Topoisomerase I-mediated cytotoxicity of N-methyl-N'-nitro-N-nitrosoguanidine: Trapping of topoisomerase I by the O6-methylguanine

Cancer Research

Volumn 61, Issue 1, 2001, Pages 53-58

  Pourquier, Philippe ^a   Waltman, Jessica L ^b   Urasaki, Yoshimasa ^a   Loktionova, Natalia A ^c   Pegg, Anthony E ^c   Nitiss, John L ^b   Pommier, Yves ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b Division of Virology Department of Infectious Diseases St Jude Children's Hospital   (United States)

^c PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; 6 O METHYLGUANINE; 8 HYDROXYGUANINE; ALKYLATING AGENT; DNA TOPOISOMERASE; GUANINE; METHYLNITRONITROSOGUANIDINE; OLIGONUCLEOTIDE;

ANIMAL CELL; ARTICLE; BASE MISPAIRING; BASE PAIRING; CELL PROLIFERATION; CHEMICAL MODIFICATION; CHO CELL; COMPLEX FORMATION; CONTROLLED STUDY; COVALENT BOND; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME DEGRADATION; GENETIC TRANSFECTION; HUMAN; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; STRAIN DIFFERENCE; YEAST;

ALKYLATING AGENTS; ANIMALS; CHO CELLS; CRICETINAE; DNA; DNA TOPOISOMERASES, TYPE I; GUANINE; HUMANS; METHYLNITRONITROSOGUANIDINE; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; SACCHAROMYCES CEREVISIAE; TRANSFECTION;

EID: 0035132902     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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