Abrogation of the S phase DNA damage checkpoint results in S phase progression or premature mitosis depending on the concentration of 7-hydroxystaurosporine and the kinetics of Cdc25C activation

Journal of Biological Chemistry

Volumn 277, Issue 29, 2002, Pages 26553-26564

  Kohn, Ethan A ^a,b   Ruth, Nicola D ^a,b   Brown, Mary Kay ^a,b   Livingstone, Mark ^a,b   Eastman, Alan ^a,b  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b CELL SIGNALING TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DNA; DRUG PRODUCTS; ENZYME KINETICS; TUMORS;

CELL CYCLE ARREST;

BIOCHEMISTRY;

7 HYDROXYSTAUROSPORINE; CELL CYCLE PROTEIN; CYCLIN A; CYCLIN B; DNA TOPOISOMERASE INHIBITOR; PHOSPHATASE; PROTEIN P53;

ARTICLE; CELL ACTIVATION; CELL CYCLE S PHASE; CELL DEATH; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DNA CONTENT; DNA DAMAGE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME KINETICS; HUMAN; HUMAN CELL; MITOSIS; PHENOTYPE; PRIORITY JOURNAL;

ALKALOIDS; BREAST; CAMPTOTHECIN; CDC25 PHOSPHATASE; CELL CYCLE PROTEINS; CELL DEATH; CELLS, CULTURED; CYCLIN A; CYCLIN B; DNA DAMAGE; DNA TOPOISOMERASES, TYPE I; ENZYME INHIBITORS; FEMALE; G1 PHASE; GENES, CDC; HUMANS; KINETICS; MITOSIS; PROTEIN-SERINE-THREONINE KINASES; S PHASE; STAUROSPORINE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0037135554     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M202040200     Document Type: Article

References (43)