Innate self recognition by an invariant, rearranged T-cell receptor and its immune consequences

Immunology

Volumn 109, Issue 2, 2003, Pages 171-184

  Stanic, Aleksandar K ^a   Park, Jang June ^a   Joyce, Sebastian ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID DERIVATIVE; ALPHA DEXTRO GALACTOSYLCERAMIDE; ALPHA DEXTRO GLUCOSYLCERAMIDE; ALPHA DEXTRO MANNOSYLCERAMIDE; CD1D ANTIGEN; CERAMIDE DERIVATIVE; CYTOKINE; GLYCOLIPID; INTERLEUKIN 2; IONOMYCIN; LIGAND; LIPID; PHORBOL 13 ACETATE 12 MYRISTATE; T LYMPHOCYTE ANTIGEN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ANTIGEN FUNCTION; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; ANTIGEN STRUCTURE; BINDING AFFINITY; CELL ACTIVITY; CELL FUNCTION; CELL LEVEL; CELL MATURATION; CELLULAR IMMUNITY; IMMUNE RESPONSE; IMMUNE SYSTEM; INFECTION; LIVER TOXICITY; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; NATURAL KILLER CELL; NONHUMAN; ONTOGENY; PRIORITY JOURNAL; PROTEIN ANALYSIS; REVIEW; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TISSUE DISTRIBUTION;

ANTIGEN PRESENTATION; ANTIGENS, CD1; CELL DIFFERENTIATION; CYTOKINES; HUMANS; IMMUNITY, CELLULAR; KILLER CELLS, NATURAL; MODELS, IMMUNOLOGICAL; T-LYMPHOCYTE SUBSETS;

EID: 0038519517     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.2003.01657.x     Document Type: Review

References (156)

1. Bendelac A, Bonneville M, Kearney JF. Autoreactivity by design: innate B and T lymphocytes. Nature Rev Immunol 2001; 1: 177-86.
2. Bendelac A, Medzhitov R. Adjuvants of immunity: harnessing innate immunity to promote adaptive immunity. J Exp Med 2002; 195:F19-23.
3. Smyth MJ, Crowe NY, Hayakawa Y, Takeda K, Yagita H, Godfrey DI. NKT cells - conductors of tumor immunity? Curr Opin Immunol 2002; 14:165-71.
4. Hong S, Wilson MT, Serizawa I et al. The natural killer T-cell ligand α-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice. Nature Med 2001; 7:1052-6.
5. Singh AK, Wilson MT, Hong S et al. Natural killer T cell activation protects mice against experimental autoimmune encephalomyelitis. J Exp Med 2001; 194:1801-11.
6. Wilson MT, Singh AK, Van Kaer L. Immunotherapy with ligands of natural killer T cells. Trends Mol Med 2002; 8:225-31.
7. Sonoda KH, Exley M, Snapper S, Balk SP, Stein-Streilein J. CD1-reactive natural killer T cells are required for development of systemic tolerance through an immune-privileged site. J Exp Med 1999; 190:1215-26.
8. Hong S, Van Kaer L. Immune privilege: keeping an eye on natural killer T cells. J Exp Med 1999; 190:1197-1200.
9. Seino KI, Fukao K, Muramoto K et al. Requirement for natural killer T (NKT) cells in the induction of allograft tolerance. Proc Natl Acad Sci USA 2001; 98:2577-81.
10. + T cells reciprocally regulate acute graft versus host disease. J Exp Med 1999; 189:1073-81.
11. Dascher CC, Hiromatsu K, Naylor JW et al. Conservation of a CD1 multigene family in the guinea pig. J Immunol 1999; 163:5478-88.
12. Chun T, Wang K, Zuckermann FA, Gaskins HR. Molecular cloning and characterization of a novel CD1 gene from the pig. J Immunol 1999; 162:6562-71.
13. Mendiratta SK, Martin WD, Hong S, Boesteanu A, Joyce S, Van Kaer L. CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity 1997; 6:469-77.
14. Porcelli SA, Modlin RL. The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids. Annu Rev Immunol 1999; 17:297-329.
15. Kronenberg M, Gapin L. The unconventional lifestyle of NKT cells. Nature Rev Immunol 2002; 2:557-68.
16. Taniguchi M, Harada M, Kojo S, Nakayama T, Wakao H. The regulatory role of Vα14 NKT cells in innate and adaptive immune response. Annu Rev Immunol 2003; 21:483-513.
17. Joyce S. CD1d and natural T cells: how their properties jump start the immune system. Cell Mol Life Sci 2001; 58:442-69.
18. Gadola SD, Zaccai NR, Harlos K et al. Structure of human CD1b with bound ligands at 2.3A, a maze for alkyl chains. Nature Immunol 2002; 3:721-26.
19. Zeng Z, Castano AR, Segelke BW, Stura EA, Peterson PA, Wilson IA. Crystal structure of mouse CD1: an MHC-like fold with a large hydrophobic binding groove. Science 1997; 277:339-45.
20. Moody DB, Briken V. Cheng TY et al. Lipid length controls antigen entry into endosomal and nonendosomal pathways for CD1b presentation. Nature Immunol 2002; 3:435-42.
21. De Silva AD, Park J-J, Matsuki N, Stanic AK, Brutkiewicz RR, Medof ME, Joyce S. Lipid protein interactions: the assembly of CD1d1 with cellular phospholipids occurs in the endoplasmic reticulum. J Immunol 2002; 168:723-33.
22. Jayawardena-Wolf J, Benlagha K, Chiu YH, Mehr R, Bendelac A. CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain. Immunity 2001; 15:897-908.
23. Sugita M, Porcelli SA, Brenner MB. Assembly and retention of CD1b heavy chains in the endoplasmic reticulum. J Immunol 1997; 159:2358-65.
24. Huttinger R, Staffler G, Majdic O, Stockinger H. Analysis of the early biogenesis of CD1b: involvement of the chaperones calnexin and calreticulin, the proteasome and beta (2)-microglobulin. Int Immunol 1999; 11:1615-23.
25. Kang SJ, Cresswell P. Calnexin, calreticulin, and ERp57 cooperate in disulfide bond formation in human CD1d heavy chain. J Biol Chem 2002; 277:44838-44.
26. Dick TP, Bangia N, Peaper DR, Cresswell P. Disulfide bond isomerization and the assembly of MHC class I-peptide complexes. Immunity 2002; 16:87-98.
27. Gao B, Adhikari R, Howarth M et al. Assembly and antigen-presenting function of MHC class I molecules in cells lacking the ER chaperone calreticulin. Immunity 2002; 16:99-109.
28. Joyce S, Woods AS, Yewdell JW et al. Natural ligand of mouse CD1d1: cellular glycosylphosphatidylinositol. Science 1998; 279:1541-44.
29. Gumperz JE, Roy C, Makowska A, Lum D et al. Murine CD1d-restricted T cell recognition of cellular lipids. Immunity 2000; 12:211-21.
30. Sugita M, Grant EP, van Donselaar E, Hsu VW, Rogers RA, Peters PJ, Brenner MB. Separate pathways for antigen presentation by CD1 molecules. Immunity 1999; 11:743-52.
31. Sugita M, Cao X, Watts GF, Rogers RA, Bonifacino JS, Brenner MB. Failure of trafficking and antigen presentation by CD1 in AP-3-deficient cells. Immunity 2002; 16:697-706.
32. Roberts TJ, Sriram V, Spence PM et al. Recycling CD1d1 molecules present endogenous antigens processed in an endocytic compartment to NKT cells. J Immunol 2002; 168:5409-14.
33. Chiu YH, Jayawardena J, Weiss A, Lee D, Park SH, Dautry-Varsat A, Bendelac A. Distinct subsets of CD1d-restricted T cells recognize self-antigens loaded in different cellular compartments. J Exp Med 1999; 189:103-10.
34. Chiu YH, Park SH, Benlagha K, Forestier C, Jayawardena-Wolf J, Savage PB, Teyton L, Bendelac A. Multiple defects in antigen presentation and T cell development by mice expressing cytoplasmic tail-truncated CD1d. Nat Immunol 2002; 3:55-60.
35. Kang SJ, Cresswell P. Regulation of intracellular trafficking of human CD1d by association with MHC class II molecules. EMBO J 2002; 21:1650-60.
36. Bilsland CAG, Milstein C. The identification of the β2-microglobulin binding antigen encoded by the human CD1D gene. Eur J Immunol 1991; 21:71-80.
37. Lagaudriere-Gesbert C, Newmyer SL, Gregers TF, Bakke O, Ploegh HL. Uncoating ATPase Hsc70 is recruited by invariant chain and controls the size of endocytic compartments. Proc Natl Acad Sci USA 2002; 99:1515-20.
38. Nordeng TW, Gregers TF, Kongsvik TL, Meresse S, Gorvel JP, Jourdan F, Motta A, Bakke O. The cytoplasmic tail of invariant chain regulates endosome fusion and morphology. Mol Biol Cell 2002; 13:1846-56.
39. Villadangos JA, Ploegh HL. Proteolysis in MHC class II antigen presentation: who's in charge? Immunity 2000; 12:233-9.
40. + T cell selection and maturation by cathepsin S. Immunity 2001; 15:909-19.
41. Honey K, Benlagha K, Beers C, Forbush KA, Teyton L, Rudensky A, Bendelac A. Thymocyte expression of cathepsin L is essential for NK T cell development. Nature Immunol; 3:1069-74.
42. von Bulow R, Schmidt B, Dierks T, Schwabauer N, Schilling K, Weber E, Uson I, von Figura K. Defective oligomerization of arylsulfatase a as a cause of its instability in lysosomes and metachromatic leukodystrophy. J Biol Chem 2002; 277:9455-61.
43. Molano A, Park SH, Chiu YH, Nosseir S, Bendelac A, Tsuji M. The IgG response to the circumsporozoite protein is MHC class II-dependent and CD1d-independent: exploring the role of GPIs in NK T cell activation and antimalarial responses. J Immunol 2000; 164:5005-9.
44. Brossay L, Tangri S, Bix M, Cardell S, Locksley R, Kronenberg M. Mouse CD1-autoreactive T cells have diverse patterns of reactivity to CD1+ targets. J Immunol 1998; 160:3681-8.
45. Park S-H, Roark JH, Bendelac A. Tissue-specific recognition of mouse CD1 molecules. J Immunol 1998; 160:3128-34.
46. Kawano T, Cui J, Koezuka Y et al. CD1d-restricted and TCR-mediated activation of Vα14 NKT cells by glycosylceramides. Science 1997; 278:1626-9.
47. Burdin N, Brossay L, Koezuka Y et al. Selective ability of mouse CD1 to present glycolipids: α-galactosylceramide specifically stimulates Vα14+ NK T lymphocytes. J Immunol 1998; 161: 3271-81.
48. Brossay L, Chioda M, Burdin N, Koezuka Y, Casorati G, Dellabona P, Kronenberg M. CD1d-mediated recognition of an α-galactosylceramide by natural killer T cells is highly conserved through mammalian evolution. J Exp Med 1998; 188:1521-8.
49. Spada FM, Koezuka Y, Porcelli SA. CD1d-restricted recognition of synthetic glycolipid antigens by human natural killer T cells. J Exp Med 1998; 188:1529-34.
50. Matsuda JL, Naidenko OV, Gapin L, Nakayama T, Taniguchi M, Wang C-R, Koezuka Y, Kronenberg M. Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers. J Exp Med 2000; 192:741-53.
51. Benlagha K, Weiss A, Beavis A, Teyton L, Bendelac A. In vivo identification of glycolipid antigen-specific T cells using fluorescent CD1d tetramers. J Exp Med 2000; 191:1895-1904.
52. Stanic AK, De Silva AD, Park JJ et al. Defective presentation of the CD1d1-restricted natural Va14Ja18 NKT lymphocyte antigen caused by β-D-glucosylceramide synthase deficiency. Proc Natl Acad Sci USA 1995; 100:1849-54.
53. Sieling PA, Chatterjee D, Porcelli SA et al. CD1 restricted T cell recognition of microbial lipoglycan antigen. Science 2003; 269: 227-30.
54. Prigozy TI, Naidenko O, Qasba P et al. Glycolipid antigen processing for presentation by CD1d molecules. Science 2001; 291:664-7.
55. Moody DB, Reinhold BB, Guy MREMB et al. Structural requirements for glycolipid recognition by CD1b-restricted T cells. Science 1997; 278:283-6.
56. Melian A, Watts GFM, Shamshiv A et al. Molecular recognition of human CD1b antigen complexes: evidence for a common pattern of interaction with αβ TCRs. J Immunol 2000; 165:4494-504.
57. Gui M, Li J, Wen LJ. Hardy RR, Hayakawa K. TCRβ chain influences but does not solely control autoreactivity of Vα14J281 T cells. J Immunol 2001; 167:6239-46.
58. Grant EP, Degano M, Rosat JP, Stenger S, Modlin RL, Wilson IA, Porcelli SA, Brenner MB. Molecular recognition of lipid antigens by T cell receptors. J Exp Med 1999; 189:195-205.
59. Garcia KC, Teyton L, Wilson IA. Structural basis for T cell recognition. Annu Rev Immunol 1999; 17:369-98.
60. Sidobre S, Naidenko OV, Sim BC, Gascoigne NR, Garcia KC, Kronenberg M. The Vα14 NKT cell TCR exhibits high-affinity binding to a glycolipid/CD1d complex. J Immunol 2002; 169:1340-8.
61. Miyamoto K, Miyake S, Yamamura T. A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing Th2 bias of natural killer T cells. Nature 2001; 413:531-4.
62. MacDonald HR. CD1d-glycolipid tetramers: a new tool to monitor natural killer T cells in health and disease. J Exp Med 2000; 192:F15-F19.
63. + thymocytes selected by MHC class I molecules. Science 1994; 263:1774-8.
64. Eberl G, Lees R, Smiley ST, Taniguchi M, Grusby MJ, MacDonald HR. Tissue-specific segregation of CD1d-dependent and CD1d-independent NK T cells. J Immunol 1999; 162:6410-9.
65. Godfrey DI, Hammond KJ, Poulton LD, Smyth MJ, Baxter AG. NKT cells: facts, functions and fallacies. Immunol Today 2000; 21:573-83.
66. + T cell receptor-α/β cells in the liver of mice. J Exp Med 1994; 180:699-704.
67. - single positive thymocyte subpopulation that expresses a highly skewed T cell antigen receptor family. Proc Natl Acad Sci USA 1992; 89:6506-10.
68. Ohteki T, Maki C, Koyasu S, Mak TW, Ohashi PS. LFA-1 is required for liver NK1.1+TCR αβ+ cell development: evidence that liver NK1.1+TCR αβ+ cells originate from multiple pathways. J Immunol 1999; 162:3753-6.
69. MacDonald HR, Lees RK, Held W. Developmentally regulated extinction of Ly-49 receptor expression permits maturation and selection of NK1.1+ T cells. J Exp Med 1998; 187:2109-14.
70. MacDonald HR. T before NK. Science 2002; 296:481-2.
71. Lee PT, Benlagha K, Teyton L, Bendelac A. Distinct functional lineages of human Vα24 natural killer T cells. J Exp Med 2002; 195:637-41.
72. Gumperz JE, Miyake S, Yamamura T, Brenner MB. Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer staining. J Exp Med 2002; 195:625-36.
73. Benlagha K, Kyin T, Beavis A, Teyton L, Bendelac A. A thymic precursor to the NK T cell lineage. Science 2002; 296:553-5.
74. + CD1d-dependent precursor stage. J Exp Med 2002; 195:835-44.
75. Gadue P, Stein PL. NK T cell precursors exhibit differential cytokine regulation and require Itk for efficient maturation. J Immunol 2002; 169:2397-406.
76. Motsinger A, Haas DW, Stanic AK, Van Kaer L, Joyce S, Unutmaz D. CD1d-restricted human natural killer T cells are highly susceptible to human immunodeficiency virus 1 infection. J Exp Med 2002; 195:869-79.
77. Fleuridor R, Wilson B, Hou R, Landay A, Kessler H. Al-Harthi L. CD1d-restricted natural killer T cells are potent targets for human immunodeficiency virus infection. Immunology 2003; 108:3-9.
78. + Vα24 natural killer T cells in human immunodeficiency virus infection. J Virol 2002; 76:7528-34.
79. + NKT cells during HIV type l infection. J Immunol 2002; 168:1490-5.
80. pos T cells promptly produce IL-4 in response to in vivo challenge with anti-CD3. J Exp Med 1994; 179:1285-95.
81. - T cells produce IL-4. J Immunol 1992; 149:1211-5.
82. + T cell development and early IL-4 production in CD1 deficient mice. Immunity 1997; 6:459-67.
83. Smiley ST, Kaplan MH, Grusby MJ. Immunoglobulin E production in the absence of interleukin-4 secreting CD1 dependent cells. Science 1997; 275:977-9.
84. + T cells: their cytokine production and hepatotoxicity in vivo and in vitro. J Immunol 2002; 169:6127-32.
85. Kadowaki N, Antonenko S, Ho S, Rissoan MC, Soumelis V, Porcelli SA, Lanier LL, Liu YJ. Distinct cytokine profiles of neonatal natural killer T cells after expansion with subsets of dendritic cells. J Exp Med 2001; 193:1221-6.
86. Naka T, Tsutsui H, Fujimoto M et al. SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-γ and IL-4 signaling in vivo. Immunity 2001; 14:535-45.
87. Arase H, Arase N, Saito T. Interferonγ production by natural killer (NK) cells and NK1.1 + T cells upon NKR-P1 cross-linking. J Exp Med 1996; 183:2391-6.
88. Matsuda JL, Gapin L, Sidobre S, Kieper WC, Tan JT, Ceredig R, Surh CD, Kronenberg M. Homeostasis of Vα14i NKT cells. Nature Immunol 2002; 3:966-74.
89. Maeda M, Lohwasser S, Yamamura T, Takei F. Regulation of NKT cells by Ly49: analysis of primary NKT cells and generation of NKT cell line. J Immunol 2001; 167:4180-6.
90. Ikarashi Y, Mikami R, Bendelac A et al. Dendritic cell maturation overrules H-2D-mediated natural killer T (NKT) cell inhibition: critical role for B7 in CD1d-dependent NKT cell interferon γ production. J Exp Med 2001; 194:1179-86.
91. Singh N, Hong S, Scherer DC, Serizawa I, Burdin N, Kronenberg M, Koezuka Y, Van Kaer L. Activation of NK T cells by CD1d and α-galactosylceramide directs conventional T cells to the acquisition of a Th2 phenotype. J Immunol 1999; 163:2373-7.
92. Carnaud C, Lee D, Donnars O, Park S-H, Beavis A, Koezuka Y, Bendelac A. Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells. J Immunol 1999; 163: 4647-50.
93. Fujii S, Shimizu K, Kronenberg M, Steinman RM. Prolonged IFN-γ-producing NKT response induced with α-galactosylceramide-loaded DCs. Nature Immunol 2002; 3:867-74.
94. Eberl G, MacDonald HR. Selective induction of NK cell proliferation and cytotoxicity by activated NKT cells. Eur J Immunol 2000; 30:985-92.
95. + T cells in IL-12-induced immune responses in vivo. J Immunol 1998; 160: 16-9.
96. Kitamura H, Iwakabe K, Yahata T et al. The natural killer T (NKT) cell ligand α-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells. J Exp Med 1999; 189:1121-7.
97. Tomura M, Yu WG, Ahn HJ et al. A novel function of Vα14+CD4+ NKT cells: stimulation of IL-12 production by antigen-presenting cells in the innate immune system. J Immunol 1999; 163:93-10.
98. Kitamura H, Ohta A, Sekimoto M et al. α-galactosylceramide induces early B-cell activation through IL-4 production by NKT cells. Cell Immunol 2000; 199:37-42.
99. Burdin N, Brossay L, Kronenberg M. Immunization with α-galactosylceramide polarizes CD1-reactive NK T cells towards Th2 cytokine synthesis. Eur J Immunol 1999; 29:2014-25.
100. Nishimura T, Kitamura H, Iwakabe K et al. The interface between innate and acquired immunity: glycolipid antigen presentation by CD1d-expressing dendritic cells to NKT cells induces the differentiation of antigen-specific cytotoxic T lymphocytes. Int Immunol 2000; 12:987-94.
101. + T cells in vivo. J Immunol 2003; 170:2540-8.
102. Gonzalez-Aseguinolaza G, Van Kaer L, Bergmann CC et al. Natural killer T cell ligand alpha-galactosylceramide enhances protective immunity induced by malaria vaccines. J Exp Med 2002; 195:617-24.
103. Shi FD, Flodstrom M, Balasa B, Kim SH, Van Gunst K, Strominger JL, Wilson SB, Sarvetnick N. Germ line deletion of the CD1 locus exacerbates diabetes in the NOD mouse. Proc Natl Acad Sci USA 2001; 98:6777-82.
104. Naumov YN, Bahjat KS, Gausling R et al. Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets. Proc Natl Acad Sci USA 2001; 98:13838-43.
105. Sharif S, Arreaza GA, Zucker P et al. Activation of natural killer T cells by α-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes. Nature Med 2001; 7:1057-62.
106. Wang B, Geng YB, Wang CR. CD1-restricted NK T cells protect nonobese diabetic mice from developing diabetes. J Exp Med 2001; 194:313-20.
107. Jahng AW, Maricic I, Pedersen B, Burdin N, Naidenko O, Kronenberg M, Koezuka Y, Kumar V. Activation of natural killer T cells potentiates or prevents experimental autoimmune encephalomyelitis. J Exp Med 2001; 194:1789-99.
108. Beaudoin L, Laloux V, Novak J, Lucas B, Lehuen A. NKT cells inhibit the onset of diabetes by impairing the development of pathogenic T cells specific for pancreatic beta cells. Immunity 2002; 17:725-36.
109. Chen H, Huang H, Paul WE. NK1.1+ CD4+ T cells lose NK1.1 expression upon in vitro activation. J Immunol 1997; 158:5112-9.
110. Eberl G, MacDonald HR. Rapid death and regeneration of NKT cells in anti-CD3ε- or IL-12-treated mice: a major role for bone marrow in NKT cell homeostasis. Immunity 1998; 9:345-53.
111. + T cells by CD1 expressing cortical thymocytes. J Exp Med 1995; 182:2091-6.
112. Coles MC, Raulet DH. NK1.1+ T cells in the liver arise in the thymus and are selected by interactions with class I molecules on CD4+CD8+ cells. J Immunol 2000; 164:2412-8.
113. + natural killer-T cell development. Eur J Immunol 1999; 29:3313-8.
114. + NK T cells in the early stages of embryogenesis. Proc Natl Acad Sci USA 1996; 93:6516-20.
115. + non-lymphoid cells residing in the extrathymic organs. Eur J Immunol 1999; 29:3962-70.
116. Shimamura M, Ohteki T, Launois P, Garcia AM, MacDonald HR. Thymus-independent generation of NK1+ T cells in vitro from fetal liver precursors. J Immunol 1997; 158:3682-9.
117. Gapin L, Matsuda JL, Surh CD, Kronenberg M. NKT cells derive from double-positive thymocytes that are positively selected by CD1d. Nature Immunol 2001; 2:971-8.
118. Chun T, Page MJ, Gapin L et al. CD1d-expressing dendritic cells but not thymic epithelial cells can mediate negative selection of NKT cells. J Exp Med 2003; 197:907-18.
119. Bendelac A, Matzinger P, Seder RA, Paul WE, Schwartz RH. Activation events during thymic selection. J Exp Med 1992; 175:731-42.
120. - thymocytes by class I molecules expressed by hematopoietic cells. J Exp Med 1993; 178:901-8.
121. + thymocytes. J Exp Med 1994; 180:395-9.
122. Walunas TL, Wang B, Wang CR, Leiden JM. The Ets1 transcription factor is required for the development of NK T cells in mice. J Immunol 2000; 164:2857-60.
123. Lacorazza HD, Miyazaki Y, Di Cristofano A et al. The ETS protein MEF plays a critical role in perforin gene expression and the development of natural killer and NK-T cells. Immunity 2002; 17:437-49.
124. Ohteki T, Yoshida H, Matsuyama T, Duncan GS, Mak TW, Ohashi PS. The transcription factor interferon regulatory factor 1 (IRF-1) is important during the maturation of natural killer 1.1+ T cell receptor-αβ+ (NK1+ T) cells, natural killer cells, and intestinal intraepithelial T cells. J Exp Med 1998; 187:967-72.
125. Elewaut D, Brossay L, Santee SM et al. Membrane lymphotoxin is required for the development of different subpopulations of NK T cells. J Immunol 2000; 165:671-9.
126. Eberl G, Lowin-Kropf B, MacDonald HR. NKT cell development is selectively impaired in Fyn-deficient mice. J Immunol 1999; 163:4091-4.
127. Gadue P, Morton N, Stein PL. The src family tyrosine kinase Fyn regulates natural killer T cell development. J Exp Med 1999; 190:1189-95.
128. Muthusamy N, Barton K, Leiden JM. Defective activation and survival of T cells lacking the Ets-1 transcription factor. Nature 1995; 377:639-42.
129. Barton K, Muthusamy N, Fischer C, Ting CN, Walunas TL, Lanier LL, Leiden JM. The Ets-1 transcription factor is required for the development of natural killer cells in mice. Immunity 1998; 9: 555-63.
130. Stein PL, Lee HM, Rich S, Soriano P. pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells. Cell 1992; 70:741-50.
131. Binstadt BA, Brumbaugh KM, Dick CJ et al. Sequential involvement of Lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation. Immunity 1996; 5:629-38.
132. Held W, Coudert JD, Zimmer J. The NK cell receptor repertoire: formation, adaptation and exploitation. Curr Opin Immunol 2003; 15:233-7.
133. Groves T, Smiley P, Cooke MP, Forbush K, Perlmutter RM, Guidos CJ. Fyn can partially substitute for Lck in T lymphocyte development. Immunity 1996; 5:417-28.
134. Campbell KS, Buder A, Deuschle U. Interactions between the amino-terminal domain of p561ck and cytoplasmic domains of CD4 and CD8 alpha in yeast. Eur J Immunol 1995; 25:2408-12.
135. Zamoyska R, Derham P, Gorman SD, von Hoegen P, Bolen JB, Veillette A, Parnes JR. Inability of CD8 alpha polypeptides to associate with p561ck correlates with impaired function in vitro and lack of expression in vivo. Nature 1989; 342:278-81.
136. Salmon P, Mong M, Kang XJ, Cado D, Robey E. The role of CD8α in the CD4 versus CD8 lineage choice. J Immunol 1999; 163:5312-8.
137. Boesteanu A, De Silva AD, Nakajima H, Leonard WJ, Peschon JJ, Joyce S. Distinct roles for signals relayed through the common cytokine receptor γ chain and interleukin 7 receptor α chain in natural T cell development. J Exp Med 1997; 186:331-6.
138. Peschon JJ, Morrissey PJ, Grabstein KH et al. Early lymphocyte expansion is severly impaired in interleukin 7 receptor deficient mice. J Exp Med 1994; 180:1955-60.
139. Kennedy MK, Glaccum M, Brown SN et al. Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J Exp Med 2000; 191:771-80.
140. Lodolce JP, Boone DL, Chai S, Swain RE, Dassopoulos T, Trettin S, Ma A. IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity 1998; 9:669-76.
141. + cell development. J Immunol 1997; 159:5931-5.
142. Lantz O, Sharara LI, Tilloy F, Anderson A, DiSanto JP. Lineage relationships and differentiation of natural killer (NK) T cells: intrathymic selection and interleukin (IL)-4 production in the absence of NKR-P1 and Ly49 molecules. J Exp Med 1997; 185:1395-401.
143. Pandey A, Ozaki K, Baumann H et al. Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin. Nature Immunol 2000; 1:59-64.
144. Park SH, Kyin T, Bendelac A, Carnaud C. The contribution of NKT cells, NK cells, and other gamma-chain-dependent non-T non-B cells to IL-12-mediated rejection of tumors. J Immunol 2003; 170:1197-1201.
145. Falcone M, Yeung B, Tucker L, Rodriguez E, Searvetnick N. A defect in IL-12-induced activation and IFN-γ secretion of peripheral natural killer T cells in nonobese diabetic mice suggests new pathogenic mechanisms for insulin-dependent diabetes mellitus (IDDM). J Exp Med 1999; 190:963-72.
146. Oya H, Kawamura T, Shimizu T et al. The differential effect of stress on natural killer T (NKT) and NK cell function. Clin Exp Immunol 2000; 121:384-90.
147. Tamada K, Harada M, Abe K, Li T, Nomoto K. IL-4-producing NK1.1+ T cells are resistant to glucocorticoid-induced apoptosis: implications for the Th1/Th2 balance. J Immunol 1998; 161: 1239-47.
148. Emoto M, Mittrucker HW, Schmits R, Mak TW, Kaufmann SH. Critical role of leukocyte function-associated antigen-1 in liver accumulation of CD4+NKT cells. J Immunol 1999; 162: 5094-8.
149. Miyamoto M, Emoto M, Brinkmann V, van Rooijen N, Schmits R, Kita E, Kaufmann SH. Contribution of NK cells to the homing of thymic CD4+NKT cells to the liver. J Immunol 2000; 165: 1729-32.
150. Kobayashi E, Motoki K, Uchida T, Fukushima H, Koezuka Y. KRN7000, a novel immunomodulator, and its antitumor activities. Oncol Res 1995; 7:529-34.
151. + T cells produce large amounts of IL-4 and IFN-γ upon activation by anti-CD3 or CD1. J Immunol 1997; 159:2240-9.
152. + NKT cells in germ-free mice. Eur J Immunol 2000; 30:620-5.
153. Shinkai K, Locksley RM. CD1, tuberculosis, and the evolution of major histocompatibility complex molecules. J Exp Med 2000; 191:907-14.
154. Chapman R, Sidrauski C, Walter P. Intracellular signalling from the endoplasmic reticulum to the nucleus. Annu Rev Cell Biol 1998; 14:459-85.
155. Carman GM, Henry SA. Phospholipid biosynthesis in yeast. Annu Rev Biochem 1989; 58:635-69.
156. Nunnari J, Walter P. Regulation of organelle biogenesis. Cell 1996; 84:389-94.