidermal growth factor mitogenic response by metabolites of linoleic and arachidonic acid in Syrian hamster embryo fibroblasts. Differential effects in tumor suppressor gene (+) and (-) phenotypes
18. The effect of leukotrienes B and selected HETEs on the proliferation of colon cancer cells
19. Effect of polyunsaturated fatty acids on the growth of murine colon adenocarcinomas in vitro and in vivo
20. Novel anti-tumor activity of 2,3,5-trimethyl-6-(3-pyridylmethyl)-1,4-benzoquinone (CV-6504) against established murine adenocarcinomas (MAC)
21. Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound
22. Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis
23. Pharmacology of leukotriene receptor antagonists and 5-lipoxygenase inhibitors in the management of asthma
24. Lipoxygenase inhibitors as potential cancer chemopreventives
25. Characterization of leukotriene A4 synthase from murine mast cells: Evidence for its identity to arachidonate 5-lipoxygenase
26. Requirement of a 5-lipoxygenase -activating protein for leukotriene synthesis
27. Cell biology of the 5-lipoxygenase pathway
28. 5-Lipoxygenase inhibitors reduce PC-3 cell proliferation and initiate nonnecrotic cell death
29. Growth control of lung cancer by interruption of 5-lipoxygenase-mediated growth factor signaling
30. Lipoxygenase-5 is overexpressed in prostate adenocarcinoma
31. Arachidonic acid stimulates prostate cancer cell growth: Critical role of 5-lipoxygenase
32. Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells
33. Inhibitors of lipoxygenase: A new class of cancer chemopreventive agents
34. Lipoxygenase inhibitors abolish proliferation of human pancreatic cancer cells
35. The mRNA overexpression of inflammatory enzymes, phospholipase A2 and cyclooxygenase, in the large bowel mucosa and neoplasms of F344 rats treated with naturally occurring carcinogen, 1-hydroxyanthraquinone
36. Acetyl-11-keto-β-boswellic acid induces apoptosis in HL-60 and CCRF-CEM cells and inhibits topoisomerase I
37. The 5- lipoxygenase-activating protein (FLAP) inhibitor, MK886, induces apoptosis independently of FLAP
38. Sequential morphologic events during apoptosis of human neutrophils. Modulation by lipoxygenase-derived eicosanoids
39. Altered eicosanoid levels in human colon cancer
40. Modulation of cellular phospholipid fatty acids and leukotriene B4 synthesis in the human intestinal cell (CaCo-2)
41. Bile salts determine leukotriene B4 synthesis in a human intestinal cell line (CaCo-2)
42. Sulindac causes rapid regression of preexisting tumors in Min/+ mice independent of prostaglandin biosynthesis
43. Constitutive expression of 8-lipoxygenase in papillomas and clastogenic effects of lipoxygenase-derived arachidonic acid metabolites in keratinocytes
44. 8S-lipoxygenase products activate peroxisome proliferator-activated receptor α and induce differentiation in murine keratinocytes
45. Identification of amino acid determinants of the positional specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2
46. 12(S)-HETE in cancer metastasis
47. Elevated 12-lipoxygenase mRNA expression correlates with advanced stage and poor differentiation of human prostate cancer
48. Expression, subcellular localization and putative function of platelet-type 12-lipoxygenase in human prostate cancer cell lines of different metastatic potential
49. The lipoxygenase metabolite 12(S)-HETE induces a cytoskeleton-dependent increase in surface expression of integfin α IIb β 3 on melanoma cells
50. 12(S)-hydroxyeicostetraenoic acid and 13(S)-hydroxyoctadecadienoic acid regulation of protein kinase C-α in melanoma cells: Role of receptormediated hydrolysis of inositol phospholipids
51. Fatty acid modulation of tumor cell adhesion to microvessel endothelium and experimental metastasis
52. Platelet-type 12-lipoxygenase in a human prostate carcinoma stimulates angiogenesis and tumor growth
53. The lipoxygenase metabolite 12(S)-HETE promotes α IIb β 3 integrin-mediated tumorcell spreading on fibronectin
54. Protein-kinase-C inhibitor calphostin C reduces B16 amelanotic melanoma cell adhesion to endothelium and lung colonization
55. Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis
56. 12(S)-hydroxyeicosatetraenoic acid receptor interacts with steroid receptor coactivator-1
57. 12-Lipoxygenase isoenzymes in mouse skin tumor development
58. Eicosanoid regulation of angiogenesis: Role of endothelial arachidonate 12-lipoxygenase
59. A 12R-lipoxygenase in human skin: Mechanistic evidence, molecular cloning, and expression
60. Discovery of a second 15S-lipoxygenase in humans
61. Occurrence of lipoxygenase products in membranes of rabbit reticulocytes. Evidence for a role of the reticulocyte lipoxygenase in the maturation of red cells
62. Expression of 15-lipoxygenase-1 in human colorectal cancer
63. Epidermal growth factor stimulates linoleic acid metabolism in BALB/c 3T3 fibroblasts
64. Characterization of 15-lipoxygenase in human breast carcinoma BT-20 cells: Stimulation of 13-HODE formation by TGFα/EGF
65. The role of linoleic acid metabolism in the proliferative response of cells overexpressing the erbB-2/HER2 oncogene
66. The correlation between 13-hydroxyoctadecadienoic acid dehydrogenase (13-HODE dehydrogenase) and intestinal cell differentiation
67. Epidermal growth factor-stimulated production of sterified 13(S)-hydroxyoctadecadienoic acid is associated with tumor suppressor phenotype in Syrian hamster embryo fibroblasts
68. Decreased 13-S-hydroxyoctadecadienoic acid levels and 15-lipoxygenase-1 expression in human colon cancers
69. Regulation of the induction of ornithine decarboxylase in short-term rat colon organ culture by dexamethasone and 13-hydroxyoctadecadienoic acid (13-HODE)
70. Induction of epidermal hyperproliferation by topical n-3 polyunsaturated fatty acids on guinea pig skin linked to decreased levels of 13-hydroxyoctadecadienoic acid (13-HODE)
71. Expression of cloned human reticulocyte 15-lipoxygenase and immunological evidence that 15-lipoxygenases of different cell types are related
72. Lipid hydroperoxide-induced apoptosis: Lack of inhibition by Bcl-2 over-expression
73. Expression of 15-lipoxygenase by human colorectal carcinoma Caco-2 cell lines during apoptosis and cell differentiation
74. Changes in expression of 15-lipoxygenase and prostaglandin-H synthase during differentiation of human tracheobronchial epithelial cells
75. Effects of type of dietary fat on phorbol ester-elicited tumor promotion and other events in mouse skin
76. Arachidonate has protumor-promoting action that is inhibited by linoleate in mouse skin carcinogenesis
77. 15-Lipoxygenase-1 mediates nonsteroidal anti-inflammatory drug-induced apoptosis independently of cyclooxygenase-2 in colon cancer cells
78. Nonsteroidal anti-inflammatory drugs induce apoptosis in esophageal cancer cells by restoring 15-lipoxygenase-1 expression
79. Nonsteroidal anti-inflammatory drugs and cancer prevention
80. 15-Lipoxygenase-2 (15-LOX-2) is expressed in benign prostatic epithelium and reduced in prostate adenocarcinoma
81. Reduced 15-lipoxygenase-2 immunostaining in prostate adenocarcinoma: Correlation with grade and expression in high-grade prostatic intraepithelial neoplasia
82. Inhibition of leukotriene biosynthesis by the leukocyte product 15-hydroxy-5,8,11,13-eicosatetraenoic acid
83. Endogenous hydroxyeicosatetraenoic acids stimulate the human polymorphonuclear leukocyte 15-lipoxygenase pathway
84. 15-Hydroxy-5,8,11,13-eicosatetraenoic acid: A potent and selective inhibitor of platelet lipoxygenase
85. Remodeling of neutrophil phospholipids with 15(S)-hydroxyeicosatetraenoic acid inhibits leukotriene B4-induced neutrophil migration across endothelium
86. Characterization of specific subcellular 15-hydroxyeicosatetraenoic acid (15-HETE) binding sites on rat basophilic leukemia cells
87. LTA4 hydrolase expression during glomerular inflammation: Correlation of immunohistochemical localization with cytokine regulation
88. Regulation of lipid signaling pathways for cell survival and apoptosis by bcl-2 in prostate carcinoma cells
89. Incorporation and effect of arachidonic acid on the growth of human myeloma cell lines
90. 15S-hydroxyeicosatetraenoic acid activates peroxisome proliferator-activated receptor γ and inhibits proliferation in PC3 prostate carcinoma cells
91. Lipoxygenase metabolites of arachidonic and linoleic acids modulate the adhesion of tumor cells to endothelium via regulation of protein kinase C
92. Regulation of 15-lipoxygenase expression by cytokines
93. Interleukin-4 mediates cell growth inhibition through activation of Stat 1
94. IL-4 determines eicosanoid formation in dendritic cells by down-regulation of 5-lipoxygenase and up-regulation of 15-lipoxygenase 1 expression
95. Regulation of cellular 15-lipoxygenase activity on pretranstational, translational, and posttranstational levels
96. A GATA binding site is involved in the regulation of 15-lipoxygenase-1 expression in human colorectal carcinoma cell line, caco-2
97. Oxidized LDL regulates macrophage gene expression through ligand activation of PPARγ
98. Differentiation and reversal of malignant changes in colon cancer through PPARγ
99. Peroxisome proliferator-activated receptors α and γ are activated by indomethacin and other non-steroidal anti-inflammatory drugs
100. The diversity of the lipoxygenase family: Many sequence data but little information on biological significance
101. Cancer chemoprevention: Progresspromise