Disulfide bond isomerization and the assembly of MHC class I-peptide complexes

Immunity

Volumn 16, Issue 1, 2002, Pages 87-98

  Dick, Tobias P ^a   Bangia, Naveen ^a   Peaper, David R ^a   Cresswell, Peter ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; DISULFIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; OXIDOREDUCTASE; TAPASIN;

ARTICLE; CELL SURFACE; CONTROLLED STUDY; DISULFIDE BOND; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; ISOMERISM; MUTAGENESIS; OXIDATION; PRIORITY JOURNAL; PROTEIN BINDING;

EID: 0036166431     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(02)00263-7     Document Type: Article

References (52)

1. Human transporters associated with antigen processing possess a promiscuous peptide-binding site
2. Evidence that transporters associated with antigen processing translocate a major histocompatibility complex class I-binding peptide into the endoplasmic reticulum in an ATP-dependent manner
3. The N-terminal region of tapasin is required to stabilize the MHC class I loading complex
4. The nature of the MHC class I peptide loading complex
5. Homozygous deletions that simultaneously eliminate expressions of class I and class II antigens of EBV-transformed B-lymphoblastoid cells. I. Reduced proliferative responses of autologous and allogeneic T cells to mutant cells that have decreased expression of class II antigens
6. Identification of the peptide binding motif for HLA-B44, one of the most common HLA-B alleles in the Caucasian population
7. Thiol oxidation and reduction in MHC class I-restricted antigen processing and presentation
8. A role for calnexin in the assembly of the MHC class I loading complex in the endoplasmic reticulum
9. Lack of HLA class I antigen expression by cultured melanoma cells FO-1 due to a defect in B2m gene expression
10. The role of ERp57 in disulfide bond formation during the assembly of major histocompatibility complex class I in a synchronized semipermeabilized cell translation system
11. Impaired immune responses and altered peptide repertoire in tapasin-deficient mice
12. Impaired assembly yet normal trafficking of MHC class I molecules in Tapasin mutant mice
13. Novel allele-specific, post-translational reduction in HLA class I surface expression in a mutant human B cell line
14. Quality control in the secretory pathway: Retention of a misfolded viral membrane glycoprotein involves cycling between the ER, intermediate compartment, and Golgi apparatus
15. Association of ERp57 with mouse MHC class I molecules is tapasin dependent and mimics that of calreticulin and not calnexin
16. Intracellular functions of N-linked glycans
17. Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC
18. The thiol oxidoreductase ERp57 is a component of the MHC class I peptide-loading complex
19. Misfolded major histocompatibility complex class I heavy chains are translocated into the cytoplasm and degraded by the proteasome
20. Monoclonal antibodies to the human multicatalytic proteinase (proteasome)
21. DsbA-DsbB interaction through their active site cysteines. Evidence from an odd cysteine mutant of DsbA
22. Soluble tapasin restores MHC class I expression and function in the tapasin-negative cell line .220
23. Cloning and functional characterization of a subunit of the transporter associated with antigen processing
24. ER-60, a chaperone with thiol-dependent reductase activity involved in MHC class I assembly
25. ER60/ERp57 forms disulfide-bonded intermediates with MHC class I heavy chain
26. An epitope common to HLA class I and class II antigens, Ig light chains, and beta 2-microglobulin
27. Reduction in susceptibility to natural killer cell-mediated lysis of human FO-1 melanoma cells after induction of HLA class I antigen expression by transfection with B2m gene
28. Functional expression and purification of the ABC transporter complex associated with antigen processing (TAP) in insect cells
29. Glycoproteins form mixed disulphides with oxidoreductases during folding in living cells
30. A cluster of mutations in HLA-A2 alpha 2 helix abolishes peptide recognition by T cells
31. A role for the thiol-dependent reductase ERp57 in the assembly of MHC class I molecules
32. Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter
33. ERp57 functions as a subunit of specific complexes formed with the ER lectins calreticulin and calnexin
34. MHC class I/beta 2-microglobulin complexes associate with TAP transporters before peptide binding
35. A critical role for tapasin in the assembly and function of multimeric MHC class I-TAP complexes
36. Mechanisms of MHC class I-restricted antigen processing
37. Use of a monoclonal antibody (W6/32) in structural studies of HLA-A,B,C, antigens
38. A point mutation in HLA-A*0201 results in failure to bind the TAP complex and to present virus-derived peptides to CTL
39. HLA-B27-restricted antigen presentation in the absence of tapasin reveals polymorphism in mechanisms of HLA class I peptide loading
40. Quantitative and qualitative influences of tapasin on the class I peptide repertoire
41. A monoclonal antibody 7G7/B6, binds to an epitope on the human interleukin-2 (IL-2) receptor that is distinct from that recognized by IL-2 or anti-Tac
42. Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP
43. Impaired assembly and transport of HLA-A and -B antigens in a mutant TxB cell hybrid
44. Retention of empty MHC class I molecules by tapasin is essential to reconstitute antigen presentation in invertebrate cells
45. Characterization of class I MHC folding intermediates and their disparate interactions with peptide and beta 2-microglobulin
46. Prominence of beta 2-microglobulin, class I heavy chain conformation, and tapasin in the interactions of class I heavy chain with calreticulin and the transporter associated with antigen processing
47. Definition of the lectin-like properties of the molecular chaperone, calreticulin, and demonstration of its copurification with endomannosidase from rat liver Golgi
48. Beta 2-microglobulin and calnexin can independently promote folding and disulfide bond formation in class I histocompatibility proteins
49. Functional equivalents of interferon-mediated signals needed for induction of an mRNA can be generated by double-stranded RNA and growth factors
50. Assembly of MHC class I molecules analyzed in vitro
51. Scanning and escape during protein-disulfide isomerase-assisted protein folding
52. Catalysis of oxidative protein folding by mutants of protein disulfide isomerase with a single active-site cysteine