Assembly and antigen-presenting function of MHC class I molecules in cells lacking the ER chaperone calreticulin

Immunity

Volumn 16, Issue 1, 2002, Pages 99-109

  Gao, Bin ^b   Adhikari, Raju ^a,b   Howarth, Mark ^a,b   Nakamura, Kimitoshi ^c   Gold, Marielle C ^d   Hill, Ann B ^d   Knee, Rai ^c   Michalak, Marek ^c   Elliott, Tim ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF ALBERTA   (Canada)

^d OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; CALNEXIN; CALRETICULIN; LECTIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; CELL LINE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENETIC TRANSFECTION; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0036169941     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(01)00260-6     Document Type: Article

References (43)

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3. The binding affinity and dissociation rates of peptides for class I major histocompatibility complex molecules
4. Functional relationship between calreticulin, calnexin, and the endoplasmic reticulum luminal domain of calnexin
5. Direct delivery of exogenous MHC class I molecule-binding oligopeptides to the endoplasmic reticulum of viable cells
6. A role for calnexin in the assembly of the MHC class I loading complex in the endoplasmic reticulum
7. Peptide-induced conformational change of the class I heavy chain
8. The role of ERp57 in disulfide bond formation during the assembly of major histocompatibility complex class I in a synchronized semipermeabilized cell translation system
9. Impaired immune responses and altered peptide repertoire in tapasin-deficient mice
10. Impaired assembly yet normal trafficking of MHC class I molecules in Tapasin mutant mice
11. Calreticulin and calnexin interact with different protein and glycan determinants during the assembly of MHC class I
12. A recycling pathway between the endoplasmic reticulum and the Golgi apparatus for retention of unassembled MHC class I molecules
13. The thiol oxidoreductase ERp57 is a component of the MHC class I peptide-loading complex
14. Detection of rare antigen-presenting cells by the lacZ T-cell activation assay suggests an expression cloning strategy for T-cell antigens
15. The multiple Iimmune-evasion genes of murine cytomegalovirus are not redundant: m4 and m152 inhibit antigen presentation in a complementary and cooperative fashion
16. Soluble tapasin restores MHC class I expression and function in the tapasin-negative cell line.220
17. Evidence for successive peptide binding and quality control stages during class I MHC assembly
18. Point mutations in the alpha 2 domain of HLA-A2.1 define a functionally relevant interaction with TAP
19. Peptide-bound major histocompatibility complex class I molecules associate with tapasin before dissociation from transporter associated with antigen processing
20. ER-60, a chaperone with thiol-dependent reductase activity involved in MHC class I assembly
21. An ER protein implicated in chaperoning peptides to MHC class I is an aminopeptidase
22. Calreticulin is essential for cardiac development
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24. A role for the thiol-dependent reductase ERp57 in the assembly of MHC class I molecules
25. Calreticulin displays in vivo peptide-binding activity and can elicit CTL responses against bound peptides
26. Functional specialization of calreticulin domains
27. ERp57 functions as a subunit of specific complexes formed with the ER lectins calreticulin and calnexin
28. Mechanisms of MHC class I - Restricted antigen processing
29. HLA-B27-restricted antigen presentation in the absence of tapasin reveals polymorphism in mechanisms of HLA class I peptide loading
30. Clustering of peptide-loaded MHC class I molecules for endoplasmic reticulum export imaged by fluorescence resonance energy transfer
31. A soluble major histocompatibility complex class i peptide-binding platform undergoes a conformational change in response to peptide epitopes
32. Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP
33. Calreticulin functions in vitro as a molecular chaperone for both glycosylated and non-glycosylated proteins
34. Intracellular transport of class I HLA molecules is affected by polymorphic residues in the binding groove
35. TAP-translocated peptides specifically bind proteins in the endoplasmic reticulum, including gp96, protein disulphide isomerase and calreticulin
36. Selective export of MHC class I molecules from the ER after their dissociation from TAP
37. Calnexin influences folding of human class I histocompatibility proteins but not their assembly with beta 2-microglobulin
38. A mutant cell in which association of class I heavy and light chains is induced by viral peptides
39. Oligosaccharide binding characteristics of the molecular chaperones calnexin and calreticulin
40. Pivotal role of calnexin and mannose trimming in regulating the endoplasmic reticulum-associated degradation of major histocompatibility complex class I heavy chain
41. The KDEL receptor mediates a retrieval mechanism that contributes to quality control at the endoplasmic reticulum
42. An extensive region of an MHC class I alpha 2 domain loop influences interaction with the assembly complex
43. Distinct patterns of folding and interactions with calnexin and calreticulin in human class I MHC proteins with altered N-glycosylation