Rational drug development using gene-targeted agents and their application in anti-gene radiotherapy

Current Genomics

Volumn 4, Issue 3, 2003, Pages 275-294

  Winters, Thomas A ^a   Pastwa, Elzbieta ^a,b   Datta, Kamal ^a   Neumann, Ronald D ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; DOUBLE STRANDED DNA; IODINE 125; LIGAND; OLIGONUCLEOTIDE; PEPTIDE NUCLEIC ACID; POLYAMIDE; PURINE; PYRIMIDINE; RADIOISOTOPE;

CYTOTOXICITY; DNA DAMAGE; DNA REPAIR; DNA SEQUENCE; DNA STRAND BREAKAGE; DRUG DESIGN; DRUG DNA BINDING; DRUG STRUCTURE; GENE EXPRESSION; GENE INACTIVATION; GENE STRUCTURE; GENE TARGETING; GENE THERAPY; GENETIC DISORDER; HUMAN; INFECTION; ISOTOPE LABELING; LIGAND BINDING; MOLECULAR RECOGNITION; NONHUMAN; PROTEIN TARGETING; RADIOTHERAPY; REVIEW; STRUCTURE ACTIVITY RELATION; TRANSCRIPTION REGULATION;

EID: 0037377541     PISSN: 13892029     EISSN: None     Source Type: Journal    
DOI: 10.2174/1389202033490420     Document Type: Review

References (304)

1. Yamamoto, A., Lucas, J. J., Hen, R. Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease. Cell, 2000, 101: 57-66.
2. Telenti, A., Bally, F. HIV epidemiology and treatment - 1999. Ocul. Immunol. Inflamm., 1999, 7: 129-32.
3. Posavad, C. M., Huang, M. L., Barcy, S., Koelle, D. M., Corey, L. Long term persistence of herpes simplex virus-specific CD8+ CTL in persons with frequently recurring genital herpes. J. Immunol., 2000, 165: 1146-52.
4. Wolfe, P. R. Practical approaches to HIV therapy. Recommendations for the year 2000. Postgrad. Med., 2000, 107: 127-8, 131-6, 138.
5. Wemmer, D. E. Designed sequence-specific minor groove ligands. Annu. Rev. Biophys. Biomolec. Struct., 2000, 29: 439-461.
6. Dervan, P. B. Molecular recognition of DNA by small molecules. Bioorg. Med. Chem., 2001, 9: 2215-2235.
7. White, S., Szewczyk, J. W., Turner, J. M., Baird, E. E., Dervan, P. B. Recognition of the four Watson-Crick base pairs in the DNA minor groove by synthetic ligands. Nature, 1998, 391: 468-471.
8. Gottesfeld, J. M., Neely, L., Trauger, J. W., Baird, E. E., Dervan, P. B. Regulation of gene expression by small molecules. Nature, 1997, 387: 202-205.
9. Dickinson, L. A., Gulizia, R. J., Trauger, J. W., Baird, E. E., Mosier, D. E., Gottesfeld, J. M., Dervan, P. B. Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands. Proc. Natl. Acad. Sci. U. S. A., 1998, 95: 12890-12895.
10. Bremer, R. E., Wurtz, N. R., Szewczyk, J. W., Dervan, P. B. Inhibition of major groove DNA binding bZIP proteins by positive patch "polyamides". Bioorg. Med. Chem., 2001, 9: 2093-2103.
11. Wurtz, N. R., Dervan, P. B. Sequence specific alkylation of DNA by hairpin pyrrole-imidazole polyamide conjugates. Chem. Biol., 2000, 7: 153-161.
12. Wang, C. C. C., Dervan, P. B. Sequence-specific trapping of Topoisomerase I by DNA binding polyamide-camptothecin conjugates. J. Am. Chem. Soc., 2001, 123: 8657-8661.
13. Mapp, A. K., Ansari, A. Z., Ptashne, M., Dervan, P. B. Activation of gene expression by small molecule transcription factors. Proc. Natl. Acad. Sci. U. S. A., 2000, 97: 3930-3935.
14. Nielsen, P. E., Egholm, M., Berg, R. H., Buchardt, O. Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide. Science, 1991, 254: 1497-1500.
15. Nielsen, P. E. Peptide nucleic acid (PNA) - From DNA recognition to antisense and DNA structure. Biophys. Chem., 1997, 68: 103-108.
16. Lohse, J., Dahl, O., Nielsen, P. E. Double duplex invasion by peptide nucleic acid: A general principle for sequence-specific targeting of double-stranded DNA. Proc. Natl. Acad. Sci. U. S. A., 1999, 96: 11804-11808.
17. Demidov, V. V., Yavnilovich, M. V., Belotserkovskii, B. P., Frankkamenetskii, M. D., Nielsen, P. E. Kinetics and Mechanism of Polyamide (Peptide) Nucleic-Acid Binding to Duplex DNA. Proc. Natl. Acad. Sci. U. S. A., 1995, 92: 2637-2641.
18. Giesen, U., Kleider, W., Berding, C., Geiger, A., Orum, H., Nielsen, P. E. A formula for thermal stability (Tm) prediction of PNA/DNA duplexes. Nucleic Acids Res., 1998, 26: 5004-5006.
19. Praseuth, D., Grigoriev, M., Guieysse, A. L., Pritchard, L. L., HarelBellan, A., Nielsen, P. E., Helene, C. Peptide nucleic acids directed to the promoter of the α-chain of the interleukin-2 receptor. Biochim. Biophys. Acta-Gene Struct. Expression, 1996, 1309: 226-238.
20. Wittung, P., Neilsen, P., Norden, B. extended DNA-recognition repertoire of petide nucleic acid (PNA): PNA-dsDNA triplex formed with cytosine-rich homopyrimidine PNA. Biochemistry, 1997, 36: 7973-7979.
21. Kuhn, H., Demidov, V. V., Nielsen, P. E., Frank-Kamenetskii, M. D. An experimental study of mechanism and specificity of peptide nucleic acid (PNA) binding to duplex DNA. J. Mol. Biol., 1999, 286: 1337-1345.
22. Diviacco, S., Rapozzi, V., Xodo, L., Helene, C., Quadrifoglio, F., Giovannangeli, C. Site-directed inhibition of DNA replication by triple helix formation. Faseb J., 2001, 15: 2660-2668.
23. Izvolsky, K. I., Demidov, V. V., Nielsen, P. E., Frank-Kamenetskii, M. D. Sequence-specific protection of duplex DNA against restriction and methylation enzymes by pseudocomplementary PNAs. Biochemistry, 2000, 39: 10908-10913.
24. Zhang, X., Ishihara, T., Corey, D. R. Strand invasion by mixed base PNAs and a PNA-peptide chimera. Nucleic Acids Res., 2000, 28: 3332-3338.
25. Mologni, L., leCoutre, P., Nielsen, P. E., Gambacorti-Passerini, C. Additive antisense effects of different PNAs on the in vitro translation of the PML/RAR alpha gene. Nucleic Acids Res., 1998, 26: 1934-1938.
26. Mologni, L., Nielsen, P. E., Gambacorti-Passerini, C. In vitro transcriptional and translational block of the bcl-2 gene operated by peptide nucleic acid. Biochem. Biophys. Res. Commun., 1999, 264: 537-543.
27. Dias, N., Dheur, S., Nielsen, P. E., Gryaznov, S., Van Aerschot, A., Herdewijn, P., Helene, C., Saison-Behmoaras, T. E. Antisense PNA tridecamers targeted to the coding region of Ha-ras mRNA arrest polypeptide chain elongation. J. Mol. Biol., 1999, 294: 403-416.
28. Doyle, D. F., Braasch, D. A., Simmons, C. G., Janowski, B. A., Corey, D. R. Inhibition of gene expression inside cells by peptide nucleic acids: Effect of mRNA target sequence, mismatched bases, and PNA length. Biochemistry, 2001, 40: 53-64.
29. Tyler-McMahon, B. M., Stewart, J. A., Jackson, J., Bitner, M. D., Fauq, A., McCormick, D. J., Richelson, E. Altering behavioral responses and dopamine transporter protein with antisense peptide nucleic acids. Biochem. Pharmacol., 2001, 62: 929-932.
30. Mologni, L., Marchesi, E., Nielsen, P. E., Gambacorti-Passerini, C. Inhibition of promyelocytic leukemia (PML)/retinoic acid receptor-α and PML expression in acute promyelocytic leukemia cells by anti-PML peptide nucleic acid. Cancer Res., 2001, 61: 5468-5473.
31. McMahon, B. M., Stewart, J. A., Jackson, J., Fauq, A., McCormick, D. J., Richelson, E. Intraperitoneal injection of antisense peptide nucleic acids targeted to the mu receptor decreases response to morphine and receptor protein levels in rat brain. Brain Res., 2001, 904: 345-349.
32. Nielsen, P. E. Antisense peptide nucleic acids. Curr. Opin. Mol. Ther., 2000, 2: 282-287.
33. Nielsen, P. E. Peptide nucleic acids as antibacterial agents via the antisense principle. Expert Opin. Investig. Drugs, 2001, 10: 331-341.
34. Malchere, C., Verheijen, J., Van der Laan, S., Bastide, L., Van Boom, J., Lebleu, B., Robbins, I. A short phosphodiester window is sufficient to direct RNase H-dependent RNA cleavage by antisense peptide nucleic acid. Antisense Nucleic Acid Drug Dev., 2000, 10: 463-468.
35. Verheijen, J. C., Chen, L., Bayly, S. F., Torrence, P. F., van der Marel, G. A., van Boom, J. H. Synthesis and RNase L binding and activation of a 2-5A-(5′)-DNA-(3′)-PNA chimera, a novel potential antisense molecule. Nucleosides Nucleotides Nucleic Acids, 2000, 19: 1821-1830.
36. Lee, R., Kaushik, N., Modak, M. J., Vinayak, R., Pandey, V. N. Polyamide nucleic acid targeted to the primer binding site of the HIV-1 RNA genome blocks in vitro HIV-1 transcription. Biochemistry, 1998, 37: 900-910.
37. Bastide, L., Boehmer, P. E., Villani, G., Lebleu, B. Inhibition of a DNA-helicase by peptide nucleic acids. Nucleic Acids Res., 1999, 27: 551-554.
38. Mayhood, T., Kaushik, N., Pandey, P. K., Kashanchi, F., Deng, L. W., Pandey, V. N. Inhibition of Tat-mediated transactivation of HIV-1 LTR transcription by polyamide nucleic acid targeted to TAR hairpin element. Biochemistry, 2000, 39: 11532-11539.
39. Kurg, R., Langel, U., Ustav, M. Inhibition of the bovine papillomavirus E2 protein activity by peptide nucleic acid. Virus Res., 2000, 66: 39-50.
40. Faruqi, A. F., Egholm, M., Glazer, P. M. Peptide nucleic acid-targeted mutagenesis of a chromosomal gene in mouse cells. Proc. Natl. Acad. Sci. U. S. A., 1998, 95: 1398-1403.
41. Wang, G., Xu, X. X., Pace, P., Dean, D. A., Glazer, P. M., Chan, P., Goodman, S. R., Shokolenko, I. Peptide nucleic acid (PNA) binding-mediated induction of human γ-globin gene expression. Nucleic Acids Res., 1999, 27: 2806-2813.
42. Wang, G., Jing, K., Balczon, R., Xu, X. X. Defining the peptide nucleic acids (PNA) length requirement for PNA binding-induced transcription and gene expression. J. Mol. Biol., 2001, 313: 933-940.
43. Demidov, V. V., Potaman, V. N., Frankkamenetskii, M. D., Egholm, M., Buchard, O., Sonnichsen, S. H., Nielsen, P. E. Stability of Peptide Nucleic-Acids in Human Serum and Cellular-Extracts. Biochem. Pharmacol., 1994, 48: 1310-1313.
44. Fraser, G. L., Holmgren, J., Clarke, P. B. S., Wahlestedt, C. Antisense inhibition of δ-opioid receptor gene function in vivo by peptide nucleic acids. Mol. Pharmacol., 2000, 57: 725-731.
45. Scarfi, S., Giovine, M., Gasparini, A., Damonte, G., Millo, E., Pozzolini, M., Benatti, U. Modified peptide nucleic acids are internalized in mouse macrophages RAW 264.7 and inhibit inducible nitric oxide synthase. FEBS Lett., 1999, 451: 264-268.
46. Shammas, M. A., Simmons, C. G., Corey, D. R., Reis, R. J. S. Telomerase inhibition by peptide nucleic acids reverses 'immortality' of transformed human cells. Oncogene, 1999, 18: 6191-6200.
47. Tyler, B. M., Jansen, K., McCormick, D. J., Douglas, C. L., Boules, M., Stewart, J. A., Zhao, L. H., Lacy, B., Cusack, B., Fauq, A., Richelson, E. Peptide nucleic acids targeted to the neurotensin receptor and administered i.p. cross the blood-brain barrier and specifically reduce gene expression. Proc. Natl. Acad. Sci. U. S. A., 1999, 96: 7053-7058.
48. Nielsen, P. E. Peptide nucleic acids as therapeutic agents. Curr. Opin. Struct. Biol., 1999, 9: 353-357.
49. Simmons, C. G., Pitts, A. E., Mayfield, L. D., Shay, J. W., Corey, D. R. Synthesis and membrane permeability of PNA-peptide conjugates. Bioorg. Med. Chem. Lett., 1997, 7: 3001-3006.
50. Aldrian-Herrada, G., Desarmenien, M. G., Orcel, H., Boissin-Agasse, L., Mery, J., Brugidou, J., Rabie, A. A peptide nucleic acid (PNA) is more rapidly internalized in cultured neurons when coupled to a retro-inverso delivery peptide. The antisense activity depresses the target mRNA and protein in magnocellular oxytocin neurons. Nucleic Acids Res., 1998, 26: 4910-4916.
51. Pooga, M., Soomets, U., Hallbrink, M., Valkna, A., Saar, K., Rezaei, K., Kahl, U., Hao, J. X., Xu, X. J., Wiesenfeld-Hallin, Z., Hokfelt, T., Bartfai, A., Langel, U. Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo. Nat. Biotechnol., 1998, 16: 857-861.
52. Ljungstrom, T., Knudsen, H., Nielsen, P. E. Cellular uptake of adamantyl conjugated peptide nucleic acids. Bioconjugate Chem., 1999, 10: 965-972.
53. Villa, R., Folini, M., Lualdi, S., Veronese, S., Daidone, M. G., Zaffaroni, N. Inhibition of telomerase activity by a cell-penetrating peptide nucleic acid construct in human melanoma cells. FEBS Lett., 2000, 473: 241-248.
54. Shi, N. Y., Boado, R. J., Pardridge, W. M. Antisense imaging of gene expression in the brain in vivo. Proc. Natl. Acad. Sci. U. S. A., 2000, 97: 14709-14714.
55. Muratovska, A., Lightowlers, R. N., Taylor, R. W., Turnbull, D. M., Smith, R. A. J., Wilce, J. A., Martin, S. W., Murphy, M. P. Targeting peptide nucleic acid (PNA) oligomers to mitochondria within cells by conjugation to lipophilic cations: implications for mitochondrial DNA replication, expression and disease. Nucleic Acids Res., 2001, 29: 1852-1863.
56. Zhang, X., Simmons, C. G., Corey, D. R. Liver cell specific targeting of peptide nucleic acid oligomers. Bioorg. Med. Chem. Lett., 2001, 11: 1269-1272.
57. Chinnery, P. F., Taylor, R. W., Dickert, K., Lill, R., Turnbull, D. M., Lightowlers, R. N. Peptide nucleic acid delivery to human mitochondria. Gene Ther., 1999, 6: 1919-1928.
58. Boffa, L. C., Scarfi, S., Mariani, M. R., Damonte, G., Allfrey, V. G., Benatti, U., Morris, P. L. Dihydrotestosterone as a selective cellular/nuclear localization vector for anti-gene peptide nucleic acid in prostatic carcinoma cells. Cancer Res., 2000, 60: 2258-2262.
59. Cutrona, G., Carpaneto, E. M., Ulivi, M., Roncella, S., Landt, O., Ferrarini, M., Boffa, L. C. Effects in live cells of a c-myc anti-gene PNA linked to a nuclear localization signal. Nat. Biotechnol., 2000, 18: 300-303.
60. Mardirossian, G., Lei, K., Rusckowski, M., Chang, F., Qu, T., Egholm, M., Hnatowich, D. J. In vivo hybridization of technetium-99m-labeled peptide nucleic acid (PNA). J. Nucl. Med., 1997, 38: 907-913.
61. Kozlov, I. A., Nielsen, P. E., Orgel, L. E. A method for the P-32 labeling of peptides or peptide nucleic acid oligomers. Bioconjugate Chem., 1998, 9: 415-417.
62. Rezaei, K., Xu, I. S., Wu, W. P., Shi, T. J., Soomets, U., Land, T., Xu, X. J., Wiesenfeld-Hallin, Z., Hokfelt, T., Bartfai, T., Langel, U. Intrathecal administration of PNA targeting galanin receptor reduces galanin-mediated inhibitory effect in the rat spinal cord. Neuroreport, 2001, 12: 317-320.
63. Wang, Y., Chang, F., Zhang, Y., Liu, N., Liu, G., Gupta, S., Rusckowski, M., Hnatowich, D. J. Pretargeting with amplification using polymeric peptide nucleic acid. Bioconjugate Chem., 2001, 12: 807-816.
64. Kuhnast, B., Dolle, F., Tavitian, B. Fluorine-18 labeling of peptide nucleic acids. J. Label. Compd. Radiopharm., 2002, 45: 1-11.
65. Moser, H. E., Dervan, P. B. Sequence-specific cleavage of double helical DNA by triple helix formation. Science, 1987, 238: 645-650.
66. Beal, P. A., Dervan, P. B. The influence of single base triplet changes on the stability of a pur-pur-pyr triple helix determined by affinity cleaving. Nucleic Acids Res., 1992, 20: 2773-2776.
67. Giovannangeli, C., Rougee, M., Garestier, T., Thuong, N. T., Helene, C. Triple-helix formation by oligonucleotides containing the 3 bases thymine, cytosine, and guanine. Proc. Natl. Acad. Sci. U.S.A., 1992, 89: 8631-8635.
68. deBizemont, T., DuvalValentin, G., Sun, J. S., Bisagni, E., Garestier, T., Helene, C. Alternate strand recognition of double-helical DNA by (T,G)-containing oligonucleotides in the presence of a triple helix-specific ligand. Nucleic Acids Res., 1996, 24: 1136-1143.
69. Noonberg, S. B., Francois, J. C., Garestier, T., Helene, C. Effect of Competing Self-Structure on Triplex Formation with Purine-Rich Oligodeoxynucleotides Containing GA Repeats. Nucleic Acids Res., 1995, 23: 1956-1963.
70. Cheng, A. J., Wang, J. C., Van Dyke, M. W. Self-association of G-rich oligodeoxyribonucleotides under conditions promoting purine-motif triplex formation. Antisense Nucleic Acid Drug Dev., 1998, 8: 215-225.
71. Ono, A., Tso, P. O. P., Kan, L. S. Triplex Formation of Oligonucleotides Containing 2′-O-Methylpseudoisocytidine in Substitution for 2′-Deoxycytidine. J. Am. Chem. Soc., 1991, 113: 4032-4033.
72. Krawczyk, S. H., Milligan, J. F., Wadwani, S., Moulds, C., Froehler, B. C., Matteucci, M. D. Oligonucleotide-Mediated Triple Helix Formation Using an N3-Protonated Deoxycytidine Analog Exhibiting pH-Independent Binding within the Physiological Range. Proc. Natl. Acad. Sci. U. S. A., 1992, 89: 3761-3764.
73. Chan, P. P., Glazer, P. M. Triplex DNA: fundamentals, advances, and potential applications for gene therapy. J. Mol. Med., 1997, 75: 267-282.
74. Marfurt, J., Parel, S. P., Leumann, C. J. Strong, specific, monodentate G-C base pair recognition by N7-inosine derivatives in the pyrimidine.purine-pyrimidine triple-helical binding motif. Nucleic Acids Res., 1997, 25: 1875-1882.
75. Vasquez, K. M., Wensel, T. G., Hogan, M. E., Wilson, J. H. High-Affinity Triple-Helix Formation by Synthetic Oligonucleotides at a Site within a Selectable Mammalian Gene. Biochemistry, 1995, 34: 7243-7251.
76. Sun, J. S., Garestier, T., Helene, C. Oligonucleotide directed triple helix formation, Curr. Opin. Struct. Biol., 1996, 6: 327-333.
77. Wyatt, J. R., Davis, P. W., Freier, S. M. Kinetics of G-quartet-mediated tetramer formation, Biochemistry, 1996, 35: 8002-8008.
78. Blume, S. W., Guarcello, V., Zacharias, W., Miller, D. M. Divalent transition metal cations counteract potassium-induced quadruplex assembly of oligo(dG) sequences. Nucleic Acids Res., 1997, 25: 617-625.
79. Bailey, C. P., Dagle, J. M., Weeks, D. L. Cationic oligonucleotides can mediate specific inhibition of gene expression in Xenopus oocytes. Nucleic Acids Res., 1998, 26: 4860-4867.
80. Belousov, E. S., Afonina, I. A., Kutyavin, I. V., Gall, A. A., Reed, M. W., Gamper, H. B., Wydro, R. M., Meyer, R. B. Triplex targeting of a native gene in permeabilized intact cells: covalent modification of the gene for the chemokine receptor CCR5. Nucleic Acids Res., 1998, 26: 1324-1328.
81. Kim, H. G., Reddoch, J. F., Mayfield, C., Ebbinghaus, S., Vigneswaran, N., Thomas, S., Jones, D. E., Miller, D. M. Inhibition of transcription of the human c-myc protooncogene by intermolecular triplex. Biochemistry, 1998, 37: 2299-2304.
82. Kim, H. G., Miller, D. M. A novel triplex-forming oligonucleotide targeted to human cyclin D1 (bcl-1, protooncogene) promoter inhibits transcription in HeLa cells. Biochemistry, 1998, 37: 2666-2672.
83. McGuffie, E. M., Pacheco, D., Carbone, G. M. R., Catapano, C. V. Antigene and antiproliferative effects of a c-myc-targeting phosphorothioate triple helix-forming oligonucleotide in human leukemia cells. Cancer Res., 2000, 60: 3790-3799.
84. Catapano, C. V., McGuffie, E. M., Pacheco, D., Carbone, G. M. R. Inhibition of gene expression and cell proliferation by triple helix-forming oligonucleotides directed to the c-myc gene. Biochemistry, 2000, 39: 5126-5138.
85. Ritchie, S., Bonham, K. The human c-Src proto-oncogene promoter contains multiple targets for triplex-forming oligonucleotides. Antisense Nucleic Acid Drug Dev., 1998, 8: 391-400.
86. Ritchie, S., Boyd, F. M., Wong, J., Bonham, K. Transcription of the human c-Src promoter is dependent on Sp1, a novel pyrimidine binding factor SPy, and can be inhibited by triplex-forming oligonucleotides. J. Biol. Chem., 2000, 275: 847-854.
87. Rininsland, F., Johnson, T. R., Chernicky, C. L., Schulze, E., Burfeind, P., Ilan, J. Suppression of insulin-like growth factor type I receptor by a triple-helix strategy inhibits IGF-I transcription and tumorigenic potential of rat C6 glioblastoma cells. Proc. Natl. Acad. Sci. U. S. A., 1997, 94: 5854-5859.
88. Morassutti, C., Scaggiante, B., Xodo, L. E., Dapas, B., Paroni, G., Tolazzi, G., Quadrifoglio, F. Reduction of mdr1 gene amplification in human multidrug-resistant LoVo DX cell line is promoted by triple helix-forming oligonucleotides. Antisense Nucleic Acid Drug Dev., 1999, 9: 261-270.
89. Hoque, A. T. M. S., Panyutin, I. G., Baum, B. J. Use of tripler-forming oligonucleotides and adenoviral constructs for studying the regulation of gene expression. Methods, 1999, 18: 266-272.
90. Piva, R., Gambari, R. New trends in molecular pharmacology: artificial modulation of gene expression by transcription modifiers. Minerva Biotechnol., 1999, 11: 193-203.
91. Giovannangeli, C., Helene, C. Triplex-forming molecules for modulation of DNA information processing. Curr. Opin. Mol. Ther., 2000, 2: 288-296.
92. Marchand, P., Resch, K., Radeke, H. H. Selective inhibition of monocyte chemoattractant protein-1 gene expression in human embryonal kidney cells by specific triple helix-forming oligonucleotides. J. Immunol., 2000, 164: 2070-2076.
93. Westin, L., Blomquist, P., Milligan, J. F., Wrange, O. Triple-Helix DNA Alters Nucleosomal Histone-DNA Interactions and Acts as a Nucleosome Barrier. Nucleic Acids Res., 1995, 23: 2184-2191.
94. Brown, P. M., Madden, C. A., Fox, K. R. Triple-helix formation at different positions on nucleosomal DNA. Biochemistry, 1998, 37: 16139-16151.
95. Brown, P. M., Fox, K. R. DNA triple-helix formation on nucleosome-bound poly(dA)• poly(dT) tracts. Biochem. J., 1998, 333: 259-267.
96. Shen, C. X., Buck, A., Mehrke, G., Polat, B., Gross, H. J., Bachem, M., Reske, S. Triplex forming oligonucleotide targeted to 3′ UTR downregulates the expression of the bcl-2 proto-oncogene in HeLa cells. Nucleic Acids Res., 2001, 29: 622-628.
97. Hai, M., Bidichandani, S. I., Hogan, M. E., Patel, P. I. Competitive binding of triplex-forming oligonucleotides in the two alternate promoters of the PMP22 gene. Antisense Nucleic Acid Drug Dev., 2001, 11: 233-246.
98. Young, S. L., Krawczyk, S. H., Matteucci, M. D., Toole, J. J. Triple helix formation inhibits transcription elongation In vitro. Proc. Natl. Acad. Sci. U. S. A., 1991, 88: 10023-10026.
99. Escude, C., Giovannangeli, C., Sun, J. S., Lloyd, D. H., Chen, J. K., Gryaznov, S. M., Garestier, T., Helene, C. Stable triple helices formed by oligonucleotide N3′->p5′ phosphoramidates inhibit transcription elongation. Proc. Natl. Acad. Sci. U. S. A., 1996, 93: 4365-4369.
100. Giovannangeli, C., Perrouault, L., Escude, C., Thuong, N., Helene, C. Specific inhibition of in vitro transcription elongation by triplex-forming oligonucleotide-intercalator conjugates targeted to HIV proviral DNA. Biochemistry, 1996, 35: 10539-10548.
101. Giovannangeli, C., Perrouault, L., Escude, C., Gryaznov, S., Helene, C. Efficient inhibition of transcription elongation in vitro by oligonucleotide phosphoramidates targeted to proviral HIV DNA. J. Mol. Biol., 1996, 261: 386-398.
102. Ebbinghaus, S. W., Fortinberry, H., Gamper, H. B. Inhibition of transcription elongation in the HER-2/neu coding sequence by triplex-directed covalent modification of the template strand. Biochemistry, 1999, 38: 619-628.
103. Bailey, C., Weeks, D. L. Understanding oligonucleotide-mediated inhibition of gene expression in Xenopus laevis oocytes. Nucleic Acids Res., 2000, 28: 1154-1161.
104. Vasquez, K. M., Dagle, J. M., Weeks, D. L., Glazer, P. M. Chromosome targeting at short polypurine sites by cationic triplex-forming oligonucleotides. J. Biol. Chem., 2001, 276: 38536-38541.
105. Faria, M., Wood, C. D., Perrouault, L., Nelson, J. S., Winter, A., White, M. R. H., Helene, C., Giovannangeli, C. Targeted inhibition of transcription elongation in cells mediated by triplex-forming oligonucleotides. Proc. Natl. Acad. Sci. U. S. A., 2000, 97: 3862-3867.
106. Giovannangeli, C., Diviacco, S., Labrousse, V., Gryaznov, S., Charneau, P., Helene, C. Accessibility of nuclear DNA to triplex-forming oligonucleotides: The integrated HIV-1 provirus as a target. Proc. Natl. Acad. Sci. U. S. A., 1997, 94: 79-84.
107. Xu, X. X. S., Glazer, P. M., Wang, G. Activation of human γ-globin gene expression via triplex-forming oligonucleotide (TFO)-directed mutations in the γ-globin gene 5′ flanking region. Gene, 2000, 242: 219-228.
108. Stamatoyannopoulos, G., Neinhuis, A., Majerus, X., Varmus, X. The Molecular Basis of Blood Diseases, W.B. Saunders Company: Philadelphia, PA 1994.
109. Svinarchuk, F., Nagibneva, I., Cherny, D., Ait-Si-Ali, S., Pritchard, L. L., Robin, P., Malvy, C., Harel-Bellan, A. Recruitment of transcription factors to the target site by triplex-forming oligonucleotides (Vol. 25: pg. 3459, 1997). Nucleic Acids Res., 1997, 25: 3459-3464.
110. Kuznetsova, S., Ait-Si-Ali, S., Nagibneva, I., Troalen, F., Le Villain, J. P., Harel-Bellan, A., Svinarchuk, F. Gene activation by triplex-forming oligonucleotide coupled to the activating domain of protein VP16. Nucleic Acids Res., 1999, 27: 3995-4000.
111. Panyutin, I. G., Neumann, R. D. Sequence-specific DNA double-strand breaks induced by triplex forming I-125 labeled oligonucleotides. Nucleic Acids Res., 1994, 22: 4979-4982.
112. Kane, S. A., Hecht, S. M., Sun, J. S., Garestier, T., Helene, C. Specific cleavage of a DNA triple helix by FeII•bleomycin. Biochemistry, 1995, 34: 16715-16724.
113. Wang, G., Glazer, P. M. Altered repair of targeted psoralen photoadducts in the context of an oligonucleotide-mediated triple-helix. J. Biol. Chem., 1995, 270: 22595-22601.
114. Grant, K. B., Dervan, P. B. Sequence-specific alkylation and cleavage of DNA mediated by purine motif triple helix formation. Biochemistry, 1996, 38: 12313-12319.
115. Guieysse, A. L., Praseuth, D., Grigoriev, M., HarelBellan, A., Helene, C. Detection of covalent triplex within human cells. Nucleic Acids Res., 1996, 24: 4210-4216.
116. Lukhtanov, E. A., Mills, A. G., Kutyavin, I. V., Gorn, V. V., Reed, M. W., Meyer, R. B. Minor groove DNA alkylation directed by major groove triplex forming oligodeoxyribonucleotides. Nucleic Acids Res., 1997, 25: 5077-5084.
117. Karamychev, V. N., Panyutin, I. G., Kim, M. K., Reed, M. W., Le, N., Paik, C. H., Carrasquillo, J. A., Neumann, R. D. DNA cleavage by decay of auger-emitting isotopes attached to oligonucleotides through linkers. J. Nuc. Med., 1998, 39: 236P.
118. Perkins, B. D., Wensel, T. G., Vasquez, K. M., Wilson, J. H. Psoralen photo-cross-linking by triplex-forming oligonucleotides at multiple sites in the human rhodopsin gene. Biochemistry, 1999, 38: 12850-12859.
119. Perkins, B. D., Wilson, J. H., Wensel, T. G. Triplex-directed site-specific DNA photo-crosslinking by oligonucleotides targeted to multiple sites in the human rhodopsin gene. Invest. Ophthalmol. Vis. Sci., 1999, 40: 4015.
120. Arimondo, P. B., Bailly, C., Boutorine, A. S., Moreau, P., Prudhomme, M., Sun, J. S., Garestier, T., Helene, C. Triple helix-forming oligonucleotides conjugated to indolocarbazole poisons direct topoisomerase I-mediated DNA cleavage to a specific site. Bioconjugate Chem., 2001, 12: 501-509.
121. Teulade-Fichou, M. P., Perrin, D., Boutorine, A., Polverari, D., Vigneron, J. P., Lehn, J. M., Sun, J. S., Garestier, T., Helene, C. Direct photocleavage of HIV-DNA by quinacridine derivatives triggered by triplex formation. J. Am. Chem. Soc., 2001, 123: 9283-9292.
122. Ziemba, A., Derosier, L. C., Methvin, R., Song, C. Y., Clary, E., Kahn, W., Milesi, D., Gorn, V., Reed, M., Ebbinghaus, S. Repair of triplex-directed DNA alkylation by nucleotide excision repair. Nucleic Acids Res., 2001, 29: 4257-4263.
123. Wang, G., Levy, D. D., Seidman, M. M., Glazer, P. M. Targeted mutagenesis in mammalian-cells mediated by intracellular triple-helix formation. Mol. Cell. Biol., 1995, 15: 1759-1768.
124. Vasquez, K. M., Wilson, J. H. Triplex-directed modification of genes and gene activity. Trends Biochem. Sci., 1998, 23: 4-9.
125. Barre, F. X., Giovannangeli, C., Helene, C., Harel-Bellan, A. Covalent crosslinks introduced via a triple helix-forming oligonucleotide coupled to psoralen are inefficiently repaired. Nucleic Acids Res., 1999, 27: 743-749.
126. Oh, D. H., Hanawalt, P. C. Triple helix-forming oligonucleotides target psoralen adducts to specific chromosomal sequences in human cells. Nucleic Acids Res., 1999, 27: 4734-4742.
127. Praseuth, D., Guieysse, A. L., Helene, C. Triple helix formation and the antigene strategy for sequence-specific control of gene expression. Biochim. Biophys. Acta-Gene Struct. Expression, 1999, 1489, 181-206.
128. Barre, F. X., Ait-Si-Ali, S., Giovannangeli, C., Luis, R., Robin, P., Pritchard, L. L., Helene, C., Harel-Bellan, A. Unambiguous demonstration of triple-helix-directed gene modification. Proc. Natl. Acad. Sci. U. S. A., 2000, 97: 3084-3088.
129. Guieysse, A. L., Praseuth, D., Giovannangeli, C., Asseline, U., Helene, C. Psoralen adducts induced by triplex-forming oligonucleotides are refractory to repair in HeLa cells. J. Mol. Biol., 2000, 296: 373-383.
130. Intody, Z., Perkins, B. D., Wilson, J. H., Wensel, T. G. Blocking transcription of the human rhodopsin gene by triplex-mediated DNA photocrosslinking. Nucleic Acids Res., 2000, 28: 4283-4290.
131. Lin, F. L. M., Majumdar, A., Klotz, L. C., Reszka, A. P., Neidle, S., Seidman, M. M. Stability of DNA triplexes on shuttle vector plasmids in the replication pool in mammalian cells. J. Biol. Chem., 2000, 275: 39117-39124.
132. Faria, M., Wood, C. D., White, M. R. H., Helene, C., Giovannangeli, C. Transcription inhibition induced by modified triple helix-forming oligonucleotides: A quantitative assay for evaluation in cells. J. Mol. Biol., 2001, 306: 15-24.
133. Puri, N., Majumdar, A., Cuenoud, B., Natt, F., Martin, P., Boyd, A., Miller, P. S., Seidman, M. M. Targeted gene knockout by 2′-O-aminoethyl modified triplex forming oligonucleotides. J. Biol. Chem., 2001, 276: 28991-28998.
134. Casey, B. P., Glazer, P. M. In Progress in Nucleic Acid Research and Molecular Biology, Vol 67; Academic Press Inc: San Diego, 2001; Vol, 67: pp. 163-192.
135. Vasquez, K. M., Wang, G., Havre, P. A., Glazer, P. M. Chromosomal mutations induced by triplex-forming oligonucleotides in mammalian cells. Nucleic Acids Res., 1999, 27: 1176-1181.
136. Wang, G., Seidman, M. M., Glazer, P. M. Mutagenesis in mammalian cells induced by triple helix formation and transcription-coupled repair. Science, 1996, 271: 802-805.
137. Majumdar, A., Khorlin, A., Dyatkina, N., Lin, F. L. M., Powell, J., Liu, J., Feiz, Z. Z., Khripine, Y., Watanabe, K. A., George, J., Glazer, P. M., Seidman, M. M. Targeted gene knockout mediated by triple helix forming oligonucleotides. Nature Genet., 1998, 20: 212-214.
138. Moser, H. E., Dervan, P. B. Sequence-specific cleavage of double helical DNA by triple helix formation. Science, 1987, 238: 645-50.
139. Strobel, S. A., Doucettestamm, L. A., Riba, L., Housman, D. E., Dervan, P. B. Site-specific cleavage of human chromosome-4 mediated by triple-helix formation. Science, 1991, 254: 1639-1642.
140. Arimondo, P. B., Moreau, P., Boutorine, A., Bailly, C., Prudhomme, M., Sun, J. S., Garestier, T., Helene, C. Recognition and cleavage of DNA by rebeccamycin- or benzopyridoquinoxaline conjugated of triple helix-forming oligonucleotides. Bioorg. Med. Chem., 2000, 8: 777-784.
141. Vasquez, K. M., Narayanan, L., Glazer, P. M. Specific mutations induced by triplex-forming oligonucleotides in mice. Science, 2000, 290: 530-533.
142. Faruqi, A. F., Datta, H. J., Carroll, D., Seidman, M. M., Glazer, P. M. Triple-helix formation induces recombination in mammalian cells via a nucleotide excision repair-dependent pathway. Mol. Cell. Biol., 2000, 20: 990-1000.
143. Wang, G., Chen, Z. W., Zhang, S. J., Wilson, G. L., Jing, K. Detection and determination of oligonucleotide tripler formation-mediated transcription-coupled DNA repair in HeLa nuclear extracts. Nucleic Acids Res., 2001, 29: 1801-1807.
144. Faruqi, A. F., Seidman, M. M., Segal, D. J., Carroll, D., Glazer, P. M. Recombination induced by triple-helix-targeted DNA damage in mammalian cells. Mol. Cell. Biol., 1996, 16: 6820-6828.
145. Raha, M., Wang, G., Seidman, M. M., Glazer, P. M. Mutagenesis by third-strand-directed psoralen adducts in repair-deficient human cells: high frequency and altered spectrum in a xeroderma pigmentosum variant. Proc. Natl. Acad. Sci. U. S. A., 1996, 93: 2941-2946.
146. Panyutin, I. G., Winters, T. A., Feinendegen, L. E., Neumann, R. D. Development of DNA-based radiopharmaceuticals carrying Auger- electron emitters for anti-gene radiotherapy. Q. J. Nucl. Med., 2000, 44: 256-267.
147. Howell, R. W. Radiation spectra for Auger-electron emitting radionuclides: report No. 2 of AAPM Nuclear Medicine Task Group No. 6. Medical Physics, 1992, 19: 1371-83.
148. Sastry, K. S. R. Biological effects of the Auger emitter I-125 - a review - report No. 1 of AAPM-nuclear-medicine-task-group No. 6. Medical Physics, 1992, 19: 1361-1370.
149. Bertoncini, C. R., Meneghini, R. DNA strand breaks produced by oxidative stress in mammalian cells exhibit 3′-phosphoglycolate termini. Nucleic Acids Res., 1995, 23: 2995-3002.
150. Buchko, G. W., Weinfeld, M. Influence of nitrogen, oxygen, and nitroimidazole radiosensitizers on DNA damage induced by ionizing radiation. Biochemistry, 1993, 32: 2186-2193.
151. Henner, W. D., Grunberg, S. M., Haseltine, W. A. Enzyme action at 3′ termini of ionizing radiation-induced DNA strand breaks. J. Biol. Chem., 1983, 258: 15198-15205.
152. Sikpi, M. O., Dry, S. M., Freedman, M. L., Lurie, A. G. Mutations caused by γ-radiation-induced double-strand breaks in a shuttle plasmid replicated in human lymphoblasts. Int. J. Radiat. Biol., 1992, 62: 555-562.
153. Dar, M. E., Jorgensen, T. J. Deletions at short direct repeats and base substitutions are characteristic mutations for bleomycin-induced double- and single-strand breaks, respectively, in a human shuttle vector system. Nucleic Acids Res., 1995, 23: 3224-3230.
154. Winters, T. A., Russell, P. S., Kohli, M., Dar, M. E., Neumann, R. D., Jorgensen, T. J. Determination of human DNA polymerase utilization for the repair of a model ionizing radiation-induced DNA strand break lesion in a defined vector substrate. Nucleic Acids Res., 1999, 27: 2423-2433.
155. Nilsen, H., Rosewell, I., Robins, P., Skjelbred, C. F., Andersen, S., Slupphaug, G., Daly, G., Krokan, H. E., Lindahl, T., Barnes, D. E. Uracil-DNA glycosylase (UNG)-deficient mice reveal a primary role of the enzyme during DNA replication. Mol. Cell, 2000, 5: 1059-65.
156. Radany, E. H., Dornfeld, K. J., Sanderson, R. J., Savage, M. K., Majumdar, A., Seidman, M. M., Mosbaugh, D. W. Increased spontaneous mutation frequency in human cells expressing the phage PBS2-encoded inhibitor of uracil-DNA glycosylase. Mutat. Res.-DNA Repair, 2000, 461: 41-58.
157. Ward, J. F. The complexity of DNA damage: Relevance to biological consequences. Int. J. Radiat. Biol., 1994, 66: 427-432.
158. Ward, J. F., Jones, G. D. D., Milligan, J. R. Biological consequences of nonhomogeneous energy deposition by ionizing-radiation. Radiat. Prot. Dosim., 1994, 52: 271-276.
159. Ward, J. F. Radiation mutagenesis: The initial DNA lesions responsible. Commentary. Radiat. Res., 1995, 142: 362-368.
160. Wallace, S. S. Enzymatic processing of radiation-induced free radical damage in DNA. Radiat. Res., 1998, 150: S60-S79.
161. Chaudhry, M. A., Weinfeld, M. The action of Escherichia coli endonuclease III on multiply damaged sites in DNA. J. Mol. Biol., 1995, 249: 914-922.
162. Pfeiffer, P. The mutagenic potential of DNA double-strand break repair. Toxicol. Lett., 1998, 96-7: 119-129.
163. Jeggo, P. A. Identification of genes involved in repair of DNA double-strand breaks in mammalian cells. Radiat. Res., 1998, 150: S80-S91.
164. Karran, P. DNA double strand break repair in mammalian cells. Curr. Opin. Genet. Dev., 2000, 10: 144-150.
165. Rao, D. V., Narra, V. R., Howell, R. W., Sastry, K. S. R. Biological consequence of nuclear versus cytoplasmic decays of I-125-cysteamine as a radioprotector against Auger cascades in vivo. Radiat. Res., 1990, 124: 188-193.
166. Howell, R. W., Rao, D. V., Hou, D. Y., Narra, V. R., Sastry, K. S. R. The question of relative biological effectiveness and quality factor for Auger emitters incorporated into proliferating mammalian-cells. Radiat. Res., 1991, 128: 282-292.
167. Narra, V. R., Howell, R. W., Harapanhalli, R. S., Sastry, K. S. R., Rao, D. V. Radiotoxicity of some I-123, I-125 and iodine-131-labeled compounds in mouse testes-implications for radiopharmaceutical design. J. Nuc. Med., 1992, 33: 2196-2201.
168. Krisch, R. E., Sauri, C. J. Further studies of DNA damage and lethality from the decay of iodine-125 in bacteriophages. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med., 1975, 27: 553-60.
169. Martin, R. F., Haseltine, W. A. Range of Radiochemical Damage to DNA with Decay of I125. Science, 1981, 213: 896-898.
170. Krisch, R. E., Krasin, F., Sauri, C. J. DNA breakage, repair and lethality after 125I decay in rec+ and recA strains of Escherichia coli. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med., 1976, 29: 37-50.
171. Geselowitz, D. A., McManaway, M. E., Hofer, K. G., Neumann, R. D. The cytotoxicity of decays of tritium and iodine-125 incorporated in DNA of mammalian cells. Implications for the low-LET dosimetry of incorporated nuclides. Radiat. Res., 1995, 142: 321-6.
172. Laster, B. H., Shani, G., Kahl, S. B., Warkentien, L. The biological effects of Auger electrons compared to α-particles and Li ions. Acta Oncol., 1996, 35: 917-923.
173. Kiefer, J., Egenolf, R., Ikpeme, S. Heavy ion-induced DNA double-strand breaks in yeast. Radiat. Res., 2002, 157: 141-148.
174. Krisch, R. E., Ley, R. D. Induction of lethality and DNA breakage by the decay of iodine-125 in bacteriophage T4. Int. J. Radiat. Biol., 1974, 25: 21-30.
175. 125I incorporated into mammalian DNA. Proc. Natl. Acad. Sci. U. S. A., 1974, 71: 4836-4838.
176. Feinendegen, L. E. Biological damage from the Auger effect, possible benefits. Radiat. Environ. Biophys., 1975, 12: 85-99.
177. Kassis, A. I., Adelstein, S. J. 5-[125]iodo-2′-deoxyuridine in the radiotherapy of solid CNS tumors in rats. Acta Oncol., 1996, 35: 935-9.
178. Kassis, A. I., Adelstein, S. J. Preclinical animal studies with radioiododeoxyuridine. J. Nucl. Med., 1996, 37: S10-S12.
179. Klecker, R. W., Jenkins, J. F., Kinsella, T. J., Fine, R. L., Strong, J. M., Collins, J. M. Clinical-Pharmacology of 5-Iodo-2′-Deoxyuridine and 5-Iodouracil and Endogenous Pyrimidine Modulation. Clin. Pharmacol. Ther., 1985, 38: 45-51.
180. Kassis, A. I., Tumeh, S. S., Wen, P. Y. C., Baranowska Kortylewicz, J., VandenAbbeele, A. D., Zimmerman, R. E., Carvalho, P. A., Garada, B. M., DeSisto, W. C., Bailey, N. O., Castronovo, F. P., Mariani, G., Black, P. M., Adelstein, S. J. Intratumoral administration of 5-[I-123]iodo-2′ deoxyuridine in a patient with a brain tumor. J. Nucl. Med., 1996, 37: S19-S22.
181. Mariani, G., Collecchi, P., Baldassarri, S., DiLuca, L., Buralli, S., Fontanini, G., BaranowskaKortylewicz, J., Adelstein, S. J., Kassis, A. I. Tumor uptake and mitotic activity pattern of 5-[I-125]iodo-2′-deoxyuridine after intravesical infusion in patients with bladder cancer. J. Nucl. Med., 1996, 37: S16-S19.
182. Mariani, G., DiSacco, S., Volterrani, D., DiLuca, L., Buralli, S., DiStefano, R., BaranowskaKortylewicz, J., Bonora, D., Matteucci, F., Ricci, S., Bellina, C. R., Falcone, A., Salvadori, P. A., Mosca, F., Adelstein, S. J., Kassis, A. I. Tumor targeting by intra-arterial infusion of 5-[I-123]iodo-2′-deoxyuridine in patients with liver metastases from colorectal cancer. J. Nucl. Med., 1996, 37: S22-S25.
183. Hofer, K. G. Biophysical aspects of Auger processes - A review. Acta Oncol., 1996, 35: 789-96.
184. McLaughlin, W. H., Milius, R. A., Pillai, K. M., Edasery, J. P., Blumenthal, R. D., Bloomer, W. D. Cytotoxicity of receptor-mediated 16 α-[125I]iodoestradiol in cultured MCF-7 human breast cancer cells. J. Natl. Cancer Inst., 1989, 81: 437-40.
185. DeSombre, E. R., Shafii, B., Hanson, R. N., Kuivanen, P. C., Hughes, A. Estrogen receptor-directed radiotoxicity with Auger electrons specificity and mean lethal dose. Cancer Res., 1992, 52: 5752-8.
186. Desombre, E. R., Pribish, J., Hughes, A. Comparison of the distribution of radioiodinated di- and tri-hydroxyphenylethylene estrogens in the immature female rat. Nucl. Med. Biol., 1995, 22: 679-87.
187. DeSombre, E. R., Hughes, A., Landel, C. C., Greene, G., Hanson, R., Schwartz, J. L. Cellular and subcellular studies of the radiation effects of Auger electron-emitting estrogens. Acta Oncol., 1996, 35: 833-840.
188. Schwartz, J. L., Mustafi, R., Hughes, A., DeSombre, E. R. DNA and chromosome breaks induced by iodine-123-labeled estrogen in Chinese hamster ovary cells. Radiat. Res., 1996, 146: 151-158.
189. DeSombre, E. R., Hughes, A., Landel, C. C., Greene, G., Hanson, R., Schwartz, J. L. Cellular and subcellular studies of the radiation effects of Auger electron-emitting estrogens. Acta Oncol., 1996, 35: 833-40.
190. DeSombre, E. R., Hughes, A., Hanson, R. N., Kearney, T. Therapy of estrogen receptor-positive micrometastases in the peritoneal cavity with Auger electron-emitting estrogens - theoretical and practical considerations. Acta Oncol., 2000, 39: 659-66.
191. Yasui, L., Hughes, A., DeSombre, E. Relative biological effectiveness of accumulated 125IdU and 125I- estrogen decays in estrogen receptor-expressing MCF-7 human breast cancer cells. Radiat. Res., 2001, 155: 328-34.
192. Beckmann, M. W., Scharl, A., Rosinsky, B. J., Holt, J. A. Breaks in DNA accompany estrogen-receptor-mediated cytotoxicity from 16 α-[125I]iodo-17 β-estradiol. J. Cancer Res. Clin. Oncol., 1993, 119: 207-14.
193. Panyutin, I. G., Neumann, R. D. Sequence-specific DNA double-strand breaks induced by triplex forming 125I labeled oligonucleotides. Nucleic Acids Res., 1994, 22: 4979-82.
194. Panyutin, I. G., Neumann, R. D. Sequence-specific DNA breaks produced by triplex-directed decay of iodine-125. Acta Oncol., 1996, 35: 817-23.
195. Delporte, C., Panyutin, I. G., Sedelnikova, O. A., Lillibridge, C. D., O'Connell, B. C., Baum, B. J. Triplex-forming oligonucleotides can modulate aquaporin-5 gene expression in epithelial cells. Antisense Nucleic Acid Drug Dev., 1997, 7: 523-9.
196. Hoque, A. T. M. S., Panyutin, I. G., Baum, B. J. Use of triplex-forming oligonucleotides and adenoviral constructs for studying the regulation of gene expression. Methods-A Companion To Methods In Enzymology, 1999, 18: 266-272.
197. 125I-labeled triplex-forming oligonucleotides is highly mutagenic following repair in human cells. Nucleic Acids Res., 1999, 27: 4282-90.
198. Sedelnikova, O. A., Luu, A. N., Karamychev, V. N., Panyutin, I. G., Neumann, R. D. Development of DNA-based radiopharmaceuticals carrying Auger- electron emitters for antigene radiotherapy. Int. J. Radiat. Oncol. Biol. Phys., 2001, 49: 391-396.
199. Panyutin, I. G., Neumann, R. D. Radioprobing of DNA: distribution of DNA breaks produced by decay of 125I incorporated into a triplex-forming oligonucleotide correlates with geometry of the triplex. Nucleic Acids Res., 1997, 25: 883-7.
200. Sedelnikova, O. A., Panyutin, I. G., Thierry, A. R., Neuman, R. D. Radiotoxicity of iodine-125-labeled oligodeoxyribonucleotides in mammalian cells. J. Nucl. Med., 1998, 39: 1412-1418.
201. Odersky, A., Panyutin, I. V., Panyutin, I. G., Schunck, C., Feldmann, E., Goedecke, W., Neumann, R. D., Obe, G., Pfeiffer, P. Repair of Sequence-specific 125I-induced Double-strand Breaks by Nonhomologous DNA End Joining in Mammalian Cell-free Extracts. J. Biol. Chem., 2002, 277: 11756-11764.
202. Sedelnikova, O. A., Panyutin, I. G., Luu, A. N., Reed, M. W., Licht, T., Gottesman, M. M., Neumann, R. D. Targeting the human mdr1 gene by I-125-labeled triplex-forming oligonucleotides. Antisense Nucleic Acid Drug Dev., 2000, 10: 443-452.
203. Karamychev, V. N, Reed, M. W., Neumann, R. D., Panyutin, I. G. Distribution of DNA strand breaks produced by iodine-123 and indium-111 in synthetic oligodeoxynucleotides. Acta Oncol., 2000, 39: 687-692.
204. Karamychev, V. N., Panyutin, I. G., Kim, M. K., Le, N., Paik, C. H., Carrasquillo, J. A., Reed, M. W., Neumann, R. D. DNA cleavage by In-111-labeled oligodeoxyribonucleotide. J. Nucl. Med., 2000, 41: 1093-1101. 105 Faria, M., Wood, C. D., Perrouault, L., Nelson, J. S., Winter, A., White, M. R. H., Helene, C., Giovannangeli, C. Targeted inhibition of transcription elongation in cells mediated by triplex-forming oligonucleotides. Proc. Natl. Acad. Sci. U. S. A., 2000, 97: 3862-3867.
205. Faria, M., Wood, C. D., Perrouault, L., Nelson, J. S., Winter, A., White, M. R. H., Helene, C., Giovannangeli, C. Targeted inhibition of transcription elongation in cells mediated by triplex-forming oligonucleotides. Proc. Natl. Acad. Sci. U. S. A., 2000, 97: 3862-3867.
206. Giovannangeli, C., Diviacco, S., Labrousse, V., Gryaznov, S., Charneau, P., Helene, C. Accessibility of nuclear DNA to triplex-forming oligonucleotides: The integrated HIV-1 provirus as a target. Proc. Natl. Acad. Sci. U. S. A., 1997, 94: 79-84.
207. Xu, X. X. S., Glazer, P. M., Wang, G. Activation of human γ-globin gene expression via triplex-forming oligonucleotide (TFO)-directed mutations in the γ-globin gene 5′ flanking region. Gene, 2000, 242: 219-228.
208. Stamatoyannopoulos, G., Neinhuis, A., Majerus, X., Varmus, X. The Molecular Basis of Blood Diseases, W.B. Saunders Company: Philadelphia, PA 1994.
209. Svinarchuk, F., Nagibneva, I., Cherny, D., Ait-Si-Ali, S., Pritchard, L. L., Robin, P., Malvy, C., Harel-Bellan, A. Recruitment of transcription factors to the target site by triplex-forming oligonucleotides (Vol. 25: pg. 3459, 1997). Nucleic Acids Res., 1997, 25: 3459-3464.
210. Kuznetsova, S., Ait-Si-Ali, S., Nagibneva, I., Troalen, F., Le Villain, J. P., Harel-Bellan, A., Svinarchuk, F. Gene activation by triplex-forming oligonucleotide coupled to the activating domain of protein VP16. Nucleic Acids Res., 1999, 27: 3995-4000.
211. Panyutin, I. G., Neumann, R. D. Sequence-specific DNA double-strand breaks induced by triplex forming I-125 labeled oligonucleotides. Nucleic Acids Res., 1994, 22: 4979-4982.
212. Kane, S. A., Hecht, S. M., Sun, J. S., Garestier, T., Helene, C. Specific cleavage of a DNA triple helix by FeII•bleomycin. Biochemistry, 1995, 34: 16715-16724.
213. Wang, G., Glazer, P. M. Altered repair of targeted psoralen photoadducts in the context of an oligonucleotide-mediated triple-helix. J. Biol. Chem., 1995, 270: 22595-22601.
214. Grant, K. B., Dervan, P. B. Sequence-specific alkylation and cleavage of DNA mediated by purine motif triple helix formation. Biochemistry, 1996, 38: 12313-12319.
215. Guieysse, A. L., Praseuth, D., Grigoriev, M., HarelBellan, A., Helene, C. Detection of covalent triplex within human cells. Nucleic Acids Res., 1996, 24: 4210-4216.
216. Lukhtanov, E. A., Mills, A. G., Kutyavin, I. V., Gorn, V. V., Reed, M. W., Meyer, R. B. Minor groove DNA alkylation directed by major groove triplex forming oligodeoxyribonucleotides. Nucleic Acids Res., 1997, 25: 5077-5084.
217. Karamychev, V. N., Panyutin, I. G., Kim, M. K., Reed, M. W., Le, N., Paik, C. H., Carrasquillo, J. A., Neumann, R. D. DNA cleavage by decay of auger-emitting isotopes attached to oligonucleotides through linkers. J. Nuc. Med., 1998, 39: 236P.
218. Perkins, B. D., Wensel, T. G., Vasquez, K. M., Wilson, J. H. Psoralen photo-cross-linking by triplex-forming oligonucleotides at multiple sites in the human rhodopsin gene. Biochemistry, 1999, 38: 12850-12859.
219. Perkins, B. D., Wilson, J. H., Wensel, T. G. Triplex-directed site-specific DNA photo-crosslinking by oligonucleotides targeted to multiple sites in the human rhodopsin gene. Invest. Ophthalmol. Vis. Sci., 1999, 40: 4015.
220. Arimondo, P. B., Bailly, C., Boutorine, A. S., Moreau, P., Prudhomme, M., Sun, J. S., Garestier, T., Helene, C. Triple helix-forming oligonucleotides conjugated to indolocarbazole poisons direct topoisomerase I-mediated DNA cleavage to a specific site. Bioconjugate Chem., 2001, 12: 501-509.
221. Teulade-Fichou, M. P., Perrin, D., Boutorine, A., Polverari, D., Vigneron, J. P., Lehn, J. M., Sun, J. S., Garestier, T., Helene, C. Direct photocleavage of HIV-DNA by quinacridine derivatives triggered by triplex formation. J. Am. Chem. Soc., 2001, 123: 9283-9292.
222. Ziemba, A., Derosier, L. C., Methvin, R., Song, C. Y., Clary, E., Kahn, W., Milesi, D., Gorn, V., Reed, M., Ebbinghaus, S. Repair of triplex-directed DNA alkylation by nucleotide excision repair. Nucleic Acids Res., 2001, 29: 4257-4263.
223. Wang, G., Levy, D. D., Seidman, M. M., Glazer, P. M. Targeted mutagenesis in mammalian-cells mediated by intracellular triple-helix formation. Mol. Cell. Biol., 1995, 15: 1759-1768.
224. Vasquez, K. M., Wilson, J. H. Triplex-directed modification of genes and gene activity. Trends Biochem. Sci., 1998, 23: 4-9.
225. Barre, F. X., Giovannangeli, C., Helene, C., Harel-Bellan, A. Covalent crosslinks introduced via a triple helix-forming oligonucleotide coupled to psoralen are inefficiently repaired. Nucleic Acids Res., 1999, 27: 743-749.
226. Oh, D. H., Hanawalt, P. C. Triple helix-forming oligonucleotides target psoralen adducts to specific chromosomal sequences in human cells. Nucleic Acids Res., 1999, 27: 4734-4742.
227. Praseuth, D., Guieysse, A. L., Helene, C. Triple helix formation and the antigene strategy for sequence-specific control of gene expression. Biochim. Biophys. Acta-Gene Struct. Expression, 1999, 1489, 181-206.
228. Barre, F. X., Ait-Si-Ali, S., Giovannangeli, C., Luis, R., Robin, P., Pritchard, L. L., Helene, C., Harel-Bellan, A. Unambiguous demonstration of triple-helix-directed gene modification. Proc. Natl. Acad. Sci. U. S. A., 2000, 97: 3084-3088.
229. Guieysse, A. L., Praseuth, D., Giovannangeli, C., Asseline, U., Helene, C. Psoralen adducts induced by triplex-forming oligonucleotides are refractory to repair in HeLa cells. J. Mol. Biol., 2000, 296: 373-383.
230. Intody, Z., Perkins, B. D., Wilson, J. H., Wensel, T. G. Blocking transcription of the human rhodopsin gene by triplex-mediated DNA photocrosslinking. Nucleic Acids Res., 2000, 28: 4283-4290.
231. Lin, F. L. M., Majumdar, A., Klotz, L. C., Reszka, A. P., Neidle, S., Seidman, M. M. Stability of DNA triplexes on shuttle vector plasmids in the replication pool in mammalian cells. J. Biol. Chem., 2000, 275: 39117-39124.
232. Faria, M., Wood, C. D., White, M. R. H., Helene, C., Giovannangeli, C. Transcription inhibition induced by modified triple helix-forming oligonucleotides: A quantitative assay for evaluation in cells. J. Mol. Biol., 2001, 306: 15-24.
233. Puri, N., Majumdar, A., Cuenoud, B., Natt, F., Martin, P., Boyd, A., Miller, P. S., Seidman, M. M. Targeted gene knockout by 2′-O-aminoethyl modified triplex forming oligonucleotides. J. Biol. Chem., 2001, 276: 28991-28998.
234. Casey, B. P., Glazer, P. M. In Progress in Nucleic Acid Research and Molecular Biology, Vol 67; Academic Press Inc: San Diego, 2001; Vol, 67: pp. 163-192.
235. Vasquez, K. M., Wang, G., Havre, P. A., Glazer, P. M. Chromosomal mutations induced by triplex-forming oligonucleotides in mammalian cells. Nucleic Acids Res., 1999, 27: 1176-1181.
236. Wang, G., Seidman, M. M., Glazer, P. M. Mutagenesis in mammalian cells induced by triple helix formation and transcription-coupled repair. Science, 1996, 271: 802-805.
237. Majumdar, A., Khorlin, A., Dyatkina, N., Lin, F. L. M., Powell, J., Liu, J., Feiz, Z. Z., Khripine, Y., Watanabe, K. A., George, J., Glazer, P. M., Seidman, M. M. Targeted gene knockout mediated by triple helix forming oligonucleotides. Nature Genet., 1998, 20: 212-214.
238. Moser, H. E., Dervan, P. B. Sequence-specific cleavage of double helical DNA by triple helix formation. Science, 1987, 238: 645-50.
239. Strobel, S. A., Doucettestamm, L. A., Riba, L., Housman, D. E., Dervan, P. B. Site-specific cleavage of human chromosome-4 mediated by triple-helix formation. Science, 1991, 254: 1639-1642.
240. Arimondo, P. B., Moreau, P., Boutorine, A., Bailly, C., Prudhomme, M., Sun, J. S., Garestier, T., Helene, C. Recognition and cleavage of DNA by rebeccamycin- or benzopyridoquinoxaline conjugated of triple helix-forming oligonucleotides. Bioorg. Med. Chem., 2000, 8: 777-784.
241. Vasquez, K. M., Narayanan, L., Glazer, P. M. Specific mutations induced by triplex-forming oligonucleotides in mice. Science, 2000, 290: 530-533.
242. Faruqi, A. F., Datta, H. J., Carroll, D., Seidman, M. M., Glazer, P. M. Triple-helix formation induces recombination in mammalian cells via a nucleotide excision repair-dependent pathway. Mol. Cell. Biol., 2000, 20: 990-1000.
243. Wang, G., Chen, Z. W., Zhang, S. J., Wilson, G. L., Jing, K. Detection and determination of oligonucleotide tripler formation-mediated transcription-coupled DNA repair in HeLa nuclear extracts. Nucleic Acids Res., 2001, 29: 1801-1807.
244. Faruqi, A. F., Seidman, M. M., Segal, D. J., Carroll, D., Glazer, P. M. Recombination induced by triple-helix-targeted DNA damage in mammalian cells. Mol. Cell. Biol., 1996, 16: 6820-6828.
245. Raha, M., Wang, G., Seidman, M. M., Glazer, P. M. Mutagenesis by third-strand-directed psoralen adducts in repair-deficient human cells: high frequency and altered spectrum in a xeroderma pigmentosum variant. Proc. Natl. Acad. Sci. U. S. A., 1996, 93: 2941-2946.
246. Panyutin, I. G., Winters, T. A., Feinendegen, L. E., Neumann, R. D. Development of DNA-based radiopharmaceuticals carrying Auger- electron emitters for anti-gene radiotherapy. Q. J. Nucl. Med., 2000, 44: 256-267.
247. Howell, R. W. Radiation spectra for Auger-electron emitting radionuclides: report No. 2 of AAPM Nuclear Medicine Task Group No. 6. Medical Physics, 1992, 19: 1371-83.
248. Sastry, K. S. R. Biological effects of the Auger emitter I-125 - a review - report No. 1 of AAPM-nuclear-medicine-task-group No. 6. Medical Physics, 1992, 19: 1361-1370.
249. Bertoncini, C. R., Meneghini, R. DNA strand breaks produced by oxidative stress in mammalian cells exhibit 3′-phosphoglycolate termini. Nucleic Acids Res., 1995, 23: 2995-3002.
250. Buchko, G. W., Weinfeld, M. Influence of nitrogen, oxygen, and nitroimidazole radiosensitizers on DNA damage induced by ionizing radiation. Biochemistry, 1993, 32: 2186-2193.
251. Henner, W. D., Grunberg, S. M., Haseltine, W. A. Enzyme action at 3′ termini of ionizing radiation-induced DNA strand breaks. J. Biol. Chem., 1983, 258: 15198-15205.
252. Sikpi, M. O., Dry, S. M., Freedman, M. L., Lurie, A. G. Mutations caused by γ-radiation-induced double-strand breaks in a shuttle plasmid replicated in human lymphoblasts. Int. J. Radiat. Biol., 1992, 62: 555-562.
253. Dar, M. E., Jorgensen, T. J. Deletions at short direct repeats and base substitutions are characteristic mutations for bleomycin-induced double- and single-strand breaks, respectively, in a human shuttle vector system. Nucleic Acids Res., 1995, 23: 3224-3230.
254. Winters, T. A., Russell, P. S., Kohli, M., Dar, M. E., Neumann, R. D., Jorgensen, T. J. Determination of human DNA polymerase utilization for the repair of a model ionizing radiation-induced DNA strand break lesion in a defined vector substrate. Nucleic Acids Res., 1999, 27: 2423-2433.
255. Nilsen, H., Rosewell, I., Robins, P., Skjelbred, C. F., Andersen, S., Slupphaug, G., Daly, G., Krokan, H. E., Lindahl, T., Barnes, D. E. Uracil-DNA glycosylase (UNG)-deficient mice reveal a primary role of the enzyme during DNA replication. Mol. Cell, 2000, 5: 1059-65.
256. Radany, E. H., Dornfeld, K. J., Sanderson, R. J., Savage, M. K., Majumdar, A., Seidman, M. M., Mosbaugh, D. W. Increased spontaneous mutation frequency in human cells expressing the phage PBS2-encoded inhibitor of uracil-DNA glycosylase. Mutat. Res.-DNA Repair, 2000, 461: 41-58.
257. Ward, J. F. The complexity of DNA damage: Relevance to biological consequences. Int. J. Radiat. Biol., 1994, 66: 427-432.
258. Ward, J. F., Jones, G. D. D., Milligan, J. R. Biological consequences of nonhomogeneous energy deposition by ionizing-radiation. Radiat. Prot. Dosim., 1994, 52: 271-276.
259. Ward, J. F. Radiation mutagenesis: The initial DNA lesions responsible. Commentary. Radiat. Res., 1995, 142: 362-368.
260. Wallace, S. S. Enzymatic processing of radiation-induced free radical damage in DNA. Radiat. Res., 1998, 150: S60-S79.
261. Chaudhry, M. A., Weinfeld, M. The action of Escherichia coli endonuclease III on multiply damaged sites in DNA. J. Mol. Biol., 1995, 249: 914-922.
262. Pfeiffer, P. The mutagenic potential of DNA double-strand break repair. Toxicol. Lett., 1998, 96-7: 119-129.
263. Jeggo, P. A. Identification of genes involved in repair of DNA double-strand breaks in mammalian cells. Radiat. Res., 1998, 150: S80-S91.
264. Karran, P. DNA double strand break repair in mammalian cells. Curr. Opin. Genet. Dev., 2000, 10: 144-150.
265. Rao, D. V., Narra, V. R., Howell, R. W., Sastry, K. S. R. Biological consequence of nuclear versus cytoplasmic decays of I-125-cysteamine as a radioprotector against Auger cascades in vivo. Radiat. Res., 1990, 124: 188-193.
266. Howell, R. W., Rao, D. V., Hou, D. Y., Narra, V. R., Sastry, K. S. R. The question of relative biological effectiveness and quality factor for Auger emitters incorporated into proliferating mammalian-cells. Radiat. Res., 1991, 128: 282-292.
267. Narra, V. R., Howell, R. W., Harapanhalli, R. S., Sastry, K. S. R., Rao, D. V. Radiotoxicity of some I-123, I-125 and iodine-131-labeled compounds in mouse testes-implications for radiopharmaceutical design. J. Nuc. Med., 1992, 33: 2196-2201.
268. Krisch, R. E., Sauri, C. J. Further studies of DNA damage and lethality from the decay of iodine-125 in bacteriophages. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med., 1975, 27: 553-60.
269. Martin, R. F., Haseltine, W. A. Range of Radiochemical Damage to DNA with Decay of I125. Science, 1981, 213: 896-898.
270. Krisch, R. E., Krasin, F., Sauri, C. J. DNA breakage, repair and lethality after 125I decay in rec+ and recA strains of Escherichia coli. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med., 1976, 29: 37-50.
271. Geselowitz, D. A., McManaway, M. E., Hofer, K. G., Neumann, R. D. The cytotoxicity of decays of tritium and iodine-125 incorporated in DNA of mammalian cells. Implications for the low-LET dosimetry of incorporated nuclides. Radiat. Res., 1995, 142: 321-6.
272. Laster, B. H., Shani, G., Kahl, S. B., Warkentien, L. The biological effects of Auger electrons compared to α-particles and Li ions. Acta Oncol., 1996, 35: 917-923.
273. Kiefer, J., Egenolf, R., Ikpeme, S. Heavy ion-induced DNA double-strand breaks in yeast. Radiat. Res., 2002, 157: 141-148.
274. Krisch, R. E., Ley, R. D. Induction of lethality and DNA breakage by the decay of iodine-125 in bacteriophage T4. Int. J. Radiat. Biol., 1974, 25: 21-30.
275. 125I incorporated into mammalian DNA. Proc. Natl. Acad. Sci. U. S. A., 1974, 71: 4836-4838.
276. Feinendegen, L. E. Biological damage from the Auger effect, possible benefits. Radiat. Environ. Biophys., 1975, 12: 85-99.
277. Kassis, A. I., Adelstein, S. J. 5-[125]iodo-2′-deoxyuridine in the radiotherapy of solid CNS tumors in rats. Acta Oncol., 1996, 35: 935-9.
278. Kassis, A. I., Adelstein, S. J. Preclinical animal studies with radioiododeoxyuridine. J. Nucl. Med., 1996, 37: S10-S12.
279. Klecker, R. W., Jenkins, J. F., Kinsella, T. J., Fine, R. L., Strong, J. M., Collins, J. M. Clinical-Pharmacology of 5-Iodo-2′-Deoxyuridine and 5-Iodouracil and Endogenous Pyrimidine Modulation. Clin. Pharmacol. Ther., 1985, 38: 45-51.
280. Kassis, A. I., Tumeh, S. S., Wen, P. Y. C., Baranowska Kortylewicz, J., VandenAbbeele, A. D., Zimmerman, R. E., Carvalho, P. A., Garada, B. M., DeSisto, W. C., Bailey, N. O., Castronovo, F. P., Mariani, G., Black, P. M., Adelstein, S. J. Intratumoral administration of 5-[I-123]iodo-2′ deoxyuridine in a patient with a brain tumor. J. Nucl. Med., 1996, 37: S19-S22.
281. Mariani, G., Collecchi, P., Baldassarri, S., DiLuca, L., Buralli, S., Fontanini, G., BaranowskaKortylewicz, J., Adelstein, S. J., Kassis, A. I. Tumor uptake and mitotic activity pattern of 5-[I-125]iodo-2′-deoxyuridine after intravesical infusion in patients with bladder cancer. J. Nucl. Med., 1996, 37: S16-S19.
282. Mariani, G., DiSacco, S., Volterrani, D., DiLuca, L., Buralli, S., DiStefano, R., BaranowskaKortylewicz, J., Bonora, D., Matteucci, F., Ricci, S., Bellina, C. R., Falcone, A., Salvadori, P. A., Mosca, F., Adelstein, S. J., Kassis, A. I. Tumor targeting by intra-arterial infusion of 5-[I-123]iodo-2′-deoxyuridine in patients with liver metastases from colorectal cancer. J. Nucl. Med., 1996, 37: S22-S25.
283. Hofer, K. G. Biophysical aspects of Auger processes - A review. Acta Oncol., 1996, 35: 789-96.
284. McLaughlin, W. H., Milius, R. A., Pillai, K. M., Edasery, J. P., Blumenthal, R. D., Bloomer, W. D. Cytotoxicity of receptor-mediated 16 α-[125I]iodoestradiol in cultured MCF-7 human breast cancer cells. J. Natl. Cancer Inst., 1989, 81: 437-40.
285. DeSombre, E. R., Shafii, B., Hanson, R. N., Kuivanen, P. C., Hughes, A. Estrogen receptor-directed radiotoxicity with Auger electrons specificity and mean lethal dose. Cancer Res., 1992, 52: 5752-8.
286. Desombre, E. R., Pribish, J., Hughes, A. Comparison of the distribution of radioiodinated di- and tri-hydroxyphenylethylene estrogens in the immature female rat. Nucl. Med. Biol., 1995, 22: 679-87.
287. DeSombre, E. R., Hughes, A., Landel, C. C., Greene, G., Hanson, R., Schwartz, J. L. Cellular and subcellular studies of the radiation effects of Auger electron-emitting estrogens. Acta Oncol., 1996, 35: 833-840.
288. Schwartz, J. L., Mustafi, R., Hughes, A., DeSombre, E. R. DNA and chromosome breaks induced by iodine-123-labeled estrogen in Chinese hamster ovary cells. Radiat. Res., 1996, 146: 151-158.
289. DeSombre, E. R., Hughes, A., Landel, C. C., Greene, G., Hanson, R., Schwartz, J. L. Cellular and subcellular studies of the radiation effects of Auger electron-emitting estrogens. Acta Oncol., 1996, 35: 833-40.
290. DeSombre, E. R., Hughes, A., Hanson, R. N., Kearney, T. Therapy of estrogen receptor-positive micrometastases in the peritoneal cavity with Auger electron-emitting estrogens - theoretical and practical considerations. Acta Oncol., 2000, 39: 659-66.
291. Yasui, L., Hughes, A., DeSombre, E. Relative biological effectiveness of accumulated 125IdU and 125I- estrogen decays in estrogen receptor-expressing MCF-7 human breast cancer cells. Radiat. Res., 2001, 155: 328-34.
292. Beckmann, M. W., Scharl, A., Rosinsky, B. J., Holt, J. A. Breaks in DNA accompany estrogen-receptor-mediated cytotoxicity from 16 α-[125I]iodo-17 β-estradiol. J. Cancer Res. Clin. Oncol., 1993, 119: 207-14.
293. Panyutin, I. G., Neumann, R. D. Sequence-specific DNA double-strand breaks induced by triplex forming 125I labeled oligonucleotides. Nucleic Acids Res., 1994, 22: 4979-82.
294. Panyutin, I. G., Neumann, R. D. Sequence-specific DNA breaks produced by triplex-directed decay of iodine-125. Acta Oncol., 1996, 35: 817-23.
295. Delporte, C., Panyutin, I. G., Sedelnikova, O. A., Lillibridge, C. D., O'Connell, B. C., Baum, B. J. Triplex-forming oligonucleotides can modulate aquaporin-5 gene expression in epithelial cells. Antisense Nucleic Acid Drug Dev., 1997, 7: 523-9.
296. Hoque, A. T. M. S., Panyutin, I. G., Baum, B. J. Use of triplex-forming oligonucleotides and adenoviral constructs for studying the regulation of gene expression. Methods-A Companion To Methods In Enzymology, 1999, 18: 266-272.
297. 125I-labeled triplex-forming oligonucleotides is highly mutagenic following repair in human cells. Nucleic Acids Res., 1999, 27: 4282-90.
298. Sedelnikova, O. A., Luu, A. N., Karamychev, V. N., Panyutin, I. G., Neumann, R. D. Development of DNA-based radiopharmaceuticals carrying Auger- electron emitters for antigene radiotherapy. Int. J. Radiat. Oncol. Biol. Phys., 2001, 49: 391-396.
299. Panyutin, I. G., Neumann, R. D. Radioprobing of DNA: distribution of DNA breaks produced by decay of 125I incorporated into a triplex-forming oligonucleotide correlates with geometry of the triplex. Nucleic Acids Res., 1997, 25: 883-7.
300. Sedelnikova, O. A., Panyutin, I. G., Thierry, A. R., Neuman, R. D. Radiotoxicity of iodine-125-labeled oligodeoxyribonucleotides in mammalian cells. J. Nucl. Med., 1998, 39: 1412-1418.
301. Odersky, A., Panyutin, I. V., Panyutin, I. G., Schunck, C., Feldmann, E., Goedecke, W., Neumann, R. D., Obe, G., Pfeiffer, P. Repair of Sequence-specific 125I-induced Double-strand Breaks by Nonhomologous DNA End Joining in Mammalian Cell-free Extracts. J. Biol. Chem., 2002, 277: 11756-11764.
302. Sedelnikova, O. A., Panyutin, I. G., Luu, A. N., Reed, M. W., Licht, T., Gottesman, M. M., Neumann, R. D. Targeting the human mdr1 gene by I-125-labeled triplex-forming oligonucleotides. Antisense Nucleic Acid Drug Dev., 2000, 10: 443-452.
303. Karamychev, V. N, Reed, M. W., Neumann, R. D., Panyutin, I. G. Distribution of DNA strand breaks produced by iodine-123 and indium-111 in synthetic oligodeoxynucleotides. Acta Oncol., 2000, 39: 687-692.
304. Karamychev, V. N., Panyutin, I. G., Kim, M. K., Le, N., Paik, C. H., Carrasquillo, J. A., Reed, M. W., Neumann, R. D. DNA cleavage by In-111-labeled oligodeoxyribonucleotide. J. Nucl. Med., 2000, 41: 1093-1101.