Benzo[a]pyrene diol epoxide adducts in DNA are potent suppressors of a normal topoisomerase I cleavage site and powerful inducers of other topoisomerase I cleavages

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 5, 2000, Pages 2040-2045

  Pommier, Yves ^a   Kohlhagen, Glenda ^a   Pourquier, Philippe ^a   Sayer, Jane M ^b   Kroth, Heiko ^b   Jerina, Donald M ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPTOTHECIN; DIHYDROXYBENZO[A]PYRENE OXIDE; DNA TOPOISOMERASE; DOUBLE STRANDED DNA; OLIGONUCLEOTIDE;

ANIMAL CELL; ARTICLE; CARCINOGENICITY; CELL STRAIN V 79; CIS TRANS ISOMERISM; CONTROLLED STUDY; DNA ADDUCT; DNA ALKYLATION; DNA CLEAVAGE; DNA SUPERCOILING; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME REPRESSION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; STEREOISOMERISM;

7,8-DIHYDRO-7,8-DIHYDROXYBENZO(A)PYRENE 9,10-OXIDE; ANIMALS; BINDING SITES; CHO CELLS; CRICETINAE; DNA ADDUCTS; DNA TOPOISOMERASES, TYPE I; HUMANS; RECOMBINANT FUSION PROTEINS; RECOMBINATION, GENETIC;

ANIMALIA; MAMMALIA;

EID: 0034090922     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.040397497     Document Type: Article

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