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Volumn 15, Issue 2, 2003, Pages 233-237

The NK cell receptor repertoire: Formation, adaptation and exploitation

Author keywords

[No Author keywords available]

Indexed keywords

CELL RECEPTOR;

EID: 0037375569     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(02)00031-6     Document Type: Review
Times cited : (29)

References (58)
  • 1
    • 0025300414 scopus 로고
    • In search of the 'missing self': MHC molecules and NK cell recognition
    • Ljunggren H.G., Kärre K. In search of the 'missing self': MHC molecules and NK cell recognition. Immunol. Today. 11:1990;237-244.
    • (1990) Immunol. Today , vol.11 , pp. 237-244
    • Ljunggren, H.G.1    Kärre, K.2
  • 2
    • 0034895155 scopus 로고    scopus 로고
    • Strategies for target cell recognition by natural killer cells
    • Diefenbach A., Raulet D.H. Strategies for target cell recognition by natural killer cells. Immunol. Rev. 181:2001;170-184.
    • (2001) Immunol. Rev. , vol.181 , pp. 170-184
    • Diefenbach, A.1    Raulet, D.H.2
  • 4
    • 0036079077 scopus 로고    scopus 로고
    • In vivo developmental stages in murine natural killer cell maturation
    • This paper proposes distinct stages of NK cell development based on phenotypic (differential expression of adhesion molecules) and functional properties. In addition, bone marrow NK cells are shown to undergo a phase of intense proliferation.
    • Kim S., Iizuka K., Kang H.-S.P., Dokun A., French A.R., Greco D., Yokoyama W.M. In vivo developmental stages in murine natural killer cell maturation. Nat. Immunol. 3:2002;523-528 This paper proposes distinct stages of NK cell development based on phenotypic (differential expression of adhesion molecules) and functional properties. In addition, bone marrow NK cells are shown to undergo a phase of intense proliferation.
    • (2002) Nat. Immunol. , vol.3 , pp. 523-528
    • Kim, S.1    Iizuka, K.2    Kang, H.-S.P.3    Dokun, A.4    French, A.R.5    Greco, D.6    Yokoyama, W.M.7
  • 5
    • 0034001276 scopus 로고    scopus 로고
    • NK cell expression of the killer cell lectin-like receptor G1 (KLRG1), the mouse homolog of MAFA, is modulated by MHC class I molecules
    • Corral L., Hanke T., Vance R.E., Cado D., Raulet D.H. NK cell expression of the killer cell lectin-like receptor G1 (KLRG1), the mouse homolog of MAFA, is modulated by MHC class I molecules. Eur. J. Immunol. 30:2000;920-930.
    • (2000) Eur. J. Immunol. , vol.30 , pp. 920-930
    • Corral, L.1    Hanke, T.2    Vance, R.E.3    Cado, D.4    Raulet, D.H.5
  • 6
    • 0030837357 scopus 로고    scopus 로고
    • Immunoglobulin superfamily inhibitory receptors: From natural killer cells to antigen-presenting cells
    • Colonna M. Immunoglobulin superfamily inhibitory receptors: from natural killer cells to antigen-presenting cells. Res. Immunol. 148:1997;169-171.
    • (1997) Res. Immunol. , vol.148 , pp. 169-171
    • Colonna, M.1
  • 9
    • 0032538916 scopus 로고    scopus 로고
    • Mouse CD94/NKG2A is a natural killer cell receptor for the nonclassical major histocompatibility complex (MHC) class I molecule Qa-1(b)
    • Vance R.E., Kraft J.R., Altman J.D., Jensen P.E., Raulet D.H. Mouse CD94/NKG2A is a natural killer cell receptor for the nonclassical major histocompatibility complex (MHC) class I molecule Qa-1(b). J. Exp. Med. 188:1998;1841-1848.
    • (1998) J. Exp. Med. , vol.188 , pp. 1841-1848
    • Vance, R.E.1    Kraft, J.R.2    Altman, J.D.3    Jensen, P.E.4    Raulet, D.H.5
  • 10
    • 0032510146 scopus 로고    scopus 로고
    • Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells
    • Lanier L.L., Corliss B.C., Wu J., Leong C., Phillips J. Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells. Nature. 391:1998;703-707.
    • (1998) Nature , vol.391 , pp. 703-707
    • Lanier, L.L.1    Corliss, B.C.2    Wu, J.3    Leong, C.4    Phillips, J.5
  • 11
    • 0035056004 scopus 로고    scopus 로고
    • Regulation of the natural killer cell receptor repertoire
    • Raulet D.H., Vance R.E., McMahon C.W. Regulation of the natural killer cell receptor repertoire. Annu. Rev. Immunol. 19:2001;291-330.
    • (2001) Annu. Rev. Immunol. , vol.19 , pp. 291-330
    • Raulet, D.H.1    Vance, R.E.2    McMahon, C.W.3
  • 12
    • 0036183321 scopus 로고    scopus 로고
    • Structure and function of major histocompatibility complex (MHC) class I specific receptors expressed on human natural killer (NK) cells
    • Borrego F., Kabat J., Kim D.-K., Lieto L., Maasho K., Pena J., Solana R., Coligan J.E. Structure and function of major histocompatibility complex (MHC) class I specific receptors expressed on human natural killer (NK) cells. Mol. Immunol. 38:2001;637-660.
    • (2001) Mol. Immunol. , vol.38 , pp. 637-660
    • Borrego, F.1    Kabat, J.2    Kim, D.-K.3    Lieto, L.4    Maasho, K.5    Pena, J.6    Solana, R.7    Coligan, J.E.8
  • 14
    • 0033060625 scopus 로고    scopus 로고
    • The natural killer gene complex genetic locus Chok encodes Ly-49D, a target recognition receptor that activates natural killing
    • Idris A.H., Smith H.R.C., Mason L.H., Ortaldo J., Scalzo A.A., Yokoyama W.M. The natural killer gene complex genetic locus Chok encodes Ly-49D, a target recognition receptor that activates natural killing. Proc. Natl. Acad. Sci. U.S.A. 96:1999;6330-6335.
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 6330-6335
    • Idris, A.H.1    Smith, H.R.C.2    Mason, L.H.3    Ortaldo, J.4    Scalzo, A.A.5    Yokoyama, W.M.6
  • 15
    • 0036644071 scopus 로고    scopus 로고
    • A ligand for the murine NK activation receptor Ly-49D: Activation of tolerized NK cells from β2-microglobulin-deficient mice
    • The authors present a demonstration that the Chinese hamster classical MHC class I molecule, Hm1-C4, is a ligand for the murine activating NKR, Ly49D. This explains the killing of the xenogeneic Chinese hamster ovary cell line CHO by murine NK cells through a Ly49D-dependent mechanism [13,14].
    • Furukawa H., Iizuka K., Poursine-Laurent J., Shastri N., Yokoyama W.M. A ligand for the murine NK activation receptor Ly-49D: activation of tolerized NK cells from β2-microglobulin-deficient mice. J. Immunol. 169:2002;126-136 The authors present a demonstration that the Chinese hamster classical MHC class I molecule, Hm1-C4, is a ligand for the murine activating NKR, Ly49D. This explains the killing of the xenogeneic Chinese hamster ovary cell line CHO by murine NK cells through a Ly49D-dependent mechanism [13,14].
    • (2002) J. Immunol. , vol.169 , pp. 126-136
    • Furukawa, H.1    Iizuka, K.2    Poursine-Laurent, J.3    Shastri, N.4    Yokoyama, W.M.5
  • 16
    • 0037123607 scopus 로고    scopus 로고
    • Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors
    • Using an elegant reporter gene assay, this paper demonstrates the interaction of a virus-encoded molecule with an activating NK cell receptor. The MHC-like protein m157 encoded by MCMV binds to the activating receptor Ly49H. Indeed, Ly49H expression (e.g. in C57BL/6 mice) correlates with low virus titers in the spleens of MCMV-infected mice. In certain mouse strains, Ly49H is not expressed (e.g. BALB/c) or m157 binds to an allelic form of the inhibitory NK cell receptor Ly49I (e.g. 129/J). These latter cases correlate with high MCMV titers in infected mice.
    • Arase H., Mocarski E.S., Campbell A.E., Hill A.B., Lanier L.L. Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors. Science. 296:2002;1323-1326 Using an elegant reporter gene assay, this paper demonstrates the interaction of a virus-encoded molecule with an activating NK cell receptor. The MHC-like protein m157 encoded by MCMV binds to the activating receptor Ly49H. Indeed, Ly49H expression (e.g. in C57BL/6 mice) correlates with low virus titers in the spleens of MCMV-infected mice. In certain mouse strains, Ly49H is not expressed (e.g. BALB/c) or m157 binds to an allelic form of the inhibitory NK cell receptor Ly49I (e.g. 129/J). These latter cases correlate with high MCMV titers in infected mice.
    • (2002) Science , vol.296 , pp. 1323-1326
    • Arase, H.1    Mocarski, E.S.2    Campbell, A.E.3    Hill, A.B.4    Lanier, L.L.5
  • 18
    • 0036326792 scopus 로고    scopus 로고
    • Definition of gene content for nine common group B haplotypes of the Caucasoid population: KIR haplotypes contain between seven and eleven KIR genes
    • Uhrberg M., Parham P., Wernet P. Definition of gene content for nine common group B haplotypes of the Caucasoid population: KIR haplotypes contain between seven and eleven KIR genes. Immunogenetics. 54:2002;221-229.
    • (2002) Immunogenetics , vol.54 , pp. 221-229
    • Uhrberg, M.1    Parham, P.2    Wernet, P.3
  • 19
    • 0036200072 scopus 로고    scopus 로고
    • A BAC contig map of the Ly49 gene cluster in 129 mice reveals extensive differences in gene content relative to C57BL/6 mice
    • Makrigiannis A.P., Pau A.T., Schwartzenberg P.L., McVicar D.W., Beck T.W., Anderson S.K. A BAC contig map of the Ly49 gene cluster in 129 mice reveals extensive differences in gene content relative to C57BL/6 mice. Genomics. 79:2002;437-444.
    • (2002) Genomics , vol.79 , pp. 437-444
    • Makrigiannis, A.P.1    Pau, A.T.2    Schwartzenberg, P.L.3    McVicar, D.W.4    Beck, T.W.5    Anderson, S.K.6
  • 21
    • 0033168152 scopus 로고    scopus 로고
    • Diversity of NK cell receptor repertoire in adult and neonatal mice
    • Kubota A., Kubota S., Lohwasser S., Mager D.L., Takei F. Diversity of NK cell receptor repertoire in adult and neonatal mice. J. Immunol. 163:1999;212-216.
    • (1999) J. Immunol. , vol.163 , pp. 212-216
    • Kubota, A.1    Kubota, S.2    Lohwasser, S.3    Mager, D.L.4    Takei, F.5
  • 23
    • 0033567959 scopus 로고    scopus 로고
    • Stochastic acquisition of Qa1 receptors during the development of fetal NK cells in vitro accounts in part but not in whole for the ability of these cells to distinguish between class I-sufficient and class I-deficient targets
    • Toomey J.A., Salcedo M., Cotterill L.A., Millrain M.M., Chrzanowska-Lightowlers Z., Lawry J., Fraser K., Gays F., Robinson J.H., Shrestha S.et al. Stochastic acquisition of Qa1 receptors during the development of fetal NK cells in vitro accounts in part but not in whole for the ability of these cells to distinguish between class I-sufficient and class I-deficient targets. J. Immunol. 163:1999;3176-3184.
    • (1999) J. Immunol. , vol.163 , pp. 3176-3184
    • Toomey, J.A.1    Salcedo, M.2    Cotterill, L.A.3    Millrain, M.M.4    Chrzanowska-Lightowlers, Z.5    Lawry, J.6    Fraser, K.7    Gays, F.8    Robinson, J.H.9    Shrestha, S.10
  • 25
    • 0033923546 scopus 로고    scopus 로고
    • Clonal analysis of NK cell development from bone marrow progenitors in vitro: Orderly acquisition of receptor gene expression
    • Williams N.S., Kubota A., Bennett M., Kumar V., Takei F. Clonal analysis of NK cell development from bone marrow progenitors in vitro: orderly acquisition of receptor gene expression. Eur. J. Immunol. 30:2000;2074-2082.
    • (2000) Eur. J. Immunol. , vol.30 , pp. 2074-2082
    • Williams, N.S.1    Kubota, A.2    Bennett, M.3    Kumar, V.4    Takei, F.5
  • 26
    • 0033696008 scopus 로고    scopus 로고
    • Clonal acquisition of inhibitory Ly49 receptors on developing NK cells is successively restricted and regulated by stromal class I MHC
    • Roth C., Carlyle J., Takizawa H., Raulet D.H. Clonal acquisition of inhibitory Ly49 receptors on developing NK cells is successively restricted and regulated by stromal class I MHC. Immunity. 13:2000;143-153.
    • (2000) Immunity , vol.13 , pp. 143-153
    • Roth, C.1    Carlyle, J.2    Takizawa, H.3    Raulet, D.H.4
  • 27
    • 0035437190 scopus 로고    scopus 로고
    • Human natural killer cells with polyclonal lectin and immunoglobulinlike receptors develop from single hematopoietic stem cells with preferential expression of NKG2A and KIR2DL2/L3/S2
    • - progenitor cells require IL-15 (or IL-2) and contact with a murine fetal liver cell line to acquire CD94 and KIR expression. Single precursors give rise to NK cells with a diverse receptor repertoire, whereby certain KIRs (such as KIR2DL2/L3/S2) are over-represented.
    • - progenitor cells require IL-15 (or IL-2) and contact with a murine fetal liver cell line to acquire CD94 and KIR expression. Single precursors give rise to NK cells with a diverse receptor repertoire, whereby certain KIRs (such as KIR2DL2/L3/S2) are over-represented.
    • (2001) Blood , vol.98 , pp. 705-713
    • Miller, J.S.1    McCullar, V.2
  • 28
    • 0027220211 scopus 로고
    • Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes
    • Petrie H.T., Livak F., Schatz D.G., Strasser A., Crispe I.N., Shortman K. Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes. J. Exp. Med. 178:1993;615-622.
    • (1993) J. Exp. Med. , vol.178 , pp. 615-622
    • Petrie, H.T.1    Livak, F.2    Schatz, D.G.3    Strasser, A.4    Crispe, I.N.5    Shortman, K.6
  • 31
    • 0035808780 scopus 로고    scopus 로고
    • Expression of natural killer receptor alleles at different Ly49 loci occurs independently and is regulated by major histocompatibility complex class I molecules
    • Tanamachi D.M., Hanke T., Takizawa H., Jamieson A.M., Raulet D.H. Expression of natural killer receptor alleles at different Ly49 loci occurs independently and is regulated by major histocompatibility complex class I molecules. J. Exp. Med. 193:2001;307-315.
    • (2001) J. Exp. Med. , vol.193 , pp. 307-315
    • Tanamachi, D.M.1    Hanke, T.2    Takizawa, H.3    Jamieson, A.M.4    Raulet, D.H.5
  • 32
    • 0033212750 scopus 로고    scopus 로고
    • Clonal acquisition of the Ly49A NK cell receptor is dependent on the trans-acting factor TCF-1
    • Held W., Kunz B., Lowin-Kropf B., van de Wetering M., Clevers H. Clonal acquisition of the Ly49A NK cell receptor is dependent on the trans-acting factor TCF-1. Immunity. 11:1999;433-442.
    • (1999) Immunity , vol.11 , pp. 433-442
    • Held, W.1    Kunz, B.2    Lowin-Kropf, B.3    Van de Wetering, M.4    Clevers, H.5
  • 33
    • 0035873419 scopus 로고    scopus 로고
    • Positive and negative roles of the trans-acting factor TCF-1 for the acquisition of distinct Ly49 MHC class I receptors by NK cells
    • Kunz B., Held W. Positive and negative roles of the trans-acting factor TCF-1 for the acquisition of distinct Ly49 MHC class I receptors by NK cells. J. Immunol. 166:2001;6181-6187.
    • (2001) J. Immunol. , vol.166 , pp. 6181-6187
    • Kunz, B.1    Held, W.2
  • 34
    • 0037108489 scopus 로고    scopus 로고
    • Crucial role of DNA methylation in determination of clonally distributed killer cell Ig-like receptor expression patterns in NK cells
    • A demonstration that expressed KIR genes are demethylated, whereas silenced ones are methylated. Importantly, demethylation in vitro, using 5-azacytidine, results in de novo KIR gene expression.
    • Santourlidis S., Trompeter H.-I., Weinhold S., Eisermann B., Meyer K.L., Wernet P., Uhrberg M. Crucial role of DNA methylation in determination of clonally distributed killer cell Ig-like receptor expression patterns in NK cells. J. Immunol. 169:2002;4253-4261 A demonstration that expressed KIR genes are demethylated, whereas silenced ones are methylated. Importantly, demethylation in vitro, using 5-azacytidine, results in de novo KIR gene expression.
    • (2002) J. Immunol. , vol.169 , pp. 4253-4261
    • Santourlidis, S.1    Trompeter, H.-I.2    Weinhold, S.3    Eisermann, B.4    Meyer, K.L.5    Wernet, P.6    Uhrberg, M.7
  • 35
    • 0029057043 scopus 로고
    • Loss of HLA class I antigens by melanoma cells: Molecular mechanisms, functional significance and clinical relevance
    • Ferrone S., Marincola F.M. Loss of HLA class I antigens by melanoma cells: molecular mechanisms, functional significance and clinical relevance. Immunol. Today. 16:1995;487-494.
    • (1995) Immunol. Today , vol.16 , pp. 487-494
    • Ferrone, S.1    Marincola, F.M.2
  • 36
    • 0033151621 scopus 로고    scopus 로고
    • The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells
    • Cohen G.B., Gandhi R.T., Davis D.M., Mandelboim O., Chen B.K., Strominger J.L., Baltimore D. The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells. Immunity. 10:1999;661-671.
    • (1999) Immunity , vol.10 , pp. 661-671
    • Cohen, G.B.1    Gandhi, R.T.2    Davis, D.M.3    Mandelboim, O.4    Chen, B.K.5    Strominger, J.L.6    Baltimore, D.7
  • 37
    • 0342948593 scopus 로고    scopus 로고
    • A role for MHC class I down-regulation in NK cell lysis of herpes virus-infected cells
    • Huard B., Früh K. A role for MHC class I down-regulation in NK cell lysis of herpes virus-infected cells. Eur. J. Immunol. 30:2000;509-515.
    • (2000) Eur. J. Immunol. , vol.30 , pp. 509-515
    • Huard, B.1    Früh, K.2
  • 39
    • 0035914743 scopus 로고    scopus 로고
    • + Natural Killer (NK) cells precludes ligand uptake from environmental cells: Implications for NK cell function
    • + Natural Killer (NK) cells precludes ligand uptake from environmental cells: implications for NK cell function. J. Exp. Med. 194:2001;1531-1539.
    • (2001) J. Exp. Med. , vol.194 , pp. 1531-1539
    • Zimmer, J.1    Ioannidis, V.2    Held, W.3
  • 40
    • 0033540084 scopus 로고    scopus 로고
    • Crystal structure of a lectin-like natural killer cell receptor bound to its MHC class I ligand
    • Tormo J., Natarajan K., Margulies D.H., Mariuzza R.A. Crystal structure of a lectin-like natural killer cell receptor bound to its MHC class I ligand. Nature. 402:1999;623-631.
    • (1999) Nature , vol.402 , pp. 623-631
    • Tormo, J.1    Natarajan, K.2    Margulies, D.H.3    Mariuzza, R.A.4
  • 42
    • 0035184735 scopus 로고    scopus 로고
    • MHC-dependent shaping of the inhibitory Ly49 receptor repertoire on NK cells: Evidence for a regulated sequential model
    • •] analyze the adaptation of the Ly49 receptor repertoire in mice transgenic for Ly49C and/or Ly49A. They show that MHC class I engagement by a transgenic Ly49 receptor limits the expression of endogenous Ly49 receptors, irrespective of their MHC class I specificity. These findings are in agreement with sequential receptor acquisition and continuous adaptation to self-MHC class I, which, as one consequence, limits further receptor acquisition.
    • •] analyze the adaptation of the Ly49 receptor repertoire in mice transgenic for Ly49C and/or Ly49A. They show that MHC class I engagement by a transgenic Ly49 receptor limits the expression of endogenous Ly49 receptors, irrespective of their MHC class I specificity. These findings are in agreement with sequential receptor acquisition and continuous adaptation to self-MHC class I, which, as one consequence, limits further receptor acquisition.
    • (2002) Eur. J. Immunol. , vol.31 , pp. 3370-3379
    • Hanke, T.1    Takizawa, H.2    Raulet, D.H.3
  • 43
    • 0025880648 scopus 로고
    • MHC class I deficiency: Susceptibility to natural killer (NK) cells and impaired NK activity
    • Liao N., Bix M., Zijlstra M., Jaenisch R., Raulet D. MHC class I deficiency: susceptibility to natural killer (NK) cells and impaired NK activity. Science. 253:1991;199-202.
    • (1991) Science , vol.253 , pp. 199-202
    • Liao, N.1    Bix, M.2    Zijlstra, M.3    Jaenisch, R.4    Raulet, D.5
  • 44
    • 0031974121 scopus 로고    scopus 로고
    • Activity and phenotype of natural killer cells in peptide transporter (TAP)-deficient patients (type I bare lymphocyte syndrome)
    • Zimmer J., Donato L., Hanau D., Cazenave J.P., Tongio M.M., Moretta A., de la Salle H. Activity and phenotype of natural killer cells in peptide transporter (TAP)-deficient patients (type I bare lymphocyte syndrome). J. Exp. Med. 187:1998;117-122.
    • (1998) J. Exp. Med. , vol.187 , pp. 117-122
    • Zimmer, J.1    Donato, L.2    Hanau, D.3    Cazenave, J.P.4    Tongio, M.M.5    Moretta, A.6    De la Salle, H.7
  • 45
    • 0036210733 scopus 로고    scopus 로고
    • A role for the src family kinase Fyn in NK cell activation and the formation of the repertoire of Ly49 receptors
    • NK cell activation by normal missing-self target cells depends in part on the src family kinase fyn. Fyn-deficient NK cells show reduced Ly49 receptor usage.
    • Lowin-Kropf B., Kunz B., Schneider P., Held W. A role for the src family kinase Fyn in NK cell activation and the formation of the repertoire of Ly49 receptors. Eur. J. Immunol. 32:2002;773-782 NK cell activation by normal missing-self target cells depends in part on the src family kinase fyn. Fyn-deficient NK cells show reduced Ly49 receptor usage.
    • (2002) Eur. J. Immunol. , vol.32 , pp. 773-782
    • Lowin-Kropf, B.1    Kunz, B.2    Schneider, P.3    Held, W.4
  • 46
    • 0036194976 scopus 로고    scopus 로고
    • Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases
    • This paper shows that activation pathways using NKG2D and the ITAM-binding molecules Syk/ZAP-70 are not required for killing normal missing-self target cells. In this case, Ly49 receptor usage is unperturbed.
    • Colucci F., Schweighofer E., Tomasello E., Turner M., Ortaldo J.R., Vivier E., Tybulewicz L.J., Di Santo J.P. Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases. Nat. Immunol. 3:2002;288-294 This paper shows that activation pathways using NKG2D and the ITAM-binding molecules Syk/ZAP-70 are not required for killing normal missing-self target cells. In this case, Ly49 receptor usage is unperturbed.
    • (2002) Nat. Immunol. , vol.3 , pp. 288-294
    • Colucci, F.1    Schweighofer, E.2    Tomasello, E.3    Turner, M.4    Ortaldo, J.R.5    Vivier, E.6    Tybulewicz, L.J.7    Di Santo, J.P.8
  • 47
    • 0037007090 scopus 로고    scopus 로고
    • Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation
    • - progenitors into NK cells, activation receptors, such as NKp46 and NKp30, are expressed before HLA class I-specific inhibitory receptors, raising the question of how tolerance is ensured. Interestingly, in immature NK cells, 2B4 may function as an inhibitory receptor and not as a co-receptor for NK cell activation (see also [48]).
    • - progenitors into NK cells, activation receptors, such as NKp46 and NKp30, are expressed before HLA class I-specific inhibitory receptors, raising the question of how tolerance is ensured. Interestingly, in immature NK cells, 2B4 may function as an inhibitory receptor and not as a co-receptor for NK cell activation (see also [48]).
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 4526-4531
    • Sivori, S.1    Falco, M.2    Marcenaro, E.3    Parolini, S.4    Biassoni, R.5    Bottino, C.6    Moretta, L.7    Moretta, A.8
  • 50
    • 0037086351 scopus 로고    scopus 로고
    • Influence of SHIP on the NK repertoire and allogeneic bone marrow transplantation
    • This paper shows that certain Ly49-defined NK cell subsets expand over time in the absence of SHIP.
    • Wang J.-W., Howson J.M., Ghansah T., Desponts C., Ninos J.M., May S.L., Nguyen K.H.T., Toyamam-Sorimachi N., Kerr W.G. Influence of SHIP on the NK repertoire and allogeneic bone marrow transplantation. Science. 295:2002;2094-2097 This paper shows that certain Ly49-defined NK cell subsets expand over time in the absence of SHIP.
    • (2002) Science , vol.295 , pp. 2094-2097
    • Wang, J.-W.1    Howson, J.M.2    Ghansah, T.3    Desponts, C.4    Ninos, J.M.5    May, S.L.6    Nguyen, K.H.T.7    Toyamam-Sorimachi, N.8    Kerr, W.G.9
  • 52
    • 0037086131 scopus 로고    scopus 로고
    • Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants
    • This paper greatly extends the authors previous data [53]. Haploidentical bone marrow transplantation (the critical point is, in fact, that one haplotype is not identical) allows for NK cell alloreactivity in the donor versus recipient direction. That feature very favorably influences engraftment and the control of acute myeloid leukemia in the recipient. Mouse experiments indeed suggest that alloreactive NK cells have not only a graft versus leukemia (GvL) effect (no relapse) but also eliminate the recipient's T cells (no graft rejection) and dendritic cells (no recipient antigen presentation to donor T cells and thus no GvHD).
    • Ruggeri L., Capanni M., Urbani E., Perruccio K., Shlomchik W.D., Tosti A., Posati S., Rogaia D., Frassoni F., Aversa F.et al. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science. 295:2002;2097-2100 This paper greatly extends the authors previous data [53]. Haploidentical bone marrow transplantation (the critical point is, in fact, that one haplotype is not identical) allows for NK cell alloreactivity in the donor versus recipient direction. That feature very favorably influences engraftment and the control of acute myeloid leukemia in the recipient. Mouse experiments indeed suggest that alloreactive NK cells have not only a graft versus leukemia (GvL) effect (no relapse) but also eliminate the recipient's T cells (no graft rejection) and dendritic cells (no recipient antigen presentation to donor T cells and thus no GvHD).
    • (2002) Science , vol.295 , pp. 2097-2100
    • Ruggeri, L.1    Capanni, M.2    Urbani, E.3    Perruccio, K.4    Shlomchik, W.D.5    Tosti, A.6    Posati, S.7    Rogaia, D.8    Frassoni, F.9    Aversa, F.10
  • 54
    • 0031568668 scopus 로고    scopus 로고
    • Class I-deficient hemopoietic cells and nonhemopoietic cells dominantly induce unresponsiveness of natural killer cells to class I-deficient bone marrow cell grafts
    • Wu M.-F., Raulet D.H. Class I-deficient hemopoietic cells and nonhemopoietic cells dominantly induce unresponsiveness of natural killer cells to class I-deficient bone marrow cell grafts. J. Immunol. 158:1997;1628-1633.
    • (1997) J. Immunol. , vol.158 , pp. 1628-1633
    • Wu, M.-F.1    Raulet, D.H.2
  • 55
    • 0031569268 scopus 로고    scopus 로고
    • Mouse natural killer subsets defined by their target specificity and their ability to be separately rendered unresponsive in vivo
    • Kung S.K., Miller R.G. Mouse natural killer subsets defined by their target specificity and their ability to be separately rendered unresponsive in vivo. J. Immunol. 158:1997;2616-2626.
    • (1997) J. Immunol. , vol.158 , pp. 2616-2626
    • Kung, S.K.1    Miller, R.G.2
  • 56
    • 0030791728 scopus 로고    scopus 로고
    • Natural killer cell tolerance in mice with mosaic expression of major histocompatibility complex class I molecules
    • Johansson M.H., Bieberich C., Jay G., Kärre K., Höglund P. Natural killer cell tolerance in mice with mosaic expression of major histocompatibility complex class I molecules. J. Exp. Med. 186:1997;353-364.
    • (1997) J. Exp. Med. , vol.186 , pp. 353-364
    • Johansson, M.H.1    Bieberich, C.2    Jay, G.3    Kärre, K.4    Höglund, P.5
  • 57
    • 0035575730 scopus 로고    scopus 로고
    • Cre recombinase-mediated inactivation of H-2Dd transgene expression: Evidence for partial missing-self recognition by Ly49A NK cells
    • Ioannidis V., Zimmer J., Beermann F., Held W. Cre recombinase-mediated inactivation of H-2Dd transgene expression: evidence for partial missing-self recognition by Ly49A NK cells. J. Immunol. 167:2001;6256-6262.
    • (2001) J. Immunol. , vol.167 , pp. 6256-6262
    • Ioannidis, V.1    Zimmer, J.2    Beermann, F.3    Held, W.4
  • 58
    • 0026032210 scopus 로고
    • Rejection of class I MHC-deficient hemopoietic cells by irradiated MHC-matched mice
    • Bix M., Liao N.-S., Zijlstra M., Loring J., Jaenisch R., Raulet D. Rejection of class I MHC-deficient hemopoietic cells by irradiated MHC-matched mice. Nature. 349:1991;329-331.
    • (1991) Nature , vol.349 , pp. 329-331
    • Bix, M.1    Liao, N.-S.2    Zijlstra, M.3    Loring, J.4    Jaenisch, R.5    Raulet, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.