Development of DNA-based radiopharmaceuticals carrying Auger-electron emitters for anti-gene radiotherapy

Quarterly Journal of Nuclear Medicine

Volumn 44, Issue 3, 2000, Pages 256-267

  Panyutin, I G ^a   Winters, T A ^a   Feinendegen, L E ^a   Neumann, R D ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Gene therapy; Nucleic acid conformation; Nucleic acids; Radionuclide imaging; Radiopharmaceuticals; Radiotherapy

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; BROMINE 77; DEOXYCYTIDINE TRIPHOSPHATE; DNA; DNA POLYMERASE; IODINE 123; IODINE 125; OLIGODEOXYRIBONUCLEOTIDE; PENTETATE INDIUM; PLASMID DNA; PURINE NUCLEOSIDE; PYRIMIDINE NUCLEOSIDE; REACTIVE OXYGEN METABOLITE; SYNTHETIC PEPTIDE;

AUGER ELECTRON SPECTROSCOPY; CANCER; CELLULAR DISTRIBUTION; DNA DAMAGE; DNA REPAIR; DNA SEQUENCE; DRUG BINDING; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; DRUG SPECIFICITY; DRUG TARGETING; GENE DELETION; GENE THERAPY; HUMAN; MULTIDRUG RESISTANCE; NUCLEIC ACID STRUCTURE; PHARMACEUTICAL ENGINEERING; PLASMID; RADIATION DOSE; RADIATION DOSE DISTRIBUTION; RADIATION INJURY; RADIATION INJURY REPAIR; RADIOISOTOPE DECAY; REVIEW; TRIPLE HELIX;

ANIMAL; DNA; DNA DAMAGE; DNA REPAIR; HUMAN; IODINE RADIOISOTOPES; NEOPLASMS; NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDES; RADIOPHARMACEUTICALS;

EID: 0033792956     PISSN: 11243937     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (66)

1. Biological damage from the Auger effects, possible benefits
2. Range of radiochemical damage to DNA with decay of iodine-125
3. 125I-DU (5-iodo-2-deoxy-uridine) in autoradiographic studies of cell proliferation
4. Estrogen receptor-directed radiotoxicity with Auger electrons: Specificity and mean lethal dose
5. The anti-gene strategy: Control of gene expression by triplex-forming-oligonucleotides
6. Triplex DNA structures
7. Triple-helical nucleic acids
8. The chemistry and biology of unusual DNA structures adopted by oligopurine oligopyrimidine sequences
9. Unusual DNA structures, chromatin and transcription
10. H-DNA and related structures
11. Progress in developments of triplex-based strategies
12. Triplex DNA: Fundamentals, advances, and potential applications for gene therapy
13. Use of supf, an escherichia-coli tyrosine suppressor transfer - RNA gene, as a mutagenic target in shuttle-vector plasmids
14. Triplex targeting of a native gene in permeabilized intact cells: Covalent modification of the gene for the chemokine receptor ccr5
15. Minor groove DNA alkylation directed by major groove triplex forming oligodeoxyribonucleotides
16. Accessibility of nuclear DNA to triplex-forming oligonucleotides: The integrated HIV-1 provirus as a target
17. Targeted gene knockout mediated by triple helix forming oligonucleotides
18. Relative biological effectiveness of alpha-particle emitters in vivo at low-doses
19. Effects of postirradiation temperature on the yields of radiation-induced single-strand and double-strand breakage in sr40 DNA
20. Radiation mutagenesis - The initial DNA lesions responsible
21. The sequence context - Mispairing of 5-hydroxycytosine and 5-hydroxyuridine in vitro
22. 125I decay and X-ray-induced HPRT mutants in CHO cells
23. The complexity of DNA damage: Relevance to biological consequences
24. 125I labeled triplex forming oligonucleotides is highly mutagenic following repair in human cells
25. Induction of double-strand breaks by S1 nuclease, mung bean nuclease and nuclease P1 in DNA containing abasic sites and nicks
26. 125I incorporated into mammalian DNA
27. DNA strand breakage and repair in human kidney cells after exposure to incorporated iodine-125 and cobalt-60 g-rays
28. 125I incorporated into DNA of mammalian cells
29. 123I and carbon
30. 125I labeled oligonucleotides
31. Sequence-specific DNA breaks produced by triplex-directed decay of iodine-125
32. 125I incorporated into a triplex-forming oligonucleotide correlates with geometry of the triplex
33. Detecting the DNA kinks in a DNA-CRP complex in solution with iodine-125 radioprobing
34. Triplex-forming oligonucleotides can modulate aquaporin-5 gene expression in epithelial cells
35. Radiotoxicity of iodine-125-labeled oligodeoxyribonucleotides in mammalian cells
36. The stability of DNA triplexes inside cells as studied by iodine-125 radioprinting
37. 125I-labeled oligonucleotides
38. 111In labeled oligonucleotides
39. 111In synthetic oligodeoxynucleotides
40. 125I-labeled oligonucleotides from tributylstannylbenzamide conjugates
41. Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells
42. Folding of RNA and DNA strands in transcription complex as revealed by Iodine-125 radioprobing
43. Tracing the nucleic acids strands in large nucleoprotein complexes with Auger electrons: Structure of a RecA-three stranded DNA complex
44. Modelling of radiation-induced DNA damage: The early physical events
45. Use of triplex-forming oligonucleotides and adenoviral constructs for studying the regulation of gene expression
46. Workshop on DNA-repair
47. Identification of genes involved in repair of DNA double-strand breaks in mammalian cells
48. Gammaray induced deoxyribonucleic acid strand breaks
49. Enzyme action at 3' termini of ionizing radiation-induced DNA strand breaks
50. Specific interaction of DNA polymerase beta and DNA ligase I in a multiprotein base excision repair complex from bovine testis
51. Two distinct human DNA diesterases that hydrolyze 3'-blocking deoxyribose fragments from oxidized DNA
52. Involvement of XRCC1 and DNA ligase III gene products in DNA base excision repair
53. Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway
54. Reconstitution of DNA base excision-repair with purified human proteins: Interaction between DNA polymerase beta and the XRCC1 protein
55. XRCC1 protein interacts with one of two distinct forms of DNA ligase III
56. Proliferating cell nuclear antigen-dependent abasic site repair in Xenopus laevis oocytes: An alternative pathway of base excision DNA repair
57. Two pathways for base excision repair in mammalian cells
58. Characterization of the DNA polymerase requirement of human base excision repair
59. Replication protein: A stimulates long patch DNA base excision repair
60. Determination of human DNA polymerase utilization for the repair of a model ionizing radiation-induced DNA strand break lesion in a defined vector substrate
61. Removal of 3'-phosphoglycolate from DNA strand-break damage in an oligonucleotide substrate by recombinant human apurinic/apyrimidinic endonuclease 1
62. Oxygen radical-induced single-strand DNA breaks and repair of the damage in a cell-free system
63. Deletions at short direct repeats and base substitutions are characteristic mutations for bleomycin-induced double- and single-strand breaks, respectively, in a human shuttle vector system
64. Use of SupF, an escherichia coli tyrosine suppressor transfer-RNA gene, as a mutagenic target in shuttle-vector plasmids
65. Mutagenesis by third-strand-directed psoralen adducts in repair-deficient human cells: High frequency and altered spectrum in xeroderma pigmentosum variant