In vivo hybridization of technetium-99m-labeled peptide nucleic acid (PNA)

Journal of Nuclear Medicine

Volumn 38, Issue 6, 1997, Pages 907-913

  Mardirossian, G ^b   Lei, K ^b   Rusckowski, M ^b   Chang, F ^b   Qu, T ^b   Egholm, M ^b   Hnatowich, D J ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b NONE

Author keywords

Hybridization; Pharmacokinetics; Technetium 99m PNA

Indexed keywords

PEPTIDE NUCLEIC ACID; TECHNETIUM 99M;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG STABILITY; HYBRIDIZATION; ISOTOPE LABELING; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; DNA, SINGLE-STRANDED; HUMANS; ISOTOPE LABELING; MALE; MICE; NUCLEIC ACID HYBRIDIZATION; OLIGODEOXYRIBONUCLEOTIDES; ORGANOTECHNETIUM COMPOUNDS; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION;

EID: 0030970532     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Watson JD, Gilman M, Witkowski J, Zoller M. Recombinant DNA , 2nd ed. New York: Scientific American Books, W.H. Freedman and Co; 1992.
2. Uhlmann E, Peyman A. Antisense oligonucleotides. Chem Rev 1990;90:543-584.
3. Dewanjee MK. Radiolabeled antisense probes: diagnosis and therapy. Diagn Oncol 1993;3:189-208.
4. Dewanjee MK, Ghafouripour AK, Kapakvanjwala M, Dewanjee S, Serafini AN, Lopez DM, Sfakinakis GN. Noninvasive imaging of c-myc oncogene messenger RNA with indium-111-antisense probes in a mammary tumor-bearing mouse model. J Nucl Med 1994;35:1054-1063.
5. Hnatowich DJ, Mardirossian G, Rusckowski M, Winnard P Jr. Protein labeling via deoxyribonucleic acid hybridization. Nucl Med Commun 1997;17:66-75.
6. Kuijpers WHA, Bos ES, Kaspersen FM, Veeneman GH, van Boeckel CAA. Specific recognition of antibody-oligonucleotide conjugates by radiolabeled antisense nucleotides: a novel approach for two-step radioimmunotherapy of cancer. Bioconj Chem 1993;4:94-102.
7. Hnatowich DJ, Winnard P Jr, Virzi F, et al. Amplification of radioactivity using complementary DNA conjugates. Proceedings, Fifth Conference on Radioimmunodetection and Radioimmunotherapy of Cancer. Princeton, NJ; 1994.
8. Wickstrom E. Oligodeoxynucleotide stability in subcellular extracts and culture media. J Biochem Biophys Methods 1986;13:97-102.
9. Cazenave C, Chevrier M, Ngugent T, Helene C. Rate of degradation of alpha- and beta-oligodeoxynucleotides in xenopus oocytes. Implications for anti-messenger strategies. Nucleic Acids Res 1987;15:10507-10521.
10. Ceruzzi M, Draper K. The intracellular and extracellular fate of oligodeoxynucleotides in tissue culture systems. Nucleosides Nucleotides 1989;8:815-818.
11. Goodchild J. Conjugates of oligonucleotides and modified oligonucleotides: a review of their synthesis and properties. Bioconj Chem 1990;1:165-187.
12. Iversen P. In vivo studies with phosphorothioate oligonucleotides: rationale for systemic therapy. In: Crooke ST, Lebleu B, eds. Antisense research and applications. Ann Arbor, MI: CRC Press;1993:462-469.
13. Hnatowich DJ, Mardirossian G, Fogarasi M, et al. Comparative properties of a technetium-99m-labeled single-stranded natural DNA and a phosphorothioate derivative in vitro and in vivo. Pharm Exp Therap 1996;276:326-334.
14. Egholm M, Buchardt O, Nielsen PE, Berg RH. Peptide nucleic acids (PNA): oligonucleotide analogs with an achiral peptide backbone. J Am Chem Soc 1992; 114: 1895-1897.
15. Egholm M, Buchardt O, Christensen L, et al. PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules. Nature 1993;365: 566-568.
16. 99mTc. J Nucl Med 1995;36:2306-2314.
17. 3-coupled oligonucleotides for technetium-99m labeling. Nucl Med Biol 1997: in press.
18. 3 and SHNH-an in vitro and animal in vivo comparison. Nucl Med Biol 1996;23:917-922.
19. Milligan JF, Matteucci MD, Martin JC. Current concepts in antisense drug design. J Med Chem 1993;36:1923-1937.
20. Cook PD. Medicinal chemistry strategies for antisense research. In: Crooke ST, Lebleu B, eds. Antisense research and applications, Boca Raton, FL: CRC Press; 1993;149-187.
21. Crooke RM. Cellular uptake, distribution and metabolism of phosphorothioate, phosphodiester and methylphosphonate oligonucleotides. In: Crooke ST, Lebleu B, eds. Antisense research and applications, Boca Raton, FL: CRC Press; 1993;427-449.
22. Dewanjee MK, Ghafouripour AK, Kapakvanjwala M, Dewanjee S, Serafini AN, Lopez DM, Sfakinakis GN. Noninvasive imaging of c-myc oncogene messenger RNA with indium-111-antisense probes in a mammary tumor-bearing mouse model. J Nucl Med 1994;35:1054-1063.
23. Pardrige WM, Boado RJ, Kang Y-S. Vector-mediated delivery of a polyamine ("peptide") nucleic analog through the blood-brain barrier in vivo. Proc Natl Acad Sci USA 1995;92:5592-5596.