Targeted Gene Knockout by 2′-O-Aminoethyl Modified Triplex Forming Oligonucleotides

Journal of Biological Chemistry

Volumn 276, Issue 31, 2001, Pages 28991-28998

  Puri, Nitin ^a   Majumdar, Alokes ^a   Cuenoud, Bernard ^b   Natt, Francois ^c   Martin, Pierre ^c   Boyd, Andre ^a   Miller, Paul S ^d   Seidman, Michael M ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NOVARTIS HORSHAM RESEARCH CENTRE   (United Kingdom)

^c NOVARTIS PHARMA AG   (Switzerland)

^d JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; CHEMICAL MODIFICATION; GENES; NUCLEIC ACIDS; PH EFFECTS; PHYSIOLOGY; SUBSTITUTION REACTIONS;

BIOLOGICAL ACTIVITY; TRIPLEX FORMING OLIGONUCLEOTIDES (TFO);

BIOCHEMISTRY;

HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MAGNESIUM; OLIGONUCLEOTIDE; PHOSPHORAMIDIC ACID DERIVATIVE; PSORALEN; PYRIMIDINE; AMIDE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; OLIGODEOXYRIBONUCLEOTIDE; PHOSPHORAMIDIC ACID; PHOSPHORIC ACID; PSORALEN DERIVATIVE;

ARTICLE; ASSAY; BINDING AFFINITY; GENE TARGETING; IN VITRO STUDY; IN VIVO STUDY; KINETICS; KNOCKOUT GENE; PH; PRIORITY JOURNAL; THERMOSTABILITY; ANIMAL; BINDING SITE; CHEMISTRY; CHO CELL; CONFORMATION; DRUG STABILITY; EXON; GENE DELETION; GENETIC PROCEDURES; GENETICS; HAMSTER; INTRON; MOLECULAR GENETICS; MUTAGENESIS; NUCLEOTIDE SEQUENCE; SYNTHESIS;

CANIS;

AMIDES; ANIMALS; BASE SEQUENCE; BINDING SITES; CHO CELLS; CRICETINAE; DRUG STABILITY; EXONS; GENETIC TECHNIQUES; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; INDICATORS AND REAGENTS; INTRONS; KINETICS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; NUCLEIC ACID CONFORMATION; OLIGODEOXYRIBONUCLEOTIDES; PHOSPHORIC ACIDS; PSORALENS; SEQUENCE DELETION;

EID: 0035800796     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M103409200     Document Type: Article

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